Correlation between plasma biochemical parameters and cardio-hepatic iron deposition in thalassemia major patients

References

• Hasanshahi F, Khanjani N. Investigating the reasons for marriage among couples with thalassemia minor, in Iran. J Commun Genet. 2021;12(4):507–513. doi: 10.1007/s12687-021-00540-5.
   PubMed Web of Science ®Google Scholar
• Jaafari Z, Sadidi N, Abdolahinia Z, et al. Prevalence of depression among Iranian patients with beta-thalassemia major: a systematic review and meta-analysis. Iran J Med Sci. 2022;47(1):15–24. doi: 10.30476/ijms.2020.85941.1557.
   PubMed Web of Science ®Google Scholar
• Yadav PK, Singh AK. A review of iron overload in beta-thalassemia major, and a discussion on alternative potent iron chelation targets. Clin Med Insight Blood Disord. 2022;16:26348535221103560. doi: 10.1177/26348535221103560.
   Google Scholar
• Coates TD. Iron overload in transfusion-dependent patients. Hematol Am Soc Hematol Educ Program. 2019;2019(1):337–344. doi: 10.1182/hematology.2019000036.
   PubMedGoogle Scholar
• Labranche R, Gilbert G, Cerny M, et al. Liver iron quantification with MR imaging: a primer for radiologists. Radiographics. 2018;38(2):392–412. doi: 10.1148/rg.2018170079.
   PubMed Web of Science ®Google Scholar
• Finelli C, Parisi S, Paolini S. Exploring the rationale for red cell transfusion in myelodysplastic syndrome patients: emerging data and future insights. Expert Rev Hematol. 2022;15:411–421.
   PubMed Web of Science ®Google Scholar
• Jensen PD, Nielsen AH, Simonsen CW, et al. Consequences of parenteral iron-dextran loading investigated in minipigs. A new model of transfusional iron overload. Blood Cells Mol Dis. 2020;83:102440. doi: 10.1016/j.bcmd.2020.102440.
   PubMed Web of Science ®Google Scholar
• Pinto VM, Poggi M, Russo R, et al. Management of the aging beta-thalassemia transfusion-dependent population–The Italian experience. Blood Rev. 2019;38:100594. doi: 10.1016/j.blre.2019.100594.
   PubMed Web of Science ®Google Scholar
• Obrzut M, Atamaniuk V, Glaser KJ, et al. Value of liver iron concentration in healthy volunteers assessed by MRI. Sci Rep. 2020;10(1):17887. doi: 10.1038/s41598-020-74968-z.
   PubMed Web of Science ®Google Scholar
• Amin K, Mileto A, Kolokythas O. MRI for liver iron quantification: concepts and current methods. Seminars in ultrasound, CT MRI. 2022;43(4):364–370. doi: 10.1053/j.sult.2022.03.006.
   Google Scholar
• Kotla NK, Dutta P, Parimi S, et al. The role of ferritin in health and disease: recent advances and understandings. Metabolites. 2022;12(7):609. doi: 10.3390/metabo12070609.
   PubMed Web of Science ®Google Scholar
• Perzia BM, Ying G-S, Dunaief JL, et al. Reduction in ferritin concentrations among patients consuming a dark-green leafy vegetable–rich, low inflammatory foods everyday. Curr Dev Nutr. 2022;6(6):nzac095. (doi: 10.1093/cdn/nzac095.
   PubMed Web of Science ®Google Scholar
• Carsote M, Vasiliu C, Trandafir AI, et al. New entity—thalassemic endocrine disease: major beta-thalassemia and endocrine involvement. Diagnostics. 2022;12(8):1921. doi: 10.3390/diagnostics12081921.
   Web of Science ®Google Scholar
• De Sanctis V, Soliman AT, Tzoulis P, et al. Pancreatic changes affecting glucose homeostasis in transfusion-dependent β-thalassemia (TDT): a short review. Acta Bio Med: Atenei Parmensis. 2021;92(3):e2021232.
   Google Scholar
• Pepe A, Sormani P, Meloni A, et al. Iron overload cardiomyopathies. In Case-based atlas of cardiovascular MR. Switzerland: Springer; 2023. p. 173–185.
   Google Scholar
• Saravani K, Ostadrahimi P, Jahanifard A. Evaluation of the level of liver enzymes and its relationship with ferritin and the frequency of blood transfusion in patients with thalassemia. Cell Mol Biomed Rep. 2024;4(2):100–110. doi: 10.55705/cmbr.2023.410242.1163.
   Google Scholar
• Taher AT, Bou-Fakhredin R, Kattamis A, et al. Improving outcomes and quality of life for patients with transfusion-dependent β-thalassemia: recommendations for best clinical practice and the use of novel treatment strategies. Expert Rev Hematol. 2021;14(10):897–909. doi: 10.1080/17474086.2021.1977116.
   PubMed Web of Science ®Google Scholar
• Valigura KMD. Iron linked diseases–mini review. In CER Comparative European Research. London: Sciemcee Publishing, 2021.
   Google Scholar
• Krittayaphong R, Viprakasit V, Saiviroonporn P, et al. Prevalence and predictors of cardiac and liver iron overload in patients with thalassemia: a multicenter study based on real-world data. Blood Cells Mol Dis. 2017;66:24–30. doi: 10.1016/j.bcmd.2017.08.002.
   PubMed Web of Science ®Google Scholar
• Saadatifar H, Niayeshfar A, Mard-Soltani M, et al. The correlation of cardiac biomarkers and myocardial iron overload based on T2* MRI in major beta-thalassemia. Int J Cardiovasc Imag. 2022;38(4):833–840. doi: 10.1007/s10554-021-02458-y.
   PubMed Web of Science ®Google Scholar
• Ayatollahi H, Mousavi Nezhad SF, Talebpour A, et al. Relation of hepcidin gene expression in blood mononuclear cells with iron overload severity among β-thalassemia major patients. Mol Biol Rep. 2020;47(12):9353–9359. doi: 10.1007/s11033-020-06012-2.
   PubMed Web of Science ®Google Scholar
• Sevimli C, Yilmaz Y, Bayramoglu Z, et al. Pancreatic MR imaging and endocrine complications in patients with beta-thalassemia: a single-center experience. Clin Exp Med. 2022;22(1):95–101. doi: 10.1007/s10238-021-00735-7.
   PubMed Web of Science ®Google Scholar
• Fianza PI, Rahmawati A, Widihastha SH, et al. Iron overload in transfusion-dependent Indonesian thalassemic patients. Anemia. 2021;2021:5581831–5581838. doi: 10.1155/2021/5581831.
   PubMed Web of Science ®Google Scholar
• Abdelazeem M, Hassan TH, Alghobashy AA, et al. Evaluation of myocardial siderosis in children with beta thalassemia at Hematology Unit of Zagazig University Hospital. ZUMJ. 2022;28(3):489–496.
   Google Scholar
• Wood JC. Estimating tissue iron burden: current status and future prospects. Br J Haematol. 2015;170(1):15–28. doi: 10.1111/bjh.13374.
   PubMed Web of Science ®Google Scholar
• Mishra NR, Biswal SS, Majhi SC. Predictors of iron overload toxicity in multi-transfused beta-thalassemic children. IJCH. 2019;6(7):341–344. doi: 10.32677/IJCH.2019.v06.i07.003.
   Google Scholar
• Wahidiyat PA, Liauw F, Sekarsari D, et al. Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging. Hematology. 2017;22(8):501–507. doi: 10.1080/10245332.2017.1292614.
   PubMed Web of Science ®Google Scholar
• Karakas Z, Yilmaz Y, Bayramoglu Z, et al. Magnetic resonance imaging during management of patients with transfusion-dependent thalassemia: a single-center experience. Radiol Med. 2018;123(8):572–576. doi: 10.1007/s11547-018-0889-0.
   PubMed Web of Science ®Google Scholar
• Khaled A, Ezzat DA, Salem HA, et al. An effective method of evaluating myocardial iron concentration in pediatric patients with thalassemia major. J Blood Med. 2019;10:227–233. doi: 10.2147/JBM.S204848.
   PubMed Web of Science ®Google Scholar
• Taghizadeh Sarvestani R, Moradveisi B, Kompany F, et al. Correlation between heart and liver iron levels measured by MRI T2* and serum ferritin in patients with β-thalassemia major. Int J Pediatr. 2016;4(3):1559–1567.
   Google Scholar
• Fahmy HS, Khater NH, El Shahat HM, et al. Reassessing the value of MRI T2∗ in the evaluation of hepatic and myocardial iron concentration: an institutional study. EJRNM. 2015;46(4):1085–1090. doi: 10.1016/j.ejrnm.2015.06.008.
   Google Scholar
• Ying H, Shen Z, Wang J, et al. Role of iron homeostasis in the heart. Herz. 2021;47(2):141–149. doi: 10.1007/s00059-021-05039-w.
   PubMed Web of Science ®Google Scholar
• Chuansumrit A, Laothamathat J, Sirachainan N, et al. Correlation between liver iron concentration determined by magnetic resonance imaging and serum ferritin in adolescents with thalassemia disease. Paediat Int Child Health. 2016;36(3):203–208. doi: 10.1179/2046905515Y.0000000037.
   PubMed Web of Science ®Google Scholar
• Darvishi-Khezri H, Karami H, Naderisorki M, et al. Moderate to severe liver siderosis and raised AST are independent risk factors for vitamin D insufficiency in β-thalassemia patients. Sci Rep. 2020;10(1):21164. doi: 10.1038/s41598-020-78230-4.
   PubMed Web of Science ®Google Scholar
• Hsu CC, Senussi NH, Fertrin KY, et al. Iron overload disorders. Hepatol Commun. 2022;6(8):1842–1854. doi: 10.1002/hep4.2012.
   PubMed Web of Science ®Google Scholar
• Heris HK, Nejati B, Rezazadeh K, et al. The evaluation of iron overload by cardiac and liver T2* in β-thalassemia: correlation with serum ferritin, heart function and liver enzymes. J Cardiovasc Thorac Res. 2021;13(1):54–60. doi: 10.34172/jcvtr.2021.18.
   PubMed Web of Science ®Google Scholar
• Mohammadifard M, Ziaee M, Sharifzadeh G, et al. The evaluation of liver enzyme elevation and its contributing factors in Birjand, Iran. Mod Care J. 2017;14(4):e68238.
   Google Scholar
• Angle CR. Chelation therapies for metal intoxication. In Toxicology of metals. Volume I. Boston: CRC Press; 2023. p. 487–504.
   Google Scholar
• Jomova K, Makova M, Alomar SY, et al. Essential metals in health and disease. Chem Biol Interact. 2022;367:110173. doi: 10.1016/j.cbi.2022.110173.
   PubMed Web of Science ®Google Scholar
• Fiorentini D, Cappadone C, Farruggia G, et al. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutr. 2021;13(4):1136. doi: 10.3390/nu13041136.
   Google Scholar
• Ghani AA, Kakar AU, Ullah Z, et al. Hematological and biochemical status of beta thalassemia in Pakistani and Afghani Patients of Quetta City, Pakistan. Warsaw, Poland, 2018.
   Google Scholar
• Munira FT, Begum S, Urmi S. Alteration of serum calcium and magnesium level in transfusion-dependent thalassemic patients with combined iron chelator therapy. J Bangladesh Soc Physiol. 2020;15(1):17–22. doi: 10.3329/jbsp.v15i1.48111.
   Google Scholar
• DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668. doi: 10.1136/openhrt-2017-000668.
   PubMed Web of Science ®Google Scholar
• Molz P, Dallemole DR, Molz WA, et al. Iron supplementation does not aggravate impaired glucose tolerance and sugar overload-induced genotoxicity in rats. Mol Cell Biochem. 2023;478(8):1719–1725. doi: 10.1007/s11010-022-04625-8.
   PubMed Web of Science ®Google Scholar
• Harrison AV, Lorenzo FR, McClain DA. Iron and the pathophysiology of diabetes. Annu Rev Physiol. 2023;85(1):339–362. doi: 10.1146/annurev-physiol-022522-102832.
   PubMedGoogle Scholar
• Mahgoub EO, Qannita R, Alalami A, et al. Diabetes mellitus progression in β-thalassemia major patients: the impact of iron overload. DOAJ. 2024;3(1):5–12.
   Google Scholar
• Ahmad F, Shehzadi I, Zahoor A. Frequency of diabetes mellitus in thalassemia major patients. PJMHS. 2022;16(3):1218–1220. doi: 10.53350/pjmhs221631218.
   Google Scholar
• Khan HAS, Mahmood F, Hotiana NA, et al. Frequency of diabetes mellitus in thalassemia major patients in Thalassemia Center, Sir Ganga Ram Hospital, Lahore. JSPARK. 2024;3(1):54–58. doi: 10.21649/jspark.v3i1.410.
   Google Scholar
• Pepe A, Pistoia L, Gamberini MR, et al. The close link of pancreatic iron with glucose metabolism and with cardiac complications in thalassemia major: a large, multicenter observational study. Diabetes Care. 2020;43(11):2830–2839. doi: 10.2337/dc20-0908.
   PubMed Web of Science ®Google Scholar
• Hashemieh M. Assessment of organ specific iron overload in transfusion-dependent thalassemia by magnetic resonance imaging techniques. IJBC. 2019;46–39(2):11.
   Google Scholar
• De Sanctis V, Soliman A, Tzoulis P, et al. A study of isolated hyperglycemia (blood glucose≥ 155 mg/dL) at 1-hour of oral glucose tolerance test (OGTT) in patients with β-transfusion-dependent thalassemia (β-TDT) followed for 12 years. Acta Biomed: Atenei Parmensis. 2021;92(4):e2021322.
   Google Scholar