Appreciation for analysis of how levonorgestrel works and reservations with the use of meloxicam as emergency contraception

References

• American Life League. 2005. My secret life. Stafford, VA: American Life League, Inc.
   Google Scholar
• Baird, D.D., C.R. Weinberg, R. McConnaughey, and A.J. Wilcox. 2002. Rescue of the corpus luteum in human pregnancy. Biology of Reproduction 68: 448–56. doi: 10.1095/biolreprod.102.008425
   Web of Science ®Google Scholar
• Banerjee, P., and A.T. Fazleabas. 2010. Endometrial responses to embryonic signals in the primate. International Journal of Developmental Biology 54: 295–302. doi: 10.1387/ijdb.082829pb
   PubMed Web of Science ®Google Scholar
• Bermas, B.L. 2014. Non-steroidal anti inflammatory drugs, glucocorticoids and disease modifying anti-rheumatic drugs for the management of rheumatoid arthritis before and during pregnancy. Current Opinion in Rheumatology 26(3). 3: 334–40. doi: 10.1097/BOR.0000000000000054
   Web of Science ®Google Scholar
• Briggs, G., R. Freeman, S. Yaffee, and J. Sumner. 2011. A Reference guide to fetal and neonatal risk. Drugs in pregnancy and lactation, 9th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins.
   Google Scholar
• Catechism of the Catholic Church. 2nd ed. 1997. Vatican City: Liberia Editrice Vaticana.
   Google Scholar
• Cha, J., X. Sun, and S.K. Dey. 2012. Mechanisms of implantation: Strategies for successful pregnancy. Nature Medicine 18: 1755–67. doi: 10.1038/nm.3012
   Web of Science ®Google Scholar
• Congregation for the Doctrine of the Faith (CDF). 2008. Instruction dignitas personae on certain bioethical questions. Boston: Pauline Books and Media. http://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_20081208_dignitas-personae_en.html.
   Google Scholar
• Correa, A., S.M. Gilboa, L.D. Botto, C.A. Moore, C.A. Hobbs, M.A. Cleves, T.J. Riehle-Colarusso, D.K. Waller, E.A. Reece, and the National Birth Defects Prevention Study. 2012. Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. American Journal of Obstetrics and Gynecology 206: 218.e1–e13. doi: 10.1016/j.ajog.2011.12.018
   PubMed Web of Science ®Google Scholar
• Crenin, M.D., W. Schlaff, D.F. Archer, L. Wan, R. Frezieres, M. Thomas, M. Rosenberg, and J. Higgins. 2006. Progesterone receptor modulator for emergency contraception: a randomized controlled trial. Obstetrics and Gynecology 108: 1089–97. doi: 10.1097/01.AOG.0000239440.02284.45
   PubMed Web of Science ®Google Scholar
• Croxatto, H.B. 2005. Progesterone receptors and opportunities for contraception. In New mechanisms for tissue-selective estrogen-free contraception, eds. H.B. Croxatto, R. Schurmann, R.U. Fuhrmann, and U. Schellschmidt, 1–17. I. Ernst Schering Research Foundation (Workshop 52). Berlin, Heidelburg: Springer-Verlag.
   Google Scholar
• Croxatto, H.B. 2008. CV: Dr. H.B. Croxatto (English). http://www.scribd.com/doc/46371443/CV-Dr-HB-croxatto-English-March-2008.
   Google Scholar
• Croxatto, H.B., V. Brache, M. Pavez, L. Cochon, M.L. Forcelledo, F. Alvarez, R. Massai, A. Faundes, and A.M. Salvatierra. 2004. Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose of a single 0.75-mg dose given on the days preceding ovulation. Contraception 70: 442–50. doi: 10.1016/j.contraception.2004.05.007
   PubMed Web of Science ®Google Scholar
• Cunningham, F.D., K.J. Leveno, S.L. Bloom, J.C. Hauth, D.J. Rouse, and C.Y. Spong (eds.). 2010. Williams obstetrics. 23rd ed. New York: McGraw Hill Medical.
   Google Scholar
• Davidoff, F., and J. Trussell. 2006. Plan B and the politics of doubt. Journal of the American Medical Association 296: 1775–7. doi: 10.1001/jama.296.14.1775
   PubMed Web of Science ®Google Scholar
• Davies, N.M., and N.M. Skjodt. 1999. Clinical pharmacokinetics of meloxicam: A cyclo-oxygenase-2 preferential nonsteroidal anti-inflammatory drug. Clinical Pharmacokinetics 36: 115–26. doi: 10.2165/00003088-199936020-00003
   PubMed Web of Science ®Google Scholar
• Delgado, G., and M.L. Davenport. 2012. Progesterone use to reverse the effects of mifepristone. Annals of Pharmacotherapy 46: e36. doi: 10.1345/aph.1R252
   PubMedGoogle Scholar
• Dorniak, P., F.W. Bazer, and T.E. Spencer. 2011. Prostaglandins regulate conceptus elongation and mediate effects of interferon tau on the ovine uterine endometrium. Biology of Reproduction 84: 1119–27. doi: 10.1095/biolreprod.110.089979
   PubMed Web of Science ®Google Scholar
• Durand, M., M. del Carmen Cravioto, E.G. Raymond, O. Duran-Sanchez, M. De la Luz Cruz-Hinojosa, A. Caell-Rodriguez, R. Schiavon, and F. Larea. 2001. On the mechanisms of action of short-term levonorgestrel administration in emergency contraception. Contraception 64: 227–34. doi: 10.1016/S0010-7824(01)00250-5
   PubMed Web of Science ®Google Scholar
• Edwards, D.R., T. Aldridge, D.D. Baird, M.J. Funk, D.A. Savitz, and K.E. Hartmann. 2012. Periconceptual over-the-counter nonsteroidal anti-inflammatory drug exposure and the risk for spontaneous abortion. Obstetrics and Gynecology 120: 113–22. doi: 10.1097/AOG.0b013e3182595671
   PubMed Web of Science ®Google Scholar
• Erdem, H., and A. Guzeloglu. 2008. Effect of meloxicam treatment during early pregnancy in Holstein Heifers. Reproduction in Domestic Animals 45: 625–28.
   Web of Science ®Google Scholar
• Erkkola, R., and B.M. Landgren. 2005. Role of progestins in contraception. Acta Obstetricia et Gynecologica Scandinavica 84: 207–16. doi: 10.1111/j.0001-6349.2005.00759.x
   PubMed Web of Science ®Google Scholar
• Glasier, A. 1997. Emergency postcoital contraception. New England Journal of Medicine 337: 1058–64. doi: 10.1056/NEJM199710093371507
   PubMed Web of Science ®Google Scholar
• Glasier, A., and W.C. Shields. 2006. Editorial: Can we improve contraceptive use? Contraception 73: 1–3. doi: 10.1016/j.contraception.2005.09.004
   PubMed Web of Science ®Google Scholar
• Hamel, R. 2010. Thinking critically about emergency contraception. Critical judgments require adequate and accurate information. Health Progress 91: 62–7.
   PubMedGoogle Scholar
• Hammond, H.A., J.B. Redman, and C.T. Caskey. 1995. In utero paternity testing following alleged sexual assault. Journal of the American Medical Association 273: 1774–7. doi: 10.1001/jama.1995.03520460056035
   Web of Science ®Google Scholar
• Hapangama, D., A. Glasier, and D.T. Baird. 2001. The effects of peri-ovulatory administration of levonorgestrel on the menstrual cycle. Contraception 63: 123–9. doi: 10.1016/S0010-7824(01)00186-X
   PubMed Web of Science ®Google Scholar
• Hernandez, R.K., M.M. Werler, P. Romitti, L. Sun, M. Anderka, and the National Birth Defects Prevention Study. 2012. American Journal of Obstetrics and Gynecology 206: 228.e1–e8. doi: 10.1016/j.ajog.2011.10.522
   PubMed Web of Science ®Google Scholar
• Ho, P.C., and M.S.W. Kwan. 1993. A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. Human Reproduction 8: 389–92.
   PubMed Web of Science ®Google Scholar
• Holmes, M.M., H.S. Resnick, D.G. Kilpatrick, and C.L. Best. 1996. Rape-related pregnancy: Estimates and descriptive characteristics from a national sample of women. American Journal of Obstetrics and Gynecology 175: 320–25. doi: 10.1016/S0002-9378(96)70141-2
   PubMed Web of Science ®Google Scholar
• Hu, Z., L. Cheng, X. Hua, and A. Glasier. 2005. Advanced provision of emergency contraception to postnatal women in China makes no difference in abortion rates: a randomized trial. Contraception 72: 111–6. doi: 10.1016/j.contraception.2005.02.004
   PubMed Web of Science ®Google Scholar
• Jabbour, H.N., and K.J. Sales. 2004. Prostaglandin receptor signalling and function in human endometrial pathology. Trends in Endocrinology and Metabolism 15: 398–404. doi: 10.1016/S1043-2760(04)00187-0
   PubMed Web of Science ®Google Scholar
• Jesam, C., A.M. Salvatierra, J.L. Schwartz, and H.B. Croxatto. 2010. Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: Potential for emergency contraception. Human Reproduction 25: 368–73. doi: 10.1093/humrep/dep392
   PubMed Web of Science ®Google Scholar
• John Paul II, Pope. 1995. Encyclical letter The Gospel of Life Evangelium vitae. Boston, MA: Pauline Books.
   Google Scholar
• Kelly, R.W., A.E. King, and H.O.D. Critchley. 2001. Cytokine control in human endometrium. Journals of Reproduction and Fertility 121: 3–19. doi: 10.1530/rep.0.1210003
   Google Scholar
• Labcorp Corporation of America. 2012. Directory of services and interpretive guide: 2012–2015.
   Google Scholar
• Lim, H., B.C. Paria, S. Das, J.E. Dinchuk, R. Langenback, J.M. Trzaskos, and S.K. Dey. 1997. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell 91: 197–208. doi: 10.1016/S0092-8674(00)80402-X
   PubMed Web of Science ®Google Scholar
• McCann, N.C., T.J. Lynch, S.O. Kim, and D.M. Duffy. 2013. The COX-2 inhibitor meloxicam prevents pregnancy when administered as an emergency contraceptive to nonhuman primates. Contraception 88: 744–8. doi: 10.1016/j.contraception.2013.09.006
   PubMed Web of Science ®Google Scholar
• Mendonca, L.L.F., M.A. Khamashta, C. Nelson-Piercey, B.J. Hunt, and G.R.V. Hughes. 2000. Non-steroidal anti-inflammatory drugs as a possible cause for reversible infertility. Rheumatology 39: 880–82. doi: 10.1093/rheumatology/39.8.880
   PubMed Web of Science ®Google Scholar
• Moore, K. L., and T. V. N. Persaud. 2008. The beginning of human development: First week. In The developing human: Clinically oriented embryology. 8th ed. Philadelphia: Saunders/Elsevier.
   Google Scholar
• Moynihan, R. 2009. Benedict and Barack: The little green book. Inside the Vatican 17 (August–September): 10–15.
   Google Scholar
• Muller, A.L., C.M. Llados, and H.B. Croxatto. 2003. Postcoital treatment with levonorgestrel does not disrupt postfertilization events in the rat. Contraception 67: 415–9. doi: 10.1016/S0010-7824(03)00021-0
   PubMed Web of Science ®Google Scholar
• Nakhai-Pour, H.R., P. Broy, O. Sheehy, and A. Berard. 2011. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. Canadian Medical Association Journal 183: 1713–20. doi: 10.1503/cmaj.110454
   PubMed Web of Science ®Google Scholar
• Noé, G., H.B. Croxatto, A.M. Salvatierra, V. Reyes, C. Villarroel, C. Munoz, G. Morales, and A. Retamales. 2010. Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation. Contraception 81: 414–20. doi: 10.1016/j.contraception.2009.12.015
   PubMed Web of Science ®Google Scholar
• Novikova, N., E. Weisberg, F.Z. Stanczyk, H.B. Croxatto, and I.S. Fraser. 2007. Effectiveness of levonorgestrel emergency contraception given before or after ovulation—A pilot study. Contraception 75: 112–8. doi: 10.1016/j.contraception.2006.08.015
   PubMed Web of Science ®Google Scholar
• Oettel, M., A. Komor, N.P. Goncharov, A. Kurischko, J. Streck, and K. Schubert. 1980. STS 557 an interceptive in rodents and baboons. Contraception 21: 537–45. doi: 10.1016/0010-7824(80)90017-7
   PubMed Web of Science ®Google Scholar
• Peck, R., and J.R. Veléz. 2013. The postovulatory mechanism of action of Plan B. National Catholic Bioethics Quarterly 13 (4): 677–716. doi: 10.5840/ncbq201313410
   Google Scholar
• Pepe, G.J., and E.D. Albrecht. 2003. Steroid endocrinology of pregnancy. In Gynecology and obstetrics, ed. John J. Sciarra, 1–34. Philadelphia: Lippincott Williams & Wilkins.
   Google Scholar
• Physicians’ Desk Reference (PDR). 2000. 54th ed. Montvale, NJ: Thomson PDR Network.
   Google Scholar
• Physicians’ Desk Reference (PDR). 2005. 59th ed. Montvale, NJ: Thomson PDR Network.
   Google Scholar
• Polis, C.B., K. Schaffer, K. Blanchard, A. Glasier, C.C. Harper, and D.A. Grimes. 2007. Advanced provision of emergency contraception for pregnancy prevention: A meta-analysis. Obstetrics and Gynecology 110: 1379–88. doi: 10.1097/01.AOG.0000295603.84568.f6
   PubMed Web of Science ®Google Scholar
• Raviele, K.M. 2014. Levonorgestrel in cases of rape: How does it work? Linacre Quarterly 81: 117–29. doi: 10.1179/2050854914Y.0000000017
   PubMedGoogle Scholar
• Raymond, E.G., J. Trussell, and C.B. Polis. 2007. Population effect of increased access to emergency contraceptive pills. Obstetrics and Gynecology 109: 181–188. doi: 10.1097/01.AOG.0000250904.06923.4a
   PubMed Web of Science ®Google Scholar
• Reznik, S.E. 2010. “Plan B:” How it works. Science shows it is not an abortifacient. Health Prog 91(1). 1 (January–February): 59–61.
   Google Scholar
• Saint Joseph Hospital. 2007. Clinical laboratory services. Lexington, KY: Saint Joseph Hospital.
   Google Scholar
• Schneider, A.P., II, C.M. Zainer, C.K. Kubat, N.K. Mullen, and A.K. Windisch. 2014. The breast cancer epidemic: 10 facts. Linacre Quarterly 81: 244–77.
   Google Scholar
• Singh, M., P. Chaundhry, and E. Asselin. 2011. Bridging endometrial receptivity and implantation: Network of hormones, cytokines, and growth factors. Journal of Endocrinology 210: 5–14. doi: 10.1530/JOE-10-0461
   PubMed Web of Science ®Google Scholar
• Speroff, L., and P. Darney. 2006. A clinical guide for contraception. 4th ed. Baltimore: William & Wilkins.
   Google Scholar
• Stedman, T.L. 2006. Stedman's medical dictionary. 28th ed. Philadelphia: Lippincott, Williams & Wilkins.
   Google Scholar
• Strauss, L.T., S.B. Gamble, W.Y. Parker, D.A. Cook, S.B. Zane, and S. Hamden. Abortion surveillance—United States, 2003. 2006. Morbidity Mortality Weekly Report 55 (SS 11): 1–32.
   Google Scholar
• Sun, X., Y.C. Ruan, J. Guo, H. Chen, L.L. Tsang, X. Zhang, X. Jiang, and H.C. Chan. 2014. Regulation of miR=101/miR-199a-3p by the epithelial sodium channel during embryo implantation: Involvement of CREB phosphorylation. Reproduction 148: 559–568. doi: 10.1530/REP-14-0386
   PubMed Web of Science ®Google Scholar
• Von Hertzen, H., Piaggio, G., Ding, J., Chen, J., Song, S., Bartfai, G., et al. of the WHO Task Force on Post-ovulatory Methods For Fertility Regulation—Special Programme. 2002. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: A WHO multicentre randomized trial. Lancet 360: 1803–10. doi: 10.1016/S0140-6736(02)11767-3
   PubMed Web of Science ®Google Scholar
• Wilcox, A.J., C.R. Weinberg, and D.D. Baird. 1998. Post-ovulatory ageing of the human oocyte and embryo failure. Human Reproduction 13: 394–97. doi: 10.1093/humrep/13.2.394
   PubMed Web of Science ®Google Scholar
• Yegnanarayan, R., and G.V. Joglekar. 1978. Anti-fertility effect of non-steroidal anti-inflammatory drugs. Japanese Journal of Pharmacology 28: 909–17. doi: 10.1254/jjp.28.909
   PubMedGoogle Scholar