348
Views
27
CrossRef citations to date
0
Altmetric
Original Articles

Activating transcription factor 6 reduces Aβ1–42 and restores memory in Alzheimer’s disease model mice

, , , , &
Pages 1015-1023 | Received 22 Apr 2019, Accepted 07 Jan 2020, Published online: 21 Jan 2020

References

  • Vassar R. BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease. Alzheimer’s Res Ther. 2014;6:89.
  • Vassar R, Kandalepas PC. The beta-secretase enzyme BACE1 as a therapeutic target for Alzheimer’s disease. Alzheimers Res Ther. 2011;3:20.
  • Tanzi RE, Bertram L. Twenty years of the Alzheimer’s disease amyloid hypothesis: a genetic perspective. Cell. 2005;120(4):545–555.
  • Li JQ, Yu JT, Jiang T, et al. Endoplasmic reticulum dysfunction in Alzheimer’s disease. Mol Neurobiol. 2015;51(1):383–395.
  • Hillary RF, FitzGerald U. A lifetime of stress: ATF6 in development and homeostasis. J Biomed Sci. 2018;25(1):48
  • Haniu M, Denis P, Young Y, et al. Characterization of Alzheimer’s beta -secretase protein BACE. A pepsin family member with unusual properties. J Biol Chem. 2000;275(28):21099–21106.
  • Westmark PR, Westmark CJ, Jeevananthan A, et al. Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient. J Vis Exp. 2011;(55)
  • Westmark CJ. What’s hAPPening at synapses? The role of amyloid beta-protein precursor and beta-amyloid in neurological disorders. Mol Psychiatry. 2013;18(4):425–434.
  • Moreno JA, Radford H, Peretti D, et al. Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration. Nature. 2012;485(7399):507–511.
  • Shen J, Chen X, Hendershot L, et al. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell. 2002;3(1):99–111.
  • Wang Y, Vera L, Fischer WH, et al. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature. 2009;460(7254):534–537.
  • Zhang Q, Li Y, Zhang L, et al. E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cell Mol Life Sci. 2013;70(1):153–165.
  • Jankowsky JL, Slunt HH, Ratovitski T, et al. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 2001;17(6):157–165.
  • Qian M, Shen X, Wang H. The distinct role of ADAM17 in APP proteolysis and microglial activation related to Alzheimer’s disease. Cell Mol Neurobiol. 2016;36(4):471–482.
  • Thuerauf DJ, Morrison LE, Hoover H, et al. Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. J Biol Chem.. 2002;277(23):20734–20739.
  • Christensen MA, Zhou W, Qing H, et al. Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Molec Cell Biol. 2004;24(2):865–874.
  • Cao G, Su P, Zhang S, et al. Ginsenoside Re reduces Abeta production by activating PPARgamma to inhibit BACE1 in N2a/APP695 cells. Eur J Pharmacol. 2016;793:101–108.
  • Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science (New York, NY). 1996;274(5284):99–102.
  • Ly PT, Wu Y, Zou H, et al. Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest. 2013;123(1):224–235.
  • Haze K, Yoshida H, Yanagi H, et al. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Molec Biol Cell. 1999;10(11):3787–3799.
  • Kokame K, Kato H, Miyata T. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J Biol Chem. 2001;276(12):9199–9205.
  • Hu X, Das B, Hou H, et al. BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. J Exper Med. 2018;215(3):927–940.
  • Shi Z, Hong Y, Zhang K, et al. BAG-1M co-activates BACE1 transcription through NF-kappaB and accelerates Abeta production and memory deficit in Alzheimer’s disease mouse model. Biochim biophys Acta Molec Basis Dis. 2017;1863(9):2398–2407.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.