- Vyse TJ, Todd JA. Genetic analysis of autoimmune disease. Cell 1996; 85: 311-8.
- Majzouh J, Muglia L. Knockout mice. New Engl J Med 1996; 334: 904-7.
- Galli-Taliadoros LA, Wood S A, Sedgwick JD, Körner H. Gene knockout technology: a methodological overview for the interested novice. J Immunol Methods 1995; 181: 1-15.
- Rohertson E, Bradley A, Kuehn M, Evans M. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 1986; 323: 445-8.
- Evans M, Kauf man M. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154-6.
- Martin G. Isolation of a pluripotent cell line from early mouse embryos cultured in media conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981; 78: 7634-8.
- Bradley A, Evans M, Kauf man M, Robertson E. Formation of germline chimaeras from embryo-derived teratocarcinoma cell lines. Nature 1984; 309: 255-6.
- Gossler A, Doetschman T, Korn R, Serfling E, Kemler R. Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc Natl Acad Sci USA 1986; 83: 9065-9.
- Robertson EJ, Bradley A, Kuehn M, Evans M. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 1986; 323: 445-8.
- Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 1985; 317: 230-4.
- Thomas K, Capecchi M. Site directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987; 51: 503-12.
- Zijlstra M, Ei E, Sajjadi F, Subramani S, Jaenisch R. Germline transmission of a disrupted beta-2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 1989; 342: 435-8.
- Crusio W E. Gene targeting studies: new methods, old problems. Trends Neurosci 1996; 19: 186-7.
- Wakeland E, Morel E, Achey K, Yui M, Longmate J. Speed congenics: a classic technique in the fast lane (relatively speaking) Immunol Today 1997; 18: 472-7.
- Olson EN, Arnold H-H, Rigby PWJ, Wold BJ. Know your neighbors: three phenotypes in null mutants of the myogenic bHEH gene MRF4. Cell 1996; 85: 1-4.
- Baubonis W, Sauer B. Genomic targeting with purified Cre recombinase. Nucleic Acids Res 1993; 21: 2025-9.
- Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, et al. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci USA 1997; 94: 9302-7.
- Sedgwick JD, Riminton DS, Cyster JG, Korner H. Tumor necrosis factor: a master-regulator of leukocyte movement. Immunol Today 2000; 21: 110-3.
- Bean A, Roach DR, Briscoe H, et al. Structural deficiencies in granuloma formation in TNF-gene targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol 1999; 162: 3504-11.
- Cook MC, Korner H, Riminton DS, et al. Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice. J Exp Med 1998; 188: 1503-10.
- Körner H, Riminton DS, Strickland DH, Eemckert FA, Pollard J, Sedgwick JD. Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J Exp Med 1997; 186: 1585-90.
- Rennert P D, Browning JE, Mebius R, Mackay F, Hochman PS. Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs. J Exp Med 1996; 184: 1999-2006.
- Matsumoto M, Fu Y-X, Molina H, Chaplin DD. Eymphotoxin-alpha-deficient and TNF receptor-1-deficient mice developmental and functional characteristics of germinal centers. Immunol Rev 1997; 156: 137-44.
- Roach DR, Briscoe H, Saunders B, France MP, Riminton S, Britton WJ. Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection. J Exp Med 2001; 193: 239-46.
- Keane J, Gershon S, Wise RP, et al. Tuberculosis associated with infliximab, a tumor necrosis factor-alpha neutralizing agent. New Engl J Med 2001; 345: 1098-104.
- Tanaka H, Kawacla N, Yaniada T, Kawacla K, Takatsu K, Nagai H. Allergen-induced airway inflammation and bronchial responsivenes s in interleukin-5 receptor alpha chain-deficient mice. Clin Exp Allergy 2000; 30: 874-81.
- Kopf M, Baumann H, Freer G, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994; 368: 339-42.
- Christ M, McCartney FN, Kulkarni AB, et al. Immune dysregulation in TGF-beta 1-deficient mice. J Immunol 1994; 153: 1936-46.
- Lee EG, Boone DL, Chai S, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000; 289: 2350-4.
- Ma A, Datta M, Margosian E, Chen J, Horak I. T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med 1995; 182: 1567-72.
- Kuhn R, Lohler J, Rennick D. Interleukin-10 deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-74.
- Ermann J, Fathman CG. Autoimmune diseases: genes, hugs and failed regulation. Nat Immunol 2001; 2: 759-61.
- Yasutomo K, Horiuchi T, Kagami S, et al Mutation in DNASEl in people with systemic lupus erythematosus. Nat Genet 2001; 28: 313-4.
- Pickering MC, Botto M, Taylor PR, Lachmann PJ, Walport MJ. Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol 2000; 76: 227-324.
- Wandstrat A, Wakeland EK. The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol 2001; 2: 802-9.
- Kozak W, Kluger MJ, Soszynski D, et al. IL-6 and IL-1 beta in fever. Studies using cytokine-deficient (knockout) mice. Ann NY Acad Sci 1998; 856: 33-47.
- Horai R, Saijo S, Tanioka H, et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin-1 receptor antagonist-deficient mice. J Exp Med 2000; 191: 313-20.
- Ma A, Datta M, Margosian E, Chen J, Horak I. T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med 1995; 182: 1567-72.
- Christ M, McCartney-Francis NL, Kulkarni AB, et al. Immune dysregulation in TGF-beta 1-deficient mice. J lmmunol 1994; 153: 1936-46.
- Marino M, Dunn A, Grail D, et al. Characterisation of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997; 94: 8093-8.
- Riminton DS, Körner H, Strickland DH, Lemckert FA, Pollard JD, Sedgwick JD. Challenging cytokine redundancy: Inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, hut not TNF-deficient mice. J Exp Med 1998; 187: 1517-28.
- Körner H, Cook M, Riminton DS, et al. Distinct roles for Lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organisation of lymphoid tissue. Eur J immunol 1997; 27: 2600-9.
- Forlow SB, White EJ, Barlow SC, et al. Severe inflammatory defect and reduced viability in CD 18 and E-selectin double-mutant mice. J Clin Invest 2000; 106: 1457-66.
- Langenbach R, Morham SG, Tiano HF, et al. Disruption of the mouse cyclooxygenase I gene. Characteristics of the mutant and areas for future study. Adv Exp Med Biol 1997; 407: 87-92.
- Dinchuk JE, Car BD, Focht RJ, et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995; 378: 406-9.
- Hopken UE, Eu B, Gerard NP, Gerard C. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med 1997; 186: 749-56.
- Gao JE, Wynn TA, Chang Y, et al. Impaired host defense, haematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor I. J Exp Med 1997; 185: 1959-68.
- Cook DN, Chen SC, Sullivan EM, et al. Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol 2001; 21: 3159-65.
- Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz HG, Moroy T. Features of systemic lupus erythematosus in Dnasel-deficient mice. Nat Genet 2000; 25: 177-81.
- Sligh JE Jr, Ballantyne CM, Rich SS, et al. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule I. Proc Nall Acad Sci USA 1993; 90: 8529-33.
Gene targeting technology and advances in the pathophysiology of inflammation
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