Leishmania gene amplification: a mechanism of drug resistance

REFERENCES

• Alexander, J. & Russell, D. G. (1992). The interaction of Leishmania species with macrophages. Advances in Parasitology, 31, 158–166.
   Web of Science ®Google Scholar
• Ashford, R. W., Desjeux, P. & DeRaadt, T. (1992). Estimation of population at risk of infection and number of cases of leishmaniasis. Parasitology Today, 8, 104–105.
   PubMedGoogle Scholar
• Beverley, S. M. & Coburn, C. M. (1990). Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extrachromosomal DNAs in other species. Molecular and Biochemical Parasitology, 42, 133–142.
   PubMed Web of Science ®Google Scholar
• Beverley, S. M., Coderre, J. A., Santi, D. V. & Schimke, R. T. (1984). Unstable DNA amplifications in methotrexate-resistant Leishmania consists of extrachromosomal circles which relocalize during stabilization. Cell, 38, 431–439.
   PubMed Web of Science ®Google Scholar
• Bryceson, A. D. M., Chulay, J. D., Muganbii, M., Were, J. B., Muigai, R., Chunge, C., Gachihi, G., Meme, J., Anawani, G. & Bhatt, S. M. (1985). Visceral leishmaniasis unresponsive to antimonial drugs. I. Clinical and immunological studies. Transactions of the Royal Society of Tropical Medicine and Hygiene, 79, 700–704.
   PubMed Web of Science ®Google Scholar
• Callahan, H. L. & Beverley, S. M. (1991). Heavy metal resistance: a new role for P-glycoproteins in Leishmania. Journal of Biological Chemistry, 266, 18427–18430.
   PubMed Web of Science ®Google Scholar
• Callahan, H. L. & Beverley, S. M. (1992). A member of the aldoketo reductase family confers methotrexate resistance in Leishmania. Journal of Biological Chemistry, 267, 24165–24168.
   PubMed Web of Science ®Google Scholar
• Coderre, J. A., Beverley, S. M., Schimke, R. T. & Santi, D. V. (1983). Overproduction of a bifunctional thymidilate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proceedings of the National Academy of Sciences of the United States of America, 80, 2132–2136.
   PubMed Web of Science ®Google Scholar
• Coons, T., Hanson, S., Bitonti, A. J., McCann, P. P. & Ullman, B. (1990). Alpha-difluoromethylornithine resistance in Leishmania donovani is associated with increased ornithine decarboxylase activity. Molecular and Biochemical Parasitology, 39, 77–90.
   PubMed Web of Science ®Google Scholar
• Detke, S., Chaudhuri, G., Kink, J. A. & Chang, K. P. (1988). DNA-amplification in tunicamycin-resistant Leishmania mexicana. Multicopies of a single 63-kilobase supercoiled molecules. Journal of Biological Chemistry, 263, 3418–3424.
   PubMed Web of Science ®Google Scholar
• Detke, S., Katakura, K. & Chang, K. P. (1989). DNA amplification in arsenite resistant Leishmania. Experimental Cell Research, 180, 161–170.
   PubMed Web of Science ®Google Scholar
• Ellemberger, T. E. & Beverley, S. M. (1987a). Biochemistry and regulation of folate and methotrexate transport in Leishmania major. Journal of Biological Chemistry, 262, 10053–10058.
   PubMed Web of Science ®Google Scholar
• Ellemberger, T. E. & Beverley, S. M. (1987b). Reductions in methotrexate and folate efflux in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification. Journal of Biological Chemistry, 262, 13501–13506.
   PubMed Web of Science ®Google Scholar
• Endicott, J. A. & Ling, V. (1989). The biochemistry of P-glycoprotein-mediated multidrug resistance. Annual Review of Biochemistry, 58, 137–171.
   PubMed Web of Science ®Google Scholar
• Gajendran, N., Dujardin, J. C., Le Ray, D., Mattyssens, G., Muyldermans, S. & Hamers, R. (1989). Abnormally migrating chromosome identifies Leishmania donovani populations. In Leishmaniasis: the Current Status and New Strategies for Control, ed. Hart, D. T. pp. 539–547. New York: Plenum Press.
   Google Scholar
• Garvey, E. P., Coderre, J. A. & Santi, D. V. (1985). Selections and properties of Leishmania resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthase. Molecular and Biochemical Parasitology, 17, 79–91.
   PubMed Web of Science ®Google Scholar
• Grogl, M., Martin, R. K., Oduola, A. M. J., Milhous, W. K. & Kyle, D. E. (1991). Characteristics of multidrug resistance in Plasmodium and Leishmania: detection of P-glycoprotein-like components. American Journal of Tropical Medicine and Hygiene, 45, 98–111.
   PubMed Web of Science ®Google Scholar
• Grogl, M., Thomason, T. N. & Frankel, E. D. (1992). Drug resistance in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous disease. American Journal of Tropical Medicine and Hygiene, 47, 171–126.
   Web of Science ®Google Scholar
• Grondin, K., Papadopoulou, B. & Ouellette, M. (1993). Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania. Nucleic Acids Research, 21, 1895–1901.
   PubMed Web of Science ®Google Scholar
• Hanson, S., Adelman, J. & Ullman, B. (1992a). Amplification and molecular cloning of the ornithine decarboxylase gene of Leishmania donovani. Journal of Biological Chemistry, 267, 2350–2359.
   PubMed Web of Science ®Google Scholar
• Hanson, S., Beverley, S. M., Wagner, W. & Ullman, B. (1992b). Unstable amplification of two extrachromosomal elements in alpha-difluoromethylornithine-resistant Leishmania donovani. Molecular and Cellular Biology, 12, 5499–5507.
   PubMed Web of Science ®Google Scholar
• Henderson, D. M., Sifri, C., D., Rogers, M., Wirth, D. F., Hendrickson, N. & Ullman, B. (1992). Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdrl gene. Molecular and Cellular Biology, 12, 2855–2865.
   PubMed Web of Science ®Google Scholar
• Hightower, R. C., Wong, M. L., Ruiz-Perez, L. & Santi, D. V. (1987). Electron microscopy of amplified DNA forms in antifolate-resistant Leishmania. Journal of Biological Chemistry, 262, 14618–14624.
   PubMed Web of Science ®Google Scholar
• Jackson, J. E., Tally, J. D., Ellis, W. Y., Mebrathu, Y. B., Lawyer, P. G., Were, J. B., Reed, S. G., Panisko, D. M. & Limmer, B. L. (1990). Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania spp from patients unresponsive to pentavalent antimony therapy. American Journal of Tropical Medicine and Hygiene, 43, 464–480.
   PubMed Web of Science ®Google Scholar
• Kapler, G. M. & Beverley, S. M. (1989). Transcriptional mapping of the amplified region encoding the dihydrofolate reductase-thymidylate synthetase of Leishmania major reveals a high density of transcripts, including overlapping and antisense RNAs. Molecular and Cellular Biology, 9, 3959–3972.
   PubMed Web of Science ®Google Scholar
• Kapler, G. M., Coburn, C. M. & Beverley, S. M. (1990). Stable transfection of the human parasite Leishmania delineates a 30 Kb region sufficient for extrachromosomal replication and expression. Molecular and Cellular Biology, 10, 1084–1094.
   PubMed Web of Science ®Google Scholar
• Katakura, K. & Chang, K. P. (1989). H DNA Amplification in Leishmania resistant to both arsenite and methotrexate. Molecular and Biochemical Parasitology, 34, 189–192.
   PubMed Web of Science ®Google Scholar
• Katakura, K., Peng, Y., Pithawalla, R., Detke, S. & Chang, K. P. (1991). Tunicamycin-resistant variants from five species of Leishmania contain amplified DNA in extrachromosomal circles of different sizes with a transcriptionally active homologous region. Molecular and Biochemical Parasitology, 44, 233–244.
   PubMed Web of Science ®Google Scholar
• Kaur, K., Coons, T., Emmett, K. & Ullman, B. (1988). Methotrexate resistant Leishmania donovani genetically deficient in the folate methotrexate transporter. Journal of Biological Chemistry, 263, 7020–7028.
   PubMed Web of Science ®Google Scholar
• Kink, J. A. & Chang, K. P. (1987). Tunicamycin resistant Leishmania mexicana amazonensis: expression of virulence associated with and increased activity of N acetylglucosamine-1-phosphate transferase and amplification of its presumptive gene. Proceedings of the National Academy of Sciences of the United States of America, 84, 1253–1257.
   PubMed Web of Science ®Google Scholar
• Liu, J., Gajendran, N., Muthui, D., Muyldermans, S., Dujardin, J. C., De Doncker, S., Jacquer, D., Le Ray, D., Mathieu-Daude, F. & Hamers, R. (1991). Chromosome rearrangement in Leishmania mexicana M379. Molecular and Biochemical Parasitology, 46, 45–52.
   PubMed Web of Science ®Google Scholar
• Liu, J., Salinas, G., Gajendran, N., Muthui, D., Muyldermans, S. & Hamers, R. (1992). DNA recombination associated with short direct repeats in Leishmania mexicana M379. Molecular and Biochemical Parasitology, 50, 351–354.
   PubMed Web of Science ®Google Scholar
• Liu, X. & Chang, K. P. (1992). The 63-kilobase amplicon of tunicamycin-resistant Leishmania amazonensis contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable marker in transfection. Molecular and Cellular Biology, 12, 4112–4122.
   PubMed Web of Science ®Google Scholar
• Modabber, M. (1987). 8th Programme Report of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. Geneva: World Health Organization.
   Google Scholar
• Navarro, M., Maingon, R., Hamers, R. & Segovia, M. (1992). Dynamics and size polymorphism of minichromosomes in Leishmania major LV-561 cloned lines. Molecular and Biochemical Parasitology, 55, 65–74.
   PubMed Web of Science ®Google Scholar
• Neal, R. A., Van Buren, J., McCoy, N. G. & Iwobi, M. (1989). Reversal of drug resistance in Trypanosoma cruzi and Leishmania donovani by verapamil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 83, 197–198.
   PubMed Web of Science ®Google Scholar
• Ouellette, M., Fase-Fowler, F. & Borst, P. (1990). The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene. EMBO Journal, 9, 1027–1033.
   PubMed Web of Science ®Google Scholar
• Ouellette, M., Hettema, E., Wüst, D., Fase-Fowler, F. & Borst, P. (1991). Direct and inverted DNA repeats associated with P-glycoproteins gene amplification in drug resistance Leishmania. EMBO Journal, 10, 1009–1016.
   PubMed Web of Science ®Google Scholar
• Papadopoulou, B., Roy, G. & Ouellette, M. (1992). A novel antifolate resistance gene on the amplified H circle of Leishmania. EMBO Journal, 11, 3601–3608.
   PubMed Web of Science ®Google Scholar
• Petrillo-Peixoto, M. L. & Beverley, S. M. (1988). Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major. Molecular and Cellular Biology, 8, 5188–5199.
   PubMed Web of Science ®Google Scholar
• Petrillo-Peixoto, M. L. & Beverley, S. M. (1989). Amplification of a new region of DNA in an unselected laboratory stock of Leishmania tarentolae: the T region. Journal of Protozoology, 36, 57–261.
   Google Scholar
• Sen Gupta, P. C. (1953). Chemotherapy of leishmanial disease: a resume of recent researches. Indian Medical Gazette, 88, 20–35.
   PubMedGoogle Scholar
• Stark, G. R. & Wahl, G. M. (1984). Gene amplification. Annual Review of Biochemistry, 53, 447–491.
   PubMed Web of Science ®Google Scholar
• Steck, E. A. (1981). The chemotherapy of protozoan infections of man. Journal of Protozoology, 28, 10–16.
   PubMedGoogle Scholar
• Tripp, C. A., Myler, P. J. & Stuart, K. (1991). A DNA sequence LD1 which occurs in several genomic organizations in Leishmania. Molecular and Biochemical Parasitology, 47, 151–160.
   PubMed Web of Science ®Google Scholar
• Tripp, C. A., Wisdom, W. A., Myler, P. J. & Stuart, K. D. (1992). A multicopy extrachromosomal DNA in Leishmania infantum contains two inverted repeats of the 27·5-kilobase LD1 sequence and encodes numerous transcripts. Molecular and Biochemical Parasitology, 55, 39–50.
   PubMed Web of Science ®Google Scholar
• White, T. C., Fase-Fowler, F., Van Luenen, H., Calafat, J. & Borst, P. (1988). The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance. Journal of Biological Chemistry, 263, 16977–16983.
   PubMed Web of Science ®Google Scholar