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Research Articles

The free cortisol calculated: correlation with the free cortisol concentrations measured with liquid chromatography-tandem mass spectrometry after equilibrium dialysis and establishment of reference intervals

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Pages 460-466 | Received 27 Mar 2023, Accepted 05 Sep 2023, Published online: 13 Sep 2023

References

  • Nieman LK. Diagnosis of cushing’s syndrome in the modern era. Endocrinol Metab Clin North Am. 2018;47(2):259–273. doi: 10.1016/j.ecl.2018.02.001.
  • Brien TG. Free cortisol in human plasma. Horm Metab Res. 1980;12(12):643–650. doi: 10.1055/s-2007-999224.
  • Hossner KL, Billiar RB. Plasma clearance and organ distribution of native and desialylated rat and human transcortin: species specificity. Endocrinology. 1981;108(5):1780–1786. doi: 10.1210/endo-108-5-1780.
  • Panton KK, Mikkelsen G, Irgens WØ, et al. New reference intervals for cortisol, cortisol binding globulin and free cortisol index in women using ethinyl estradiol. Scand J Clin Lab Invest. 2019;79(5):314–319. doi: 10.1080/00365513.2019.1622031.
  • Bonte HA, van den Hoven RJ, van der Sluijs Veer G, et al. The use of free cortisol index for laboratory assessment of pituitary-adrenal function. Clin Chem Lab Med. 1999;37(2):127–132. doi: 10.1515/CCLM.1999.023.
  • Hamrahian AH, Oseni TS, Arafah BM. Measurements of serum free cortisol in critically ill patients. N Engl J Med. 2004;350(16):1629–1638. doi: 10.1056/NEJMoa020266.
  • Vincent RP, Etogo-Asse FE, Dew T, et al. Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairment. Ann Clin Biochem. 2009;46(Pt 6):505–507. doi: 10.1258/acb.2009.009030.
  • Poomthavorn P, Lertbunrian R, Preutthipan A, et al. Serum free cortisol index, free cortisol, and total cortisol in critically ill children. Intensive Care Med. 2009;35(7):1281–1285. doi: 10.1007/s00134-009-1480-x.
  • Watanobe H, Nigawara T, Nasushita R, et al. A case of cyclical cushing’s disease associated with corticosteroid-binding globulin deficiency: a rare pitfall in the diagnosis of cushing’s disease. Eur J Endocrinol. 1995;133(3):317–319. doi: 10.1530/eje.0.1330317.
  • MacMahon W, Thompson J, Bowers W, et al. A simplified ultrafiltration method for determination of serum free cortisol. Clin Chim Acta. 1983;131(3):171–184. doi: 10.1016/0009-8981(83)90086-4.
  • Le Roux CW, Sivakumaran S, Alaghband-Zadeh J, et al. Free cortisol index as a surrogate marker for serum free cortisol. Ann Clin Biochem. 2002;39(Pt 4):406–408. doi: 10.1258/000456302760042182.
  • Sofer Y, Osher E, Limor R, et al. Gender determines serum free cortisol: higher levels in men. Endocr Pract. 2016;22(12):1415–1421. doi: 10.4158/EP161370.OR.
  • Kirchhoff F, Briegel J, Vogeser M. Quantification of free serum cortisol based on equilibrium dialysis and isotope dilution-liquid chromatography-tandem mass spectrometry. Clin Biochem. 2011;44(10-11):894–899. doi: 10.1016/j.clinbiochem.2011.04.005.
  • Bhake RC, Kluckner V, Stassen H, et al. Continuous free cortisol Profiles-Circadian rhythms in healthy men. J Clin Endocrinol Metab. 2019;104(12):5935–5947. doi: 10.1210/jc.2019-00449.
  • Molenaar N, Johan Groeneveld AB, Dijstelbloem HM, et al. Assessing adrenal insufficiency of corticosteroid secretion using free versus total cortisol levels in critical illness. Intensive Care Med. 2011;37(12):1986–1993. doi: 10.1007/s00134-011-2342-x.
  • Solberg HE. The IFCC recommendation on estimation of reference intervals. The RefVal program. Clin Chem Lab Med. 2004;42:710–714.
  • Coolens JL, Van Baelen H, Heyns W. Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J Steroid Biochem. 1987;26(2):197–202. doi: 10.1016/0022-4731(87)90071-9.
  • Hubert P, Nguyen-Huu JJ, Boulanger B, et al. Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal - Part I. J. Pharm Biomed Anal. 2004;36:579–586.
  • Hubert P, Nguyen-Huu JJ, Boulanger B, et al. Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal - Part II. J Pharm Biomed Anal. 2007;45(1):70–81. doi: 10.1016/j.jpba.2007.06.013.
  • Hubert P, Nguyen-Huu JJ, Boulanger B, et al. Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal-Part III. J Pharm Biomed Anal. 2007;45(1):82–96. doi: 10.1016/j.jpba.2007.06.032.
  • Hubert P, Nguyen-Huu JJ, Boulanger B, et al. Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal. Part IV. Examples of application. J Pharm Biomed Anal. 2008;48(3):760–771. doi: 10.1016/j.jpba.2008.07.018.
  • Hammond J, Wentz P, Statland BE, et al. Daily variation of lipids and hormones in sera of healthy subjects. Clin Chim Acta. 1976;73(2):347–352. doi: 10.1016/0009-8981(76)90181-9.
  • Maes M, Mommen K, Hendrickx D, et al. Components of biological variation, including seasonality, in blood concentrations of TSH, TT3, FT4, PRL, cortisol and testosterone in healthy volunteers. Clin Endocrinol (Oxf). 1997;46(5):587–598. doi: 10.1046/j.1365-2265.1997.1881002.x.
  • Molenaar N, Groeneveld AB, de Jong MF. Three calculations of free cortisol versus measured values in the critically ill. Clin Biochem. 2015;48(16-17):1053–1058. doi: 10.1016/j.clinbiochem.2015.07.014.
  • Cameron A, Henley D, Carrell R, et al. Temperature-responsive release of cortisol from its binding globulin: a protein thermocouple. J Clin Endocrinol Metab. 2010;95(10):4689–4695. doi: 10.1210/jc.2010-0942.
  • Limor R, Tordjman K, Marcus Y, et al. Serum free cortisol as an ancillary tool in the interpretation of the low-dose 1-μg ACTH test. Clin Endocrinol. 2011;75(3):294–300. doi: 10.1111/j.1365-2265.2011.04080.x.
  • Ho JT, Al-Musalhi H, Chapman MJ, et al. Septic shock and sepsis: a comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab. 2006;91(1):105–114. doi: 10.1210/jc.2005-0265.
  • Insert Elecsys Cortisol II.07027150500.V2.en.pdf. Roche Diagnostics
  • Insert Elecsys Cortisol.11875116122.V20.en.pdf. Roche Diagnostics

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