234
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-κB and GFAP in spinal astrocytes in a mouse model

, , , , &
Pages 896-903 | Received 14 Aug 2018, Accepted 19 Feb 2019, Published online: 20 Mar 2019

References

  • Mercadante S, Fulfaro F. Management of painful bone metastases. Curr Opin Oncol. 2007;19:308–314.
  • Abdelaziz DM, Stone LS, Komarova SV. Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin. Breast Cancer Res Treat. 2014;143:227–237.
  • Iba K, Yamashita T. [Control of bone remodeling by nervous system. Nerve distribution and pain in bone tissue]. Clin Calcium. 2010;20:1793–1799.
  • Halvorson KG, Sevcik MA, Ghilardi JR, et al. Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer. Clin J Pain. 2006;22:587–600.
  • Guo CH, Bai L, Wu HH, et al. The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain. Int J Mol Med. 2016;38:1433–1442.
  • Jiang W, Wang Y, Sun W, et al. Morin suppresses astrocyte activation and regulates cytokine release in bone cancer pain rat models. Phytother Res. 2017;31:1298–1304.
  • Moalem G, Tracey DJ. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev. 2006;51:240–264.
  • Ren K, Dubner R. Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Curr Opin Anaesthesiol. 2008;21:570–579.
  • Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci. 2007;10:1361–1368.
  • Halassa MM, Fellin T, Takano H, et al. Synaptic islands defined by the territory of a single astrocyte. J Neurosci. 2007;27:6473–6477.
  • Gao YJ, Ji RR. Targeting astrocyte signaling for chronic pain. Neurotherapeutics. 2010;7:482–493.
  • Zhang HW, Iida Y, Andoh T, et al. Mechanical hypersensitivity and alterations in cutaneous nerve fibers in a mouse model of skin cancer pain. J Pharmacol Sci. 2003;91:167–170.
  • Fujita M, Andoh T, Ohashi K, et al. Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice. Eur J Pain. 2010;14:588–594.
  • Garrison CJ, Dougherty PM, Kajander KC, et al. Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res. 1991;565:1–7.
  • Wei F, Guo W, Zou S, et al. Supraspinal glial-neuronal interactions contribute to descending pain facilitation. J Neurosci. 2008;28:10482–10495.
  • Guo W, Wang H, Watanabe M, et al. Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci. 2007;27:6006–6018.
  • Song T, Ma X, Gu K, et al. Thalidomide represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-κB/p38/JNK signaling. J Neuroimmunol. 2016;290:1–8.
  • Asher C, Furnish T. Lenalidomide and thalidomide in the treatment of chronic pain. Expert Opin Drug Saf. 2013;12:367–374.
  • Gu X, Zheng Y, Ren B, et al. Injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-alpha expression in a mouse model. Mol Pain. 2010;6:64.
  • Li Q, Zhang X. Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-alpha expression in a mouse model. Int Immunopharmacol. 2015;29:818–823.
  • Zhou JJ, Cheng C, Qiu Z, et al. Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis. Neurosci Bull. 2015;31:763–768.
  • Khalid S, Ullah MZ, Khan AU, et al. Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-kappaB and Nrf2 Signaling. Front Pharmacol. 2018;9:140.
  • Lim H, Lee H, Noh K, et al. IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury. Pain. 2017;158:1666–1677.
  • Wullaert A, Bonnet MC, Pasparakis M. NF-κB in the regulation of epithelial homeostasis and inflammation . Cell Res. 2011;21:146–158.
  • Jayakumar AR, Tong XY, Ruiz-Cordero R, et al. Activation of NF-kappaB mediates astrocyte swelling and brain edema in traumatic brain injury. J Neurotrauma. 2014;31:1249–1257.
  • Gao S, Mo J, Chen L, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-kappaB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016;103:44–56.
  • Douglass JD, Dorfman MD, Fasnacht R, et al. Astrocyte IKKbeta/NF-kappaB signaling is required for diet-induced obesity and hypothalamic inflammation. Mol Metab. 2017;6:366–373.
  • Zhou YQ, Liu Z, Liu HQ, et al. Targeting glia for bone cancer pain. Expert Opin Ther Targets. 2016;20:1365–1374.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.