Recent advances and future options for New Zealand agriculture derived from animal cloning and transgenics

References

• Adams , AM , Pratt , SL , Gibbons , JR , Arat , S , Respess , DS and Stice , SL . 2004 . Production of a cloned calf using kidney cells obtained from a 48‐hour cooled carcass . Reproduction, Fertility and Development , 16 : 133
   Google Scholar
• Anonymous . 2006 . Transgenic milk prospects turn sour . Nature Biotechnology , 24 : 368
   Google Scholar
• Anonymous . 2007 . The emperor's new clones . Nature Biotechnology , 25 : 1
   PubMedGoogle Scholar
• Archer , GS , Dindot , S , Friend , TH , Walker , S , Zaunbrecher , G , Lawhorn , B and Piedrahita , JA . 2003a . Hierarchical phenotypic and epigenetic variation in cloned swine . Biology of Reproduction , 69 : 430 – 436 .
   PubMed Web of Science ®Google Scholar
• Archer , GS , Friend , TH , Piedrahita , J , Nevill , CH and Walker , S . 2003b . Behavioral variation among cloned pigs . Applied Animal Behaviour Science , 82 : 151 – 161 .
   Google Scholar
• Baguisi , A , Behboodi , E , Melican , DT , Pollock , JS , Destrem‐pes , MM , Cammuso , C , Williams , JL , Nims , SD , Porter , CA , Midura , P and others . 1999 . Production of goats by somatic cell nuclear transfer . Nature Biotechnology , 17 : 456 – 461 .
   PubMed Web of Science ®Google Scholar
• Baker , RL , Shannon , P , Garrick , DJ , Blair , HT and Wickham , B . 1990 . The future impact of new opportunities in reproductive physiology and molecular biology on genetic improvement programmes . Proceedings of the New Zealand Society of Animal Production , 50 : 197 – 210 .
   Google Scholar
• Baranyi , M , Hiripi , L , Szabo , L , Catunda , AP , Harsanyi , I , Komaromy , P and Bosze , Z . 2007 . Isolation and some effects of functional, low‐phenylalanine kappa‐casein expressed in the milk of transgenic rabbits . Journal of Biotechnology , 128 : 383 – 392 .
   PubMedGoogle Scholar
• Behboodi , E , Ayres , SL , Memili , E , O'Coin , M , Chen , LH , Reggio , BC , Landry , AM , Gavin , WG , Meade , HM , Godke , RA and others . 2005 . Health and reproductive profiles of malaria antigen‐producing transgenic goats derived by somatic cell nuclear transfer . Cloning and Stem Cells , 7 : 107 – 118 .
   PubMedGoogle Scholar
• Bortvin , A , Eggan , K , Skaletsky , H , Akutsu , H , Berry , DL , Yanagimachi , R , Page , DC and Jaenisch , R . 2003 . Incomplete reactivation of Oct4‐related genes in mouse embryos cloned from somatic nuclei . Development , 130 : 1673 – 1680 .
   PubMed Web of Science ®Google Scholar
• Bousquet , D and Blondin , P . 2004 . Potential uses of cloning in breeding schemes: dairy cattle . Cloning and Stem Cells , 6 : 190 – 197 .
   PubMedGoogle Scholar
• Brem , G , Brenig , B , Müller , M and Springmann , K . 1989 . FAO animal production and health paper 76: ex situ cryoconservation of genomes and genes of endangered cattle breeds by means of modern biotechnological methods http://www.fao.org/ docrep/004/T0094E/T0094E00.htm [accessed 26 September 2006]
   Google Scholar
• Brophy , B , Smolenski , G , Wheeler , T , Wells , D , L'Huillier , P and Laible , G . 2003 . Cloned transgenic cattle produce milk with higher levels of beta‐casein and kappa‐casein . Nature Biotechnology , 21 : 157 – 162 .
   PubMedGoogle Scholar
• Carroll , JA , Carter , DB , Korte , SW and Prather , RS . 2005 . Evaluation of the acute phase response in cloned pigs following a lipopolysaccharide challenge . Domestic Animal Endocrinology , 29 : 564 – 572 .
   PubMedGoogle Scholar
• Carter , DB , Lai , L , Park , KW , Samuel , M , Lattimer , JC , Jordan , KR , Estes , DM , Besch‐Williford , C and Prather , RS . 2002 . Phenotyping of transgenic cloned piglets . Cloning and Stem Cells , 4 : 131 – 145 .
   PubMedGoogle Scholar
• Cerasoli , DM , Griffiths , EM , Doctor , BP , Saxena , A , Fe‐dorko , JM , Greig , NH , Yu , QS , Huang , Y , Wilgus , H , Karatzas , CN and others . 2005 . In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger . Chemico‐Biological Interactions , 157–158 : 363 – 365 .
   PubMed Web of Science ®Google Scholar
• Chavatte‐Palmer , P , Heyman , Y , Richard , C , Monget , P , Le‐Bourhis , D , Kann , G , Chilliard , Y , Vignon , X and Renard , JP . 2002 . Clinical, hormonal, and hematologic characteristics of bovine calves derived from nuclei from somatic cells . Biology of Reproduction , 66 : 1596 – 1603 .
   PubMed Web of Science ®Google Scholar
• Chen , M , Liu , XW , Wang , ZK , Song , J , Qi , QS and Wang , PG . 2005 . Modification of plant N‐glycans processing: the future of producing therapeutic protein by transgenic plants . Medicinal Research Reviews , 25 : 343 – 360 .
   PubMedGoogle Scholar
• Chesne , P , Adenot , PG , Viglietta , C , Baratte , M , Boulanger , L and Renard , JP . 2002 . Cloned rabbits produced by nuclear transfer from adult somatic cells . Nature Biotechnology , 20 : 366 – 369 .
   PubMedGoogle Scholar
• Chong , S and Whitelaw , E . 2004 . Epigenetic germline inheritance . Current Opinion in Genetics and Development , 14 : 692 – 696 .
   PubMed Web of Science ®Google Scholar
• Chrenek , P , Boulanger , L , Heyman , Y , Uhrin , P , Laurincik , J , Bulla , J and Renard , JP . 2001 . Sexing and multiple genotype analysis from a single cell of bovine embryo . Theriogenology , 55 : 1071 – 1081 .
   PubMed Web of Science ®Google Scholar
• Cibelli , JB , Stice , SL , Golueke , PJ , Kane , JJ , Jerry , J , Black‐well , C , Ponce de Leon , FA and Robl , JM . 1998 . Cloned transgenic calves produced from nonquiescent fetal fibroblasts . Science , 280 : 1256 – 1258 .
   PubMed Web of Science ®Google Scholar
• Clark , AJ . 1998 . The mammary gland as a bioreactor: expression, processing, and production of recombinant proteins . Journal of Mammary Gland Biology and Neoplasia , 3 : 337 – 350 .
   PubMed Web of Science ®Google Scholar
• Clark , A , Bessos , H , Bishop , J , Brown , P , Harris , S , Lathe , R , McClenaghan , M , Prowse , C , Simons , J , Whitehaw , C and others . 1989 . Expression of human anti‐he‐mophilic factor IX in the milk of transgenic sheep . Bio/Technology , 7 : 487 – 492 .
   Google Scholar
• Constant , F , Guillomot , M , Heyman , Y , Vignon , X , Laigre , P , Servely , JL , Renard , JP and Chavatte‐Palmer , P . 2006 . Large offspring or large placenta syndrome? Morphometric analysis of late gestation bovine placentomes from somatic nuclear transfer pregnancies complicated by hydrallantois . Biology of Reproduction , 75 : 122 – 130 .
   PubMedGoogle Scholar
• Cox , A and Zhong , R . 2005 . Current advances in xenotrans‐plantation . Hepatobiliary and Pancreatic Diseases International , 4 : 490 – 494 .
   PubMedGoogle Scholar
• de Boo , HA and Harding , JE . 2006 . The developmental origins of adult disease (Barker) hypothesis . Australian and New Zealand Journal of Obstetrics and Gynaecology , 46 : 4 – 14 .
   PubMed Web of Science ®Google Scholar
• de Sousa , PA , King , T , Harkness , L , Young , LE , Walker , SK and Wilmut , I . 2001 . Evaluation of gestational deficiencies in cloned sheep fetuses and placentae . Biology of Reproduction , 65 : 23 – 30 .
   PubMed Web of Science ®Google Scholar
• Dean , W , Santos , F and Reik , W . 2003 . Epigenetic reprogram‐ming in early mammalian development and following somatic nuclear transfer . Seminars in Cell and Developmental Biology , 14 : 93 – 100 .
   PubMed Web of Science ®Google Scholar
• Dematawewa , CM and Berger , PJ . 1998 . Break‐even cost of cloning in genetic improvement of dairy cattle . Journal of Dairy Science , 81 : 1136 – 1147 .
   PubMedGoogle Scholar
• Edmunds , T , Van Patten , SM , Pollock , J , Hanson , E , Ber‐nasconi , R , Higgins , E , Manavalan , P , Ziomek , C , Meade , H , McPherson , JM and others . 1998 . Trans‐genically produced human antithrombin: structural and functional comparison to human plasma‐derived antithrombin . Blood , 91 : 4561 – 4571 .
   PubMed Web of Science ®Google Scholar
• Eggan , K , Akutsu , H , Loring , J , Jackson‐Grusby , L , Klemm , M , Rideout , WM III , Yanagimachi , R and Jaenisch , R . 2001 . Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation . Proceedings of the National Academy of Sciences, USA , 98 : 6209 – 6214 .
   PubMed Web of Science ®Google Scholar
• Einsiedel , EF . 2005 . Public perceptions of transgenic animals . Revue Scientifique et Technique (International Office of Epizootics) , 24 : 149 – 157 .
   PubMed Web of Science ®Google Scholar
• ERMA . 2001 . “ Environmental risk management authority decision ” . http://www.ermanz.govt.nz/appfiles/ execsumm/pdf/GMF98009–011.pdf [accessed 29 September 2006]
   Google Scholar
• Everitt , GC , Jury , KE , Dalton , DC and Ward , JDB . 1978 . Beef production from the dairy herd. I Calving records from Friesian cows mated to Friesian and beef breed bulls . New Zealand Journal of Agricultural Research , 21 : 197 – 208 .
   Web of Science ®Google Scholar
• Faber , DC , Ferre , LB , Metzger , J , Robl , JM and Kasinathan , P . 2004 . Agro‐economic impact of cattle cloning . Cloning and Stem Cells , 6 : 198 – 207 .
   PubMedGoogle Scholar
• FAO/WHO . 2003 . “ Guideline for the conduct of food safety assessment of foods derived from recombinant‐DNA plants ” . www.codexalimentarius.net/down‐load/standards/10021/CXG_045e.pdf [accessed 21 May 2006]
   Google Scholar
• FAO/WHO . 2005 . “ Project document—guideline for the conduct of food safety assessment of foods derived from recombinant‐DNA animals ” . In Report of the fifth session of the codex ad hoc intergovernmental task force on foods derived from biotechnology ALINORM 06/29/34. http://www.codexalimen‐tarius.net/download/report/653/al29_34e.pdf [accessed 13 September 2006]
   Google Scholar
• FDA . 2006 . “ A risk‐based approach to evaluate animal clones and their progeny ” . http://www.fda.gov/ cvm/CloneRiskAssessment.htm [accessed 22 January 2007]
   Google Scholar
• Forsyth , NR , Musio , A , Vezzoni , P , Simpson , AH , Noble , BS and McWhir , J . 2006 . Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromosomal abnormalities . Cloning and Stem Cells , 8 : 16 – 23 .
   PubMedGoogle Scholar
• 2005 . “ Forum Proceedings ” . In Hosted by the University of Illinois at Urbana Champaign Agricultural Genome Science and Public Policy Program and the Pew Initiative on Food and Biotechnology. A future for animal technology? http://pewagbiotech. org/events/1205/proceedings.pdf [accessed 18 January 2007]
   Google Scholar
• Galli , C , Lagutina , I , Crotti , G , Colleoni , S , Turini , P , Pon‐derato , N , Duchi , R and Lazzari , G . 2003 . Pregnancy: a cloned horse born to its dam twin . Nature , 424 : 635
   PubMed Web of Science ®Google Scholar
• Gao , S , Chung , YG , Williams , JW , Riley , J , Moley , K and Latham , KE . 2003 . Somatic cell‐like features of cloned mouse embryos prepared with cultured myoblast nuclei . Biology of Reproduction , 69 : 48 – 56 .
   PubMedGoogle Scholar
• Garrick , DJ and Snell , RG . 2005 . Emerging technologies for identifying superior dairy cows in New Zealand . New Zealand Veterinary Journal , 53 : 390 – 399 .
   PubMed Web of Science ®Google Scholar
• Garry , FB , Adams , R , McCann , JP and Odde , KG . 1996 . Postnatal characteristics of calves produced by nuclear transfer cloning . Theriogenology , 45 : 141 – 152 .
   Web of Science ®Google Scholar
• Giraldo , AM , Lynn , JW , Godke , RA and Bondioli , KR . 2006 . Proliferative characteristics and chromosomal stability of bovine donor cells for nuclear transfer . Molecular Reproduction and Development , 73 : 1230 – 1238 .
   PubMedGoogle Scholar
• GloFish . 2004 . “ GloFish fluorescent zebra fish now available in most US markets ” . http://www.glofish. com/pressreleases/pr.AvailableMostUSMarkets. pdf [accessed 29 September 2006]
   Google Scholar
• GTC . 2006 . “ European Commission approves ATryn ” . http:// www.gtc‐bio.com/pressreleases/pr080206.html [accessed 13 September 2006]
   Google Scholar
• Gutierrez‐Adan , A , Maga , EA , Meade , H , Shoemaker , CF , Medrano , JF , Anderson , GB and Murray , JD . 1996 . Alterations of the physical characteristics of milk from transgenic mice producing bovine kappa‐casein . Journal of Dairy Science , 79 : 791 – 799 .
   PubMedGoogle Scholar
• Harris , A . 1997 . Towards an ovine model of cystic fibrosis . Human Molecular Genetics , 6 : 2191 – 2194 .
   PubMedGoogle Scholar
• Herath , CB , Ishiwata , H , Shiojima , S , Kadowaki , T , Katsuma , S , Ushizawa , K , Imai , K , Takahashi , T , Hirasawa , A , Takahashi , S and others . 2006 . Developmental aberrations of liver gene expression in bovine fetuses derived from somatic cell nuclear transplantation . Cloning and Stem Cells , 8 : 79 – 95 .
   PubMedGoogle Scholar
• Heyman , Y , Chavatte‐Palmer , P , LeBourhis , D , Camous , S , Vignon , X and Renard , JP . 2002a . Frequency and occurrence of late‐gestation losses from cattle cloned embryos . Biology of Reproduction , 66 : 6 – 13 .
   PubMedGoogle Scholar
• Heyman , Y , Zhou , Q , Lebourhis , D , Chavatte‐Palmer , P , Renard , JP and Vignon , X . 2002b . Novel approaches and hurdles to somatic cloning in cattle . Cloning and Stem Cells , 4 : 47 – 55 .
   PubMedGoogle Scholar
• Hiendleder , S , Zakhartchenko , V and Wolf , E . 2005 . Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear‐mitochondrial interactions to mitochondrial complementation and mitochon‐drial DNA recombination . Reproduction, Fertility and Development , 17 : 69 – 83 .
   PubMed Web of Science ®Google Scholar
• Hiiragi , T and Solter , D . 2005 . Reprogramming is essential in nuclear transfer . Molecular Reproduction and Development , 70 : 417 – 421 .
   PubMed Web of Science ®Google Scholar
• Hill , JR and Dobrinski , I . 2006 . Male germ cell transplantation in livestock . Reproduction, Fertility and Development , 18 : 13 – 18 .
   PubMed Web of Science ®Google Scholar
• Hill , JR , Roussel , AJ , Cibelli , JB , Edwards , JF , Hooper , NL , Miller , MW , Thompson , JA , Looney , CR , West‐husin , ME , Robl , JM and others . 1999 . Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies) . Theriogenology , 51 : 1451 – 1465 .
   PubMed Web of Science ®Google Scholar
• Hill , JR , Burghardt , RC , Jones , K , Long , CR , Looney , CR , Shin , T , Spencer , TE , Thompson , JA , Winger , QA and Westhusin , ME . 2000 . Evidence for placental abnormality as the major cause of mortality in first‐trimester somatic cell cloned bovine fetuses . Biology of Reproduction , 63 : 1787 – 1794 .
   PubMed Web of Science ®Google Scholar
• Hill , JR , Schlafer , DH , Fisher , PJ and Davies , CJ . 2002 . Abnormal expression of trophoblast major histocompatibility complex class I antigens in cloned bovine pregnancies is associated with a pronounced endometrial lymphocytic response . Biology of Reproduction , 67 : 55 – 63 .
   PubMedGoogle Scholar
• Hiripi , L , Makovics , F , Halter , R , Baranyi , M , Paul , D , Carn‐wath , JW , Bosze , Z and Niemann , H . 2003 . Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbits . DNA and Cell Biology , 22 : 41 – 45 .
   PubMedGoogle Scholar
• Hochedlinger , K and Jaenisch , R . 2002 . Monoclonal mice generated by nuclear transfer from mature B and T donor cells . Nature , 415 : 1035 – 1038 .
   PubMed Web of Science ®Google Scholar
• Hoffert , KA , Batchelder , CA , Bertolini , M , Moyer , AL , Famula , TR , Anderson , DL and Anderson , GB . 2005 . Measures of maternal‐fetal interaction in day‐30 bovine pregnancies derived from nuclear transfer . Cloning and Stem Cells , 7 : 289 – 305 .
   PubMedGoogle Scholar
• House of Lords . 1999 . “ Select Committee on European Communities, UK, 2 ” . In Report: EC regulation of genetic modification in agriculture, evidence Q1107
   Google Scholar
• Humpherys , D , Eggan , K , Akutsu , H , Hochedlinger , K , Rideout , WM III , Biniszkiewicz , D , Yanagimachi , R and Jaenisch , R . 2001 . Epigenetic instability in ES cells and cloned mice . Science , 293 : 95 – 97 .
   PubMed Web of Science ®Google Scholar
• Humpherys , D , Eggan , K , Akutsu , H , Friedman , A , Hochedlinger , K , Yanagimachi , R , Lander , ES , Golub , TR and Jaenisch , R . 2002 . Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei . Proceedings of the National Academy of Sciences, USA , 99 : 12889 – 12894 .
   PubMed Web of Science ®Google Scholar
• Hyttinen , JM , Peura , T , Tolvanen , M , Aalto , J , Alhonen , L , Sinervirta , R , Halmekyto , M , Myohanen , S and Janne , J . 1994 . Generation of transgenic dairy cattle from transgene‐analyzed and sexed embryos produced in vitro . Biotechnology (NY) , 12 : 606 – 608 .
   PubMedGoogle Scholar
• IFIC . 2006 . “ Food biotechnology: a study of US consumer atti‐tudinal trends, 2006 report from the International Food Information Council ” . Available at: http:// www.ific.org/research/upload/2006% 20Biotech %20Consumer%20Research%20Report.pdf [accessed 24 January 2007]
   Google Scholar
• Jaenisch , R . 1976 . Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus . Proceedings of the National Academy of Sciences of the USA , 73 : 1260 – 1264 .
   PubMed Web of Science ®Google Scholar
• Jaenisch , R and Mintz , B . 1974 . Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA . Proceedings of the National Academy of Sciences of the USA , 71 : 1250 – 1254 .
   PubMed Web of Science ®Google Scholar
• Jaenisch , R , Fan , H and Croker , B . 1975 . Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal . Proceedings of the National Academy of Sciences of the USA , 72 : 4008 – 4012 .
   PubMed Web of Science ®Google Scholar
• Jaenisch , R , Eggan , K , Humpherys , D , Rideout , W and Hochedlinger , K . 2002 . Nuclear cloning, stem cells and genomic reprogramming . Cloning and Stem Cells , 4 : 389 – 396 .
   PubMedGoogle Scholar
• Jost , B , Vilotte , JL , Duluc , I , Rodeau , JL and Freund , JN . 1999 . Production of low‐lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland . Nature Biotechnology , 17 : 160 – 164 .
   PubMedGoogle Scholar
• Kang , JX , Wang , JD , Wu , L and Kang , ZB . 2004 . Transgenic mice—Fat‐1 mice convert n‐6 to n‐3 fatty acids . Nature , 427 : 504
   PubMed Web of Science ®Google Scholar
• Kang , YK , Park , JS , Koo , DB , Choi , YH , Kim , SU , Lee , KK and Han , YM . 2002 . Limited demethylation leaves mosaic‐type methylation states in cloned bovine pre‐implantation embryos . Embo Journal , 21 : 1092 – 1100 .
   PubMedGoogle Scholar
• Kao , BT , Lewis , KA , DePeters , EJ and Van Eenennaam , AL . 2006 . Endogenous production and elevated levels of long‐chain n‐3 fatty acids in the milk of transgenic mice . Journal of Dairy Science , 89 : 3195 – 3201 .
   PubMedGoogle Scholar
• Karatzas , CN . 2003 . Designer milk from transgenic clones . Nature Biotechnology , 21 : 138 – 139 .
   PubMedGoogle Scholar
• Kato , Y , Tani , T , Sotomaru , Y , Kurokawa , K , Kato , J , Doguchi , H , Yasue , H and Tsunoda , Y . 1998 . Eight calves cloned from somatic cells of a single adult . Science , 282 : 2095 – 2098 .
   PubMed Web of Science ®Google Scholar
• Kato , Y , Tani , T and Tsunoda , Y . 2000 . Cloning of calves from various somatic cell types of male and female adult, newborn and fetal cows . Journal of Reproduction and Fertility , 120 : 231 – 237 .
   PubMedGoogle Scholar
• Kay , JK , Roche , JR , Kolver , ES , Thomson , NA and Baumgard , LH . 2005 . A comparison between feeding systems (pasture and TMR) and the effect of vitamin E supplementation on plasma and milk fatty acid profiles in dairy cows . Journal of Dairy Research , 72 : 322 – 332 .
   PubMed Web of Science ®Google Scholar
• Kelly , L . 2005 . The safety assessment of foods from transgenic and cloned animals using the comparative approach . Revue Scientifique et Technique (International Office of Epizootics) , 24 : 61 – 74 .
   PubMedGoogle Scholar
• Kikyo , N and Wolffe , AP . 2000 . Reprogramming nuclei: insights from cloning, nuclear transfer and heterokaryons . Journal of Cell Science , 113 : 11 – 20 .
   PubMedGoogle Scholar
• Kremenskoy , M , Kremenska , Y , Suzuki , M , Imai , K , Taka‐hashi , S , Hashizume , K , Yagi , S and Shiota , K . 2006 . DNA methylation profiles of donor nuclei cells and tissues of cloned bovine fetuses . Journal of Reproduction and Development , 52 : 259 – 266 .
   PubMedGoogle Scholar
• Kruip , TAM and den Daas , JHG . 1997 . In vitro produced and cloned embryos: effects on pregnancy, parturition and offspring . Theriogenology , 47 : 43 – 52 .
   Web of Science ®Google Scholar
• Kubota , C , Yamakuchi , H , Todoroki , J , Mizoshita , K , Tabara , N , Barber , M and Yang , X . 2000 . Six cloned calves produced from adult fibroblast cells after long‐term culture . Proceedings of the National Academy of Sciences, USA , 97 : 990 – 995 .
   PubMed Web of Science ®Google Scholar
• Kuhholzer , B , Hawley , RJ , Lai , L , Kolber‐Simonds , D and Prather , RS . 2001 . Clonal lines of transgenic fibroblast cells derived from the same fetus result in different development when used for nuclear transfer in pigs . Biology of Reproduction , 64 : 1695 – 1698 .
   PubMed Web of Science ®Google Scholar
• Laible , G and Wells , DN . 2006 . Transgenic cattle applications: the transition from promise to proof . Biotechnology and Genetic Engineering Reviews , 22 : 125 – 150 .
   PubMedGoogle Scholar
• Laible , G , Brophy , B , Knighton , D and Wells , DN . 2007 . Compositional analysis of dairy products derived from clones and cloned transgenic cattle . Theriogenology , 67 : 166 – 177 .
   PubMedGoogle Scholar
• Lanza , RP , Cibelli , JB , Blackwell , C , Cristofalo , VJ , Francis , MK , Baerlocher , GM , Mak , J , Schertzer , M , Chavez , EA , Sawyer , N and others . 2000 . Extension of cell life‐span and telomere length in animals cloned from senescent somatic cells . Science , 288 : 665 – 669 .
   PubMed Web of Science ®Google Scholar
• Lanza , RP , Cibelli , JB , Faber , D , Sweeney , RW , Henderson , B , Nevala , W , West , MD and Wettstein , PJ . 2001 . Cloned cattle can be healthy and normal . Science , 294 : 1893 – 1894 .
   PubMed Web of Science ®Google Scholar
• Lee , BC , Kim , MK , Jang , G , Oh , HJ , Yuda , F , Kim , HJ , Shamim , MH , Kim , JJ , Kang , SK , Schatten , G and others . 2005 . Dogs cloned from adult somatic cells . Nature , 436 : 641
   PubMed Web of Science ®Google Scholar
• Lee , RS , Peterson , AJ , Donnison , MJ , Ravelich , S , Ledgard , AM , Li , N , Oliver , JE , Miller , AL , Tucker , FC , Breier , B and others . 2004 . Cloned cattle fetuses with the same nuclear genetics are more variable than contemporary half‐siblings resulting from artificial insemination and exhibit fetal and placental growth deregulation even in the first trimester . Biology of Reproduction , 70 : 1 – 11 .
   PubMedGoogle Scholar
• Lewis , IM , French , AJ , Tecirlioglu , RT , Vajta , G , Mc‐Clintock , AE , Nicholas , KR , Zuelke , KA , Holland , MK and Trounson , AO . 2004 . Commercial aspects of cloning and genetic modification in cattle . Australian Journal of Experimental Agriculture , 44 : 1105 – 1111 .
   Google Scholar
• Li , N , Wells , DN , Peterson , AJ and Lee , RS . 2005 . Perturbations in the biochemical composition of fetal fluids are apparent in surviving bovine somatic cell nuclear transfer pregnancies in the first half of gestation . Biology of Reproduction , 73 : 139 – 148 .
   PubMedGoogle Scholar
• Li , Y , Dai , Y , Du , W , Zhao , C , Wang , H , Wang , L , Li , R , Liu , Y , Wan , R and Li , N . 2006a . Cloned endangered species takin (Budorcas taxicolor) by inter‐species nuclear transfer and comparison of the blastocyst development with yak (Bos grunniens) and bovine . Molecular Reproduction and Development , 73 : 189 – 195 .
   PubMed Web of Science ®Google Scholar
• Li , Z , Sun , X , Chen , J , Liu , X , Wisely , SM , Zhou , Q , Renard , JP , Leno , GH and Engelhardt , JF . 2006b . Cloned ferrets produced by somatic cell nuclear transfer . Developmental Biology , 293 : 439 – 448 .
   PubMedGoogle Scholar
• Loi , P , Clinton , M , Vackova , I , Fulka , J Jr , Feil , R , Palmieri , C , Salda , LD and Ptak , G . 2006 . Placental abnormalities associated with post‐natal mortality in sheep somatic cell clones . Theriogenology , 65 : 1110 – 1121 .
   PubMedGoogle Scholar
• McCann , JC and Ames , BN . 2005 . Is docosahexaenoic acid, an n‐3 long‐chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals . American Journal of Clinical Nutrition , 82 : 281 – 295 .
   PubMed Web of Science ®Google Scholar
• McClintock , AE . 1998 . Impact of cloning on cattle breeding systems . Reproduction, Fertility and Development , 10 : 667 – 669 .
   PubMedGoogle Scholar
• McMillen , IC and Robinson , JS . 2005 . Developmental origins of the metabolic syndrome: prediction, plasticity, and programming . Physiological Reviews , 85 : 571 – 633 .
   PubMed Web of Science ®Google Scholar
• Maga , EA , Shoemaker , CF , Rowe , JD , Bondurant , RH , Anderson , GB and Murray , JD . 2006a . Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland . Journal of Dairy Science , 89 : 518 – 524 .
   PubMed Web of Science ®Google Scholar
• Maga , EA , Walker , RL , Anderson , GB and Murray , JD . 2006b . Consumption of milk from transgenic goats expressing human lysozyme in the mammary gland results in the modulation of intestinal microflora . Transgenic Research , 15 : 515 – 519 .
   PubMed Web of Science ®Google Scholar
• Mannen , H , Kojima , T , Oyama , K , Mukai , F , Ishida , T and Tsuji , S . 1998 . Effect of mitochondrial DNA variation on carcass traits of Japanese black cattle . Journal of Animal Science , 76 : 36 – 41 .
   PubMed Web of Science ®Google Scholar
• Martin , M , Adams , C and Wiseman , B . 2004 . Pre‐weaning performance and health of pigs born to cloned (fetal cell derived) swine versus non‐cloned swine . Theriogenology , 62 : 113 – 122 .
   PubMedGoogle Scholar
• Massoud , M , Attal , J , Thepot , D , Pointu , H , Stinnakre , MG , Theron , MC , Lopez , C and Houdebine , LM . 1996 . The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits . Reproduction Nutrition Development , 36 : 555 – 563 .
   PubMedGoogle Scholar
• Mikus , T , Poplstein , M , Sedlakova , J , Landa , V , Jenikova , G , Trefil , P , Lidicky , J and Maly , P . 2004 . Generation and phenotypic analysis of a transgenic line of rabbits secreting active recombinant human erythropoietin in the milk . Transgenic Research , 13 : 487 – 498 .
   PubMedGoogle Scholar
• Miller , HI , Conko , G and Kershen , DL . 2006 . Why spurning food biotech has become a liability . Nature Biotechnology , 24 : 1075 – 1077 .
   PubMedGoogle Scholar
• Mitra , A , Hruska , KS , Wellnitz , O , Kerr , DE , Capuco , AV and Wall , RJ . 2003 . Expression of lysostaphin in milk of transgenic mice affects the growth of neonates . Transgenic Research , 12 : 597 – 605 .
   PubMed Web of Science ®Google Scholar
• Morrow , C , Berg , M , McDonald , R , Wells , D , Peterson , A and Lee , R . 2005 . Composition of allantoic fluid in cattle pregnant with AI‐, IVP‐or nuclear transfer‐generated embryos . Reproduction, Fertility and Development , 17 : 177
   Google Scholar
• Nagashima , H , Giannakis , C , Ashman , RJ and Nottle , MB . 2004 . Sex differentiation and germ cell production in chimeric pigs produced by inner cell mass injection into blastocysts . Biology of Reproduction , 70 : 702 – 707 .
   PubMedGoogle Scholar
• Ng , RK and Gurdon , JB . 2005 . Maintenance of epigenetic memory in cloned embryos . Cell Cycle , 4 : 760 – 763 .
   PubMed Web of Science ®Google Scholar
• Nicholas , FW . 1996 . Genetic improvement through reproductive technology . Animal Reproduction Science , 42 : 205 – 214 .
   Google Scholar
• Niemann , H , Halter , R , Carnwath , JW , Herrmann , D , Lemme , E and Paul , D . 1999 . Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep . Transgenic Research , 8 : 237 – 247 .
   PubMed Web of Science ®Google Scholar
• Northoff , E . 2004 . Loss of domestic animal breeds alarming http://www.fao.org/newsroom/en/ news/2004/39892/index.html [accessed 26 September 2006]
   Google Scholar
• Oback , B and Wells , D . 2002 . Donor cells for nuclear cloning: many are called, but few are chosen . Cloning and Stem Cells , 4 : 147 – 168 .
   PubMedGoogle Scholar
• Oback , B and Wells , DN . 2003 . Cloning cattle . Cloning and Stem Cells , 5 : 243 – 256 .
   PubMedGoogle Scholar
• Oback , B and Wells , DN . 2006 . Donor cell differentiation, re‐programming and cloning efficiency—elusive or illusive correlation . Molecular Reproduction and Development , doi: 10.1002/mrd.20654
   Google Scholar
• Ogonuki , N , Inoue , K , Yamamoto , Y , Noguchi , Y , Tanemura , K , Suzuki , O , Nakayama , H , Doi , K , Ohtomo , Y , Satoh , M and others . 2002 . Early death of mice cloned from somatic cells . Nature Genetics , 30 : 253 – 254 .
   PubMed Web of Science ®Google Scholar
• Ogura , A , Inoue , K , Ogonuki , N , Lee , J , Kohda , T and Ishino , F . 2002 . Phenotypic effects of somatic cell cloning in the mouse . Cloning and Stem Cells , 4 : 397 – 405 .
   PubMedGoogle Scholar
• Ohgane , J , Wakayama , T , Senda , S , Yamazaki , Y , Inoue , K , Ogura , A , Marh , J , Tanaka , S , Yanagimachi , R and Shiota , K . 2004 . The Sall3 locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice . Genes to Cells , 9 : 253 – 260 .
   PubMed Web of Science ®Google Scholar
• Pace , MM , Augenstein , ML , Betthauser , JM , Childs , LA , Eilertsen , KJ , Enos , JM , Forsberg , EJ , Golueke , PJ , Graber , DF , Kemper , JC and others . 2002 . Ontogeny of cloned cattle to lactation . Biology of Reproduction , 67 : 334 – 339 .
   PubMedGoogle Scholar
• Palmquist , DL , Beaulieu , AD and Barbano , DM . 1993 . Feed and animal factors influencing milk fat composition . Journal of Dairy Science , 76 : 1753 – 1771 .
   PubMed Web of Science ®Google Scholar
• Paleyanda , RK , Velander , WH , Lee , TK , Scandella , DH , Gwazdauskas , FC , Knight , JW , Hoyer , LW , Drohan , WN and Lubon , H . 1997 . Transgenic pigs produce functional human factor VIII in milk . Nature Biotechnology , 15 : 971 – 975 .
   PubMed Web of Science ®Google Scholar
• Park , JK , Lee , YK , Lee , P , Chung , HJ , Kim , S , Lee , HG , Seo , MK , Han , JH , Park , CG , Kim , HT and others . 2006 . Recombinant human erythropoietin produced in milk of transgenic pigs . Journal of Biotechnology , 122 : 362 – 371 .
   PubMed Web of Science ®Google Scholar
• Parker , MH , Birck‐Wilson , E , Allard , G , Masiello , N , Day , M , Murphy , KP , Paragas , V , Silver , S and Moody , MD . 2004 . Purification and characterization of a recombinant version of human alpha‐fetoprotein expressed in the milk of transgenic goats . Protein Expression and Purification , 38 : 177 – 183 .
   PubMedGoogle Scholar
• Petters , RM . 1994 . Transgenic livestock as genetic models of human disease . Reproduction, Fertility and Development , 6 : 643 – 645 .
   PubMedGoogle Scholar
• Pharming . 2005 . “ Pharming announces partnership with AgResearch for human lactoferrin ” . http://www. pharming. com/index.php?act=show&pg=160&h l=agresearch [accessed 29 September 2006]
   Google Scholar
• Pharming . 2006 . “ Pharming confirms positive outlook for rhC1INH ” . http://www.pharming.com/index. php?act=show&pg=265 [accessed 21 May 2006]
   Google Scholar
• Polejaeva , IA , Chen , SH , Vaught , TD , Page , RL , Mullins , J , Ball , S , Dai , Y , Boone , J , Walker , S , Ayares , DL and others . 2000 . Cloned pigs produced by nuclear transfer from adult somatic cells . Nature , 407 : 86 – 90 .
   PubMed Web of Science ®Google Scholar
• Pollock , DP , Kutzko , JP , Birck‐Wilson , E , Williams , JL , Echelard , Y and Meade , HM . 1999 . Transgenic milk as a method for the production of recombinant antibodies . Journal of Immunological Methods , 231 : 147 – 157 .
   PubMed Web of Science ®Google Scholar
• Powell , AM , Talbot , NC , Wells , KD , Kerr , DE , Pursel , VG and Wall , RJ . 2004 . Cell donor influences success of producing cattle by somatic cell nuclear transfer . Biology of Reproduction , 71 : 210 – 216 .
   PubMedGoogle Scholar
• Powell , K . 2003 . Barnyard biotech—lame duck or golden goose? . Nature Biotechnology , 21 : 965 – 967 .
   PubMedGoogle Scholar
• Pursel , VG , Pinkert , CA , Miller , KF , Bolt , DJ , Campbell , RG , Palmiter , RD , Brinster , RL and Hammer , RE . 1989 . Genetic engineering of livestock . Science , 244 : 1281 – 1288 .
   PubMed Web of Science ®Google Scholar
• Reh , WA , Maga , EA , Collette , NM , Moyer , A , Conrad‐Brink , JS , Taylor , SJ , DePeters , EJ , Oppenheim , S , Rowe , JD , BonDurant , RH and others . 2004 . Hot topic: using a stearoyl‐CoA desaturase transgene to alter milk fatty acid composition . Journal of Dairy Science , 87 : 3510 – 3514 .
   PubMedGoogle Scholar
• Renard , JP , Zhou , Q , LeBourhis , D , Chavatte‐Palmer , P , Hue , I , Heyman , Y and Vignon , X . 2002 . Nuclear transfer technologies: between successes and doubts . Theriogenology , 57 : 203 – 222 .
   PubMed Web of Science ®Google Scholar
• Rodriguez , A , Castro , FO , Aguilar , A , Ramos , B , Del Barco , DG , Lleonart , R and De la Fuente , J . 1995 . Expression of active human erythropoietin in the mammary gland of lactating transgenic mice and rabbits . Biological Research , 28 : 141 – 153 .
   PubMedGoogle Scholar
• Roemer , I , Reik , W , Dean , W and Klose , J . 1997 . Epigenetic inheritance in the mouse . Current Biology , 7 : 277 – 280 .
   PubMed Web of Science ®Google Scholar
• Rudenko , L , Matheson , JC , Adams , AL , Dubbin , ES and Green‐lees , KJ . 2004 . Food consumption risks associated with animal clones: what should be investigated? . Cloning and Stem Cells , 6 : 79 – 93 .
   PubMedGoogle Scholar
• Rudenko , L , Matheson , JC and Sundlof , SF . 2007 . Animal cloning and the FDA‐the risk assessment paradigm under public scrutiny . Nature Biotechnology , 25 : 39 – 43 .
   PubMedGoogle Scholar
• Rudolph , NS . 1999 . Biopharmaceutical production in transgenic livestock . Trends in Biotechnology , 17 : 367 – 374 .
   PubMed Web of Science ®Google Scholar
• Sahi , T . 1994 . Genetics and epidemiology of adult‐type hypolactasia . Scandinavian Journal of Gastroen‐terology Supplement , 202 : 7 – 20 .
   PubMedGoogle Scholar
• Salamone , D , Baranao , L , Santos , C , Bussmann , L , Artuso , J , Werning , C , Prync , A , Carbonetto , C , Dabsys , S , Munar , C and others . 2006 . High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow . Journal of Biotechnology , 124 : 469 – 472 .
   PubMedGoogle Scholar
• Sansinena , MJ , Taylor , SA , Taylor , PJ , Denniston , RS and Godke , RA . 2003 . Production of nuclear transfer llama (Lama glama) embryos from in vitro matured llama oocytes . Cloning and Stem Cells , 5 : 191 – 198 .
   PubMedGoogle Scholar
• Santos , F , Zakhartchenko , V , Stojkovic , M , Peters , A , Jenu‐wein , T , Wolf , E , Reik , W and Dean , W . 2003 . Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos . Current Biology , 13 : 1116 – 1121 .
   PubMed Web of Science ®Google Scholar
• Scherf , B . 2000 . “ One third of farm animal breeds face extinction ” . http://www.fao.org/NEWS/2000/001201‐e.htm [accessed 26 September 2006]
   Google Scholar
• Schmidt , C . 2006 . Belated approval of first recombinant protein from animal . Nature Biotechnology , 24 : 877
   PubMedGoogle Scholar
• Schnieke , AE , Kind , AJ , Ritchie , WA , Mycock , K , Scott , AR , Ritchie , M , Wilmut , I , Colman , A and Campbell , KH . 1997 . Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts . Science , 278 : 2130 – 2133 .
   PubMed Web of Science ®Google Scholar
• Schutz , MM , Freeman , AE , Lindberg , GL , Koehler , CM and Beitz , DC . 1994 . The effect of mitochondrial DNA on milk production and health of dairy cattle . Livestock Production Science , 37 : 283 – 295 .
   Google Scholar
• Shimozawa , N , Ono , Y , Kimoto , S , Hioki , K , Araki , Y , Shinkai , Y , Kono , T and Ito , M . 2002 . Abnormalities in cloned mice are not transmitted to the progeny . Genesis , 34 : 203 – 207 .
   PubMedGoogle Scholar
• Shin , T , Kraemer , D , Pryor , J , Liu , L , Rugila , J , Howe , L , Buck , S , Murphy , K , Lyons , L and Westhusin , M . 2002 . A cat cloned by nuclear transplantation . Nature , 415 : 859
   PubMed Web of Science ®Google Scholar
• Simonsson , S and Gurdon , J . 2004 . DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei . Nature Cell Biology , 6 : 984 – 990 .
   PubMed Web of Science ®Google Scholar
• Small , B . Genetic engineering: New Zealand public attitudes 2001, 2003, and 2005 . Proceedings of the Talking Biotechnology—Reflecting on Science in Society Conference . November 29 2005 , Wellington, New Zealand. —2 December. CDROM.
   Google Scholar
• Smeaton , DC , Harris , BL , Xu , ZZ and Vivanco , WH . 2003a . Factors affecting commercial application of embryo technologies in New Zealand: a modelling approach . Theriogenology , 59 : 617 – 634 .
   PubMedGoogle Scholar
• Smeaton , DC , McGowan , LT , Scott , ML , Tervit , HR and Cameron , CA . 2003b . Survival of in vitro produced cattle embryos from embryo transfer to weaning . Proceedings of the New Zealand Society of Animal Production , 63 : 57 – 60 .
   Google Scholar
• Smeaton , DC , Woodward , SJR , Wells , DN and Smith , JF . 2004 . Gross margin analyses of using cloned embryos in cattle . Proceedings of the New Zealand Society of Animal Production , 64 : 262 – 267 .
   Google Scholar
• Smith , SL , Everts , RE , Tian , XC , Du , F , Sung , LY , Rod‐riguez‐Zas , SL , Jeong , BS , Renard , JP , Lewin , HA and Yang , X . 2005 . Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning . Proceedings of the National Academy of Sciences, USA , 102 : 17582 – 17587 .
   PubMed Web of Science ®Google Scholar
• Soler , E , Le Saux , A , Guinut , F , Passet , B , Cohen , R , Merle , C , Charpilienne , A , Fourgeux , C , Sorel , V , Piriou , A and others . 2005 . Production of two vaccinating recombinant rotavirus proteins in the milk of transgenic rabbits . Transgenic Research , 14 : 833 – 844 .
   PubMedGoogle Scholar
• Stinnakre , MG , Vilotte , JL , Soulier , S and Mercier , JC . 1994 . Creation and phenotypic analysis of alpha‐lactal‐bumin‐deficient mice . Proceedings of the National Academy of Sciences, USA , 91 : 6544 – 6548 .
   PubMedGoogle Scholar
• Sung , LY , Gao , S , Shen , H , Yu , H , Song , Y , Smith , SL , Chang , CC , Inoue , K , Kuo , L , Lian , J and others . 2006 . Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer . Nature Genetics , 38 : 1323 – 1328 .
   PubMedGoogle Scholar
• Suteevun , T , Parnpai , R , Smith , SL , Chang , CC , Muenthai‐song , S and Tian , XC . 2006 . Epigenetic characteristics of cloned and in vitro‐fertilized swamp buffalo (Bubalus bubalis) embryos . Journal of Animal Science , 84 : 2065 – 2071 .
   PubMed Web of Science ®Google Scholar
• Takahashi , S and Ito , Y . 2004 . Evaluation of meat products from cloned cattle: biological and biochemical properties . Cloning and Stem Cells , 6 : 165 – 171 .
   PubMedGoogle Scholar
• Tamashiro , KL , Wakayama , T , Blanchard , RJ , Blanchard , DC and Yanagimachi , R . 2000 . Postnatal growth and behavioral development of mice cloned from adult cumulus cells . Biology of Reproduction , 63 : 328 – 334 .
   PubMedGoogle Scholar
• Tamashiro , KL , Wakayama , T , Akutsu , H , Yamazaki , Y , Lachey , JL , Wortman , MD , Seeley , RJ , D'Alessio , DA , Woods , SC , Yanagimachi , R and others . 2002 . Cloned mice have an obese phenotype not transmitted to their offspring . Nature Medicine , 8 : 262 – 267 .
   PubMed Web of Science ®Google Scholar
• The Royal Society . 2001 . “ The use of genetically modified animals ” . http://www.royalsociety.org/displaypage‐doc.asp?id=11513 [accessed 18 January 2007]
   Google Scholar
• Tian , XC , Kubota , C , Sakashita , K , Izaike , Y , Okano , R , Tabara , N , Curchoe , C , Jacob , L , Zhang , Y , Smith , S and others . 2005 . Meat and milk compositions of bovine clones . Proceedings of the National Academy of Sciences, USA , 102 : 6261 – 6266 .
   PubMedGoogle Scholar
• Toledo , JR , Sanchez , O , Segui , RM , Garcia , G , Montanez , M , Zamora , PA , Rodriguez , MP and Cremata , JA . 2006 . High expression level of recombinant human erythropoietin in the milk of non‐transgenic goats . Journal of Biotechnology , 123 : 225 – 235 .
   PubMed Web of Science ®Google Scholar
• Van Berkel , PH , Welling , MM , Geerts , M , Van Veen , HA , Ravensbergen , B , Salaheddine , M , Pauwels , EK , Pieper , F , Nuijens , JH and Nibbering , PH . 2002 . Large scale production of recombinant human lactoferrin in the milk of transgenic cows . Nature Biotechnology , 20 : 484 – 487 .
   PubMed Web of Science ®Google Scholar
• Van den Hout , JM , Kamphoven , JH , Winkel , LP , Arts , WF , de Klerk , JB , Loonen , MC , Vulto , AG , Cromme‐Di‐jkhuis , A , Weisglas‐Kuperus , N , Hop , W and others . 2004 . Long‐term intravenous treatment of Pompe disease with recombinant human alpha‐glucosi‐dase from milk . Pediatrics , 113 : e448 – 457 .
   PubMed Web of Science ®Google Scholar
• Van Doorn , MB , Burggraaf , J , Van Dam , T , Eerenberg , A , Levi , M , Hack , CE , Schoemaker , RC , Cohen , AF and Nuijens , J . 2005 . A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema . Journal of Allergy and Clinical Immunology , 116 : 876 – 883 .
   PubMed Web of Science ®Google Scholar
• Van Vleck , LD . 1999 . Implications of cloning for breed improvement strategies: are traditional methods of animal improvement obsolete? . Journal of Animal Science , 77 ( Supplement 2 ) : 111 – 121 .
   PubMedGoogle Scholar
• van Wagtendonk‐de Leeuw , AM , Aerts , BJG and den Dass , JHG . 1998 . Abnormal offspring following in vitro production of bovine preimplantation embryos: a field study . Theriogenology , 49 : 883 – 894 .
   PubMedGoogle Scholar
• Velander , WH , Johnson , JL , Page , RL , Russell , CG , Subra‐manian , A , Wilkins , TD , Gwazdauskas , FC , Pittius , C and Drohan , WN . 1992 . High‐level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C . Proceedings of the National Academy of Sciences, USA , 89 : 12003 – 12007 .
   PubMed Web of Science ®Google Scholar
• Vermij , P . 2007 . FDA's cloning report bypasses ethics, exposes European dilemma . Nature Biotechnology , 25 : 7 – 8 .
   PubMedGoogle Scholar
• Vilotte , JL . 2002 . Lowering the milk lactose content in vivo: potential interests, strategies and physiological consequences . Reproduction, Nutrition, Development , 42 : 127 – 132 .
   PubMedGoogle Scholar
• Wakayama , T , Perry , AC , Zuccotti , M , Johnson , KR and Yanagimachi , R . 1998 . Full‐term development of mice from enucleated oocytes injected with cumulus cell nuclei . Nature , 394 : 369 – 374 .
   PubMed Web of Science ®Google Scholar
• Wakayama , T and Yanagimachi , R . 2001 . Mouse cloning with nucleus donor cells of different age and type . Molecular Reproduction and Development , 58 : 376 – 383 .
   PubMed Web of Science ®Google Scholar
• Wall , RJ , Kerr , DE and Bondioli , KR . 1997 . Transgenic dairy cattle: genetic engineering on a large scale . Journal of Dairy Science , 80 : 2213 – 2224 .
   PubMed Web of Science ®Google Scholar
• Wall , RJ , Powell , AM , Paape , MJ , Kerr , DE , Bannerman , DD , Pursel , VG , Wells , KD , Talbot , N and Hawk , HW . 2005 . Genetically enhanced cows resist intramammary Staphylococcus aureus infection . Nature Biotechnology , 23 : 445 – 451 .
   PubMed Web of Science ®Google Scholar
• Walsh , MK , Lucey , JA , Govindasamy‐Lucey , S , Pace , MM and Bishop , MD . 2003 . Comparison of milk produced by cows cloned by nuclear transfer with milk from non‐cloned cows . Cloning and Stem Cells , 5 : 213 – 219 .
   PubMedGoogle Scholar
• Wang , L , Duan , E , Sung , LY , Jeong , BS , Yang , X and Tian , XC . 2005 . Generation and characterization of pluripotent stem cells from cloned bovine embryos . Biology of Reproduction , 73 : 149 – 155 .
   PubMedGoogle Scholar
• Wells , DN . 2003 . Cloning in livestock agriculture . Reproduction Supplement , 61 : 131 – 150 .
   PubMedGoogle Scholar
• Wells , DN . 2004 . “ The integration of cloning by nuclear transfer in the conservation of animal genetic resources ” . In Farm animal genetic resources , Edited by: Simm , G , Villanuva , B , Sinclair , KD and Townsend , S . 223 – 241 . British Society of Animal Science .
   Google Scholar
• Wells , DN , Misica , PM , Day , AM and Tervit , HR . 1997 . Production of cloned lambs from an established embryonic cell line: a comparison between in vivo‐and in vitro‐matured cytoplasts . Biology of Reproduction , 57 : 385 – 393 .
   PubMedGoogle Scholar
• Wells , DN , Misica , PM , Tervit , HR and Vivanco , WH . 1998 . Adult somatic cell nuclear transfer is used to preserve the last surviving cow of the Enderby Island cattle breed . Reproduction, Fertility and Development , 10 : 369 – 378 .
   PubMedGoogle Scholar
• Wells , DN , Misica , PM and Tervit , HR . 1999 . Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells . Biology of Reproduction , 60 : 996 – 1005 .
   PubMed Web of Science ®Google Scholar
• Wells , DN , Laible , G , Tucker , FC , Miller , AL , Oliver , JE , Xiang , T , Forsyth , JT , Berg , MC , Cockrem , K , L'Huillier , PJ and others . 2003 . Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle . Theriogenology , 59 : 45 – 59 .
   PubMed Web of Science ®Google Scholar
• Wells , DN , Forsyth , JT , McMillan , V and Oback , B . 2004 . Review: the health of somatic cell cloned cattle and their offspring . Cloning and Stem Cells , 6 : 101 – 110 .
   PubMedGoogle Scholar
• Wilmut , I , Schnieke , AE , McWhir , J , Kind , AJ and Campbell , KH . 1997 . Viable offspring derived from fetal and adult mammalian cells . Nature , 385 : 810 – 813 .
   PubMed Web of Science ®Google Scholar
• Wilmut , I , Beaujean , N , de Sousa , PA , Dinnyes , A , King , TJ , Paterson , LA , Wells , DN and Young , LE . 2002 . Somatic cell nuclear transfer . Nature , 419 : 583 – 587 .
   PubMed Web of Science ®Google Scholar
• Woods , GL , White , KL , Vanderwall , DK , Li , GP , Aston , KI , Bunch , TD , Meerdo , LN and Pate , BJ . 2003 . A mule cloned from fetal cells by nuclear transfer . Science , 301 : 1063
   PubMed Web of Science ®Google Scholar
• Woolliams , JA . 2004 . “ Managing populations at risk ” . In Farm animal genetic resources , Edited by: Simm , G , Villanuva , B , Sinclair , KD and Townsend , S . 85 – 106 . British Society of Animal Science .
   Google Scholar
• Woolliams , JA and Wilmut , I . 1999 . New advances in cloning and their potential impact on genetic variation in livestock . Animal Science , 68 : 245 – 256 .
   Google Scholar
• Wright , G , Carver , A , Cottom , D , Reeves , D , Scott , A , Simons , P , Wilmut , I , Garner , I and Colman , A . 1991 . High level expression of active human alpha‐1‐antitrypsin in the milk of transgenic sheep . Biotechnology (NY) , 9 : 830 – 834 .
   PubMedGoogle Scholar
• Xue , F , Tian , XC , Du , F , Kubota , C , Taneja , M , Dinnyes , A , Dai , Y , Levine , H , Pereira , LV and Yang , X . 2002 . Aberrant patterns of X chromosome inactivation in bovine clones . Nature Genetics , 31 : 216 – 220 .
   PubMed Web of Science ®Google Scholar
• Yamazaki , Y , Makino , H , Hamaguchi‐Hamada , K , Hamada , S , Sugino , H , Kawase , E , Miyata , T , Ogawa , M , Yanagimachi , R and Yagi , T . 2001 . Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer . Proceedings of the National Academy of Sciences, USA , 98 : 14022 – 14026 .
   PubMedGoogle Scholar
• Yamazaki , Y , Fujita , TC , Low , EW , Alarcon , VB , Yanagimachi , R and Marikawa , Y . 2006 . Gradual DNA demethylation of the Oct4 promoter in cloned mouse embryos . Molecular Reproduction and Development , 73 : 180 – 188 .
   PubMedGoogle Scholar
• Yang , L , Chavatte‐Palmer , P , Kubota , C , O'Neill , M , Hoagland , T , Renard , JP , Taneja , M , Yang , X and Tian , XC . 2005 . Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones . Molecular Reproduction and Development , 71 : 431 – 438 .
   PubMed Web of Science ®Google Scholar
• Yonai , M , Kaneyama , K , Miyashita , N , Kobayashi , S , Goto , Y , Bettpu , T and Nagai , T . 2005 . Growth, reproduction, and lactation in somatic cell cloned cows with short telomeres . Journal of Dairy Science , 88 : 4097 – 4110 .
   PubMedGoogle Scholar
• Zhou , Q , Renard , JP , Le Friec , G , Brochard , V , Beaujean , N , Cherifi , Y , Fraichard , A and Cozzi , J . 2003 . Generation of fertile cloned rats by regulating oocyte activation . Science , 302 : 1179
   PubMed Web of Science ®Google Scholar