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Research Article

THE EFFECTS OF CITICOLINE AND LAMOTRIGINE ALONE AND IN COMBINATION FOLLOWING PERMANENT MIDDLE CEREBRAL ARTERY OCCLUSION IN RATS

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Pages 183-196 | Published online: 07 Jul 2009

References

  • Alvarez, X. A., Laredo, M., Corzo, D., Fernández-Novoa, L., Mouzo, R., & Perea, J. E., et al. (1997). Citicoline improves memory performance in elderly subjects. Methods and Findings in Expeirmental and Clinical Pharmacology, 19, 201–210.
  • Aronowski, J., Strong, R., & Grotta, J. C. (1996). Citicoline for treatment of experimental focal ischemia: Histological and behavioral outcome. Neurological Research, 18, 570–574.
  • Astrup, J., Siesjo, B. K., & Symon, L. (1981). Threshold in cerebral ischemia: The is- chemic penumbra. Stroke, 12, 725.
  • Bacher, A., & Zomow, M. H. (1997). Lamotrigine inhibits extracellular glutamate ac- cumulation during transient global cerebral ischemia in rabbits. Anesthesiology, 86, 459–463.
  • Balkan, S., Özben, T., Balkan, E., Oguz, N., Serteser, M., & Gümüs¸lü, S. (1997). Effects of lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats. Acta Neurologica Scandinavica, 95, 140–146.
  • Bazan, N. G. (1970). Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochimica et Biophysica Acta, 218, 1–10.
  • Calabresi, P., Centonze, D., Marfia, G. A., Pisani, A., & Bernardi, G. (1999). An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. British Journal of Pharmacology, 126, 689–696.
  • Calabresi, P., Picconi, B., Saulle, E., Centonze, D., Hainsworth, A. H., & Bernardi, G. (2000). Is pharmacological neuroprotection dependent on reduced glutamate release? Stroke, 31, 766–773.
  • Clark, W., Gunion-Rinker, L., Lessov, N., & Hazel, K. (1998). Citicoline treatment for experimental intracerebral hemorrhage in mice. Stroke, 29, 2136–2140.
  • Clarke, W. M., Warach, S. J., Pettignew, L.C., Gammans, R. E., & Sabounjian, L. A. (1997). A randomized dose-response trial of citicoline in acute ischemic stroke pa- tients. Citicoline Stroke Study Group. Neurology, 49, 671–678.
  • Clarke, W. M., Williams, B. J., Selzer, K. A., Zweifler, R. M., Sabounjian, L. A., & Gammans,R. E. (1999). Citicoline Stroke Study Group: A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke, 30, 2592–2597.
  • Crumrine, R. C., Bergstrand, K., Cooper, A. T., Faison, W. L., & Cooper, B. R. (1997). Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest. Stroke, 28, 2230–2236.
  • De Medio, G. E., Brunett, M., Dorman, R. V., Droz, B., Horrocks, L. A., & Porcellati, G. (1983). Phospholipid metabolism during central and peripheral damage and recovery in nervous tissue. Original article series. Birth Defects, 19, 175–187.
  • Dorman, R. V., Dabrowiecki, Z., De Medio, G. E., Trovarelli, G., Porcellati, G., & Horroks, L. A. (1980). Control of lipid metabolism in ischemic brain CDP amines. In L. A. Horroks, G. B. Ansell, & G. Porcellati (Ed.), Phospholipids in the nervous system. Vol I: Metabolism (pp. 123–135). New York: Raven Press.
  • Dyker, A. G., & Lees, K. R. (1998). Duration of neuroprotective treatment for ischemic stroke. Stroke, 29, 535–542.
  • Finkelstein, S. P., Fisher, M., Furlan, A. J., Goldstein, L. B., Gorelick, P. B., & Kaste, M., et al. (1999). Stroke therapy academic industry roundtable. Recommendations for stan- dards regarding preclinical neuroprotective and restorative drug development. Stroke, 30, 2752–2758.
  • Fisher, M., Meadows, M., Do, T., Weise, J., Trubetskoy, V., & Charette, M., et al. (1995). Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats. Journal of Cerebral Blood Flow and Metabolism, 15, 953–959.
  • Gilland, E., Puka-Sundvall, M., Andine, P., Bona, E., & Hagberg, H. (1994). Hypoxic- ischemic injury in the neonatal rat brain: Effects of pre- and post-treatment with the glutamate release inhibitor BW1003C87. Brain Research Development, 83, 79–84.
  • Hayaishi, O., Ozawa, K., Araki, C., Ishii, S., & Kondo, Y. (1961). Biochemistry of brain injury and brain edema. Japanese Journal of Medical Progress, 48, 519–539.
  • Kakihana, M., Fukuda, N., Suno, M., & Nagaoka, A. (1988). Effects of CDP-choline on neurological deficits and cerebral glucose metabolism in a rat model of cerebral ischemia. Stroke, 19, 217–222.
  • Koizumi, J., Yoshida, Y., Nakazawa, T., & Ooneda, G. (1986). Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in re- circulation can be introduced in the ischemic area. Japanese Journal of Stroke, 8, 1–8.
  • Kuwashima, J., Fujitani, B., Nakamura, K., Kadokawa, T., Yoshida, K., & Shimizu, M. (1976). Biochemical changes in unilateral brain injury in the rat: A possible role of fatty acid accumulation. Brain Research, 110, 547–557.
  • Leach, M. J., Baxter, M. G., & Critchley M. A. (1991). Neurochemical and behavioral aspects of lamotrigine. Epilepsia, 32(Suppl 2), S4–S8.
  • Leach, M. J., Marden, C. M., & Miller, A. A. (1986). Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II Neurochemical studies on the mechanism of action. Epilepsia, 27, 490–497.
  • Lyden, P. D., & Lonzo, L. (1994). Combination therapy protects ischemic brain in rats; a glutamate antagonist plus an γ-aminobutyric acid agonist. Stroke, 25, 189–196.
  • Majeswska, M. D., Strosznajder, J., & Lazarewicz, J. (1978). Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids. Brain Research, 158, 423–434.
  • Minematsu, K., & Fisher, M. (1993). MK-801 reduces extensive infarction after suture middle cerebral artery occlusion in rats. Cerebrovascular Disease, 3, 99–104.
  • Minematsu, K., Li, L., Fisher, M., Sotak, C. H., Davis, M. A., & Fiandaca, M. S. (1992). Diffusion weighted magnetic resonance imaging: Rapid and quantitative detection of focal brain ischemia. Neurology, 42, 235–240.
  • Mykita, S., Golly, F., Dreyfus, H., Freysz, L., & Massarelli, R. (1986). Effects of CDP- choline on hypocampic neurons in culture. Journal of Neurochemistry, 47, 223–2231.
  • Önal, M. Z., & Fisher, M. (1997). Acute ischemic stroke therapy: A clinical overview. European Journal of Neurology, 38, 141–154.
  • Önal, M. Z., & Fisher, M. (1996). Thrombolytic and cytoprotective therapies for acute ischemic stroke: A clinical overview. Drugs Today, 32, 573–592.
  • Önal, M. Z., Li, F., Tatlisumak, T., Locke, K. W., Sandage, B. W., & Fisher, M. (1997). Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke, 28, 1060–1065.
  • Phillis, J. W., Song, D., & O’Regan, M. H. (1997). Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and other amino acids from rat cerebral cor- tex. Brain Research, 758, 9–16.
  • Rataud, J., Debemot, F., Mary, V., Pratt, S., & Stutzmann, J. M. (1994). Comparative study of voltage sensitive sodium channel blockers in focal ischemia and electric con- vulsions in rodents. Neuroscience Letters, 172, 19–23.
  • Scatton, B. (1994). Excitatory amino acid receptor antagonists. A novel treatment for is- chemic cerebrovascular diseases. Science, 55, 25–26.
  • Schabitz, W. R., & Fisher, M. (2001). Pharmacologic neuroprotection for stroke. In M. Fisher (Ed.), Stroke therapy (pp. 275–285). Boston: Butterworth-Heinemann.
  • Schabitz, W. R., Li, F., Irie, K., Sandage, B. W., Locke, K. W., & Fisher, M. (1999). Synergistic effects of a combination of low dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke, 30, 427–432.
  • Schabitz, W. R., Weber, J., Takano, K., Sandage, B. W., Locke, K. W., & Fisher, M. (1996). The effects of prolonged treatment with citicoline in temporary experimental focal cerebral ischemia. Journal of Neurological Sciences, 138, 21–25.
  • Shuaib, A., Mahmood, R. H., Wishart, T., Kanthan, R., Murabit, M. A., & Ijaz, S., et al. (1995). Neuroprotective effects of lamotrigine in global ischemia in gerbils: A histo- logical, in vivo micro dialysis and behavioral study. Brain Research, 702, 199–206.
  • Smith, S. E., Lekieffre, D., Sowinski, P., & Meldrum, B. S. (1993). Cerebroprotective effect of BW619C89 after focal or global cerebral ischemia in the rat. Neuroreport, 4, 1339–1342.
  • Smith, S. E., & Meldrum, B. S. (1995). Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke, 26, 117–122.
  • Spiers, P. A., Myers, D., Hochanadel, G. S., Lieberman, H. R., & Wurtman, R. J. (1996). Citicoline improves verbal memory in aging. Archives of Neurology, 53, 441–448.
  • Trovarelli, G., De Medio, G. E., Dorman, R. V., Piccinin, G. L., Horrocks, L. A., & Porcellatti, G. (1981). Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil. Neurochemical Research, 6, 821–833.
  • Wang, S. J., Huang, C. C., Hsu, K. S., Tsai, J. J., & Gean, P. W. (1996). Presynaptic inhibition of excitatory neurotransmission by lamotrigine in the rat amygdalar neu- rons. Synapse, 24, 248–255.
  • Weiss, G. B. (1995). Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Science, 56, 637–660.
  • Wiard, R. P., Dickerson, M. C., Beek, O., Norton, R., & Cooper, B. R. (1995). Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke, 26, 466–472.
  • Yamamoto, M., Shimizu, M., & Okamiya, H. (1990). Pharmacological actions of a new TRH analogue, YM-14673, in rats subjected to cerebral ischemia and anoxia. Euro- pean Journal of Pharmacology, 181, 207–214.
  • Yatsu, F. M., & Moss, S. A. (1971). Brain lipid changes following hypoxia. Stroke, 2, 587–593.
  • Zea, L. E., Weinstein, P. R., Carlson, S., & Cummins, R. (1989). Reversible middle cere- bral artery occlusion without craniectomy in rats. Stroke, 20, 84–91.
  • Zivin, J. A. (1998). Current status of new drug development for ischemic stroke. In M. Fisher. (Ed.), Monographs in clinical neuroscience (pp 128–138). Basel: Karger.

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