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Original Articles

Alpha adrenergic receptors have role in the inhibitory effect of electrical low frequency stimulation on epileptiform activity in rats

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Pages 496-504 | Received 26 Jul 2020, Accepted 05 May 2021, Published online: 30 Jun 2021

References

  • Giordano C, Marchiò M, Timofeeva E, et al. Neuroactive peptides as putative mediators of antiepileptic ketogenic diets. Front Neurol. 2014;5:63.
  • Jallon P. Epilepsy in developing countries. Epilepsia. 1997;38(10):1143–1151.
  • Blume WT. The progression of epilepsy. Epilepsia. 2006;47(Suppl 1):71–78.
  • Morrell MJ. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011;77(13):1295–1304.
  • Panuccio G, D’Antuono M, De Guzman P, et al. In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy. Neurobiol Dis. 2010;39(3):372–380.
  • Shiri Z, Levesque M, Etter G, et al. Optogenetic low-frequency stimulation of specific neuronal populations abates ictogenesis. J Neurosci. 2017;37(11):2999–3008.
  • Wang Y, Liang J, Xu C, et al. Low-frequency stimulation in anterior nucleus of thalamus alleviates kainate-induced chronic epilepsy and modulates the hippocampal EEG rhythm. Exp Neurol. 2016;276:22–30.
  • Fisher R, Salanova V, Witt T, et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010;51(5):899–908.
  • McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815–846.
  • Hertz L, Chen Y. Importance of astrocytes for potassium ion (K(+)) homeostasis in brain and glial effects of K(+) and its transporters on learning. Neurosci Biobehav Rev. 2016;71:484–505.
  • Ghasemi Z, Naderi N, Shojaei A, et al. Effect of low-frequency electrical stimulation on the high-K(+)-induced neuronal hyperexcitability in rat hippocampal slices. Neuroscience. 2018;369:87–96.
  • Sadeghian A, Salari Z, Azizi H, et al. The role of dopamine D2-like receptors in a "depotentiation-like effect" of deep brain stimulation in kindled rats. Brain Res. 2020;1738:146820.
  • Milner TA, Lee A, Aicher SA, et al. Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes. J Comp Neurol. 1998;395(3):310–327.
  • Liu JS, Li JB, Gong XW, et al. Spatiotemporal dynamics of high-K+-induced epileptiform discharges in hippocampal slice and the effects of valproate. Neurosci Bull. 2013;29(1):28–36.
  • Zhong K, Wu D-C, Jin M-M, et al. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiol Dis. 2012;48(1):20–26.
  • Ghotbedin Z, Janahmadi M, Mirnajafi-Zadeh J, et al. Electrical low frequency stimulation of the kindling site preserves the electrophysiological properties of the rat hippocampal CA1 pyramidal neurons from the destructive effects of amygdala kindling: the basis for a possible promising epilepsy therapy. Brain Stimul. 2013;6(4):515–523.
  • Kole MH, Ilschner SU, Kampa BM, et al. Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci. 2008;11(2):178–186.
  • Szot P, Lester M, Laughlin M, et al . The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors. Neuroscience. 2004;126(3):795–803.
  • Carr DB, Andrews GD, Glen WB, et al. alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents. J Physiol. 2007;584(Pt 2):437–450.
  • Toprani S, Durand DM. Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation. Exp Neurol. 2013;240:28–43.
  • Haj-Dahmane S, Shen R-Y. Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus. J Neurosci. 2014;34(44):14560–14570.
  • Lazzaro SC, Hou M, Cunha C, et al. Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation. Learn Mem. 2010;17(10):489–493.
  • Scheiderer CL, Dobrunz LE, McMahon LL. Novel form of long-term synaptic depression in rat hippocampus induced by activation of alpha 1 adrenergic receptors. J Neurophysiol. 2004;91(2):1071–1077.
  • Ahmadirad N, Fathollahi Y, Janahmadi M, et al. Low-frequency electrical stimulation reduces the impairment in synaptic plasticity following epileptiform activity in rat hippocampal slices through α1, but not α2, adrenergic receptors. Neuroscience. 2019;406:176–185.
  • Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975;24(17):1639–1641.
  • Asgari A, Semnanian S, Atapour N, et al. Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats. Neurol Sci. 2014;35(8):1255–1260.
  • Namvar S, Fathollahi Y, Javan M, et al. The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat. J Neurol Sci. 2017;375:450–459.
  • Williams JT, Henderson G, North RA. Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones. Neuroscience. 1985;14(1):95–101.
  • Grenhoff J, Svensson TH. Clonidine modulates dopamine cell firing in rat ventral tegmental area. Eur J Pharmacol. 1989;165(1):11–18.

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