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Anatomical Pathology

Real-time PCR quantification of human telomerase reverse transcriptase (hTERT) in colorectal cancer

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Pages 25-30 | Received 14 Feb 2007, Accepted 21 May 2007, Published online: 06 Jul 2009

References

  • Vogelstein B, Kinzler K W. The multistep nature of cancer. Trends Genet 1993; 9: 138–41
  • Vogt P K. Cancer genes. West J Med 1993; 158: 273–8
  • Blackburn E H. Telomerases. Annu Rev Biochem 1992; 61: 113–29
  • Nugent C I, Lundblad V. The telomerase reverse transcriptase: components and regulation. Genes Dev 1998; 12: 1073–85
  • Shay J W, Wright W E. The reactivation of telomerase activity in cancer progression. Trends Genet 1996; 12: 129–31
  • Holt S E, Shay J E. Role of telomerase in cellular proliferation and cancer. J Cell Physiol 1999; 180: 10–18
  • Wright W E, Shay J W. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev 2001; 11: 98–103
  • Kim N W, Piatyszek M A, Prowse K R, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011–5
  • Shay J W, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787–91
  • Feng J, Funk W D, Wang S S, et al. The RNA component of human telomerase. Science 1995; 269: 1236–41
  • Meyerson M, Counter C M, Eatom E N, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997; 90: 785–95
  • Nakayama J, Tahara H, Tahara E, et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinoma. Nat Genet 1998; 18: 65–68
  • Fang D C, Joanne Y, Luo Y, et al. Detection of telomerase activity in biopsy samples of colorectal cancer. J Gastroenterol Hepatol 1999; 14: 328–32
  • Yan P, Saraga E P, Bouzourene H, et al. Telomerase activation in colorectal cacinogenesis. J Pathol 1999; 189: 207–12
  • Niiyama H, Mizumoto K, Sato N, et al. Quantitative analysis of hTERT mRNA expression in colorectal cancer. Am J Gastroenterol 2001; 96: 1895–900
  • Shoji Y, Yoshinaga K, Inoue A, Iwasaki A, et al. Quantification of telomerase activity in sporadic colorectal carcinoma. Cancer 2000; 88: 1304–9
  • Kanamaru T, Tanaka K I, Kotani J, et al. Telomerase activity and hTERT in development and progression of adenoma to colorectal cancer. Int J Mol Med 2002; 10: 205–10
  • Ghori A, Usselmann B, Ferryman S, et al. Telomerase expression of malignant epithelial cells correlates with Dukes' stage in colorectal cancer. Colorectal Dis 2002; 4: 441–6
  • Bustin S A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000; 25: 169–93
  • De Kok J B, Ruers T J, van Muijen G N, et al. Real-Time quantification of human telomerase reverse transcriptase mRNA in tumors and healthy tissues. Clin Chem 2000; 46: 313–8
  • Cheng A J, Tang R P, Wang J Y, et al. Possible role of telomerase activation in the cancer predisposition of patients with hereditary nonpolyposis colorectal cancers. J Natl Cancer Inst 1998; 90: 316–21
  • Kawanishi-Tabata R, Lopez F, Fratantonio S, et al. Telomerase activity in stage II colorectal carcinoma. Cancer 2002; 95: 1834–39
  • Myung S J, Yang S K, Chang H S, et al. Clinical usefulness of telomerase for the detection of colon cancer in ulcerative colitis patients. J Gastroenterol 2005; 20: 1578–83
  • Tahara H, Yasui W, Tahara E, et al. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in colorectal tumor and non-tumor tissue sections. Oncogene 1999; 18: 1561–7
  • Gertler R, Rosenberg R, Stricker D, et al. Prognostic potential of the telomerase subunit human telomerase reverse transcriptase in tumor tissue and nontumorous mucosa from patients with colorectal carcinoma. Cancer 2002; 95: 2103–11
  • Ulaner G A, Hu J F, Vu T H, et al. Regulation of telomerase by alternative splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary endometrium and myometrium. Int J Cancer 2000; 85: 330–5
  • Lledo S M, Garcia-Granero E, Dasi F, et al. Real time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA in patients with colorectal cancer. Colorectal Dis 2004; 6: 236–42
  • Iacopetta B. Are there two sides to colorectal cancer?. Int J Cancer 2002; 101: 403–8
  • Kapiteijn E, Liefers G J, Los L C, et al. Mechanisms of oncogenesis in colon versus rectal cancer. J Pathol 2001; 195: 171–8
  • Birkenkamp-Demtroder K, Olesen S H, et al. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut 2005; 54: 374–84

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