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Clinical Features - Review

Management of hyperuricemia and gout in obese patients undergoing bariatric surgery

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Pages 523-535 | Received 19 Feb 2018, Accepted 04 Jun 2018, Published online: 22 Jun 2018

References

  • Williams PT. Effects of diet, physical activity and performance, and body weight on incident gout in ostensibly healthy, vigorously active men. Am J Clin Nutr. 2008 May;87(5):1480–1487.
  • Zhang Y, Chen C, Choi H, et al. Purine-rich foods intake and recurrent gout attacks. Ann Rheum Dis. 2012 Sep;71(9):1448–1453.
  • Kuo CF, Grainge MJ, Zhang W, et al. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol. 2015;11(11):649–662.
  • Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388(10055):2039–2052.
  • Roddy E, Choi HK. Epidemiology of gout. Rheum Dis Clin North Am. 2014;40(2):155–175.
  • Hak AE, Curhan GC, Grodstein F, et al. Menopause, postmenopausal hormone use and risk of incident gout. Ann Rheum Dis. 2010;69(7):1305–1309.
  • Jung JH, Kim J-H, Lee YH, et al. Serum uric acid levels and hormone replacement therapy type: a retrospective case-control study of postmenopausal women. Conf Paper in Annals Rheum Dis. 2017 Jun;76(Suppl 2):1037.3–1038.
  • Mumford SL, Dasharathy SS, Pollack AZ, et al. Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: findings from the bioCycle study. Hum Reprod. 2013 Jul;28(7):1853–1862.
  • Herrera BM, Lindgren CM. The genetics of obesity. Curr Diab Rep. 2010;10(6):498–505.
  • Yamashita S, Matsuzawa Y, Tokunaga K, et al. Studies on the impaired metabolism of uric acid in obese subjects: marked reduction of renal urate excretion and its improvement by a low-calorie diet. Int J Obes. 1986;10(4):255–264.
  • Hindman D, Liu S, Miner JN. Urate handling in the human body. Curr Rheumatol Rep. 2016;18:34.
  • Dehghan A, Köttgen A, Yang Q, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372(9654):1953–1961.
  • Yamagishi K, Tanigawa T, Kitamura A, et al. CIRCS Investigators. The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people. Rheumatology (Oxford). 2010;49(8):1461–1465.
  • Enomoto A, Endou H. Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol. 2005;9(3):195–205.
  • Shafiu M, Johnson RJ, Turner ST, et al. Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in caucasians with hypertension. Kidney Blood Press Res. 2012;35(6):477–482.
  • Cheng Q, Aleksunes LM, Manautou JE, et al. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm. 2008;5(1):77–91.
  • Tana C, Giamberardino MA, Cipollone F. microRNA profiling in atherosclerosis, diabetes, and migraine. Ann Med. 2017;49(2):93–105.
  • Zhang X, Yang X, Wang M, et al. Association between SLC2A9 (GLUT9) gene polymorphisms and gout susceptibility: an updated meta-analysis. Rheumatol Int. 2016;36(8):1157–1165.
  • Chino Y, Samukawa Y, Sakai S, et al. SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria. Biopharm Drug Dispos. 2014;35(7):391–404.
  • Liu WC, Hung CC, Chen SC, et al. The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese. Exp Diabetes Res. 2011;2011:527520.
  • Huffman JE, Albrecht E, Teumer A, et al. Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLoS ONE. 2015;10(3):e0119752.
  • Sorensen LB. Degradation of uric acid in man. Metabolism. 1959;8(5):687–703.
  • Dalbeth N, House ME, Gamble GD, et al. Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge. Arthritis Res Ther. 2014;16(1):R34.
  • Matsuo H, Nakayama A, Sakiyama M, et al. ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. Sci Rep. 2014;4:3755.
  • Ichida K, Matsuo H, Takada T, et al. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun. 2012;16:764.
  • Wei FJ, Cai CY, Yu P, et al. Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients. Genet Mol Res. 2015;14(4):15471–15481.
  • Finucane MM, Stevens GA, Cowan MJ, et al. Global burden of metabolic risk factors of chronic diseases collaborating group (Body mass index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9•1 million participants. Lancet. 2011;377(9765):557–567.
  • Bucci M, Tana C, Giamberardino MA, et al. Lp(a) and cardiovascular risk: investigating the hidden side of the moon. Nutr Metab Cardiovasc Dis. 2016;26(11):980–986.
  • Tana C, Tafuri E, Tana M, et al. New insights into the cardiovascular risk of migraine and the role of white matter hyperintensities: is gold all that glitters? J Headache Pain. 2013;14:9.
  • Tana C, Santilli F, Martelletti P, et al. Correlation between migraine severity and cholesterol levels. Pain Pract. 2015;15(7):662–670.
  • Tana C, Tana M, Rossi S, et al. Hepatic artery resistive index (HARI) and non-alcoholic fatty liver disease (NAFLD) fibrosis score in NAFLD patients: cut-off suggestive of non-alcoholic steatohepatitis (NASH) evolution. J Ultrasound. 2016;19(3):183–189.
  • Ticinesi A, Lauretani F, Ceda GP, et al. Uric acid and endothelial function in elderly community-dwelling subjects. Exp Gerontol. 2017 Mar;89:57–63.
  • Sjöström L, Lindroos AK, Peltonen M, et al. Swedish obese subjects study scientific group. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–2693.
  • Busetto L, Sergi G, Enzi G, et al. Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. Obes Res. 2004;12(8):1256–1263.
  • Segato G, Busetto L, De Luca M, et al. Weight loss and changes in use of antidiabetic medication in obese type 2 diabetics after laparoscopic gastric banding. Surg Obes Relat Dis. 2010;6(2):132–137.
  • Zambon S, Romanato G, Sartore G, et al. Bariatric surgery improves atherogenic LDL profile by triglyceride reduction. Obes Surg. 2009;19(2):190–195.
  • Choi HK, Ford ES, Li C, et al. Prevalence of the metabolic syndrome in patients with gout: the third national health and nutrition examination survey. Arthritis Rheum. 2007;57(1):109–115.
  • Rai SK, Fung TT, Lu N, et al. The dietary approaches to stop hypertension (DASH) diet, western diet, and risk of gout in men: prospective cohort study. BMJ. 2017 May 9;357:j1794.
  • Khanna D, Fitzgerald JD, Khanna PP, et al. American college of rheumatology. 2012 American college of rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012;64(10):1431–1446.
  • Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017;76(1):29–42.
  • Maiuolo J, Oppedisano F, Gratteri S, et al. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8–14.
  • Rivard C, Thomas J, Lanaspa MA, et al. Sack and sugar, and the aetiology of gout in England between 1650 and 1900. Rheumatology (Oxford). 2013 Mar;52(3):421–426.
  • Jamnik J, Rehman S, Blanco Mejia S, et al. Fructose intake and risk of gout and hyperuricemia: a systematic review and meta-analysis of prospective cohort studies. BMJ Open. 2016;6(10):e013191.
  • Juraschek SP, Miller ER, Gelber AC. Body mass index, obesity, and prevalent gout in the United States in 1988–1994 and 2007–2010. Arthritis Care Res (Hoboken). 2013;65(1):127–132.
  • Dessein PH, Shipton EA, Stanwix AE, et al. Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study. Ann Rheum Dis. 2000;59(7):539–543.
  • Choi HK, Atkinson K, Karlson EW, et al. Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. Arch Intern Med. 2005;165(7):742–748.
  • Dalbeth N, Chen P, White M, et al. Impact of bariatric surgery on serum urate targets in people with morbid obesity and diabetes: a prospective longitudinal study. Ann Rheum Dis. 2014;73(5):797–802.
  • Oberbach A, Neuhaus J, Inge T, et al. Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia. Metabolism. 2014;63(2):242–249.
  • Ishizaka N, Ishizaka Y, Toda A, et al. Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals. J Rheumatol. 2010;37(2):410–416.
  • Andersson C, Weeke P, Brendorp B, et al. Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial. Nutr Metab (Lond). 2009;6:42.
  • Kim TH, Lee SS, Yoo JH, et al. The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus. Diabetol Metab Syndr. 2012;4(1):3.
  • Matsuura F, Yamashita S, Nakamura T, et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism. 1998;47:929–933.
  • Lee J, Lee JY, Lee JH, et al. Visceral fat obesity is highly associated with primary gout in metabolically obese but normal weighted population: a case control study. Arthritis Res Ther. 2015;17:79.
  • Shaw OM, Pool B, Dalbeth N, et al. The effect of diet-induced obesity on the inflammatory phenotype of non-adipose-resident macrophages in an in vivo model of gout. Rheumatology (Oxford). 2014;53(10):1901–1905.
  • Vuolteenaho K, Koskinen A, Moilanen E. Leptin - a link between obesity and osteoarthritis. applications for prevention and treatment. Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):103–108.
  • Karbowska J, Kochan Z. Role of adiponectin in the regulation of carbohydrate and lipid metabolism. J Physiol Pharmacol. 2006;57(Suppl 6):103–113.
  • Milan G, Granzotto M, Scarda A, et al. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res. 2002;10(11):1095–1103.
  • Fruehwald-Schultes B, Peters A, Kern W, et al. Serum leptin is associated with serum uric acid concentrations in humans. Metabolism. 1999;48:677–680.
  • Matsubara M, Chiba H, Maruoka S, et al. Elevated serum leptin concentrations in women with hyperuricemia. J Atheroscler Thromb. 2002;9:28–34.
  • Bo S, Gambino R, Durazzo M, et al. Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction. J Endocrinol Invest. 2008;31(6):499–504.
  • Facchini F, Chen YD, Hollenbeck CB, et al. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA. 1991;266:3008–3011.
  • Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm. 2010;2010:802078.
  • Quinones Galvan A, Natali A, Baldi S, et al. Effect of insulin on uric acid excretion in humans. Am J Physiol. 1995;268:E1–5.
  • Kwon H, Pessin JE. Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne). 2013;4:71.
  • Lee JJ, Ahn J, Hwang J, et al. Relationship between uric acid and blood pressure in different age groups. Clin Hypertens. 2015;21:14.
  • McAdams-DeMarco MA, Maynard JW, Baer AN, et al. Hypertension and the risk of incident gout in a population-based study: the atherosclerosis risk in communities cohort. J Clin Hypertens (Greenwich). 2012;14(10):675–679.
  • Matsubara K, Matsuzawa Y, Jiao S, et al. Relationship between hypertriglyceridemia and uric acid production in primary gout. Metabolism. 1989;38(7):698–701.
  • Chen JH, Pan WH, Hsu CC, et al. Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study. Arthritis Care Res (Hoboken). 2013;65(1):133–140.
  • Ouppatham S, Bancha S, Choovichian P. The relationship of hyperuricemia and blood pressure in the Thai army population. J Postgrad Med. 2008;54(4):259–262.
  • Huang J, Sun Y, Niu K, et al. Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study. Clin Exp Hypertens. 2015;37(6):498–504.
  • Mellen PB, Bleyer AJ, Erlinger TP, et al. Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in community studies. Hypertension. 2006;48:1037–1042.
  • Kang DH, Han L, Ouyang X, et al. Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol. 2005;25(5):425–433.
  • Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38:1101–1106.
  • Kang DH, Park SK, Lee IK, et al. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16(12):3553–3562.
  • Lyngdoh T, Vuistiner P, Marques-Vidal P, et al. Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS ONE. 2012;7:e39321.
  • Rasheed H, Hughes K, Flynn TJ, et al. Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels. Circ Cardiovasc Genet. 2014;7:830–837.
  • Nielsen SM, Bartels EM, Henriksen M, et al. Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies. Ann Rheum Dis. 2017;76(11):1870–1882.
  • Maglio C, Peltonen M, Neovius M, et al. Effects of bariatric surgery on gout incidence in the Swedish obese subjects study: a non-randomised, prospective, controlled intervention trial. Ann Rheum Dis. 2017;76(4):688–693.
  • Dalbeth N, Pool B, Yip S, et al. Effect of bariatric surgery on the inflammatory response to monosodium urate crystals: a prospective study. Ann Rheum Dis. 2013;72(9):1583–1584.
  • Lieske JC, Mehta RA, Milliner DS, et al. Kidney stones are common after bariatric surgery. Kidney Int. 2015;87:839–845.
  • Sinha MK, Collazo-Clavell ML, Rule A, et al. Hyperoxaluric nephrolithiasis is a complication of Roux-en-Y gastric bypass surgery. Kidney Int. 2007;72:100–107.
  • Kumar R, Lieske JC, Collazo-Clavell ML, et al. Fat malabsorption and increased oxalate absorption are common after roux-en-Y gastric bypass surgery. Surgery. 2011;149(5):654–661.
  • Froeder L, Arasaki CH, Malheiros CA, et al. Response to dietary oxalate after bariatric surgery. Clin J Am Soc Nephrol. 2012;7:2033–2040.
  • Semins MJ, Asplin JR, Steele K, et al. The effect of restrictive bariatric surgery on urinary stone risk factors. Urology. 2010;76:826–829.
  • DeFoor WR, Asplin JR, Kollar L, et al. Prospective evaluation of urinary metabolic indices in severely obese adolescents after weight loss surgery. Surg Obes Relat Dis. 2016;12(2):363–367.
  • Trinchieri A, Montanari E. Prevalence of renal uric acid stones in the adult. Urolithiasis. 2017;45:553–562.
  • Kang EH, Lee EY, Lee YJ, et al. Clinical feature and risk factors of postsurgical gout. Ann Rheum Dis. 2008;67(9):1271–1275.
  • Craig MH, Poole GV, Hauser CJ. Postsurgical gout. Am Surg. 1995;61:56–59.
  • Antozzi P, Soto F, Arias F, et al. Development of acute gouty attack in the morbidly obese population after bariatric surgery. Obes Surg. 2005;15(3):405–407.
  • Friedman JE, Dallal RM, Lord JL. Gouty attacks occur frequently in postoperative gastric bypass patients. Surg Obes Relat Dis. 2008;4(1):11–13.
  • Romero-Talamás H, Daigle CR, Aminian A, et al. The effect of bariatric surgery on gout: a comparative study. Surg Obes Relat Dis. 2014;10(6):1161–1165.
  • Edholm D, Kullberg J, Haenni A, et al. Preoperative 4-week low-calorie diet reduces liver volume and intrahepatic fat, and facilitates laparoscopic gastric bypass in morbidly obese. Obes Surg. 2011;21(3):345–350.
  • Fris RJ. Preoperative low energy diet diminishes liver size. Obes Surg. 2004;14:1165–1170.
  • Busetto L, Marangon M, De Stefano F. High-protein low-carbohydrate diets: what is the rationale? Diabetes Metab Res Rev. 2011;27(3):230–232.
  • Gero D, Steinert RE, Le Roux CW, et al. Do food preferences change after bariatric surgery? Curr Atheroscler Rep. 2017;19(9):38.
  • Genes N, Chisolm-Straker M. Monoarticular arthritis update: current evidence for diagnosis and treatment in the emergency department. Emerg Med Pract. 2012;14(5):1–19.
  • Neogi T. Gout. Ann Intern Med. 2016;165(1):ITC1–ITC16.
  • McLean L. The pathogenesis of gout. In: Hochberg M, editor Rheumatology. Edinburgh: Mosby; 2003. p. 1903–1918.
  • Roddy E, Zhang W, Doherty M. Are joints affected by gout also affected by osteoarthritis? Ann Rheum Dis. 2007;66(10):1374–1377.
  • Ma LD, Sun RX, Xin Y, et al. Clinical characteristics in gout patients with different body mass index. Zhonghua Nei Ke Za Zhi. 2017;56(5):353–357.
  • de Boer TN, van Spil WE, Huisman AM, et al. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage. 2012;20(8):846–853.
  • Simopoulou T, Malizos KN, Iliopoulos D, et al. Differential expression of leptin and leptin’s receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage. 2007;15(8):872–883.
  • Felson DT. Weight and osteoarthritis. J Rheumatol. 1995;43:7–9.
  • Yusuf E, Nelissen RG, Ioan-Facsinay A, et al. Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann Rheum Dis. 2010;69(4):761–765.
  • Masuko K, Murata M, Suematsu N, et al. A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation. Clin Exp Rheumatol. 2009;27(2):347–353.
  • Favero M, El-Hadi H, Belluzzi E, et al. Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study. Rheumatology (Oxford). 2017;56(10):1784–1793.
  • Hui W, Litherland GJ, Elias MS, et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 2012;71(3):455–462.
  • Messier SP, Loeser RF, Mitchell MN, et al. Exercise and weight loss in obese older adults with knee osteoarthritis: a preliminary study. J Am Geriatr Soc. 2000;48(9):1062–1072.
  • Froehling DA, Daniels PR, Mauck KF, et al. Incidence of venous thromboembolism after bariatric surgery: a population-based cohort study. Obes Surg. 2013;23(11):1874–1879.
  • Karason K, Lindroos AK, Stenlöf K, et al. Relief of cardiorespiratory symptoms and increased physical activity after surgically induced weight loss: results from the Swedish obese subjects study. Arch Intern Med. 2000;160(12):1797–1802.
  • Busetto L, Sergi G. Visceral fat and respiratory complications. Diabetes Obes Metab. 2005;7(4):301–306.
  • Oldmeadow LB, Edwards ER, Kimmel LA, et al. No rest for the wounded: early ambulation after hip surgery accelerates recovery. ANZ J Surg. 2006;76(7):607–611.
  • Siu AL, Penrod JD, Boockvar KS, et al. Early ambulation after hip fracture: effects on function and mortality. Arch Intern Med. 2006;166(7):766–771.
  • Richette P, Poitou C, Garnero P, et al. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis. 2011;70(1):139–144.
  • Busetto L, Dicker D, Azran C, et al. Practical recommendations of the obesity management task force of the European association for the study of obesity for the post-bariatric surgery medical management. Obes Facts. 2017;10(6):597–632.
  • Choi HK, Atkinson K, Karlson EW, et al. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med. 2004;350(11):1093–1103.
  • Choi HK, Gao X, Vitamin CG. C intake and the risk of gout in men: a prospective study. Arch Intern Med. 2009;169(5):502–507.
  • Choi HK, Curhan G. Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Arthritis Rheum. 2007;57(5):816–821.
  • Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study. Lancet. 2004;363(9417):1277–1281.
  • Schumacher HR Jr., Boice JA, Daikh DI, et al. Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis. BMJ. 2002;324(7352):1488–1492.
  • Rubin BR, Burton R, Navarra S, et al. Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout: a randomized controlled trial. Arthritis Rheum. 2004;50(2):598–606.
  • Neogi T. Clinical practice. Gout N Engl J Med. 2011;364(5):443–452.
  • Khanna D, Khanna PP, Fitzgerald JD, et al. American college of rheumatology. 2012 American college of rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken). 2012;64(10):1447–1461.
  • Nuki G. An appraisal of the 2012 American college of rheumatology guidelines for the management of gout. Curr Opin Rheumatol. 2014;26(2):152–161.
  • Wilbur K, Makowsky M. Colchicine myotoxicity: case reports and literature review. Pharmacotherapy. 2004;24(12):1784–1792.
  • Man CY, Cheung IT, Cameron PA, et al. Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial. Ann Emerg Med. 2007;49(5):670–677.
  • Janssens HJ, Janssen M, van de Lisdonk EH, et al. Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial. Lancet. 2008;371:1854–1860.
  • Wechalekar MD, Vinik O, Schlesinger N, et al. Intra-articular glucocorticoids for acute gout. Cochrane Database Syst Rev. 2013;(4):CD009920.
  • Iezzi A, Ferri C, Mezzetti A, et al. COX-2: friend or foe? Curr Pharm Des. 2007;13(16):1715–1721.
  • Schlesinger N, Alten RE, Bardin T, et al. Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions. Ann Rheum Dis. 2012;71(11):1839–1848.
  • Kim SC, Newcomb C, Margolis D, et al. Severe cutaneous reactions requiring hospitalization in allopurinol initiators: a population-based cohort study. Arthritis Care Res (Hoboken). 2013 Apr;65(4):578–584.
  • Faruque LI, Ehteshami-Afshar A, Wiebe N, et al. A systematic review and meta-analysis on the safety and efficacy of febuxostat versus allopurinol in chronic gout. Semin Arthritis Rheum. 2013;43(3):367–375.
  • Fink HA, Wilt TJ, Eidman KE, et al. Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American college of physicians clinical guideline. Ann Intern Med. 2013;158(7):535–543.
  • Qaseem A, Dallas P, Forciea MA, et al. Clinical guidelines committee for the American college of physicians. Dietary and pharmacologic management to prevent recurrent nephrolithiasis in adults: a clinical practice guideline from the American college of physicians. Ann Intern Med. 2014;161(9):659–667.
  • Goldfarb DS, MacDonald PA, Gunawardhana L, et al. Randomized controlled trial of febuxostat versus allopurinol or placebo in individuals with higher urinary uric acid excretion and calcium stones. Clin J Am Soc Nephrol. 2013;8:1960–1967.
  • Rush RM Jr. Gout and the postoperative bariatric surgery patient. Surg Obes Relat Dis. 2008;4(1):14–15.
  • Sundy JS, Becker MA, Baraf HS, et al. Pegloticase Phase 2 study investigators. Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study. Arthritis Rheum. 2008;58(9):2882–2891.
  • Saag KG, Fitz-Patrick D, Kopicko J, et al. Lesinurad combined with allopurinol: A randomized, double-blind, placebo-controlled study in gout patients with an inadequate response to standard-of-care allopurinol (a US-based study). Arthritis Rheumatol. 2017;69(1):203–212.
  • Bardin T, Keenan RT, Khanna PP, et al. Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). Ann Rheum Dis. 2017;76(5):811–820.
  • Dalbeth N, Jones G, Terkeltaub R, et al. Lesinurad, a selective uric acid reabsorption inhibitor, in combination with febuxostat in patients with tophaceous gout: findings of a Phase III clinical trial. Arthritis Rheumatol. 2017;69(9):1903–1913.
  • McAdams DeMarco MA, Maynard JW, Baer AN, et al. Diuretic use, increased serum urate levels, and risk of incident gout in a population-based study of adults with hypertension: the atherosclerosis risk in communities cohort study. Arthritis Rheum. 2012;64(1):121–129.
  • Ticinesi A, Nouvenne A, Borghi L, et al. Water and other fluids in nephrolithiasis: state of the art and future challenges. Crit Rev Food Sci Nutr. 2017;57(5):963–974.
  • Zhang Y, Neogi T, Chen C, et al. Low-dose aspirin use and recurrent gout attacks. Ann Rheum Dis. 2014;73(2):385–390.
  • Prezioso D, Strazzullo P, Lotti T, et al. CLU working group. Dietary treatment of urinary risk factors for renal stone formation. A review of CLU working group. Arch Ital Urol Androl. 2015;87(2):105–120.
  • Choi HK, Soriano LC, Zhang Y, et al. Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study. BMJ. 2012;344:d8190.
  • Desager JP, Hulhoven R, Harvengt C. Uricosuric effect of fenofibrate in healthy volunteers. J Clin Pharmacol. 1980;20(10):560–564.
  • Ogata N, Fujimori S, Oka Y, et al. Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients. Nucleosides Nucleotides Nucleic Acids. 2010;29(4–6):321–324.

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