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Annals of Tropical Medicine & Parasitology Volume 88, 1994 - Issue 2
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Original Articles

Randomized trial of mefloquine alone and artesunate followed by mefloquine for the treatment of acute uncomplicated falciparum malaria

S. LooareesuwanDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok10400, Thailand
,
S. VanijanontaDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok10400, Thailand
,
C. ViravanDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok10400, Thailand
,
P. WilairatanaDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok10400, Thailand
,
P. CharoenlarpDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok10400, Thailand
&
M. AndrialMedical Department, Mepha Ltd., Pharmaceutical Research, Development and Manufacture, Aesch-Basel, Switzerland
Pages 131-136 | Received 22 Nov 1993, Accepted 04 Jan 1994, Published online: 15 Nov 2016

REFERENCES

  • Bunnag, D. & Harinasuta, T. (1987). The current status of drug resistance in malaria. International Journal for Parasitology, 17, 169–180.
  • Bunnag, D., Viravan, C., Looareesuwan, S., Karbwang, J. & Harinasuta, T. (1991). Clinical trial of artesunate and artemether on multidrug resistant falciparum malaria in Thailand: a preliminary report. Southeast Asian Journal of Tropical Medicine and Public Health, 22, 380–385.
  • Chongsuphajaisiddhi, T., Sabcharoen, A., Chanthavanich, P., Singhasivanon, V., Wernsdorfer, W. H. & Sheth, U. K. (1987). A phase III clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in Thailand. Bulletin of the World Health Organization, 65, 223–226.
  • Harinasuta, T., Bunnag, D., Vanijanonta, S., Charoenlarp, P., Suntharasamai, P., Chittamas, S., Sheth, U. K. & Wernsdorfer, W. H. (1987). Mefloquine, sulfadoxine, and pyrimethamine in the treatment of symptomatic falciparum malaria: a double-blind trial for determining the most effective dose. Bulletin of the World Health Organization, 63, 363–367.
  • Klayman, D. L. (1985). Qjnghaosu (artemisinin): an antimalarial drug from China. Science, 228, 1049–1055.
  • Looareesuwan, S., Harinasuta, T. & Chongsuphajaisiddhi, T. (1992a). Drug resistant malaria with special reference to Thailand. Southeast Asia Journal of Tropical Medicine and Public Health, 23, 621–634.
  • Looareesuwan, S., Kyle, D. E., Viravan, C., Vanijanonta, S., Wilairatana, P., Charoenlarp, P., Canfield, C. J. & Webster, H. K. (1992b). Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine. American Journal of Tropical Medicine and Hygiene, 47, 794–799.
  • Looareesuwan, S., Viravan, C., Vanijanonta, S., Wilairatana, P., Charoenlarp, P., Canfield, C. & Kyle, D. E. (1993). Treatment of acute uncomplicated falciparum malaria with a short course of artesunate followed by mefloquine. Southeast Asian Journal of Tropical Medicine and Public Health, 24, 230–234.
  • Looareesuwan, S., Viravan, S., Vanijanonta, S., Wijlairatana, P., Suntharasamai, P., Charoenlarp, P., Arnold, K., Kyle, D. E., Canfield, C. & Webster, K. (1992c). A randomised trial of mefloquine, artesunate and artesunate followed by mefloquine in acute uncomplicated falciparum malaria. Lancet, i, 821–824.
  • Looareesuwan, S., Wilairatana, P., Vanijanonta, S., Kyle, D. & Webster, K. (1992d). Efficacy of quinine-tetracycline for acute uncomplicated falciparum malaria in Thailand. Lancet, i, 369.
  • Navaratnam, V., Mahamad, M., Mansor, S. M. & Wernsdorfer, W. (1992). Pharmacokinetics of mefloquine: a comparison of two commercial formulations. In Proceedings of the 13th International Congress for Tropical Medicine and Malaria, Thailand, p. 281.
  • Nosten, F., Imvithaya, S., Vincenti, M., Delmas, G., Libihar, G., Hausler, B. & White, N. J. (1987). Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. Bulletin of the World Health Organization, 65, 891–896.
  • Nosten, F., Ter Kuile, F., Chongsuphajaisiddhi, T., Luxemburger, C., Webster, H. K., Edstein, M., Phaipun, L., Lay Thew, K. & White, N. J. (1991). Mefloquine-resistant falciparum malaria on the Thai-Burmese border. Lancet, i, 1140–1143.
  • Ter Kuile, F., Dolan, G., Nosten, F., Edstein, M., Luxemburger, C., Phaipun, L., Chongsuphajaisiddhi, T., Webster, H. K. & White, N. J. (1993). Halo-fantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria. Lancet, i, 1044–1049.
  • Ter Kuile, F., Nosten, F., Thieren, M., Luxemburger, C., Edstein, M. D., Chongsuphajaisiddhi, T., Phaipum, L., Webster, H. K. & White, N. J. (1992). High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria. Journal of Infectious Diseases, 166, 1303–1340.
  • Warrell, D. A., Molyneux, M. E. & Beales, P. F. (1990). Severe and complicated malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84(Suppl. 2), 1–65.
  • World Health Organization (1973). Advances in Malaria Chemotherapy. Technical Report Series No. 529. Geneva: WHO.

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