A nonlinear association between resting heart rate and ischemic stroke among community elderly hypertensive patients

References

• Nanchen D. Resting heart rate: what is normal? Heart. 2018;104(13):1048–1049.
   PubMed Web of Science ®Google Scholar
• Bohm M, Reil JC, Deedwania P, et al. Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease. Am J Med. 2015;128(3):219–228.
   PubMed Web of Science ®Google Scholar
• Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol. 2007;74(2):224–242.
   PubMed Web of Science ®Google Scholar
• Hillis GS, Woodward M, Rodgers A, et al. Resting heart rate and the risk of death and cardiovascular complications in patients with type 2 diabetes mellitus. Diabetologia. 2012;55(5):1283–1290.
   PubMed Web of Science ®Google Scholar
• Zhang M, Han C, Wang C, et al. Association of resting heart rate and cardiovascular disease mortality in hypertensive and normotensive rural Chinese. J Cardiol. 2017;69(5):779–784.
   PubMed Web of Science ®Google Scholar
• Tadic M, Cuspidi C, Grassi G. Heart rate as a predictor of cardiovascular risk. Eur J Clin Invest. 2018;48:3.
   Web of Science ®Google Scholar
• Palatini P, Julius S. Elevated heart rate: a major risk factor for cardiovascular disease. Clin Exp Hypertens. 2004;26(7–8):637–644.
   PubMed Web of Science ®Google Scholar
• O’Neal WT, Qureshi WT, Judd SE, et al. Heart rate and ischemic stroke: the REasons for geographic and racial differences in stroke (REGARDS) study. Int J Stroke. 2015;10(8):1229–1235.
   PubMed Web of Science ®Google Scholar
• Lonn EM, Rambihar S, Gao P, et al. Heart rate is associated with increased risk of major cardiovascular events, cardiovascular and all-cause death in patients with stable chronic cardiovascular disease: an analysis of ONTARGET/TRANSCEND. Clin Res Cardiol. 2014;103(2):149–159.
   PubMed Web of Science ®Google Scholar
• Fox K, Bousser MG, Amarenco P, et al. Heart rate is a prognostic risk factor for myocardial infarction: a post hoc analysis in the PERFORM (Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack) study population. Int J Cardiol. 2013;168(4):3500–3505.
   PubMed Web of Science ®Google Scholar
• Mao Q, Huang JF, Lu X, et al. Heart rate influence on incidence of cardiovascular disease among adults in China. Int J Epidemiol. 2010;39(6):1638–1646.
   PubMed Web of Science ®Google Scholar
• Bemelmans RH, van der Graaf Y, Nathoe HM, et al. The risk of resting heart rate on vascular events and mortality in vascular patients. Int J Cardiol. 2013;168(2):1410–1415.
   PubMed Web of Science ®Google Scholar
• Lindgren M, Robertson J, Adiels M, et al. Resting heart rate in late adolescence and long term risk of cardiovascular disease in Swedish men. Int J Cardiol. 2018;259:109–115.
   PubMed Web of Science ®Google Scholar
• Liu LS. [2010 Chinese guidelines for the management of hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39(7):579–615.
   PubMedGoogle Scholar
• Wang A, Liu X, Guo X, et al. Resting heart rate and risk of hypertension: results of the Kailuan cohort study. J Hypertens. 2014;32(8):1600–1605.
   PubMed Web of Science ®Google Scholar
• Wang A, Chen S, Wang C, et al. Resting heart rate and risk of cardiovascular diseases and all-cause death: the Kailuan study. Plos One. 2014;9(10):e110985.
   PubMed Web of Science ®Google Scholar
• Zhang D, Wang W, Li F. Association between resting heart rate and coronary artery disease, stroke, sudden death and noncardiovascular diseases: a meta-analysis. CMAJ. 2016;188(15): E384–E392.
   PubMed Web of Science ®Google Scholar
• Sharashova E, Wilsgaard T, Mathiesen EB, et al. Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: the Tromso Study. J Epidemiol Community Health. 2016;70(9):902–909.
   PubMed Web of Science ®Google Scholar
• Woodward M, Webster R, Murakami Y, et al. The association between resting heart rate, cardiovascular disease and mortality: evidence from 112,680 men and women in 12 cohorts. Eur J Prev Cardiol. 2014;21(6):719–726.
   PubMed Web of Science ®Google Scholar
• Benetos A, Rudnichi A, Thomas F, et al. Influence of heart rate on mortality in a French population: role of age, gender, and blood pressure. Hypertension. 1999;33(1):44–52.
   PubMed Web of Science ®Google Scholar
• Hsia J, Larson JC, Ockene JK, et al. Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study. BMJ. 2009;338:b219.
   PubMedGoogle Scholar
• Stokes JR, Kannel WB, Wolf PA, et al. The relative importance of selected risk factors for various manifestations of cardiovascular disease among men and women from 35 to 64 years old: 30 years of follow-up in the Framingham Study. Circulation. 1987;75(6 Pt 2):V65–V73.
   PubMed Web of Science ®Google Scholar
• Palatini P, Julius S. Association of tachycardia with morbidity and mortality: pathophysiological considerations. J Hum Hypertens. 1997;11(Suppl 1):S19–S27.
   PubMedGoogle Scholar
• Caetano J, Delgado AJ. Heart rate and cardiovascular protection. Eur J Intern Med. 2015;26(4):217–222.
   PubMed Web of Science ®Google Scholar
• Lang CC, Gupta S, Kalra P, et al. Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: clinical evidence and pathophysiological mechanisms. Atherosclerosis. 2010;212(1):1–8.
   PubMed Web of Science ®Google Scholar
• Custodis F, Gertz K, Balkaya M, et al. Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice. Stroke. 2011;42(6):1742–1749.
   PubMed Web of Science ®Google Scholar
• Custodis F, Baumhakel M, Schlimmer N, et al. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2008;117(18):2377–2387.
   PubMed Web of Science ®Google Scholar
• Custodis F, Fries P, Muller A, et al. Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice. J Vasc Res. 2012;49(5):432–440.
   PubMed Web of Science ®Google Scholar
• Glasser SP, Arnett DK, McVeigh GE, et al. Vascular compliance and cardiovascular disease: a risk factor or a marker? Am J Hypertens. 1997;10(10 Pt 1):1175–1189.
   PubMed Web of Science ®Google Scholar
• Raij L, Gonzalez-Ochoa AM. Vascular compliance in blood pressure. Curr Opin Nephrol Hypertens. 2011;20(5):457–464.
   PubMed Web of Science ®Google Scholar