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Scandinavian Journal of Clinical and Laboratory Investigation Volume 68, 2008 - Issue 8
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Original Article

Indoleamine 2,3‐dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study

P. Niinisalo Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, University of Tampere, Medical School, Tampere, Finland
,
A. Raitala Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland
,
M. Pertovaara Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
,
S. S. Oja The Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
,
T. Lehtimäki Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School, University of Tampere, Tampere, Finland
,
M. Kähönen Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
,
A. Reunanen Department of Health and Functional Capacity, National Public Health Institute, Helsinki/Turku, Finland
,
A. Jula Department of Health and Functional Capacity, National Public Health Institute, Helsinki/Turku, Finland
,
L. Moilanen Department of Medicine, Kuopio University Hospital, Kuopio, Finland
,
Y. A. Kesäniemi Department of Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
,
M. S. Nieminen Department of Medicine, University of Helsinki, Helsinki, Finland
&
M. Hurme Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland; The Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
 show all
Pages 767-770 | Received 03 Apr 2008, Accepted 01 Jun 2008, Published online: 08 Jul 2009

References

  • Nyström T. C‐reactive protein: a marker or a player?. Clin Sci (Lond) 2007; 113: 79–81
  • Cao J. J., Arnold A. M., Manolio T. A., Polak J. F., Psaty B. M., Hirsch C. H., et al. Association of carotid artery intima‐media thickness, plaques, and C‐reactive protein with future cardiovascular disease and all‐cause mortality: the Cardiovascular Health Study. Circulation 2007; 116: 32–8
  • Wilson A. M., Ryan M. C., Boyle A. J. The novel role of C‐reactive protein in cardiovascular disease: risk marker or pathogen. Int J Cardiol 2006; 106: 291–7
  • Pertovaara M., Raitala A., Juonala M., Lehtimäki T., Huhtala H., Oja S. S., et al. Indoleamine 2,3‐dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study. Clin Exp Immunol 2007; 148: 106–11
  • Wirleitner B., Rudzite V., Neurauter G., Murr C., Kalnins U., Erglis A., et al. Immune activation and degradation of tryptophan in coronary heart disease. Eur J Clin Invest 2003; 33: 550–4
  • Mellor A. L., Munn D. H. Tryptophan catabolism and regulation of adaptive immunity. J Immunol 2003; 170: 5809–13
  • Mellor A. L., Munn D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004; 4: 762–74
  • Raitala A., Karjalainen J., Oja S. S., Kosunen T. U., Hurme M. Indoleamine 2,3‐dioxygenase (IDO) activity is lower in atopic than in non‐atopic individuals and is enhanced by environmental factors protecting from atopy. Mol Immunol 2006; 43: 1054–6
  • Aromaa A., Koskinen S. Health and functional capacity in Finland. Baseline results of the Health 2000 Health Examination Survey. 2004, Publications of the National Public Health Institute B12/2004
  • Niiranen T., Jula A., Kantola I., Moilanen L., Kähönen M., Kesäniemi Y. A., et al. Home‐measured blood pressure is more strongly associated with atherosclerosis than is clinic blood pressure: the Finn‐HOME Study. J Hypertens 2007; 25: 1225–31
  • Laich A., Neurauter G., Widner B., Fuchs D. More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC. Clin Chem 2002; 48: 579–81
  • Pertovaara M., Raitala A., Lehtimaki T., Karhunen P. J., Oja S. S., Jylhä M., et al. Indoleamine 2,3‐dioxygenase activity in nonagenarians is markedly increased and predicts mortality. Mech Ageing Dev 2006; 127: 497–9
  • Schroecksnadel K., Zangerle R., Bellmann‐Weiler R., Garimorth K., Weiss G., Fuchs D. Indoleamine‐2, 3‐dioxygenase and other interferon‐gamma‐mediated pathways in patients with human immunodeficiency virus infection. Curr Drug Metab 2007; 8: 225–36
  • Samelson‐Jones B. J., Yeh S. R. Interactions between nitric oxide and indoleamine 2,3‐dioxygenase. Biochemistry 2006; 45: 8527–38
  • Robertson A. K., Hansson G. K. T cells in atherogenesis: for better or for worse?. Arterioscler Thromb Vasc Biol 2006; 26: 2421–32

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