603
Views
46
CrossRef citations to date
0
Altmetric
Original Articles

Enriched environment improves post-stroke cognitive impairment and inhibits neuroinflammation and oxidative stress by activating Nrf2-ARE pathway

ORCID Icon, , , , , , & show all
Pages 641-649 | Received 13 Aug 2019, Accepted 01 Jul 2020, Published online: 27 Jul 2020

References

  • Sun JH, Tan L, Yu JT. Post-stroke cognitive impairment: epidemiology, mechanisms and management. Ann Transl Med. 2014;2(8):80
  • Cumming TB, Brodtmann A, Darby D, et al. The importance of cognition to quality of life after stroke. J Psychosom Res. 2014;77(5):374–379.
  • Teuschl Y, Matz K, Brainin M. Prevention of post-stroke cognitive decline: a review focusing on lifestyle interventions. Eur J Neurol. 2013;20(1):35–49.
  • Li YW, Li QY, Wang JH, et al. Contribution of p38 MAPK to the ameliorating effect of enriched environment on the cognitive deficits induced by chronic cerebral hypoperfusion. Cell Physiol Biochem. 2016;40(3-4):549–557.
  • White JH, Bartley E, Janssen H, et al. Exploring stroke survivor experience of participation in an enriched environment: a qualitative study. Disabil Rehabil. 2015;37(7):593–600.
  • Narasimhalu K, Lee J, Leong YL, et al. Inflammatory markers and their association with post stroke cognitive decline. Int J Stroke. 2015;10(4):513–518.
  • Quattromani MJ, Cordeau P, Ruscher K, et al. Enriched housing down-regulates the Toll-like receptor 2 response in the mouse brain after experimental stroke. Neurobiol Dis. 2014;66:66–73.
  • Jurgens HA, Johnson RW. Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection. Brain Behav Immun. 2012;26(6):1006–1016.
  • Jin XF, Wang S, Shen M, et al. Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain Res Bull. 2017;134:236–245.
  • Ren ZX, Zhao YF, Cao T, et al. Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity. Acta Pharmacol Sin. 2016;37(10):1315–1324.
  • Yang HL, Lin SW, Lee CC, et al. Induction of Nrf2-mediated genes by Antrodia salmonea inhibits ROS generation and inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages. Food Funct. 2015;6(1):230–241.
  • Chen Z, Mao X, Liu A, et al. Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: involvement of Nrf2 pathway. Neurochem Res. 2015;40(1):186–194.
  • Wang Y, Huang Y, Xu Y, et al. A Dual AMPK/Nrf2 activator reduces brain inflammation after stroke by enhancing microglia M2 polarization. Antioxid Redox Signal. 2018;28(2):141–163.
  • Kulesh AA, Drobakha VE, Nekrasova IV, et al. Neuroinflammatory, neurodegenerative and structural brain biomarkers of the main types of post-stroke cognitive impairment in acute period of ischemic stroke. Vestn Akad Med Nauk Sssr. 2016;71(4):304–312.
  • Ruscher K, Johannesson E, Brugiere E, et al. Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. J Cereb Blood Flow Metab. 2009;29(11):1796–1805.
  • Cekanaviciute E, Buckwalter MS. Astrocytes: Integrative regulators of neuroinflammation in stroke and other neurological diseases. Neurotherapeutics. 2016;13(4):685–701.
  • Gonçalves LV, Herlinger AL, Ferreira TAA, et al. Environmental enrichment cognitive neuroprotection in an experimental model of cerebral ischemia: biochemical and molecular aspects. Behav Brain Res. 2018;348:171–183.
  • Yang X, Geng K, Zhang J, et al. Sirt3 Mediates the inhibitory effect of Adjudin on astrocyte activation and glial scar formation following ischemic stroke. Front Pharmacol. 2017;8:943
  • Sampedro-Piquero P, De Bartolo P, Petrosini L, et al. Astrocytic plasticity as a possible mediator of the cognitive improvements after environmental enrichment in aged rats. Neurobiol Learn Mem. 2014;114:16–25.
  • Ashton RS, Conway A, Pangarkar C, et al. Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling. Nat Neurosci. 2012;15(10):1399–1406.
  • Zhang X, Huang G, Liu H, et al. Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutr Neurosci. 2012;15(2):55–61.
  • Berretta A, Tzeng YC, Clarkson AN. Post-stroke recovery: the role of activity-dependent release of brain-derived neurotrophic factor. Expert Rev Neurother. 2014;14(11):1335–1344.
  • Quesseveur G, David DJ, Gaillard MC, et al. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Transl Psychiatry. 2013;3:e253
  • Cao W, Duan J, Wang X, et al. Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus. Behav Brain Res. 2014;265:76–83.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.