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Original

Hyperproinsulinemia segregates young adult patients with newly diagnosed autoimmune (type 1) and non‐autoimmune (type 2) diabetes

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Pages 585-594 | Received 31 Jan 2005, Accepted 07 Jul 2005, Published online: 08 Jul 2009

References

  • American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183–97
  • Alberti K. G. M. M., Zimmet P. Z., for the WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus: provisional report of a WHO Consultation. Diabet Med 1998; 15: 539–53
  • Rosenbloom A. L., Joe J. R., Young R. S., Winter W. E. Emerging epidemic of type 2 diabetes in youth. Diabetes Care 1999; 22: 345–54
  • Pozzilli P., Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult). Diabetes Care 2001; 24: 1460–7
  • Landin‐Olsson M., Arnqvist H. J., Blohmé G., Littorin B., Lithner F., Nyström L., et al. Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus. Autoimmunity 1999; 29: 57–63
  • Decochez K., Tits J., Coolens J. ‐L., van Gaal L., Krzentowski G., Winnock F., et al. High frequency of persisting or increasing islet‐specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. Diabetes Care 2000; 23: 838–44
  • Borg H., Arnqvist H. J., Björk E., Bolinder J., Eriksson J. W., Nyström L., et al. Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15–34 yrs) in the Diabetes Incidence Study in Sweden (DISS). Diabetologia 2003; 36: 173–81
  • Arnqvist H. J., Littorin B., Nyström L., Scherstén B., Östman J., Blohmé G., et al. Difficulties in classifying diabetes at presentation in the young adult. Diabet Med 1993; 10: 606–13
  • Tuomi T., Carlsson A., Li H., Isomaa B., Miettinen A., Nilsson A., et al. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 1999; 48: 150–7
  • Törn C., Landin‐Olsson M., Östman J., Scherstén B., Arnqvist H., Blohmé G., et al. Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Diabetes Metab Res Rev 2000; 16: 442–7
  • Gordon P., Hendricks C. M., Roth J. Circulating proinsulin‐like component in man: increased proportion in hypoinsulinemic states. Diabetologia 1974; 10: 469–74
  • Temple R. C., Carrington C. A., Luzio S. D., Owens D. R., Schneider A. E., Sobey W. J., et al. Highly specific insulin assay reveals uniform insulin deficiency in non‐insulin‐dependent diabetics. Lancet 1989; i: 1648–9
  • Saad M. F., Kahn S. E., Nelson R. G., Pettitt D. J., Knowler W. C., Schwartz M. W., et al. Disproportionately elevated proinsulin in Pima Indians with non‐insulin‐dependent diabetes mellitus. J Clin Endocrinol Metab 1990; 70: 1247–53
  • Kahn S. E., Halban P. A. Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of type 2 diabetes. Diabetes 1997; 46: 1725–32
  • Röder M. E., Porte D., Schwartz R. S., Kahn S. E. Disproportionately elevated proinsulin levels reflect the degree of impaired β‐cell secretory capacity in patients with non‐insulin‐dependent diabetes mellitus. J Clin Endocrinol Metab 1998; 83: 604–8
  • Pfutzner A., Kunt T., Hohberg C., Mondok A., Pahler S., Konrad T., et al. Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes. Diabetes Care 2004; 27: 682–7
  • Davies M. J., Rayman G., Gray I. P., Day J. L., Hales C. N. Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose tolerance. Diabet Med 1993; 10: 313–20
  • Haffner S. M., Gonzales C., Mykkänen L., Stern M. Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: the Mexico City Diabetes Study. Diabetologia 1997; 40: 830–7
  • Nijpels G., Popp‐Snijders C., Kostense P. J., Bouter L. M., Heine R. J. Fasting proinsulin and 2‐hour post‐load glucose concentrations predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia 1996; 39: 113–8
  • Wareham N. J., Byrne C. D., Williams R., Day N. E., Hales C. N. Fasting proinsulin concentrations predict the development of type 2 diabetes. Diabetes Care 1999; 22: 262–70
  • Zethelius B., Hales C. N., Lithell H., Berne C. Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population‐based, 7‐year follow‐up study in 70‐year‐old men. Diabetes Care 2004; 27: 1433–8
  • Landin‐Olsson M., Sundkvist G., Lernmark Å. Prolonged incubation in the two‐colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin‐dependent) diabetes mellitus. Diabetologia 1987; 30: 327–32
  • Borg H., Fernlund P., Sundkvist G. Measurement of antibodies against glutamic acid decarboxylase 65 (GADA): two new 125I assays compared with [35S]GAD 65‐ligand binding assay. Clin Chem 1997; 43: 779–85
  • Borg H., Fernlund P., Sundkvist G. Protein tyosine phosphatase‐like protein IA2‐antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus. Clin Chem 1997; 43: 2358–63
  • Kjems L. L., Röder M. E., Dinesen B., Hartling S. G., Jörgensen P. N., Binder C. Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies. Clin Chem 1993; 39: 2146–50
  • Sobey W. J., Beer S. F., Carrington C. A., Clark P. M., Frank B. H., Gray I. P., et al. Sensitive and specific two‐site immunoradiometric assays for human insulin, proinsulin, 65‐66 split and 32‐33 split proinsulins. Biochem J 1989; 260: 535–41
  • Gottsäter A., Owens D. R., Luzio S., Sundkvist G. Proinsulin secretion during the first 3 years after diagnosis in diabetic patients with or without islet cell antibodies. Diabetes Care 1996; 19: 659–62
  • Nauck M. A., Siegel E. G., Creutzfeldt W. Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin. Pancreas 1991; 6: 645–52
  • Hartling S. G., Röder M. E., Dinesen B., Binder C. Proinsulin, C‐peptide and insulin in normal subjects during eight hours hyperglycemic clamp. Eur J Endocrinol 1996; 134: 197–200
  • Törn C., Landin‐Olsson M., Lernmark Å., Scherstén B., Östman J., Arnqvist H. J., et al. Combinations of beta‐cell specific autoantibodies at diagnosis of diabetes in young adults reflect different courses of beta‐cell damage. Autoimmunity 2001; 33: 115–20
  • Hartling S. G., Lindgren F., Dahlqvist G., Persson B., Binder C. Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 1989; 38: 1271–4
  • Lindgren F. A., Hartling S. G., Dahlqvist G. G., Binder C., Efendic S., Persson B. E. Glucose‐induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients. Diabet Med 1991; 8: 638–43

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