An in silico kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-dihydroguanosine metabolism from intracellular formation to urinary excretion

References

• Poulsen HE, Nadal LL, Broedbaek K, et al. Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid. Biochim Biophys Acta. 2014;1840(2):801–808.
   PubMed Web of Science ®Google Scholar
• Lam PM, Mistry V, Marczylo TH, et al. Rapid measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry. Free Radic Biol Med. 2012;52(10):2057–2063.
   PubMed Web of Science ®Google Scholar
• Hu CW, Cooke MS, Tsai YH, et al. 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine concentrations in various human body fluids: implications for their measurement and interpretation. Arch Toxicol. 2015;89(2):201–210.
   PubMed Web of Science ®Google Scholar
• Evans MD, Saparbaev M, Cooke MS. DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides. Mutagenesis. 2010;25(5):433–442.
   PubMed Web of Science ®Google Scholar
• Deng XS, Tuo J, Poulsen HE, et al. Prevention of oxidative DNA damage in rats by brussels sprouts. Free Radic Res. 1998;28(3):323–333.
   PubMed Web of Science ®Google Scholar
• Weimann A, Belling D, Poulsen HE. Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry. Nucleic Acids Res. 2002;30(2):E7.
   PubMed Web of Science ®Google Scholar
• Kjaer LK, Cejvanovic V, Henriksen T, et al. Cardiovascular and all-cause mortality risk associated with urinary excretion of 8-oxoGuo, a biomarker for RNA oxidation, in patients with type 2 diabetes: a prospective cohort study. Dia Care. 2017;40(12):1771–1778.
   PubMed Web of Science ®Google Scholar
• Jorgensen A, Kalliokoski O, Forsberg K, et al. A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats. Free Radic Biol Med. 2017;104:64–74.
   PubMed Web of Science ®Google Scholar
• Jorgensen A, Krogh J, Miskowiak K, et al. Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. J Affect Disord. 2013;149(1–3):355–362.
   PubMed Web of Science ®Google Scholar
• Gedik CM, Collins A. Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J. 2005;19(1):82–84.
   PubMed Web of Science ®Google Scholar
• Hah SS, Mundt JM, Kim HM, et al. Measurement of 7,8-dihydro-8-oxo-2'-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry. Proc Natl Acad Sci USA. 2007;104(27):11203–11208.
   PubMed Web of Science ®Google Scholar
• Loft S, Larsen PN, Rasmussen A, et al. Oxidative DNA damage after transplantation of the liver and small intestine in pigs. Transplantation. 1995;59:16–20.
   PubMed Web of Science ®Google Scholar
• Roszkowski K, Jozwicki W, Blaszczyk P, et al. Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer. Med Sci Monit. 2011;17(6):CR329–33.
   PubMed Web of Science ®Google Scholar
• Grew IS, Cejvanovic V, Broedbaek K, et al. Diurnal variation of urinary markers of nucleic acid oxidation. Scand J Clin Lab Invest. 2014;74(4):336–343.
   PubMed Web of Science ®Google Scholar
• Bianconi E, Piovesan A, Facchin F, et al. An estimation of the number of cells in the human body. Ann Hum Biol. 2013;40(6):463–471.
   PubMed Web of Science ®Google Scholar
• Jaruga P, Dizdaroglu M. Repair of products of oxidative DNA base damage in human cells. Nucleic Acids Res. 1996;24(8):1389–1394.
   PubMed Web of Science ®Google Scholar
• Helbock HJ, Beckman KB, Shigenaga MK, et al. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci USA. 1998;95(1):288–293.
   PubMed Web of Science ®Google Scholar
• ICRP. Report of the task group on reference man. Ann ICRP. 1979;3:iii.
   Google Scholar
• Leinonen J, Lehtimaki T, Toyokuni S, et al. New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus. FEBS Lett. 1997;417(1):150–152.
   PubMed Web of Science ®Google Scholar
• Cejvanovic V, Kjaer LK, Bergholdt HKM, et al. Iron induced RNA-oxidation in the general population and in mouse tissue. Free Radic Biol Med. 2018;115:127–135.
   PubMed Web of Science ®Google Scholar
• Nielsen B, Cejvanovic V, Wortwein G, et al. Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neurosci Lett. 2019;690:1–5.
   PubMed Web of Science ®Google Scholar
• Sharova LV, Sharov AA, Nedorezov T, et al. Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res. 2009;16(1):45–58.
   PubMed Web of Science ®Google Scholar
• Cadet J, Davies KJA, Medeiros MH, et al. Formation and repair of oxidatively generated damage in cellular DNA. Free Radic Biol Med. 2017;107:13–34.
   PubMed Web of Science ®Google Scholar
• Shih BB, Farrar MD, Vail A, et al. Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress. Free Radic Biol Med. 2020;160:40–46.
   PubMed Web of Science ®Google Scholar
• Rozalski R, Siomek A, Gackowski D, et al. Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice. Int J Biochem Cell Biol. 2005;37(6):1331–1336.
   PubMed Web of Science ®Google Scholar
• Evans MD, Mistry V, Singh R, et al. Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Free Radic Biol Med. 2016;99:385–391.
   PubMed Web of Science ®Google Scholar
• Chao MR, Evans MD, Hu CW, et al. Biomarkers of nucleic acid oxidation - A summary state-of-the-art. Redox Biol. 2021;42:101872.
   PubMed Web of Science ®Google Scholar
• Haghdoost S, Sjolander L, Czene S, et al. The nucleotide pool is a significant target for oxidative stress. Free Radic Biol Med. 2006;41(4):620–626.
   PubMed Web of Science ®Google Scholar
• Samaranayake GJ, Troccoli CI, Zhang L, et al. The existence of MTH1-independent 8-oxodGTPase activity in cancer cells as a compensatory mechanism against on-target effects of MTH1 inhibitors. Mol Cancer Ther. 2020;19(2):432–446.
   PubMed Web of Science ®Google Scholar
• Mathews CK. Deoxyribonucleotide metabolism, mutagenesis and cancer. Nat Rev Cancer. 2015;15(9):528–539.
   PubMed Web of Science ®Google Scholar
• Loft S, Danielsen P, Lohr M, et al. Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA. Arch Biochem Biophys. 2012;518(2):142–150.
   PubMed Web of Science ®Google Scholar