Publication Cover
The Journal of Psychology
Interdisciplinary and Applied
Volume 132, 1998 - Issue 4
59
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Physiological Mechanisms of Sexual Dysfunction Side Effects Associated With Antidepressant Medication

Pages 407-416 | Received 07 Nov 1996, Published online: 02 Apr 2010

References

  • Adler-Graschinsky , E. , Butta , N. V. and Elgoyhen , A. B. 1986 . Serotonin reuptake inhibitors and the prejunctional effects of serotonin on peripheral sympathetic nerves . Life Sciences , 39 : 61 – 68 .
  • Akhtar , S. and Thomson , A. Jr. 1980 . Schizophrenia and sexuality: A review and a report of twelve unusual cases . Journal of Clinical Psychiatry , 41 : 166 – 174 .
  • Baldessarini , R. J. and Marsh , E. 1990 . Fluoxetine and side effects (letter) . Archives of General Psychiatry , 47 : 191 – 192 .
  • Balogh , S. , Hendricks , S. E. and Kang , J. 1992 . Treatment of fluoxetine-induced anorgasmia with amantadine (letter) . Journal of Clinical Psychiatry , 53 : 212 – 213 .
  • Balon , R. , Yeragani , V. K. , Pohl , R. and Ramesh , C. 1993 . Sexual dysfunction during antidepressant treatment . Journal of Clinical Psychiatry , 54 : 209 – 212 .
  • Benfield , P. , Heel , R. C. and Lewis , S. P. 1986 . Fluoxetine: A review of it pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness . Drugs , 32 : 481 – 508 .
  • Cohen , L. S. and Rosenbaum , J. F. 1987 . Clonazepam: New uses and potential problems . Journal of Clinical Psychiatry , 48 ( 10 ) : 50 – 55 . Suppl.
  • Crews , F. T. , Paul , S. M. and Goodwin , F. K. 1981 . Accelerating B-receptor desensitization in combined administration of antidepressants and phenoxybenzamine . Nature , 290 : 787 – 788 .
  • Cushman , P. Jr. 1972 . Sexual behavior in heroin addiction and methadone maintenance . New York State Journal of Medicine , 92 : 1261 – 1265 .
  • Decastro , R. M. 1985 . Reversal of MAOI-induced anorgasmia with cyproheptadine (letter) . American Journal of Psychiatry , 142 : 783
  • De Vane , C. L. 1994 . Pharmacokinetics of the newer antidepressants: Clinical relevance . American Journal of Medicine , 97 ( Suppl. 6A ) : 13S – 23S .
  • Dubovsky , S. L. and Thomas , M. 1995 . Serotonergic mechanisms and current and future psychiatric practice . Journal of Clinical Psychiatry , 52 ( Suppl. 2 ) : 38 – 48 .
  • Feder , R. 1991 . Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients . Journal of Clinical Psychiatry , 52 : 163 – 164 .
  • Feiger , A. , Kiev , A. , Shrivastava , R. K. , Wisselink , P. G. and Wilcox , C. S. 1996 . Nefazodone versus sertraline in outpatients with major depression: Focus on efficacy, tolerability, and effects on sexual function and satisfaction . Journal of Clinical Psychiatry , 57 ( Suppl. 2 ) : 53 – 62 .
  • Gartrell , N. 1986 . Increased libido in women receiving trazodone . American Journal of Psychiatry , 143 : 781 – 782 .
  • Ghadirian , A.-M. , Annable , L. and Belanger , M-C. 1992 . Lithium, benzodiazepine, and sexual function in bipolar patients . American Journal of Psychiatry , 149 : 801 – 805 .
  • Ghadirian , A. M. , Chouinard , G. and Annable , L. 1982 . Sexual dysfunction and plasma prolactin levels in neuroleptic-treated schizophrenic outpatients . Journal of Nervous and Mental Disease , 170 : 463 – 466 .
  • Gitlin , M. J. 1994 . Psychotropic medications and their effects on sexual function: Diagnosis, biology, and treatment approaches . Journal of Clinical Psychiatry , 55 ( 9 ) : 406 – 413 .
  • Gitlin , M. J. 1995 . Treatment of sexual side effects with dopaminergic agents (letter) . Journal of Clinical Psychiatry , 56 ( 3 ) : 124
  • Goldbloom , D. S. and Kennedy , S. H. 1991 . Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia . Journal of Clinical Psychiatry , 52 : 261 – 262 .
  • Goodnick , P. J. 1989 . Influence of fluoxetine on plasma levels of desipramine (letter) . American Journal of Psychiatry , 146 : 552
  • Goodnick , P. J. , Henry , J. H. and Buki , V. M. V. 1995 . Treatment of depression in patients with diabetes mellitus . Journal of Clinical Psychiatry , 56 : 128 – 136 .
  • Goodwin , G. M. 1996 . How do antidepressants affect serotonin receptors: The role of serotonin receptors in the therapeutic and side effect profile of the SSRIs . Journal of Clinical Psychiatry , 57 ( Suppl. 4 ) : 9 – 13 .
  • Greenberg , H. R. 1971 . Inhibition of ejaculation by chlorpromazine . Journal of Nervous and Mental Disease , 152 : 364 – 366 .
  • Herman , J. B. , Brotman , A. W. , Pollack , M. H. , Falk , W. E. , Biederman , J. and Rosenbaum , J. F. 1990 . Fluoxetine-induced sexual dysfunction . Journal of Clinical Psychiatry , 51 : 25 – 27 .
  • Hollander , E. and McCarley , A. 1992 . Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers . Journal of Clinical Psychiatry , 53 : 207 – 209 .
  • Hyman , S. E. and Nestler , E. J. 1996 . Initiation and adaptation: A paradigm for understanding psychotropic drug action . American Journal of Psychiatry , 153 : 151 – 162 .
  • Jacobsen , F. M. 1992 . Fluoxetine-induced sexual dysfunction and an open trial of yohimbine . Journal of Clinical Psychiatry , 53 : 119 – 122 .
  • Jani , N. N. , Wise , T. N. , Kass , E. and Sessler , A. 1988 . Trazodone and anorgasmia (letter) . American Journal of Psychiatry , 145 : 896
  • Jefferson , J. W. 1995 . Psychotropic medications with their effects on sexual function (letter) . Journal of Clinical Psychiatry , 56 ( 1 ) : 536 – 537 .
  • Kapur , S. and Remington , G. 1996 . Serotonin-dopamine interaction and its relevance to schizophrenia . American Journal of Psychiatry , 153 : 466 – 476 .
  • Katz , R. J. and Rosenthal , M. 1994 . Adverse reaction of cyproheptadine with serotonergic antidepressants (letter) . Journal of Clinical Psychiatry , 55 ( 5 ) : 314 – 315 .
  • Kilts , C. D. 1994 . Recent pharmacologic advances in antidepressant therapy . American Journal of Medicine , 97 ( Suppl 6A ) : 6S – 12S .
  • Kline , M. D. 1989 . Fluoxetine and anorgasmia (letter) . American Journal of Psychiatry , 146 : 804 – 805 .
  • Kogeorgos , J. and de Alwis , C. 1986 . Priapism and psychotropic medication . British Journal of Psychiatry , 149 : 241 – 243 .
  • Lesko , L. M. , Stotland , N. L. and Segraves , R. T. 1982 . Three cases of female anorgasmia with MAOIs . American Journal of Psychiatry , 139 : 1353 – 1354 .
  • Lydiard , R. B. , Howell , E. F. , Laraia , M. T. and Ballenger , J. C. 1987 . Sexual side effects of alprazolam (letter) . American Journal of Psychiatry , 144 : 254 – 255 .
  • McCormick , S. , Olin , J. and Brotman , A. W. 1990 . Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients . Journal of Clinical Psychiatry , 51 : 383 – 384 .
  • Mendels , J. 1995 . Sertraline for premature ejaculation (letter) . Journal of Clinical Psychiatry , 56 : 59
  • Monteiro , W. H. , Noshirvani , H. F. , Marks , I. M. and Lelliott , P. T. 1987 . Anorgasmia from clomipramine in obsessive-compulsive disorder: A controlled trial . British Journal of Psychiatry , 151 : 107 – 112 .
  • Patt , N. 1985 . More on trazodone and priapism (letter) . American Journal of Psychiatry , 142 : 783 – 784 .
  • Patterson , W. M. 1993 . Fluoxetine-induced sexual dysfunction (letter) . Journal of Clinical Psychiatry , 54 ( 2 ) : 71
  • Pearlstein , T. B. and Stone , A. B. 1994 . Long-term fluoxetine treatment of late luteal phase dysphoria . Journal of Clinical Psychiatry , 55 ( 8 ) : 332 – 335 .
  • Pollack , M. H. and Hammerness , P. 1993 . Adjunctive yohimbine for treatment of refractory depression . Biological Psychiatry , 33 : 220 – 221 .
  • Popli , A. P. , Baldessarini , R. J. and Cole , J. A. 1994 . Interactions of serotonin reuptake inhibition with tricyclic antidepressants (letter) . Archives of General Psychiatry , 51 : 666 – 667 .
  • Preskorn , S. H. 1996 . Reducing the risk of drug-drug interactions: A goal of rational drug development . Journal of Clinical Psychiatry , 57 ( Suppl. 1 ) : 3 – 6 .
  • Price , L. H. , Charney , D. S. , Delgado , P. L. and Heninger , G. R. 1991 . Serotonin function and depression: Neuroendocrine and mood responses to intravenous L-tryptophan in depressed patients and healthy comparison subjects . American Journal of Psychiatry , 148 : 1515 – 1525 .
  • Raskin , D. E. 1985 . Trazodone and priapism (letter) . American Journal of Psychiatry , 142 : 142 – 143 .
  • Robinson , D. S. , Roberts , D. L. , Smith , J. M. , Springfellow , J. C. , Kaplita , S. R. , Seminara , J. A. and Marcus , R. W. 1996 . The safety profile of nefazodone . Journal of Clinical Psychiatry , 57 ( Suppl. 2 ) : 31 – 38 .
  • Rothschild , A. J. 1995 . Selective serotonin reuptake inhibitor-induced sexual dysfunction: Efficacy of a drug holiday . American Journal of Psychiatry , 152 : 1514 – 1516 .
  • Sangal , R. 1985 . Inhibited female orgasm as a side effect of alprazolam (letter) . American Journal of Psychiatry , 142 : 1222 – 1223 .
  • Schiavi , R. C. , Stimmel , B. B. , Mandeli , J. and White , D. 1995 . Chronic alcoholism and male sexual function . American Journal of Psychiatry , 152 : 1045 – 1051 .
  • Schwartz , M. F. , Bauman , J. E. and Masters , W. H. 1982 . Hyperprolactinemia and sexual disorders in men . Biological Psychiatry , 17 : 861 – 876 .
  • Segraves , R. T. 1987 . Treatment of premature ejaculation with lorazepam (letter) . American Journal of Psychiatry , 144 : 1240
  • Segraves , R. T. 1989 . Effects of psychotropic drugs on human erection and ejaculation . Archives of General Psychiatry , 46 : 275 – 284 .
  • Segraves , R. T. 1992 . Overview of sexual dysfunction complicating the treatment of depression . Journal of Clinical Psychiatry Monographs , 10 ( 2 ) : 4 – 10 .
  • Segraves , R. T. 1994 . Sexual side effects of Prozac and other SSRIs . Menninger Letter , 2 ( 5 ) : 7
  • Service , R. F. 1996 . Combinatorial chemistry hits the drug market . Science , 272 : 1266 – 1268 .
  • Singh , R. 1961 . A case of inhibition of ejaculation as a side effect of Mellaril . American Journal of Psychiatry , 117 : 1041 – 1042 .
  • Spoont , M. R. 1992 . Modulatory role of serotonin in neural information processing: Implications for human psychopathology . Psychological Bulletin , 112 : 330 – 350 .
  • Stark , P. and Hardison , C. D. 1985 . A review of multicenter controlled studies of fluoxetine, imipramine and placebo in outpatients with major depressive disorder . Journal of Clinical Psychiatry , 46 ( 3 ) : 53 – 58 . Sec. 2
  • Sullivan , G. 1988 . Increased libido in three men treated with trazodone . Journal of Clinical Psychiatry , 49 : 202 – 203 .
  • Sussman , N. 1994 . The potential benefits of serotonin receptor-specific agents . Journal of Clinical Psychiatry , 55 ( Suppl. 2 ) : 45 – 51 .
  • Taylor , D. P. , Carter , R. B. , Eison , A. S. , Mullins , U. L. , Smith , H. L. , Torrente , J. R. , Wright , R. N. and Yocca , F. D. 1995 . Pharmacology and neurochemistry of nefazodone. A novel antidepressant drug . Journal of Clinical Psychiatry , 56 ( Suppl. 6 ) : 3 – 11 .
  • Walker , P. W. , Cole , J. O. , Gardner , E. A. , Hughes , A. R. , Johnston , J. A. , Batey , S. R. and Lineberry , C. G. 1993 . Improvements in fluoxetine-associated sexual dysfunction in patients switched to bupropion . Journal of Clinical Psychiatry , 54 : 458 – 465 .
  • Weizman , R. , Weizman , A. , Levi , J. , Gura , V. , Zevin , D. , Moaz , B. , Wijsenbeek , H. and David , M. B. 1983 . Sexual dysfunction associated with hyperprolactinemia in males and females undergoing hemodialysis . Psychosomatic Medicine , 45 : 259 – 269 .
  • Wernicke , J. F. 1985 . The side effect profile and safety of fluoxetine . Journal of Clinical Psychiatry , 46 ( 3 ) : 59 – 67 . Sec. 2
  • Wesson , M. L. , Finnegan , D. M. and Clark , P. I. 1996 . Continuing clozapine despite neutropenia . British Journal of Psychiatry , 168 : 217 – 220 .
  • Wise , T. N. 1994 . Sertraline as a treatment for premature ejaculation (letter) . Journal of Clinical Psychiatry , 55 : 417
  • Zajecka , J. , Fawcett , J. , Schaff , M. , Jeffriess , H. and Guy , C. 1991 . The role of serotonin in sexual dysfunction: Fluoxetine-associated orgasm dysfunction . Journal of Clinical Psychiatry , 54 : 66 – 68 .
  • Zitrin , A. , Beach , F. A. , Barchas , J. D. and Dement , W. C. 1970 . Sexual behavior of male cats after administration of paracholorophenylalanine . Science , 170 : 868 – 870 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.