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Original Article

Resting heart rate and relation to disease and longevity: past, present and future

Pages 108-116 | Received 09 Sep 2018, Accepted 02 Jan 2019, Published online: 14 Feb 2019

References

  • Saba MM, Ventura HO, Saleh M, et al. Ancient Egyptian medicine and the concept of heart failure. J Card Fail. 2006;12:416–421.
  • Ghasemzadeh N, Zafari AM. A brief journey into the history of the arterial pulse. Cardiol Res Pract. 2011;2011:164832.
  • Bedford DE. The ancient art of feeling the pulse. Br Heart J. 1951;13:423–437.
  • Vlachopoulos C, O'rourke M. Genesis of the normal and abnormal arterial pulse. Curr Probl Cardiol. 2000;25:303–367.
  • DiFrancesco D. Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol. 1993;55:455–472.
  • DiFrancesco D, Borer JS. The funny current. Cellular basis for the control of heart rate. Drugs. 2007;67: 15–24.
  • Berne & Levy. Physiology. 4th edn. Mosby; 1998. Elsevier, The Netherlands.
  • Purves D, Augustine GJ, Fitzpatrick D, et al. Autonomic Regulation of Cardiovascular Function. 2001; [cited 2016 Nov 12]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK11075/
  • Yasuma F, Hayano J-I. Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm? Chest. 2004;125:683–690.
  • Barbieri R, Triedman JK, Saul JP. Heart rate control and mechanical cardiopulmonary coupling to assess central volume: a systems analysis. Am J Physiol Regul Integr Comp Physiol. 2002;283:R1210–R1220.
  • Bainbridge FA. The influence of venous filling upon the rate of the heart. J Physiol (Lond). 1915;50:65–84.
  • Levine H. Rest heart rate and life expectancy. J Am Coll Cardiol. 1997;1104–1106.
  • Noujaim SF, Lucca E, Muñoz V, et al. From mouse to whale: a universal scaling relation for the PR interval of the electrocardiogram of mammals. Circulation. 2004;110:2802–2808.
  • Azbel MY. Universal biological scaling and mortality. Proc Natl Acad Sci USA. 1994;91:12453–12457.
  • Coburn AF, Grey RM, Rivera SM. Observations on the relation of heart rate, life span, weight and mineralization in the digoxin-treated A-J mouse. Johns Hopkins Med J. 1971;128:169–193.
  • Gent S, Kleinbongard P, Dammann P, et al. Heart rate reduction and longevity in mice. Basic Res Cardiol. 2015;110:2.
  • Jensen MT, Marott JL, Allin KH, et al. Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: the Copenhagen City Heart Study. Eur J Prev Cardiol. 2012;19:102–108.
  • Colman RJ, Beasley TM, Kemnitz JW, et al. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014;5:3557.
  • Beere PA, Glagov S, Zarins CK. Retarding effect of lowered heart rate on coronary atherosclerosis. Science. 1984;226:180–182.
  • Kaplan JR, Manuck SB, Adams MR, et al. Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Circulation. 1987;76:1364–1372.
  • Reil J-C, Hohl M, Reil G-H, et al. Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. Eur Heart J. 2013;34:2839–2849.
  • Libby B, Zipes M. Braunwald’s Heart Disease. A textbook of cardiovascular medicine. Saunders. 2008. Elsevier, The Netherlands.
  • Ostchega Y, Porter KS, Hughes J, et al. Resting pulse rate reference data for children, adolescents, and adults: United States, 1999–2008. Natl Health Stat Rep. 2011;41:1–16.
  • Jensen MT, Wod M, Galatius S, et al. Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart Br Card Soc. 2017;104:30–36.
  • Khera R, Lu Y, Saxena A, et al. The impact of 2017 ACC/AHA guidelines on the prevalence of hypertension and eligibility for anti-hypertensive therapy in the United States and China: Nationally representative cross sectional study. Khera R, Lu Y, Lu J, Saxena A, Nasir K, Jiang L, Krumholz HM. BMJ. 2018;11:362:k2357. doi:10.1136/bmj.k2357. PMID:29997129
  • Inoue T, Iseki K, Iseki C, et al. Elevated resting heart rate is associated with white blood cell count in middle-aged and elderly individuals without apparent cardiovascular disease. Angiology. 2012;63:541–546.
  • Sajadieh A, Nielsen O, Rasmussen V, et al. Increased heart rate and reduced heart rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease. Eur Heart J. 2004;25:363–370.
  • Pedersen BK, Saltin B. Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25:1–72.
  • Jensen MT, Suadicani P, Hein HO, et al. Elevated resting heart rate, physical fitness and all-cause mortality: a 16-year follow-up in the Copenhagen Male Study. Heart Br Heart. 2013;99:882–887.
  • Rennie KL, Hemingway H, Kumari M, et al. Effects of moderate and vigorous physical activity on heart rate variability in a British study of civil servants. Am. J. Epidemiol. 2003;158:135–143.
  • Aladin AI, Whelton SP, Al-Mallah MH, et al. Relation of resting heart rate to risk for all-cause mortality by gender after considering exercise capacity (the Henry Ford Exercise Testing Project). Am. J. Cardiol. 2014;114:1701–1706.
  • den Hoed M, Eijgelsheim M, Esko T, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013;45:621–631.
  • Eppinga RN, Hagemeijer Y, Burgess S, et al. Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality. Nat Genet. 2016;48:1557–1563.
  • Havlik RJ, Garrison RJ, Fabsitz R, et al. Variability of heart rate, P-R, QRS and Q-T durations in twins. J Electrocardiol. 1980;13:45–48.
  • Van Hulle CA, Corley R, Zahn-Waxler C, et al. An exploration of the genetic and environmental etiology of heart rate in infancy and middle childhood. Twin Res. 2000;3:259–265.
  • Dyer AR, Persky V, Stamler J, et al. Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am J Epidemiol. 1980;112:736–749.
  • Greenland P, Daviglus ML, Dyer AR, et al. Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry. Am J Epidemiol. 1999;149:853–862.
  • Hsia J, Larson JC, Ockene JK, et al. Group for the WHIR. Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study. BMJ. 2009;338:b219.
  • Zhang D, Shen X, Qi X. Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis. CMAJ. 2015;188:E53–63.
  • Shaper AG, Wannamethee G, Macfarlane PW, et al. Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men. Br Heart J. 1993;70:49–55.
  • Kannel WB, Kannel C, Paffenbarger RS, et al. Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J. 1987;113:1489–1494.
  • Jouven X, Empana JP, Escolano S, et al. Relation of heart rate at rest and long-term (>20 years) death rate in initially healthy middle-aged men. Am J Cardiol. 2009;103:279–283.
  • Custodis F, Roggenbuck U, Lehmann N, et al. Resting heart rate is an independent predictor of all-cause mortality in the middle aged general population. Clin Res Cardiol. 2016;105:601–612.
  • Kristal-Boneh E, Silber H, Harari G, et al. The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male israeli employees (the CORDIS Study). Eur Heart J. 2000;21:116–124.
  • Fujiura Y, Adachi H, Tsuruta M, RJD, et al. Heart rate and mortality in a Japanese general population: An 18-year follow-up study. J Clin Epidemiol. 2001;54:495–500.
  • Cooney MT, Vartiainen E, Laatikainen T, et al. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am Heart J. 2010;159:612–619.e3.
  • Gillum RF, Makuc DM, Feldman JJ. Pulse rate, coronary heart disease, and death: the NHANES I Epidemiologic Follow-up Study. Am Heart J. 1991;121:172–177.
  • Jensen MT, Marott JL, Jensen GB. Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers. Int J Cardiol. 2011;151:148–154.
  • Nauman J, Janszky I, Vatten LJ, et al. Temporal changes in resting heart rate and deaths from ischemic heart disease. JAMA. 2011;306:2579–2587.
  • Hartaigh BÓ, Gill TM, Shah I, et al. Association between resting heart rate across the life course and all-cause mortality: longitudinal findings from the Medical Research Council (MRC) National Survey of Health and Development (NSHD). J Epidemiol Commun Health. 2014;68:883–889.
  • Palatini P, Casiglia E, Pauletto P, et al. Relationship of tachycardia with high blood pressure and metabolic abnormalities: a study with mixture analysis in three populations. Hypertension. 1997;30:1267–1273.
  • Julius S, Palatini P, Nesbitt SD. Tachycardia: an important determinant of coronary risk in hypertension. J Hypertens Suppl. 1998;16:S9–S15.
  • Palatini P, Thijs L, Staessen JA, et al. Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. Arch Intern Med. 2002;162:2313–2321.
  • King DE, Everett CJ, Mainous AG, et al. Long-term prognostic value of resting heart rate in subjects with prehypertension. Am J Hypertens. 2006;19:796–800.
  • Palatini P, Dorigatti F, Zaetta V, et al. Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study. J Hypertens. 2006;24:1873–1880.
  • Ho JE, Bittner V, Demicco DA, et al. Usefulness of heart rate at rest as a predictor of mortality, hospitalization for heart failure, myocardial infarction, and stroke in patients with stable coronary heart disease (Data from the Treating to New Targets [TNT] trial). Am J Cardiol. 2010;105:905–911.
  • Ó Hartaigh B, Bosch JA, Pilz S, et al. Influence of resting heart rate on mortality in patients undergoing coronary angiography (from the Ludwigshafen Risk and Cardiovascular Health [LURIC] study). Am J Cardiol. 2012;110:515–520.
  • Fox K, Bousser M-G, Amarenco P, et al. Heart rate is a prognostic risk factor for myocardial infarction: a post hoc analysis in the PERFORM (Prevention of cerebrovascular and cardiovascular events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack) study population. Int J Cardiol. 2013;168:3500–3505.
  • Fox K, Borer JS, Camm JA, et al. Resting heart rate in cardiovascular disease. J Am Coll Cardiol. 2007;50:823–830.
  • Palatini P, Julius S. Heart rate and the cardiovascular risk. J Hypertens. 1997;15:3–17.
  • Diaz A, Bourassa MG, Guertin M-C, et al. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J. 2005;26:967–974.
  • Granger CB, Goldberg RJ, Dabbous O, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345–2353.
  • Bangalore S, Messerli FH, Ou F-S, CRUSADE Investigators, et al. The association of admission heart rate and in-hospital cardiovascular events in patients with non-ST-segment elevation acute coronary syndromes: results from 135 164 patients in the CRUSADE quality improvement initiative. Eur Heart J. 2010;31:552–560.
  • Disegni E, Goldbourt U, Reicher-Reiss H, et al. The predictive value of admission heart rate on mortality in patients with acute myocardial infarction. SPRINT Study Group. Secondary Prevention Reinfarction Israeli Nifedipine Trial. J Clin Epidemiol. 1995;48:1197–1205.
  • Jensen MT, Pereira M, Araujo C, et al. Heart rate at admission is a predictor of in-hospital mortality in patients with acute coronary syndromes: Results from 58 European hospitals: The European Hospital Benchmarking by Outcomes in acute coronary syndrome Processes study. Eur Heart J Acute Cardiovasc Care. 2016;7:149–157.
  • Madsen EB, Gilpin E, Henning H, et al. Prediction of late mortality after myocardial infarction from variables measured at different times during hospitalization. Am J Cardiol. 1984;53:47–54.
  • Hjalmarson A, Gilpin EA, Kjekshus J, et al. Influence of heart rate on mortality after acute myocardial infarction. Am J Cardiol. 1990;65:547–553.
  • Parodi G, Bellandi B, Valenti R, et al. Heart rate as an independent prognostic risk factor in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Atherosclerosis. 2010;211:255–259.
  • Bolli R, Fisher DJ, Entman ML. Factors that determine the occurrence of arrhythmias during acute myocardial ischemia. Am Heart J. 1986;111:261–270.
  • Jensen MT, Kaiser C, Sandsten KE, BASKET-PROVE investigators, et al. Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes–results from the BASKET PROVE trial. Int J Cardiol. 2013;168:3802–3806.
  • Cucherat M. Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials. Eur Heart J. 2007;28:3012–3019.
  • Kjekshus JK. Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials. Am J Cardiol. 1986;57:43F–49F.
  • Fosbøl EL, Seibaek M, Brendorp B, et al. Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study. Int J Cardiol. 2010;140:279–286.
  • McAlister FA, Wiebe N, Ezekowitz JA, et al. Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure. Ann Intern Med. 2009;150:784–794.
  • Flannery G, Gehrig-Mills R, Billah B, et al. Analysis of randomized controlled trials on the effect of magnitude of heart rate reduction on clinical outcomes in patients with systolic chronic heart failure receiving beta-blockers. Am J Cardiol. 2008;101:865–869.
  • Jensen MT, Marott JL, Lange P, et al. Resting heart rate is a predictor of mortality in chronic obstructive pulmonary disease. Eur Respir J. 2012;42:341–349.
  • Lo SS, Sutton MS, Leslie RD. Information on type 1 diabetes mellitus and QT interval from identical twins. Am J Cardiol. 1993;72:305–309.
  • Carnethon MR, Yan L, Greenland P, et al. Resting heart rate in middle age and diabetes development in older age. Diab Care. 2008;31:335–339.
  • Shigetoh Y, Adachi H, Yamagishi S, et al. Higher heart rate may predispose to obesity and diabetes mellitus: 20-year prospective study in a general population. Am J Hypertens. 2009;22:151–155.
  • Gundersen HJ, Neubauer B. A long-term diabetic autonomic nervous abnormality. Reduced variations in resting heart rate measured by a simple and sensitive method. Diabetologia. 1977;13:137–140.
  • Ewing DJ, Campbell IW, Clarke BF. Heart rate changes in diabetes mellitus. Lancet Lond Lancet. 1981;1:183–186.
  • Jensen MT, Sogaard P, Andersen HU, et al. Prevalence of systolic and diastolic dysfunction in patients with type 1 diabetes without known heart disease: the Thousand & 1 Study. Diabetologia. 2014;57:672–680.
  • Jørgensen PG, Jensen MT, Mogelvang R, et al. Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics. Diab Vasc Dis Res. 2016;13:321–330.
  • Lo SS, Leslie RD, Sutton MS. Effects of type 1 diabetes mellitus on cardiac function: a study of monozygotic twins. Br Heart J. 1995;73:450–455.
  • Hillis GS, Woodward M, Rodgers A, et al. Resting heart rate and the risk of death and cardiovascular complications in patients with type 2 diabetes mellitus. Diabetologia. 2012;55:1283–1290.
  • Paterson AD, Rutledge BN, Cleary PA, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group, et al. The effect of intensive diabetes treatment on resting heart rate in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study. Diabetes Care. 2007;30:2107–2112.
  • Gupta V, Sheffield D, Verne GN. Evidence for autonomic dysregulation in the irritable bowel syndrome. Dig Dis Sci. 2002;47:1716–1722.
  • Koopman FA, Tang MW, Vermeij J, et al. Autonomic dysfunction precedes development of rheumatoid arthritis: a prospective cohort study. EBioMedicine. 2016;6:231–237.
  • Jouven X, Escolano S, Celermajer D, et al. Heart rate and risk of cancer death in healthy men. PloS One. 2011;6:e21310.
  • Wannamethee G, Shaper AG, Macfarlane PW. Heart rate, physical activity, and mortality from cancer and other noncardiovascular diseases. Am J Epidemiol. 1993;137:735–748.
  • van Kruijsdijk RCM, van der Graaf Y, Bemelmans RHH, SMART Study Group, et al. The relation between resting heart rate and cancer incidence, cancer mortality and all-cause mortality in patients with manifest vascular disease. Cancer Epidemiol. 2014;38:715–721.
  • Lee DH, Park S, Lim SM, et al. Resting heart rate as a prognostic factor for mortality in patients with breast cancer. Breast Cancer Res Treat. 2016;159:375–384.
  • Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997;336:525–533.
  • Rehsia NS, Dhalla NS. Mechanisms of the beneficial effects of beta-adrenoceptor antagonists in congestive heart failure. Exp Clin Cardiol. 2010;15:e86–e95.
  • Riganti C, Campia I, Kopecka J, et al. Pleiotropic effects of cardioactive glycosides. Curr Med Chem. 2011;18:872–885.
  • Fox K, Ford I, Steg PG, et al. Ivabradine for patients with stable coronary artery disease and left-vetricular systolic dysfuntion (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372:807–816.
  • Fox K, Ford I, Steg PG, BEAUTIFUL investigators, et al. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet. 2008;372:817–821.
  • Swedberg K, Komajda M, Böhm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet. 2010;376:875–885.
  • Fox K, Ford I, Steg PG, SIGNIFY Investigators, et al. Ivabradine in stable coronary artery disease without clinical heart failure. N Engl J Med. 2014;371:1091–1099.
  • Ferrari R, Fox KM. The role of heart rate may differ according to pathophysiological setting: from SHIFT to SIGNIFY. Eur Heart J. 2015;36:2042–2046.
  • Ponikowski P, Voors AA, Anker SD, ESC Scientific Document Group, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129–2200.
  • Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol. 2004;33:30–42.
  • 2015 Global health care outlook | Deloitte SEA | Life Sciences and Health Care Industry Reports & Services. Deloitte Singap. [cited 2017 Oct 18]. 2015;1–18. Available from: https://www2.deloitte.com/gu/en/pages/life-sciences-and-healthcare/articles/2015-health-care-outlook.html
  • Janssen I, Katzmarzyk PT, Church TS, et al. The Cooper Clinic Mortality Risk Index: clinical score sheet for men. Am J Prev Med. 2005;29:194–203.
  • Palatini P, Rosei EA, Casiglia E, et al. Management of the hypertensive patient with elevated heart rate: statement of the Second Consensus Conference endorsed by the European Society of Hypertension. J Hypertens. 2016;34:813–821.
  • Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37:2315–2381.
  • Kaiser DW, Harrington RA, Turakhia MP. Wearable fitness trackers and heart disease. JAMA Cardiol. 2016;1:239.

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