34
Views
4
CrossRef citations to date
0
Altmetric
Miscellaneous

Pyrosequencing assay for genotyping of the Transcobalamin II 776C>G polymorphism

&
Pages 247-251 | Received 14 Jun 2006, Accepted 21 Sep 2006, Published online: 08 Jul 2009

References

  • Regec A. L., Quadros E. V., Rothenberg S. P. Transcobalamin II expression is regulated by transcription factor(s) binding to a hexameric sequence (TGGTCC) in the promoter region of the gene. Arch Biochem Biophys 2002; 407: 202–8
  • Swanson D. A., Pangilinan F., Mills J. L., Kirke P. N., Conley M., Weiler A., et al. Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population. Birth Defects Res A Clin Mol Teratol 2005; 73: 239–44
  • von Castel‐Dunwoody K. M., Kauwell G. P., Shelnutt K. P., Vaughn J. D., Griffin E. R., Maneval D. R., et al. Transcobalamin 776C‐>G polymorphism negatively affects vitamin B12 metabolism. Am J Clin Nutr 2005; 81: 1436–41
  • Namour F., Olivier J., Abdelmouttaleb I., Adjalla C., Debard R., Salvat C., et al. Transcobalamin codon 259 polymorphism in HT‐29 and Caco‐2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood. Blood 2001; 97: 1092–8
  • Namour F., Guy M., Aimone‐Gastin I., de Nonancourt M., Mrabet N., Gueant J. L. Isoelectrofocusing phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphism. Biochem Biophys Res Commun 1998; 251: 769–74
  • Zetterberg H., Palmér M., Boreström C., Rymo L., Blennow K. The transcobalamin codon 259 polymorphism should be designated 776C>G, not 775G>C. Blood 2003; 101: 3749–50; reply 50–1
  • Afman L. A., Lievers K. J., van der Put N. M., Trijbels F. J., Blom H. J. Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet 2002; 10: 433–8
  • Miller J. W., Ramos M. I., Garrod M. G., Flynn M. A., Green R. Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults. Blood 2002; 100: 718–20
  • Alessio A. C., Hoehr N. F., Siqueira L. H., Bydlowski S. P., Annichino‐Bizzacchi J. M. Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B(12) concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children. Thromb Res; 2006, Epub ahead of print
  • Afman L. A., Van Der Put N. M., Thomas C. M., Trijbels J. M., Blom H. J. Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects. Q J Med 2001; 94: 159–66
  • Zetterberg H., Regland B., Palmér M., Rymo L., Zafiropoulos A., Arvanitis D. A., et al. The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion. Hum Reprod 2002; 17: 3033–6
  • Ronaghi M., Uhlén M., Nyrén P. A sequencing method based on real‐time pyrophosphate. Science 1998; 281: 363–5
  • Nilsson T. K., Johansson C. A. A novel method for diagnosis of adult hypolactasia by genotyping of the ‐13910 C/T polymorphism with Pyrosequencing technology. Scand J Gastroenterol 2004; 39: 287–90
  • McCaddon A., Blennow K., Hudson P., Regland B., Hill D. Transcobalamin polymorphism and homocysteine. Blood 2001; 98: 3497–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.