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Research Article

Determination of potentially hallucinogenic N-dimethylated indoleamines in human urine by HPLC/ESI-MS-MS

Pages 547-556 | Published online: 08 Jul 2009

  • Axelrod J. The enzymatic N-methylation of serotonin and other amines. J Pharmacol Exp Ther 1962; 138: 28-33.
  • Thompson MA, Weinshilboun RM. Rabbit lung indolethylamine N-methyltransferase. J Biol Chem 1998; 273: 34502-10.
  • Narasimhachari N, Baumann P, Pak HS, Carpenter WT, Zocchi AF, Hokanson L, Fujimori M, Himwich HE. Gas chromatographic-mass spectrometric identification of urinary bufotenine and dimethyltryptamine in drug-free chronic schizophrenic patients. Biol Psychiatr 1974; 8: 293-305.
  • Räisänen M, Kärkkäinen J. Mass fragmentographic quantification of urinary N,N-dimethyltryptamine and bufotenine. J Chromatogr 1979; 162: 579-84.
  • Räisänen M. The presence of free and conjugated bufotenin in normal human urine. Life Sei 1984; 34: 2041 -45.
  • Glennon RA. Do classical hallucinogens act as 5-HT2 agonists or antagonists? Neuropsychopharmacology 1990; 3: 509-17.
  • Eglen RM, Perkins LA, Walsh LK, Whiting RL. Agonist action of indole derivatives at 5-HTl-like, 5-HT3, and 5HT4 receptors in vitro. J Autonom Pharmacol 1992; 12: 321-33.
  • Räisänen M, Kärkkäinen J. Quantitative assay of the N-methylated metabolites of tryptamine and serotonin by gas chromatography mass spectrometry as applied to the determination of lung indoleethylamine N-methyltransferase activity. Biomed Mass Spectrom 1978; 5: 596-600.
  • Kärkkäinen J, Räisänen M, Naukkarinen H, Spoov J, Rimon R. Urinary excretion of free bufotenin by psychiatric patients. Biol Psychiatry 1988; 24: 441-6.
  • Karkkainen J, Raisanen M, Huttunen MO, Kallio E, Naukkarinen H, Virkkunen M. Urinary excretion of bufotenin (N,N-dimethyl-5hydroxytryptamine) is increased in suspicious violent offenders: a confirmatory study. Psychiatry Res 1995; 58: 145-52.
  • Karkkäinen J, Räisänen M. Nialamide, an MAO inhibitor, increases urinary excretion of endogenously produced bufotenin in man. Biol Psychiatry 1992; 32: 1042-8.
  • Sitaram BR, Lockett L, McLeish M, Hayasaka Y, Blackman GL, McLeod WR. Gas chromatographic-mass spectroscopic characterisation of the psychotomimetic indolealkylamines and their in vivo metabolites. J Chromatogr 1987; 422: 13-23.
  • Kysilka R, Wurst M, Pacáková V, ?tulik K, Ha?kovec L. High-performance liquid Chromatographie determination of hallucinogenic indoleamines with simultaneous UV photometric and voltammetric detection. J Chromatogr 1985; 320: 414-20.
  • Sitaram BR, Blackman GL, McLeod WR, Vaughan GN. The ion-pair extraction, purification, and liquid Chromatographie analysis of indolealkylamines in human urine. Anal Biochem 1983; 128: 11-20.
  • Sitaram BR, Lockett L, Blackman GL, McLeod WR. Urinary excretion of 5-methoxy-N,Ndimethyltryptamine, N,N-dimethyltryptamine and their N-oxides in the rat (Short communication). Biochem Pharmacol 1987; 36: 2235-7.
  • Sitaram BR, Lockett L, Talomsin R, Blackman GL, McLeod WR. In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat. Biochem Pharmacol 1987; 36: 1509-12.
  • Sitaram BR, Talomsin R, Blackman GL, McLeod WR. Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography. Biochem Pharmacol 1987; 36: 1503-8.
  • Sitaram BR, Talomsin R, Blackman GL, McLeod WR, Vaughan GN. Separation of the indolealkylamines and their analogues tetrahydro-ß-carbolines by liquid chromatography. J Chromatogr 1983; 275: 21-9.
  • Walker RW, Mandel LR, Kleinman JE, Gillin JC, Wyatt RJ, Wandenheuvel WJA. Improved selective ion monitoring mass-spectrometric assay for the determination of N,N-dimethyltryptamine in human blood utilizing capillary column gas chromatography. J Chromatogr 1979; 162: 539-46.
  • Riceberg LJ, Van Vunakis H. Determination of N,N-dimethylindolealkylamines in plasma, blood and urine extracts by radioimmunoassay and high pressure liquid chromatography. J Pharmacol Exp Ther 1978; 206: 158-66.
  • Fuller RW, Snoddy HD, Perry KW. Tissue distribution, metabolism and effects of bufotenine administered to rats. Neuropharmacology 1995; 34: 799-804.
  • Callaway JC, Raymon LP, Heam WL, McKenna DJ, Grob CS, Brito GS, Mash DC. Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with Ayahuasca. J Anal Toxicol 1996; 20: 492-7.
  • Räisänen M, Kärkkäinen J. Deuterium labelling of tryptamine, serotonin and their N-methylated metabolites using solvent exchange reactions. Acta ChemScand 1979; B33: 11-14.

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