Clinical Case Report: SUCCESSFUL TREATMENT OF MULTIPLE SCLEROSIS WITH MAGNETIC FIELDS

REFERENCES

• Acheson, E. D., Bachrach, C. A. & Wright, F. M. (1960). Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation and other variables. Acta Psychiatrica Neurologica Scandinavica, 35 (suppl 147). 132–147.
   Google Scholar
• Adams, R. D. & Victor, M. (1985). Principles of neurology (pp. 699–717). New York: McGraw-Hill Book Company.
   Google Scholar
• Adey, W. R. (1986). The sequence and energetics of cell membrane transductive coupling to intracellular enzyme systems. Bioeleclrochemistry and Bioenergetics, 15, 447–456.
   Web of Science ®Google Scholar
• Angeli, A., Gatti, G., Sartori, M. L., DelPonte, D., Garagnola, R. (1988). Effect of exogenous melatonin on human natural killer (NK) cell activity: An approach to the immunomodulatory role of the pineal gland. In D. Gupta, A. Attanasio & R. J. Reiter (Eds.), The pineal gland and cancer. London: Brain Research Promotion.
   Google Scholar
• Anninos, P. A., Tsagas, N., Sandyk, R. & Derpapas, K. (1991). Magnetic stimulation in the treatment of partial seizures. International Journal of Neuroscience, 60, 141–171.
   PubMed Web of Science ®Google Scholar
• Ansimov, V. N., Loktionov, A. S., Khavinson, V. K. & Morozov, V. G. (1989). Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. Mechanisms of Ageing and Development, 49, 245–257.
   PubMed Web of Science ®Google Scholar
• Anton-Tay, F. (1974). Melatonin: effects on brain function. Advances in Biochemical Psychopharmacology, 11, 315–324.
   PubMedGoogle Scholar
• Arendt, J. (1978). Melatonin assays in body fluids. Journal of Neural Transmission, 13 (suppl), 265–278.
   Google Scholar
• Armstrong, S. M. & Redman, J. R. (1991). Melatonin: a chronobiotic with anti-aging properties? Medical Hypotheses, 34, 300–309.
   PubMed Web of Science ®Google Scholar
• Aubert, C. H., Janiaud, P. & Lecalvez, J. (1980). Effect of pinealectomy and melatonin on mammary tumor growth in sprague-dawley rats under different conditions of lighting. Journal of Neural Transmission, 47, 121–130.
   PubMed Web of Science ®Google Scholar
• Axelrod, J. (1974). The pineal gland: a neurochemical transducer. Chemical signals from nerves regulate synthesis of melatonin and convey information about internal clocks. Science, 1134, 1341–1348.
   Google Scholar
• Bailey, C. J., Atkins, T. W. & Matty, A. J. (1974). Melatonin inhibition of insulin secretion in the rat and mouse. Hormone Research, 5, 21–28.
   PubMed Web of Science ®Google Scholar
• Bamford, C. R., Sibley, W. A. & Thies, C. (1983). Seasonal variation of MS exacerbations in Arizona. Neurology, 33, 1537–1544.
   PubMed Web of Science ®Google Scholar
• Bardasano, J. L., Meyer, A. J. & Picazo, L. (1985). Ultrastructure of the pineal cells of the homing pigeon Columba livia and magnetic fields (first trials). Journal fuer Hirnforschung, 26, 471–475.
   PubMedGoogle Scholar
• Bauer, H. J. (1978). Problems of symptomatic therapy in multiple sclerosis. Neurology, 28, 8–20.
   PubMed Web of Science ®Google Scholar
• Bawin, S. M. & Adey, W. R. (1976). Sensitivity of calcium binding in cerebral tissue to weak environmental electric fields oscillating at low frequency. Proceedings of the National Academy of Sciences, U.S.A., 73, 1999–2003.
   PubMed Web of Science ®Google Scholar
• Bell, G., Marino, A., Chesson, A. & Struve, F. (1992). Electrical states in the rabbit brain can be altered by light and electromagnetic fields. Brain Research, 570, 307–315.
   PubMed Web of Science ®Google Scholar
• Bindoni, M. & Rizzo, R. (1965). Hippocampal evoked potentials and convulsive activity after electrolytic lesions of the pineal body in chronic experiments on rabbits. Archives of Science and Biology (Bologna), 49, 223–233.
   PubMedGoogle Scholar
• Birk, K., Ford, C., Smeltzer, S., Ryan, D., Miller, R. & Rudick, R. A. (1990). The clinical course of multiple sclerosis during pregnancy and the puerperium. Archives of Neurology, 47, 738–742.
   PubMed Web of Science ®Google Scholar
• Blackman, C. F. (1988). Stimulation of brain tissue in vitro by extremely low frequency, low intensity, sinusoidal electromagnetic fields. In M. E. O'Connor & Lovely, R. H. (Eds.), Electromagnetic fields and neurobehavioral function. New York: Alan R. Liss.
   Google Scholar
• Blask, D. E. (1984). The pineal: an oncostatic gland? In R. J. Reiter (Ed.), The pineal gland (pp. 253–284). New York: Raven Press.
   Google Scholar
• Bliss, V. L. & Heppner, F. H. (1976). Circadian activity rhythm influenced by near zero magnetic field. Nature, 261, 411–412.
   PubMed Web of Science ®Google Scholar
• Brown, F. A. & Scow, K. M. (1978). Magnetic induction of a circadian cycle in hamsters. Journal of Interdisciplinary Cycle Research, 9, 137–145.
   Google Scholar
• Cassone, V. M., Roberts, M. H. & Moore, R. Y. (1987). Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei. Neuroscience Letters, 81, 29–34.
   PubMed Web of Science ®Google Scholar
• Cottrell, S. S. & Wilson, S. A. K. (1929). The affective symptomatology of disseminated sclerosis: a study of 100 cases. Journal of Neurology and Psychopathology, 7, 1–30.
   Google Scholar
• Cremer-Bartels, G., Krause, K. & Kuechle, H. J. (1983). Influence of low magnetic field-strength variations on the retina and pineal gland of quails and humans. Graefe's Archives of Clinical and Experimental Ophthalmology, 220, 248–252.
   PubMed Web of Science ®Google Scholar
• Cremer-Bartels, G., Krause, K., Mitoskas, G. & Brodersen, D. (1984). Magnetic field of the earth as additional Zeitgeber for endogenous rhythms? Naturwissenschaften, 71, 567–574.
   PubMed Web of Science ®Google Scholar
• Csaba, G. & Barath, P. (1971). Are Langerhans' islets influenced by the pineal body? Experientia, 27, 962.
   PubMedGoogle Scholar
• Demaine, C. & Semm, P. (1985). The avian pineal gland as an independent magnetic sensor. Neuroscience Letters, 62, 119–122.
   PubMed Web of Science ®Google Scholar
• Demaine, C. & Semm, P. (1986). Magnetic fields abolish the nychthemeral rhythmicity of responses of Purkinje cells to the pineal hormone melatonin in the pigeon's cerebellum. Neuroscience Letters, 72, 158–162.
   PubMed Web of Science ®Google Scholar
• Dhar, M., Dayal, S. S., Babu, C. S. R. & Arora, S. R. (1982). Effect of melatonin on glucose tolerance and blood glucose circadian rhythm in rabbits. Indian Journal of Physiology and Pharmacology, 27, 109–117.
   Google Scholar
• Drexler, J., Meaney, T. F. & McCormack, L. J. (1957). The calcified pineal body and carcinoma. Cleveland Clinic Quarterly, 24, 242–247.
   PubMedGoogle Scholar
• Franklin, G. M., Nelson, L. M., Filley, C. M. & Heaton, R. K. (1989). Cognitive loss in multiple sclerosis. Case reports and review of the literature. Archives of Neurology, 46, 162–167.
   PubMed Web of Science ®Google Scholar
• Frick, E. & Scheid-Seydel, L. (1958). Untersuchungen mit Markirtem Globulin zur Frage der Abstammung der Liquoreiweisskorper. Klinische Wochenschrift, 36, 857–863.
   PubMedGoogle Scholar
• Friedman, H., Becker, R. O. & Bachman, C. H. (1963). Geomagnetic parameters and psychiatric hospital admissions. Nature, 200, 626–628.
   PubMed Web of Science ®Google Scholar
• Friedman, H., Becker, R. O. & Bachman, C. H. (1965). Psychiatric ward behaviour and geophysical parameters. Nature, 205, 1050–1052.
   Web of Science ®Google Scholar
• Gorray, K. C. & Quay, W. B. (1978). Effects of pinealectomy and sham pinealectomy on blood glucose levels in the alloxan-diabetic rat. Hormone Metabolic Research, 10, 389–392.
   PubMed Web of Science ®Google Scholar
• Gorray, K. C., Quay, W. B. & Ewart, R. B. L. (1979). Effects of pinealectomy and pineal incubation medium and sonicates on insulin release by isolated pancreatic islets in vitro. Hormone Metabolic Research, 11, 432–436.
   PubMed Web of Science ®Google Scholar
• Gould, J. L. (1984). Magnetic field sensitivity in animals. Annual Review of Physiology, 46, 585–598.
   PubMed Web of Science ®Google Scholar
• Hughes, R. A. C. (1991). Prospects for the treatment of multiple sclerosis. Journal of the Royal Society of Medicine, 84, 63–65.
   PubMed Web of Science ®Google Scholar
• Jankovic, B. D., Isakovic, K. & Petrovic, S. (1970). Effect of pinealectomy on immune reactions in the rat. Immunology, 18, 1–5.
   PubMed Web of Science ®Google Scholar
• Jankovic, B. D., Maric, D., Ranin, J. & Veljic, J. (1991). Magnetic fields, brain and immunity: effect on humoral and cell-mediated immune responses. International Journal of Neuroscience, 59, 25–43.
   PubMed Web of Science ®Google Scholar
• Joffe, R. T., Lippert, G. P. & Gray, T. A. (1987). Mood disorder and multiple sclerosis. Archives of Neurology, 44, 376–378.
   PubMed Web of Science ®Google Scholar
• Kamback, D. O., Rich, R. A. & Relkin, R. (1982). Effect of pinealectomy on fatty acid composition of rat brain myelin. Endocrinology, 110, 907–909.
   PubMed Web of Science ®Google Scholar
• Kavaliers, M. & Ossenkopp, K. P. (1992). Magnetic fields, opioid systems, and day-night rhythms of behavior In M. C. Moore-Ede, S. S. Campbell & R. J. Reiter (Eds.), Electromagnetic fields and circadian rhythmicity (pp. 95–117). Boston: Birkhauser.
   Google Scholar
• Keshavan, M. S., Gangadhar, B. N., Gautman, R. U., Ajiit, V. B. & Kapur, R. L. (1981). Convulsive threshold in humans and rats and magnetic field changes: observation during total eclipse. Neuroscience Letters, 22, 205–208.
   PubMed Web of Science ®Google Scholar
• Kurtzké, J. F., Beebe, G. W. & Norman, J. E. (1979). Epidemiology of multiple sclerosis in US veterans, I: Race, sex, and geographic distribution. Neurology, 29, 1228–1235.
   PubMed Web of Science ®Google Scholar
• Lapin, V. & Ebels, I. (1981). The role of the pineal gland in neuroendocrine control mechanisms of neoplastic growth. Journal of Neural Transmission, 50, 275–282.
   PubMed Web of Science ®Google Scholar
• Lewy, A. J., Nurnberger, J. I., Wehr, T. A., Pack, D., Becker, L. E., Powell, R. L. & Newsome, D. A. (1985). Supersensitivity to light: Possible trait marker for manic depressive illness. American Journal of Psychiatry, 142, 725–721.
   PubMed Web of Science ®Google Scholar
• Limburg, C. C. (1950). The geographic distribution of multiple sclerosis and its estimated prevalence in the U.S. Proceedings of the Association for Research in Nervous and Mental Diseases, 28, 15–24.
   PubMed Web of Science ®Google Scholar
• Lukaszyk, A. & Reiter, R. J. (1975). Histophysiological evidence for the secretion of polypeptides in the pineal gland. American Journal of Anatomy, 143, 451–464.
   PubMedGoogle Scholar
• Maestroni, G. J. M., Conti, A. & Pierpaoli, W. (1987 a). Melatonin counteracts the effect of acute stress on the immune system via an opiatergic system. In G. P. Trentini, C. De Gaetani & P. Pevet (Eds.), Fundamentals and clinics in pineal research (pp. 277–279). New York: Raven Press.
   Google Scholar
• Maestroni, G. J. M., Conti, A. & Pierpaoli, W. (1987 b). The pineal gland and the circadian, opiatergic, immunoregulatory role of melatonin. Annals of the New York Academy of Science, 496, 67–77.
   PubMed Web of Science ®Google Scholar
• McFarlin, D. E. & McFarland, H. (1982). Multiple sclerosis. New England Journal of Medicine, 307, 1183–1188.
   PubMed Web of Science ®Google Scholar
• Milcu, S. M., Nanu, L. & Milcu, I. (1971). The effect of pinealectomy on plasma insulin in rats. In G. E. W. Wolstenholme & J. Knight (Eds.), The pineal gland (pp. 345–360). London: Churchill Livingstone.
   Google Scholar
• Miles, A. & Philbrick, D. R. S. (1988). Melatonin and psychiatry. Biological Psychiatry, 23, 405–425.
   PubMed Web of Science ®Google Scholar
• Milligan, N. M., Newcombe, R., Compston & D. A. S. (1987). A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis. 1. clinical effects. Journal of Neurology, Neurosurgery, and Psychiatry, 50, 511–516.
   PubMed Web of Science ®Google Scholar
• Minden, S. L. & Schiffer, R. B. (1990). Affective disorders in multiple sclerosis. Review and recommendations for clinical research. Archives of Neurology, 47, 98–104.
   PubMed Web of Science ®Google Scholar
• Murthy, G. G. & Modes, R. R. (1975). Effects of melatonin and serotonin on 14C-glucose metabolism in rabbit adipose tissue. Experientia, 15, 383–384.
   Google Scholar
• Olcese, J. M. (1992). Magnetoreception in rodents: involvement of the eyes and the pineal organ may be evidence for a chronobiological substrate. In M. C. Moore-Ede, S. S. Campbell & R. J. Reiter (Eds.), Electromagnetic fields and circadian rhythmicity (pp. 63–73). Boston: Birkhauser.
   Google Scholar
• Olcese, J. & Reuss, S. (1986). Magnetic field effects on pineal gland melatonin synthesis: comparative studies on albino and pigmented rodents. Brain Research, 369, 365–368.
   PubMed Web of Science ®Google Scholar
• Olcese, J., Reuss, S. & Semm, P. (1988). Geomagnetic field detection in rodents. Life Sciences, 42, 605–613.
   PubMed Web of Science ®Google Scholar
• O'Reilly, M. A. R. & O'Reilly, P. M. R. (1991). Temporal influences on relapses of multiple sclerosis. European Neurology, 31, 391–395.
   PubMed Web of Science ®Google Scholar
• Pazo, J. H. (1979). Effects of melatonin on spontaneous and evoked neuronal activity in the mesencephalic reticular formation. Brain Research Bulletin, 4, 725–730.
   PubMed Web of Science ®Google Scholar
• Pelham, R. W., Vaughan, G. M., Sandock, K. L. & Vaughan, M. K. (1973). Twenty-four-hour cycle of a melatonin-like substance in the plasma of human males. Clinical Endocrinology & Metabolism, 37, 341–344.
   Google Scholar
• Perry, F. S., Reichmanis, M., Marino, A. A. & Becker, R. O. (1981). Environmental power frequency magnetic fields and suicide. Health Physician, 41, 267–277.
   PubMed Web of Science ®Google Scholar
• Pierpaoli, W. & Maestroni, G. J. M. (1988). Neuroimmunomodulation: some recent views and findings. International Journal of Neuroscience, 39, 165–175.
   PubMed Web of Science ®Google Scholar
• Poser, C. M. (1992). Multiple sclerosis. Observations and reflections-a personal memoir. Journal of the Neurological Sciences, 107, 127–140.
   PubMed Web of Science ®Google Scholar
• Prevedello, M. R., Ritta, M. N. & Cardinali, D. P. (1979). Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles. Neuroscience Letters, 13, 29–34.
   PubMed Web of Science ®Google Scholar
• Prineas, J. W. (1970). The etiology and pathogenesis of multiple sclerosis. In P. J. Vinken & G. W. Bruyn (Eds.), Multiple sclerosis and other demyelinating diseases (pp. 107–160). Amsterdam: North Holland.
   Google Scholar
• Quay, W. B. & Gorray, K. C. (1980). Pineal effects on metabolism and glucose homeostasis: evidence for lines of humoral mediation of pineal influences on tumor growth. Journal of Neural Transmission, 47, 107–120.
   PubMed Web of Science ®Google Scholar
• Rabson, S. M. & Mendenhall, E. N. (1956). Familial hypertrophy of pineal body, hyperplasia of adrenal cortex and diabetes mellitus. American Journal of Clinical Pathology, 26, 283–290.
   PubMed Web of Science ®Google Scholar
• Rajaram, M. & Mitra, S. (1981). Correlation between convulsive seizure and geomagnetic activity. Neuroscience Letters, 24, 187–191.
   PubMed Web of Science ®Google Scholar
• Reichmanis, M., Perry, F. S., Marino, A. A. & Becker, R. O. (1979). Relation between suicide and electromagnetic field of overhead power lines. Physiology, Chemistry & Physics, 11, 395–403.
   PubMedGoogle Scholar
• Reiter, R. J. (1992). Changes in circadian melatonin synthesis in the pineal gland of animals exposed to extremely low frequency electromagnetic radiation: A summary of observations and speculation on their implications. In . In M. C. Moore-Ede, S. S. Campbell & R. J. Reiter (Eds.), Electromagnetic fields and circadian rhythmicity (pp. 13–27). Boston: Birkhauser.
   Google Scholar
• Relkin. R. & Schneck, L. (1975). Effects of pinealectomy on rat brain myelin. Proceedings of the Society for Experimental Biology and Medicine, 148, 337–338.
   PubMed Web of Science ®Google Scholar
• Relkin, R., Fok, W. Y. & Schneck, L. (1973). Pinealectomy and brain myelination. Endocrinology, 92, 1426–1428.
   PubMed Web of Science ®Google Scholar
• Relia, W. & Lapin, V. (1976). Immunocompetence of pinealectomized and simultaneously pinealectomized and thymectomized rats. Oncology, 33, 3–6.
   PubMed Web of Science ®Google Scholar
• Richardson, B. A., Yaga, K., Reiter, R. J. & Hoover, P. (in press). Suppression of nocturnal pineal N-acetyltransferase activity and melatonin content by inverted magnetic fields and induced eddy currents. International Journal of Neuroscience.
   Google Scholar
• Roberts, H. (1966). On the etiology, rational treatment and prevention of multiple sclerosis. Southern Medical Journal, 59, 940–950.
   PubMed Web of Science ®Google Scholar
• Rose, A. S., Kuzma, J. W., Kurtzke, J. F., Namerow, N. S., Sibley, W. A. & Tourtellote, W. W. (1970). Cooperative study in the evaluation of therapy in multiple sclerosis: ACTH versus placebo. Neurology, 20 (suppl), 1–59.
   PubMed Web of Science ®Google Scholar
• Rosen, A. D. & Lubowsky, J. (1987). Magnetic field influence on central nervous system function. Experimental Neurology, 95, 679–687.
   PubMed Web of Science ®Google Scholar
• Rosen, L. N., Targum, S. D., Terman, M., Bryant, M. J., Hoffman, H., Kasper, S. F., Hamovit, J. R., Docherty, J. P., Welch, B. & Rosenthal, N. (1990). Prevalence of seasonal affective disorder at four latitudes. Psychiatry Research, 31, 131–144.
   PubMed Web of Science ®Google Scholar
• Rosen, L. N., Livingstone. I. R & Rosenthal, N. E. (1991). Multiple sclerosis and latitude: a new perspective on an old association. Medical Hypotheses, 36, 376–378.
   PubMed Web of Science ®Google Scholar
• Ruhenstroth-Bauer, G., Baumer, H., Kugler, J., Spatz, R., Sonning, W. & Filipiak, B. (1984). Epilepsy and weather: A significant correlation between the onset of epileptic seizures and specific atmospherics-a pilot study. International Journal of Biometerology, 28, 333–340.
   PubMed Web of Science ®Google Scholar
• Rudick, R. A. (1990). Helping patients live with multiple sclerosis. Postgraduate Medicine, 88, 197–207.
   PubMed Web of Science ®Google Scholar
• Rudolph, K., Wirz-Justice, A., Krauchi, K. & Feer, H. (1988). Static magnetic fields decrease nocturnal pineal cAMP in the rat. Brain Research, 446, 159–160.
   PubMed Web of Science ®Google Scholar
• Sandyk, R. (1991). Coexisting bipolar affective disorder and multiple sclerosis: The role of the pineal gland. International Journal of Neuroscience, 59, 267–270.
   PubMed Web of Science ®Google Scholar
• Sandyk, R. (1992 a). The pineal gland and multiple sclerosis. (Editorial). International Journal of Neuroscience, 63, 206–215.
   Web of Science ®Google Scholar
• Sandyk, R. (1992 b). The pineal gland and the clinical course of multiple sclerosis. International Journal of Neuroscience, 62, 65–74.
   PubMed Web of Science ®Google Scholar
• Sandyk, R. (in press a). Weak magnetic fields antagonize the effects of melatonin on blood glucose levels in Parkinson's disease. International Journal of Neuroscience.
   Google Scholar
• Sandyk, R. (in press b). Weak magnetic fields as a novel therapeutic modality in Parkinson's disease. International Journal of Neuroscience.
   Google Scholar
• Sandyk, R. & Awerbuch, G. I. (1991). The pineal gland in multiple sclerosis. International Journal of Neuroscience, 61, 61–67.
   PubMed Web of Science ®Google Scholar
• Sandyk, R. & Anninos, P. A. (1992). Magnetic fields alter the circadian periodicity of seizures. International Journal of Neuroscience, 63, 265–274.
   PubMed Web of Science ®Google Scholar
• Sandyk, R. & Anninos, P. A. (in press). Attenuation of epilepsy with application of external magnetic fields: A case report. International Journal of Neuroscience.
   Google Scholar
• Sandyk, R. & Awerbuch, G. I. (in press). Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis. International Journal of Neuroscience.
   Google Scholar
• Sandyk, R., Anninos, P. A., Tsagas, N. & Derpapas, K. (1992). Magnetic fields in the treatment of Parkinson's disease. International Journal of Neuroscience, 63, 141–150.
   PubMed Web of Science ®Google Scholar
• Scheinberg, L. C., Giesser, B. S. & Slater, R. J. (1983). Management of the chronic MS patient. Neurology and Neurosurgery Update Series, 21, 2–7.
   Google Scholar
• Schiffer, R. B., Wineman, N. M. & Weitkamp, L. R. (1986). Association between bipolar affective disorder and multiple sclerosis. American Journal of Psychiatry, 143, 94–95.
   PubMed Web of Science ®Google Scholar
• Seegal, F., Wolpaw, J. R. & Dowman, R. (1989). Chronic exposure of primates to 60-Hz electric and magnetic fields: II. Neurochemical effects. Bioelectromagnetics, 10, 289–301.
   PubMed Web of Science ®Google Scholar
• Semm, P. (1983). Neurobiological investigations on the magnetic sensitivity of the pineal gland in rodents and pigeons. Comparative Biochemistry and Physiology, 76A, 683–689.
   Google Scholar
• Semm, P. (1992). Pineal function in mammals and birds is altered by earth-strength magnetic fields. In M. C. Moore-Ede, S. S. Campbell & R. J. Reiter (Eds.), Electromagnetic fields and circadian rhythmicity (pp. 53–62). Boston: Birkhauser.
   Google Scholar
• Semm, P., Schneider, T. & Vollrath, L. (1980). Effects of an earth-strength magnetic field on electrical activity of pineal cells. Nature, 288, 607–608.
   PubMed Web of Science ®Google Scholar
• Sibley, W. A. & Foley, J. M. (1965). Seasonal variation in multiple sclerosis and retrobulbar neuritis in northeastern ohio. Transmission of the American Neurological Association, 90, 295–297.
   Google Scholar
• Sibley, W. A. & Paty, D. W. (1981). A comparison of multiple sclerosis in Arizona (USA) and Ontario (Canada)-preliminary report. Acta Neurologica Scandinavica (suppl 87), 64, 60–65.
   Web of Science ®Google Scholar
• Sibley, W. A., Bamford, C. R. & Laquna, F. (1975). Anamnestic studies in multiple sclerosis: a relationship between familial multiple sclerosis and neoplasia. Neurology, 28, 125–129.
   Google Scholar
• Skwerer, R. G., Jacobsen, F. M., Ducan, C. C., Kelly, K. A., Sack, D. A., Tamarkin, L., Gaist, P. A., Kasper, S. F. & Rosenthal, N. E. (1988). Neurobiology of seasonal affective disorder and phototherapy. Journal of Biological Rhythms, 3, 135–154.
   PubMed Web of Science ®Google Scholar
• Stutz, A. M. (1971). Effects of weak magnetic fields on gerbil spontaneous activity. Annals New York Academy of Sciences, 187, 312–323.
   Google Scholar
• Tapp, E. (1982). The pineal gland in malignancy. In R. J. Reiter (Ed.), The pineal gland (pp. 171–188). Boca Raton: CRC Press.
   Google Scholar
• Taub, R. G. & Rucker, C. W. (1954). The relationship of retrobulbar neuritis to multiple sclerosis. American Journal of Ophthalmology, 37, 494–497.
   PubMed Web of Science ®Google Scholar
• Trentini, G. P., De Gaetani, C. F., Criscuolo, M. Migaldi, M. & Ferrari, G. (1987). Pineal calcification in different physiopathological conditions in humans. In G. P. Trentini, C. De Gaetani & P. Pevet (Eds.), Fundamentals and clinics in pineal research vol. 44 (pp. 291–304). New York: Raven Press.
   Google Scholar
• Vasquez, B. J., Anderson, L. E., Lowery, C. I. & Adey, W. R. (1988). Diurnal patterns in brain biogenic amines of rats exposed to 60-Hz electric fields. Bioelectromagnetics, 9, 229–236.
   PubMed Web of Science ®Google Scholar
• Venkataraman, K. (1976). Epilepsy and solar activity. Neurology (Bombay), 24, 148–152.
   Google Scholar
• Waksman, B. H. & Reynolds, W. E. (1984). Multiple sclerosis as a disease of immune regulation. Proceedings of the Society of Experimental Biology and Medicine, 175, 282–294.
   PubMed Web of Science ®Google Scholar
• Warren, S. A. & Warren, K. G. (1981). Multiple sclerosis and associated diseases: a relationship to diabetes mellitus. Canadian Journal of Neurological Sciences, 8, 35–39.
   PubMed Web of Science ®Google Scholar
• Warren, S. A. & Warren, K. G. (1982). Multiple sclerosis and diabetes mellitus: further evidence of a relationship. Canadian Journal of Neurological Sciences, 11, 415–419.
   Google Scholar
• Weiner, H. L. & Hauser, S. L. (1982). Neuroimmunology. I: Immunoregulation in neurological disease. Annals of Neurology, 11, 437–449.
   PubMed Web of Science ®Google Scholar
• Weinschenker, B. G. & Ebers, G. C. (1987). The natural history of multiple sclerosis. Canadian Journal of Neurological Sciences, 14, 255–261.
   PubMed Web of Science ®Google Scholar
• Welker, H. A., Semm, P., Willig, R. P., Commentz, J. C., Wiltschko, W. & Vollrath, L. (1983). Effects of an artificial magnetic field on serotonin N-acetyltransferase activity and melatonin content of the rat pineal gland. Experimental Brain Research, 50, 426–432.
   PubMed Web of Science ®Google Scholar
• Welsh, M. G. (1985). Pineal calcification: structural and functional aspects. Pineal Research Reviews, 3, 41–68.
   Google Scholar
• Wever, R. (1968). Einfluss schwacher Elektro-Magnetischer Felder auf die Circadiane Periodik des Menschen. Naturwissenschaften, 55, 29–32.
   PubMed Web of Science ®Google Scholar
• Wever, R. (1992). Circadian rhythmicity of man under the influence of weak electromagnetic fields. In M. C. Moore-Ede, S. S. Campbell & R. J. Reiter (Eds.), Electromagnetic fields and circadian rhythmicity (pp. 121–139). Boston: Birkhauser.
   Google Scholar
• White, R. F. (1990). Emotional and cognitive correlates of multiple sclerosis. Journal of Neuropsychiatry, 2, 422–428.
   PubMedGoogle Scholar
• Whitlock, F. A. & Siskind, M. M. (1980). Depression as a major symptom of multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 43, 861–865.
   PubMed Web of Science ®Google Scholar
• Wilson, B. W. (1988). Chronic exposure to ELF fields may induce depression. Bioelectromagnetics, 9, 195–205.
   PubMed Web of Science ®Google Scholar
• Wilson, B. W., Anderson, L. E., Hilton, D. I. & Phillips, R. D. (1981). Chronic exposure to 60-Hz electric field: effects on pineal function in the rat. Bioelectromagnetics, 2, 371–380.
   PubMed Web of Science ®Google Scholar
• Wisniewski, H. M. & Keith, A. B. (1977). Chronic relapsing experimental allergic encephalomyelitis: An experimental model of multiple sclerosis. Annals of Neurology, 1, 144–148.
   PubMed Web of Science ®Google Scholar
• Wuthrich, R. & Rieder, H. P. (1970). The seasonal incidence of multiple sclerosis in Switzerland. European Neurology, 3, 257–264.
   PubMed Web of Science ®Google Scholar
• Zeigler, L. H. (1929). Multiple sclerosis: a clinical review and follow-up study. Minnesota Medicine, 12, 778–783.
   Google Scholar
• Zeise, M. L. & Semm, P. (1985). Melatonin lowers excitability of guinea pig hippocampal neurons in vitro. Journal of Comparative Physiology A, 157, 23–29.
   PubMed Web of Science ®Google Scholar