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ORIGINAL ARTICLE

DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome

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Pages 721-728 | Received 11 May 2005, Accepted 15 Sep 2005, Published online: 08 Jul 2009

References

  • Insler V., Lunenfeld B. Pathophysiology of polycystic ovarian disease: New insights. Hum Reprod 1991; 6: 1025–9
  • Wild R. A. Obesity, lipids, cardiovascular risk, and androgen excess. Am J Med 1995; 98: 27S–32S
  • Gregorini S. D., Lespi P. J., Alvarez G. R. Endometrial carcinoma with polycystic ovaries. Report of two cases in women younger than 40 years old. Medicina (Buenos Aires) 1997; 57: 202–9
  • Spremovic‐Radjenovic S., Radosavljevic A., Petkovic S., Matijasevic S., Cvetkovic M., Lazovic G., et al. The polycystic ovary syndrome associated with ovarian tumor. Srp Arh Celok Lek 1997; 125: 375–7
  • Powolny M., Pietrzak P., Borucki W. A case of coexistence of polycystic ovary syndrome and ovarian carcinoma. Ginekol Pol 1999; 70: 291–8
  • Elliott J. L., Hosford S. L., Demopoulos R. I., Perloe M., Sills E. S. Endometrial adenocarcinoma and polycystic ovary syndrome: risk factors, management and prognosis. South Med J 2001; 94: 521–9
  • Floyd R. A. The role of 8‐hydroxyguanine in carcinogenesis. Carcinogenesis 1990; 11: 1447–50
  • Ames B. N. Dietary carcinogens and anticarcinogens. Science 1983; 221: 1254–6
  • Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radic Biol Med 1990; 8: 583–9
  • Cerutti P. A. Oxidant stress and carcinogenesis. Eur J Clin Invest 1991; 21: 1–5
  • Cerutti P. A., Trump B. F. Inflammation and oxidative stress in carcinogenesis. Cancer Cells 1991; 3: 1–7
  • Cheng K. C., Cahil D. S., Kasai H., Nishimura S., Loeb L. A. 8‐Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J Biol Chem 1992; 267: 162–6
  • Halliwell B., Gutteridge J. M. C. Oxygen is a toxic gas: an introduction to oxygen toxicity and reactive oxygen species. Free radicals in biology and medicine., B Halliwell, J. M. C Gutteridge, editors. Oxford University Press, Oxford 1999; p. 83, In
  • Konukoglu D., Akcay T., Dincer Y., Hatemi H. The susceptibility of red blood cells to autoxidation in type 2 diabetic patients with angiopathy. Metabolism 1999; 48: 1481–4
  • Dincer Y., Alademir Z., Ilkova H., Akcay T. Susceptibility of glutathione and glutathione‐related antioxidant activity to hydrogen peroxide in patients with type 2 diabetes: Effects of glycemic control. Clin Biochem 2002; 35: 291–7
  • Dincer Y., Akcay T., Alademir Z., Ilkova H. Effect of oxidative stress on glutathione pathway in red blood cells from patients with IDDM. Metabolism 2002; 51: 1360–2
  • Dincer Y., Ozer E., Kadıoglu P., Hatemi H., Akcay T. Effect of sex hormones on lipid peroxidation in women with polycystic ovary syndrome, healthy women and men. Endoc Res 2001; 27: 306–9
  • Sabuncu T., Vural H., Harma M., Harma M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin Biochem 2001; 34: 403–7
  • Collins A. R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004; 26: 249–61
  • Dincer Y., Akcay T., Alademir Z., Ilkova H. Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes. Mutat Res 2002; 505: 75–81
  • Beutler E., Duran O., Duarte B. M. K. Improved method for the determination of blood glutathione. J Lab Clin Med 1963; 51: 882–8
  • Singh N. P., McCoy M. T., Tice R. R., Schneider E. L. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184–91
  • Collins A. R., Ai‐guo M., Duthie S. J. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat Res 1995; 336: 679–9
  • Collins A. R., Raslova K., Somorovska M., Petrovska H., Ondrusova A., Vohnout B., et al. DNA damage in diabetes: correlation with a clinical marker. Free Radic Biol Med 1998; 25: 373–7
  • Schildkraut J. M., Schwingl P. J., Bastos E., Evanoff A., Hughes C. Epithelial ovarian cancer risk among women with polycystic ovary syndrome. Obstet Gynecol 1996; 88: 554–9
  • Peltola V., Huhtaniemi I., Metsa‐Ketela T., Ahotupa M. Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology 1996; 137: 102–5
  • Chainy G. B. N., Samantaray S., Samanta L. Testosterone induced changes in testicular antioxidant system. Andrologia 1997; 29: 343–9
  • Hanukoglu I., Rapoport R., Weiner L., Sklan D. Electron leakage from the mitochondrial NADPH‐adrenodoxin reductase‐adrenodoxin‐P450ssc (cholesterol side chain cleavage) system. Arch Biochem Biophys 1993; 305: 488–9
  • Ripple M. O., Henry W. F., Rago R. P., Wilding C. Prooxidant‐antioxidant shift induced by androgen treatment of human prostate carcinoma cells. J Natl Cancer Inst 1997; 89: 40–8
  • Ho S. M., Roy D. Sex hormone‐induced nuclear DNA damage and lipid peroxidation in the dorsolateral prostates of Noble rats. Cancer Lett 1994; 84: 152–5
  • Halliwell B., Gutteridge J. M. C. Detection of free radicals and other reactive species. Free radicals in biology and medicine., B Halliwell, J. M. C Gutteridge, editors. Oxford University Press, Oxford 1999; p. 338, In
  • Araghi‐Niknam M., Ardestani S. K., Molitor M., Inserra P., Eskelson C. D., Watson R. R. Dehydroepiandrosterone (DHEA) sulfate prevents reduction in tissue vitamin E and increased lipid peroxidation due to murine retrovirus infection of aged mice. Proc Soc Exp Biol Med 1998; 218: 207–10
  • Bastianetto S., Ramassamy C., Poirier J., Quirion R. Dehydroepi‐androsterone (DHEA) protects hippocampal cells from oxidative stress‐induced damage. Brain Res Mol Brain Res 1999; 66: 31–5
  • Gallo M., Aragno M., Gatto V., Tamagno E., Brignardello E., Manti R., et al. Protective effect of dehydroepiandrosterone against lipid peroxidation in human liver cell line. Eur J Endocrinol 1999; 141: 35–9
  • Toledano M. B., Leonard W. J. Modulation of transcription factor NF‐kappa B binding activity by oxidation‐reduction in vitro. Proc Natl Acad Sci USA 1991; 88: 4322–8
  • Bergelson S., Pinkus R., Daniel V. Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S‐transferase gene expression. Cancer Res 1994; 54: 36–40
  • Mutlu‐Turkoglu U., Dogru‐Abbasoglu S., Aykaç‐Toker G., Mırsal H., Beyazyürek M., Uysal M. Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism. J Lab Clin Med 2000; 136: 281–7
  • Guetta V., Cannon R. O. Cardiovascular effects of estrogen and lipid‐lowering therapies in postmenopausal women. Circulation 1990; 93: 1927–8
  • Liehr J. G., DaGue B. B., Ballatore A. M., Jenkin J. Diethylstilbestrol (DES) quinone: a reactive intermediate in DES metabolism. Biochem Pharmacol 1983; 32: 3708–11
  • Liehr J. G., Roy D. Free radical generation by redox cycling of estrogens. Free Radical Biol Med 1990; 8: 413–15

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