135
Views
1
CrossRef citations to date
0
Altmetric
Brief Report

Transient Howell-Jolly-body-like cytoplasmic inclusions in neutrophils after severe intoxication with alpha-lipoic acid

ORCID Icon, , & ORCID Icon
Pages 8-11 | Received 01 Jun 2020, Accepted 14 Nov 2020, Published online: 21 Dec 2020

References

  • Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997;29:315–331.
  • Bain BJ. Blood Cells: a Practical Guide. London (UK): Gower Medical Publishing; 1989.
  • Teichert J, Kern J, Tritschler HJ, et al. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int J Clin Pharmacol Ther. 1998;36:625–628.
  • Omman R, Kwong C, Shepherd D, et al. Revisiting Howell-Jolly body-like cytoplasmic inclusions in neutrophils: a report of two cases and confirmation of nuclear origin. J Hematol. 2017;6:101–104.
  • Slagel DD, Lager DJ, Dick FR. Howell-Jolly body-like inclusions in the neutrophils of patients with acquired immunodeficiency syndrome. Am J Clin Pathol. 1994;101:429–431.
  • Rowe RG, Esrick E. Howell-Jolly–like bodies in neutrophils. Blood. 2015;125:2729.
  • Chang B, Huang RS, Dasgupta A, et al. Prevalence of Howell-Jolly body-like inclusions in HIV patients and their correlation with CD4 counts and HIV RNA viral load. Ann Clin Lab Sci. 2015;45:23–26.
  • Andre E, Chevalier C, Scheiff JM. Howell-Jolly-like bodies in leucocytes: first description in leucocytes other than neutrophils. Eur J Haematol. 2011;86:182–183.
  • Abdel-Monem H, Prakasam A, Thiagarajan P. Howell-Jolly body-like inclusions in neutrophils of a transplant recipient in association with ganciclovir therapy. Arch Pathol Lab Med. 2010;134:809–810.
  • Kahwash E, Gewirtz AS. Howell-Jolly body-like inclusions in neutrophils. Arch Pathol Lab Med. 2003;127:1389–1390.
  • Ismail N, McBride JW. Tick-borne emerging infections: ehrlichiosis and anaplasmosis. Clin Lab Med. 2017;37:317–340.
  • Narang V, Bhar VS, Sharma P, et al. Puzzling neutrophilic inclusions in a child with autoimmune hepatitis. J Hematopathol. 2013;6:51–52.
  • Tong YT, Nguyen ND, Wahed A. Howell-Jolly body-like inclusions in neutrophils of patients with myelodysplastic syndrome: a novel correlation. Arch Pathol Lab Med. 2018.
  • Revol B, Thiebaut-Bertrand A, Carré M, et al. Quantification of Howell-Jolly body-like inclusions in ganciclovir toxicity using CellaVision DM96 analyser. Br J Haematol. 2016;174:637–639.
  • Solmonson A, DeBerardinis RJ. Lipoic acid metabolism and mitochondrial redox regulation. J Biol Chem. 2018;293:7522–7530.
  • Emir DF, Ozturan IU, Yilmaz S. Alpha lipoic acid intoxicatıon: an adult. Am J Emerg Med. 2018;36:1125.e3–e5.
  • Gulen M, Simsek Y, Oner E, et al. First description of the alpha lipoic acid intoxication in an adult patient worldwide following oral administration. Am J Emerg Med. 2018;36:1126.e5–e6.
  • Hadzik B, Grass H, Mayatepek E, et al. Fatal non-accidental alpha-lipoic acid intoxication in an adolescent girl. Klin Padiatr. 2014;226:292–294.
  • Moretti R, Angeletti C, Minora S. Multiple organ failure and shock following acute alpha lipoic acid (ALA) intoxication. Clin Toxicol (Phila). 2019;57:749–751.
  • Lai Y-S, Shih C-Y, Huang Y-F, et al. Antiplatelet activity of alpha-lipoic acid. J Agric Food Chem. 2010;58:8596–8603.
  • Liu J, Song Q, Huang Y, et al. R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy. Platelets. 2018;29:695–701.
  • Packer L, Witt EH, Tritschler HJ. alpha-Lipoic acid as a biological antioxidant. Free Rad BiolMed. 1995;19:227–250.
  • Linnane AW, Kios M, Vitetta L. The essential requirement for superoxide radical and nitric oxide formation for normal physiological function and healthy aging. Mitochondrion. 2007;7:1–5.
  • Linnane AW, Eastwood H. Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging. Ann N Y Acad Sci. 2006; 1067:47–55.
  • Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol. 2002;182:84–90.
  • Ludin A, Gur-Cohen S, Golan K, et al. Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment. Antioxid Redox Signal. 2014;21:1605–1619.
  • Sackett K, Cunderlik M, Sahni N, et al. Extreme hyperferritinemia: causes and impact on diagnostic reasoning. Am J Clin Pathol. 2016;145:646–650.
  • Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol. 2017;29:401–409.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.