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Using C. elegans notch mutants in an undergraduate cancer biology laboratory course to demonstrate oncogenic effects on cell proliferation

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References

  • Austin, J., and J. Kimble. 1987. “Glp-1 is Required in the Germ Line for Regulation of the Decision between Mitosis and Meiosis in C. Elegans.” Cell 51 (4): 589–599.10.1016/0092-8674(87)90128-0
  • Bishop, L. J., and A. L. Nolen. 2001. “Animals in Research and Education: Ethical Issues.” Kennedy Institute of Ethics Journal 11 (1): 91–112.10.1353/ken.2001.0006
  • Cole, R. L., and T. R. Mertens. 1966. “A Laboratory Exercise Demonstrating Chromosome Morphology and Number.” The American Biology Teacher 28 (2): 114–119.
  • Corsi, A. K., B. Wightman, and M. Chalfie. 2015. “A Transparent Window into Biology: A Primer on Caenorhabditis Elegans.” Genetics 200 (2): 387–407.10.1534/genetics.115.176099
  • De Mattos, J. C. P., F. J. S. Dantas, A. Caldeira-de-Araújo, and M. O. Moraes. 2004. “Agarose Gel Electrophoresis System in the Classroom: Detection of DNA Strand Breaks through the Alteration of Plasmid Topology.” Biochemistry and Molecular Biology Education 32 (4): 254–257.10.1002/(ISSN)1539-3429
  • Howard, D. R., and J. A. Miskowski. 2005. “Using a Module-Based Laboratory to Incorporate Inquiry into a Large Cell Biology Course.” Cell Biology Education 4 (3): 249–260.10.1187/cbe.04-09-0052
  • Jacobs-McDaniels, N. L., E. M. Maine, R. Craig Albertson, and J. R. Wiles. 2013. “Using Model Organisms in an Undergraduate Laboratory to Link Genotype, Phenotype, and the Environment.” Journal of Biological Education 47 (1): 52–59.10.1080/00219266.2012.727847
  • Kersten, K., K. E. de Visser, M. H. van Miltenburg, and J. Jonkers. 2017. “Genetically Engineered Mouse Models in Oncology Research and Cancer Medicine.” EMBO Molecular Medicine 9 (2): 137–153.10.15252/emmm.201606857
  • Kodoyianni, V., E. M. Maine, and J. Kimble. 1992. “Molecular Basis of Loss-of-Function Mutations in the Glp-1 Gene of Caenorhabditis Elegans.” Molecular Biology of the Cell 3 (11): 1199–1213.10.1091/mbc.3.11.1199
  • Lee, C., E. B. Sorensen, T. R. Lynch, and J. Kimble. 2016. C. Elegans GLP-1/Notch Activates Transcription in a Probability Gradient across the Germline Stem Cell Pool. Elife 5.
  • Pepper, A. S., D. J. Killian, and E. J. Hubbard. 2003. “Genetic Analysis of Caenorhabditis Elegans Glp-1 Mutants Suggests Receptor Interaction or Competition.” Genetics 163 (1): 115–132.
  • Stiernagle T. 2006. Maintenance of C. elegans. WormBook: 1–11.
  • Weng, A. P., A. A. Ferrando, W. Lee, J. P. Morris, L. B. Silverman, C. Sanchez-Irizarry, S. C. Blacklow, A. T. Look, and J. C. Aster. 2004. “Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia.” Science 306 (5694): 269–271.10.1126/science.1102160
  • Yochem, J., and I. Greenwald. 1989. “Glp-1 and Lin-12, Genes Implicated in Distinct Cell-Cell Interactions in C. Elegans, Encode Similar Transmembrane Proteins.” Cell 58 (3): 553–563.10.1016/0092-8674(89)90436-4

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