112
Views
6
CrossRef citations to date
0
Altmetric
Regular Articles

Toxicopathological evaluation of a 28-day repeated dose administration of Zea mays L. (Poaceae), Stigma maydis aqueous extract on key metabolic markers of Wistar rats

, &

References

  • Aboyade, O.M., Yakubu, M.T., Grierson, D.S. & Afolayan, A.J. 2009. Studies on the toxicological effect of the aqueous extract of fresh, dried, and boiled berries of Solanum aculeastrum Dunal in male Wistar rats. Human and Experimental Toxicology 28: 765–775.
  • Ajani, E.O., Sabiu, S., Bamisaye, F.A., Ibrahim, S. & Salau, B.A. 2014. Evaluation of the acute and sub-acute toxicity effect of ethanolic leaves extract of Lagenaria breviflora (Bitter gourd) on hepatic and renal function of rats. Journal of Pharmacy and Biological Sciences 9: 61–68.
  • Amresh, G.R., Singh, P.N. & Rao, C.V. 2008. Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals. Journal of Ethnopharmacology 116: 454–460.
  • Anofi, O.T.A. & Mutiu, I.K. 2015. Toxicopathological evaluation of hydroethanol extract of Dianthus basuticus in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. Article ID 348519.
  • Ashafa, A.O.T. & Olunu, O.O. 2011. Toxicological evaluation of ethanolic root extract of Morinda lucida (L.) Benth. (Rubiaceae) in male Wistar rats. Journal of Natural Pharmacy 2: 108–114.
  • Ashafa, A.O.T., Sunmonu, T.O. & Afolayan, A.J. 2010. Toxicological evaluation of aqueous leaf and berry extracts of Phytolacca dioica L. in male Wistar rats. Food and Chemical Toxicology 48: 1886–1889.
  • Dias, F.D.L. & Takahashi, C.S. 1994. Cytogenetic evaluation of aqueous extracts of the medicinal plants Alpinia mutans rose (Zingerberaceae) and Pogostemum hyneanus benth (Labitae) on Wistar rats and Allium cepa (Liliaceae) root tip cells. Brazilian Journal of Genetics 17: 175–180.
  • Drury, R.A.B. & Wallington, E.A. 1980. Carleton’s Histological Techniques, 5th edn. Oxford, Oxford University Press, pp. 36–148.
  • Ebrahimzadeh, M.A., Pourmorad, F. & Hafe, S. 2008. Antioxidant activities of Iranian corn silk. Turkish Journal of Biology 32: 43–49.
  • Fernanda, C.F., Andrea, G. & Cláudia, M. 2012. Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica. Revista Brasileira de Farmacognosia 22: 1104–1110.
  • Geddis, A.E. 2013. Inherited thrombocytopenias: an approach to diagnosis and management. International Journal of Laboratory Hematology 35: 14–25.
  • Ghada, M., Eltohami, M.S., Adurahman, H.N., Mahmoud, M.E. & Mudawi, I. 2014. In vitro study of the effect of corn silk on glucose uptake by isolated rat hemi-diaphragm. World Journal of Pharmaceutical Research 3(4): 2190–2195.
  • Grases, F., March, J.G., Ramis, M. & Costa-Bauzá, A. 1993. The influence of Zea mays on urinary risk factors for kidney stones in rats. Phytotherapy Research 7: 146–149.
  • Gruchy, G.C. 1976. Clinical Hematology in Medical Practice. Oxford/London, Blackwell Scientific pp. 33–57,
  • Guevara, P., Perez-Amador, M.C., Zuniga, B. & Snook, M. 2000. Flavones in corn silks and resistance to insect attacks. Phyton, International Journal of Experimental Botany 69: 151–156.
  • Idu, M., Timothy, O. & Omogbai, E.K.I. 2008. Hypotensive effects and acute toxicity property of methanol extract of Baissea axillaries Hau. Journal of Biological Sciences 8: 675–678.
  • Jianyou, G., Tongjun, L., Linna, H. & Yongmei, L. 2009. The effects of corn silk on glycemic metabolism. Nutrition Metabolism 6: 47.
  • Kim, K.A., Choi, S.K. & Choi, H.S. 2004. Corn silk induces nitric oxide synthase in murine macrophages. Experimental and Molecular Medicine 36: 545–550.
  • Lorke, D. 1983. A new approach to practical acute toxicity testing. Achieves of Toxicology 4: 275–287.
  • Maksimović, Z.A. & Kovacevic, N. 2003. Preliminary assay on the antioxidative activity of Maydis stigma extracts. Fitoterapia 74: 144–147.
  • Maksimović, Z., Dobric, S., Kovacevic, N. & Milovanovic, Z. 2004. Diuretic activity of Maydis stigma extract in rats. Pharmazy 59: 967–971.
  • NATIONAL INSTITUTE OF HEALTH (NIH). 1985. Care and Use of Laboratory Animals. Washington DC, National Institute of Health Publication, p. 85.
  • NATIONAL RESEARCH COUNCIL (NRC). 2006. Toxicity testing for assessing environmental agents. Interim Report, National Academies Press, Washington DC, USA.
  • NATIONAL RESEARCH COUNCIL (NRC). 2011. Guide for the Care and Use of Laboratory Animals, 8th edn. Washington DC, National Research Council, 118 pp.
  • Nigam, P.K. 2007. Biochemical markers of myocardial injury. Indian Journal of Clinical Biochemistry 22: 10–17.
  • Oloyede, O.B. & Sunmonu, T.O. 2009. Potassium bromate content of selected bread samples in Ilorin, Central Nigeria and its effect on some enzymes of rat liver and kidney. Food and Chemical Toxicology 47: 2067–2070.
  • ORGANISATION OF ECONOMIC CO-OPERATION AND DEVELOPMENT (OECD). 2001. Guideline for testing of chemicals. Acute oral toxicity – acute toxicity class method, 423. Adopted 17 December, 2001.
  • ORGANISATION OF ECONOMIC CO-OPERATION AND DEVELOPMENT (OECD). 2006. Report of the validation of the updated test guideline 407: Repeat dose 28-d ay oral toxicity study in laboratory rats. Series on testing and assessment No. 59, ENV/JM/MONO(2006)26.
  • Polenakovic, M. & Sikole, A. 1996. Is erythropoietin a survival factor for red blood cells? Journal of the American Society of Nephrology 7: 1178–1182.
  • Prut, L. & Belzung, C. 2003. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European Journal Pharmacology 463: 3–33.
  • Sabiu, S., Wudil, A.M. & Sunmonu, T.O. 2014. Combined administration of Telfaira occidentalis and Vernonia amygdalina leaf powders ameliorates Garlic-induced hepatotoxicity in Wistar rats. Pharmacologia 5: 191–198.
  • Sabiu, S., Ajani, E.O., Abubakar, A.A., Sulyman, A.O., Nurain, I.O., Irondi, E.A., Abubakar, A.Y. & Quadri, D.F. 2015a. Toxicological evaluations of Stigma maydis aqueous extract on hematological and lipid parameters of Wistar rats. Toxicology Reports 2: 638–644.
  • Sabiu, S., Sunmonu, T.O., Ajani, E.O. & Ajiboye, T.O. 2015b. Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats. Revista Brasileira de Farmacognosia 25: 29–34.
  • Sabiu, S., O’neill, F.H. & Ashafa, A.O.T. 2016a. Kinetics of α-amylase and α-glucosidase inhibitory potential of Zea mays Linnaeus (Poaceae), Stigma maydis aqueous extract: An in vitro assessment. Journal of Ethnopharmacology 183: 1–8. doi:10.1016/j.jep.2016.02.024.
  • Sabiu, S., O’neill, F.H. & Ashafa, A.O.T. 2016b. Zea mays, Stigma maydis prevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes. Pharmaceutical Biology, http://doI.org/10.1080/13880209.20161178307.
  • Sireatawong, S., Lertprasertsuke, N. & Srisawat, U. 2008. Acute and sub-chronic toxicity study of the water extract from Tiliacora trianora (Colebr.) Diels in rats. Songklankarin Journal of Science and Technology 30: 729–737.
  • Sunmonu, T.O. & Oloyede, O.B. 2006. Nephrotoxicity of crude oil contaminated catfish (Clarias gariepinus) on albino rats. Nigerian Journal of Biochemistry and Molecular Biology 26: 25–34.
  • Turner, R.A. 1972. Screening Procedures in Pharmacology. New York. Academic Press.
  • Ukwuani, A.N., Abubakar, M.G., Hassan, S.W. & Agaie, B.M. 2012. Toxicological studies of hydromethanolic leaves extract of Grewia crenata. International Journal of Pharmaceutical Science and Drug Research 4: 245–249.
  • Wooley, A. 2003. A Guide to Practical Toxicology Evaluation, Prediction and Risk Determination – General and reproductive toxicology. New York, Taylor and Francis, pp. 80–106.
  • WORLD HEALTH ORGANIZATION (WHO). 1998. Basic OECD principles of GLP. Geneva, Switzerland. Available at: www.who.int/tdrold/publications/publications/pdf/pr15/info.pdf. (accessed 24 August 2016).
  • Zhao, W., Yin, Y., Yu, Z., Liu, J. & Chen, F. 2012. Comparison of anti-diabetic effects of polysaccharides from corn silk on normal and hyperglycemia rats. International Journal of Biological Macromolecules 50: 1133–1137.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.