Reference interval and preanalytical properties of serum neurofilament light chain in Scandinavian adults

References

• Yuan A, Rao MV, Veeranna  , et al. Neurofilaments at a glance. J Cell Sci. 2012;125:3257–3263.
   PubMed Web of Science ®Google Scholar
• Khalil M, Teunissen CE, Otto M, et al. Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol. 2018;14(10):577–589.
   PubMed Web of Science ®Google Scholar
• Lu CH, Macdonald-Wallis C, Gray E, et al. Neurofilament light chain: a prognostic biomarker in amyotrophic lateral sclerosis. Neurology. 2015;84(22):2247–2257.
   PubMed Web of Science ®Google Scholar
• Lycke JN, Karlsson JE, Andersen O, et al. Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis. J Neurol Neurosurg Ery Psychiatry. 1998;64(3):402–404.
   PubMed Web of Science ®Google Scholar
• Skillback T, Farahmand B, Bartlett JW, et al. CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival. Neurology. 2014;83(21):1945–1953.
   PubMed Web of Science ®Google Scholar
• Meeter LH, Dopper EG, Jiskoot LC, et al. Neurofilament light chain: a biomarker for genetic frontotemporal dementia. Ann Clin Transl Neurol. 2016;3(8):623–636.
   PubMed Web of Science ®Google Scholar
• Rojas JC, Karydas A, Bang J, et al. Plasma neurofilament light chain predicts progression in progressive supranuclear palsy. Ann Clin Transl Neurol. 2016;3(3):216–225.
   PubMed Web of Science ®Google Scholar
• Shahim P, Gren M, Liman V, et al. Serum neurofilament light protein predicts clinical outcome in traumatic brain injury. Sci Rep. 2016;6(1):36791.
   PubMed Web of Science ®Google Scholar
• Shahim P, Zetterberg H, Tegner Y, et al. Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports. Neurology. 2017;88(19):1788–1794.
   PubMed Web of Science ®Google Scholar
• Moseby-Knappe M, Mattsson N, Nielsen N, et al. Serum neurofilament light chain for prognosis of outcome after cardiac arrest. JAMA Neurol. 2019;76(1):64–71.
   PubMed Web of Science ®Google Scholar
• Rosen H, Karlsson JE, Rosengren L. CSF levels of neurofilament is a valuable predictor of long-term outcome after cardiac arrest. J Neurol Sci. 2004;221:19–24.
   PubMed Web of Science ®Google Scholar
• De Marchis GM, Katan M, Barro C, et al. Serum neurofilament light chain in patients with acute cerebrovascular events. Eur J Neurol. 2018;25(3):562–568.
   PubMed Web of Science ®Google Scholar
• Gattringer T, Pinter D, Enzinger C, et al. Serum neurofilament light is sensitive to active cerebral small vessel disease. Neurology. 2017;89(20):2108–2114.
   PubMed Web of Science ®Google Scholar
• Rosengren LE, Karlsson JE, Karlsson JO, et al. Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF. J Neurochem. 2002;67(5):2013–2018.
   Web of Science ®Google Scholar
• Norgren N, Rosengren L, Stigbrand T. Elevated neurofilament levels in neurological diseases. Brain Res. 2003;987(1):25–31.
   PubMed Web of Science ®Google Scholar
• Jessen Krut J, Mellberg T, Price RW, et al. Biomarker evidence of axonal injury in neuroasymptomatic HIV-1 patients. PLoS One. 2014;9(2):e88591.
   PubMed Web of Science ®Google Scholar
• Rissin DM, Kan CW, Campbell TG, et al. Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol. 2010;28(6):595–599.
   PubMed Web of Science ®Google Scholar
• Wilke C, Preische O, Deuschle C, et al. Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum. J Neurol Neurosurg Psychiatry. 2016;87(11):1270–1272.
   PubMed Web of Science ®Google Scholar
• Kuhle J, Barro C, Disanto G, et al. Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity. Mult Scler. 2016;22(12):1550–1559.
   PubMed Web of Science ®Google Scholar
• Pujol-Calderon F, Portelius E, Zetterberg H, et al. Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke. Neurosci Lett. 2019;698:58–63.
   PubMed Web of Science ®Google Scholar
• Kuhle J, Barro C, Andreasson U, et al. Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa. Clin Chem Lab Med. 2016;54(10):1655–1661.
   PubMed Web of Science ®Google Scholar
• Clinical and Laboratory Standards Institute (CLSI). Defining, establishing, and verifying reference intervals in the clinical laboratory. Approved Guideline-3rd ed. p. C28–A3. Suite: CLSI; 2008.
   Google Scholar
• Lahti A, Petersen PH, Boyd JC, et al. Partitioning of nongaussian-distributed biochemical reference data into subgroups. Clin Chem. 2004;50(5):891–900.
   PubMed Web of Science ®Google Scholar
• Yilmaz A, Blennow K, Hagberg L, et al. Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls. Expert Rev Mol Diagn. 2017;17(8):761–770.
   PubMed Web of Science ®Google Scholar
• Bergman J, Dring A, Zetterberg H, et al. Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS. Neurol Neuroimmunol Neuroinflamm. 2016;3(5):e271.
   PubMed Web of Science ®Google Scholar
• Mattsson N, Andreasson U, Zetterberg H, et al. Association of Plasma Neurofilament Light with neurodegeneration in patients with Alzheimer disease. JAMA Neurol. 2017;74(5):557–566..
   PubMed Web of Science ®Google Scholar
• Worms PM. The epidemiology of motor neuron diseases: a review of recent studies. J Neurol Sci. 2001;191(1–2):3–9.
   PubMed Web of Science ®Google Scholar
• Goodin DS. The epidemiology of multiple sclerosis: insights to disease pathogenesis. Handb Clin Neurol. 2014;122:231–266.
   PubMedGoogle Scholar
• Keshavan A, Heslegrave A, Zetterberg H, et al. Stability of blood-based biomarkers of Alzheimer’s disease over multiple freeze-thaw cycles. Alzheimers Dement (Amst). 2018;10:448–451.
   PubMedGoogle Scholar
• Burgdorf KS, Simonsen J, Sundby A, et al. Socio-demographic characteristics of Danish blood donors. PLoS One. 2017;12(2):e0169112.
   PubMed Web of Science ®Google Scholar