Advanced search
Publication Cover
Journal of Macromolecular Science, Part B
Physics
Volume 60, 2021 - Issue 5
Submit an article Journal homepage
238
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Preparation and Characterization of Poly(l-lactide-co-glycolide-co-ε-caprolactone) Porous Microspheres

Chao Zhanga Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Zhihua Zhoua Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China;b Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan, P. R. China;c Key Laboratory of Theoretical Organic Chemistry and Function Molecule of Ministry of Education, Hunan University of Science and Technology, Xiangtan, P. R. ChinaCorrespondence[email protected] [email protected]
View further author information
,
Wenjuan Liub Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Tianlong Huangd Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha, P. R. ChinaView further author information
,
Yanmin Zhaoa Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Ping Chena Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Ziwei Zhoua Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Dan Wanga Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Meiling Yia Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
&
Jianjun Fanga Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaCorrespondence[email protected] [email protected]
View further author information
 show all
Pages 313-323 | Received 22 Aug 2020, Accepted 31 Oct 2020, Published online: 30 Nov 2020

References

  • Nair, L. S.; Laurencin, C. T. Biodegradable Polymers as Biomaterials. Prog. Polym. Sci. 2007, 32, 762–798. DOI: 10.1016/j.progpolymsci.2007.05.017.
  • Straub, J. A.; Chickering, D. E.; Church, C. C.; Shah, B.; Hanlon, T.; Bernstein, H. Porous PLGA Microparticles: AI-700, an Intravenously Administered Ultrasound Contrast Agent for Use in Echocardiography. J. Control. Release 2005, 108, 21–32. DOI: 10.1016/j.jconrel.2005.07.020.
  • Aberturas, M. R.; Molpeceres, J.; Guzman, M.; Garcia, F. Development of a New Cyclosporine Formulation Based on Poly(caprolactone) Microspheres. J. Microencapsul. 2002, 19, 61–72. DOI: 10.1080/02652040110055270.
  • Gelse, K.; Poschl, E.; Aigner, T. Collagens-Structure, Function, and Biosynthesis. Adv. Drug Deliv. Rev. 2003, 55, 1531–1546. DOI: 10.1016/j.addr.2003.08.002.
  • Jiang, Y.; Hou, Y.; Fang, J.; Liu, W.; Zhao, Y.; Huang, T.; Cui, J.; Yang, Y.; Zhou, Z. Preparation and Characterization of PVA/SA/HA Composite Hydrogels for Wound Dressing. Int. J. Polym. Anal. Charact. 2019, 24, 132–141. DOI:10.1080/1023666X.2018.1558567.
  • Kirker, K. R.; Luo, Y.; Nielson, J. H.; Shelby, J.; Prestwich, G. D. Glycosaminoglycan Hydrogel Films as Bio-Interactive Dressings for Wound Healing. Biomaterials 2002, 23, 3661–3671. DOI:10.1016/s0142-9612(02)00100-x.
  • Baruch, L.; Machluf, M. Alginate-Chitosan Complex Coacervation for Cell Encapsulation: Effect on Mechanical Properties and on Long-Term Viability. Biopolymers 2006, 82, 570–579. DOI: 10.1002/bip.20509.
  • Jayakumar, R.; Nwe, N.; Tokura, S.; Tamura, H. Sulfated Chitin and Chitosan as Novel Biomaterials. Int. J. Biol. Macromol. 2007, 40, 175–181. DOI: 10.1016/j.ijbiomac.2006.06.021.
  • Zhou, Z.; Liu, L.; Liu, Q.; Yi, Q.; Zhao, Y.; Zeng, W.; Liu, X. Biological Assessment of Composite Materials Based on Poly-L-lactide and Bovine Bone. Int. J. Polym. Mater. Polym. Biomater. 2013, 62, 81–84. DOI: 10.1080/00222348.2012.672295.
  • Zhou, Z.; Liu, L.; Liu, Q.; Yi, Q.; Zeng, W.; Zhao, Y. Effect of Surface Modification of Bioactive Glass on Properties of Poly-L-lactide Composite Materials. J. Macromol. Sci. B Phys. 2012, 51, 1637–1646. DOI: 10.1080/00222348.2012.672295.
  • Mahmoudifar, N.; Doran, P. M. Chondrogenic Differentiation of Human Adipose-Derived Stem Cells in Polyglycolic Acid Mesh Scaffolds under Dynamic Culture Conditions. Biomaterials 2010, 31, 3858–3867. DOI: 10.1016/j.biomaterials.2010.01.090.
  • Zhang, Q.; Zhou, Z.; Peng, C.; Huang, T.; Liu, W.; Liu, Q.; Zhou, H.; Wang, W.; Yan, H. Preparation and Properties of Novel Maleated Poly(D, L-lactide-co-glycolide) Porous Scaffolds for Tissue Engineering. J. Macromol. Sci. B Phys. 2017, 56, 505–515. DOI: 10.1080/00222348.2017.1330132.
  • Zhou, Z.; Huang, H.; Huang, T.; Peng, C.; Zhou, H.; Liu, Q.; Zeng, N.; Liu, L.; Cao, D.; He, S.; et al. Synthesis and Characterization of Novel Maleated Poly(D,L-lactide-co-glycolide) by Direct Melt Copolymerization. Polym. Bull. 2015, 72, 1531–1543. DOI: 10.1007/s00289-015-1354-z.
  • Baki, A.; Rahman, C. V.; White, L. J.; Scurr, D. J.; Qutachi, O.; Shakesheff, K. M. Surface Modification of PdlLGA Microspheres with Gelatine Methacrylate: Evaluation of Adsorption, Entrapment, and Oxygen Plasma Treatment Approaches. Acta Biomater. 2017, 53, 450–459. DOI: 10.1016/j.actbio.2017.01.042.
  • Peng, Z.; Zou, T. In-Vitro Degradation Behaviors of Composite Scaffolds Based on 1,4-Butadnediamine Modified Poly(lactide-co-glycolide) and Nanobioceramics. J. Macromol. Sci. B Phys. 2019, 58, 505–517. DOI: 10.1080/00222348.2019.1593601.
  • Cui, J.; Zhou, Z.; Yang, Y.; Liu, W.; Zhao, Y.; Peng, C.; Huang, T.; Zhou, H.; Liu, L.; Zhang, Q. Synthesis, Characterization, and Degradation Behaviors of Poly(D,L-lactide-co-glycolide) Modified by Maleic Anhydride and Ethanediamine. Int. J. Polym. Anal. Charact. 2017, 22, 575–586. DOI: 10.1080/1023666X.2017.1344819.
  • Wu, W.; Fang, J. J.; Liu, W.; Zhao, Y. H.; Huang, T. L.; Zhao, Y. M.; Li, X. F.; Cui, J. L.; Yang, Y.; Zhou, Z. H. Preparation and Properties of BMPLGA/NBAG-β-TCP Composite Scaffold Materials. Int. J. Polym. Anal. Charact. 2018, 23, 710–720. DOI: 10.1080/1023666X.2018.1499275.
  • Zhou, Z.; Cao, D.; Liu, L.; Liu, Q.; Zhao, Y.; Zeng, W.; Yi, Q.; Yang, Z.; Zhou, J. Fabrication and Properties of Gelatin/Chitosan Microspheres Loaded with 5-Fluorouracil. J. Macromol. Sci. B Phys. 2013, 52, 973–983. DOI: 10.1080/00222348.2012.746910.
  • Zhang, Q.; Fang, J.; Liu, W.; Zhao, Y.; Huang, T.; Cui, J.; Yang, Y.; Zhou, Z. Synthesis and Characterization of Poly(D,L-lactide-co-glycolide) Modified by Maleic Anhydride and 1,4-Butanediamine. Int. J. Polym. Anal. Charact. 2018, 23, 474–482. DOI: 10.1080/1023666X.2018.1478618.
  • Cristescu, R.; Doraiswamy, A.; Socol, G.; Grigorescu, S.; Axente, E.; Mihaiescu, D.; Moldovan, A.; Narayan, R. J.; Stamatin, I.; Mihailescu, I. N.; et al. Polycaprolactone Biopolymer Thin Films Obtained by Matrix Assisted Pulsed Laser Evaporation. Appl. Surf. Sci. 2007, 253, 6476–6479. DOI: 10.1016/j.apsusc.2007.01.064.
  • Bao, T. Q.; Franco, R. A.; Lee, B. T. Preparation and Characterization of Novel Poly(ε-caprolactone)/Biphasic Calcium Phosphate Hybrid Composite Microspheres. J. Biomed. Mater. Res. B Appl. Biomater. 2011, 98, 272–279. DOI:10.1016/j.bej.2012.02.005.
  • Dastidar, D. G.; Saha, S.; Chowdhury, M. Porous Microspheres: Synthesis, Characterisation and Applications in Pharmaceutical & Medical Fields. Int. J. Pharm. 2018, 548, 34–48. DOI: 10.1016/j.ijpharm.2018.06.015.
  • Lu, Y.; Chen, S. C. Micro and Nano-Fabrication of Biodegradable Polymers for Drug Delivery. Adv. Drug. Deliv. Rev. 2004, 56, 1621–1633. DOI: 10.1016/j.addr.2004.05.002.
  • Katti, D. S.; Robinson, K. W.; Ko, F. K.; Laurencin, C. T. Bioresorbable Nanofiber-Based Systems for Wound Healing and Drug Delivery: Optimization of Fabrication Parameters. J. Biomed. Mater. Res. B Appl. Biomater. 2004, 70, 286–296. DOI: 10.1002/jbm.b.30041.
  • Chandy, T.; Wilson, R. F.; Rao Gundu, H. R.; Das, G. Changes in Cisplatin Delivery Due to Surface-Coated Poly(lactic acid)-Poly(epsilon-caprolactone) Microspheres. J. Biomater. Appl. 2002, 16, 275–291. DOI: 10.1106/088532802024246.
  • Sinha, V. R.; Bansal, K.; Kaushik, K.; Kumria, R.; Trehan, A. Poly-Epsilon-Caprolactone Microspheres and Nanospheres: An Overview. Int. J. Pharm. 2004, 278, 1–23. DOI: 10.1016/j.ijpharm.2004.01.044.
  • Zhou, Z.; Wu, W.; Fang, J.; Yin, J. Polymer-Based Porous Microcarriers as Cell Delivery Systems for Applications in Bone and Cartilage Tissue Engineering. Int. Mater. Rev. 2020. DOI: 10.1080/09506608.2020.1724705.
  • Yan, H.; Zhou, Z.; Huang, T.; Peng, C.; Liu, Q.; Zhou, H.; Zeng, W.; Liu, L.; Ou, B.; He, S.; Huang, H. Controlled Release in Vitro of Icariin from Gelatin/Hyaluronic Acid Composite Microspheres. Polym. Bull. 2016, 73, 1055–1066. DOI: 10.1007/s00289-015-1534-x..
  • Crotts, G.; Park, T. G. Preparation of Porous and Nonporous Biodegradable Polymeric Hollow Microspheres. J. Control. Release 1995, 35, 91–105. DOI:10.1016/0168-3659(95)00010-6.
  • Hong, Y.; Gao, C.; Shi, Y.; Shen, J. Preparation of Porous Polylactide Microspheres by Emulsion-Solvent Evaporation Based on Solution Induced Phase Separation. Polym. Adv. Technol. 2005, 16, 622–627. DOI: 10.1002/pat.629.
  • McDonald, P. F.; Lyons, J. G.; Geever, L. M.; Higginbotham, C. L. In Vitro Degradation and Drug Release from Polymer Blends Based on Poly(D,L-lactide), Poly(L-lactide-glycolide) and Poly(ε-caprolactone). J. Mater. Sci. 2010, 45, 1284–1292. DOI: 10.1007/s10853-009-4080-9.
  • Elzein, T.; Nasser-Eddine, M.; Delaite, C.; Bistac, S.; Dumas, P. FTIR Study of Polycaprolactone Chain Organization at Interfaces. J. Colloid Interface Sci. 2004, 273, 381–338. DOI: 10.1016/j.jcis.2004.02.001.
  • Seal, B. L.; Otero, T. C.; Panitch, A. Polymeric Biomaterials for Tissue and Organ Regeneration. Mater. Sci. Eng. R Rep. 2001, 34, 147–230. DOI: 10.1016/S0927-796X(01)00035-3.
  • Wu, W.; Zhou, Z. H.; Liu, W. J.; Zhao, Y. H.; Zhao, Y. M.; Huang, T. L.; Li, X. F.; Fang, J. J. Preparation and In-Vitro Degradation Behavior of Poly(L-lactide-co-glycolide-co-ε-caprolactone) Terpolymer. J. Macromol. Sci. B Phys. 2019, 58, 568–577. DOI: 10.1080/00222348.2019.1601809.
  • Das, G. S.; Rao, G. H.; Wilson, R. F.; Chandy, T. Colchicine Encapsulation within Poly(ethylene glycol)-Coated Poly(lactic acid)/Poly(epsilon-caprolactone) Microspheres-Controlled Release Studies. Drug Deliv. 2000, 7, 129–138. DOI: 10.1080/10717540050120160.
  • Yang, Y.; Liu, W. J.; Fang, J. J.; Zhao, Y. H.; Zhao, Y. M.; Huang, T. L.; Cui, J. L.; Wu, W.; Li, X. F.; Zhou, Z. H. Synthesis and Characterization of Terpolymers of Poly(L-lactide-glycolide-ε-caprolactone). J. Macromol. Sci. B Phys. 2018, 57, 562–571. DOI: 10.1080/00222348.2018.1493171.
  • McGlohorn, J. B.; Grimes, L. W.; Webster, S. S.; Burg, K. J. L. Characterization of Cellular Carriers for Use in Injectable Tissue-Engineering Composites. J. Biomed. Mater. Res. A 2003, 66, 441–449. DOI: 10.1002/jbm.a.10546.
  • Sahoo, S. K.; Panda, A. K.; Labhasetwar, V. Characterization of Porous PLGA/PLA Microparticles as a Scaffold for Three Dimensional Growth of Breast Cancer Cells. Biomacromolecules 2005, 6, 1132–1139. DOI: 10.1021/bm0492632.
  • Kim, T. K.; Yoon, J. J.; Lee, D. S.; Park, T. G. Gas Foamed Open Porous Biodegradable Polymeric Microspheres. Biomaterials 2006, 27, 152–159. DOI: 10.1016/j.biomaterials.2005.05.081.
  • Liu, X.; Jin, X.; Ma, P. X. Nanofibrous Hollow Microspheres Self-Assembled from Star-Shaped Polymers as Injectable Cell Carriers for Knee Repair. Nat. Mater. 2011, 10, 398–406. DOI: 10.1038/NMAT2999.
  • Baimark, Y.; Srisa-Ard, M.; Puntumchai, A. Synthesis of Poly(D,L-lactic acid-co-glycolic acid-co-ε-caprolactone) Terpolyesters by Direct Polycondensation. Curr. Res. Chem. 2009, 2, 10–17. DOI: 10.3923/crc.2010.10.17.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.