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Research Article

Diagnosing sucrase-isomaltase deficiency: a comparison of a 13C-sucrose breath test and a duodenal enzyme assay

Hanna Fjeldheim Dalea Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway;b Department of Clinical Support, Lovisenberg Diaconal Hospital, Oslo, NorwayCorrespondence[email protected]
View further author information
,
Milada Hagenc Faculty of Health Science, Oslo Metropolitan University, Oslo, Norway;d Department of Research, Lovisenberg Diaconal Hospital, Oslo, NorwayView further author information
,
Chirajyoti Debe Gastroenterology Translational Research Division, Arnold Palmer Hospital, Specialty Diagnostic Laboratory, Orlando, USAView further author information
,
Viggo Skara Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, NorwayView further author information
&
Jørgen Valeura Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway;f Institute of Clinical Medicine, University of Oslo, Oslo, NorwayView further author information
Received 29 Jan 2024, Accepted 05 Jul 2024, Published online: 10 Jul 2024

References

  • Andersen MK, Skotte L, Jørsboe E, et al. Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in greenlandic cohorts. Gastroenterology. 2022;162(4):1171–1182.e3. doi: 10.1053/j.gastro.2021.12.236.
  • Chey DWCB, Lembo A, Patel DB, et al. Congenital sucrase-isomaltase deficiency: what, when, and how? Gastroenterol & Hepatol. 2020;16(10):1–11.
  • Dahlqvist A. Assay of intestinal disaccharidases. Scand J Clin Lab Invest. 1984;44(2):169–172. doi: 10.3109/00365518409161400.
  • Karnsakul W, Luginbuehl U, Hahn D, et al. Disaccharidase activities in dyspeptic children: biochemical and molecular investigations of maltase-glucoamylase activity. J Pediatr Gastroenterol Nutr. 2002;35(4):551–556. doi: 10.1097/00005176-200210000-00017.
  • Ritchie BK, Brewster DR, Davidson GP, et al. 13C-sucrose breath test: novel use of a noninvasive biomarker of environmental gut health. Pediatrics. 2009;124(2):620–626. doi: 10.1542/peds.2008-2257.
  • Wardill HR, Bowen JM, Gibson RJ. Biomarkers of small intestinal mucosal damage induced by chemotherapy: an emerging role for the 13C sucrose breath test. J Support Oncol. 2013;11(2):61–67. doi: 10.1016/j.suponc.2012.06.004.
  • Schillinger RJ, Mwakamui S, Mulenga C, et al. 13)C-sucrose breath test for the non-invasive assessment of environmental enteropathy in Zambian adults. Front Med (Lausanne). 2022;9:904339. (doi: 10.3389/fmed.2022.904339.
  • Robayo-Torres CC, Diaz-Sotomayor M, Hamaker BR, et al. 13C-labeled-starch breath test in congenital sucrase-isomaltase deficiency. J Pediatr Gastroenterol Nutr. 2018;66(Suppl 3):61–64.
  • Ghoos Y, Geypens B, Maes B, et al. Breath tests in gastric emptying and transit studies: technical aspects of 13CO2-breath tests. Progress in understanding and management of gastro-intestinal motility disorders. Belgium: Katholieke Universiteit Leuven ; 1993; p. 169–180.
  • Dahlqvist A, Nordström C. The distribution of disaccharidase activities in the villi and crypts of the small-intestinal mucosa. Biochim Biophys Acta. 1966;113(3):624–626. doi: 10.1016/s0926-6593(66)80024-3.
  • Deb C, Campion S, Derrick V, et al. Sucrase-isomaltase gene variants in patients with abnormal sucrase activity and functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2021;72(1):29–35. doi: 10.1097/MPG.0000000000002852.
  • Kim SB, Calmet FH, Garrido J, et al. Sucrase-isomaltase deficiency as a potential masquerader in irritable bowel syndrome. Dig Dis Sci. 2020;65(2):534–540. doi: 10.1007/s10620-019-05780-7.
  • Robayo-Torres CC, Opekun AR, Quezada-Calvillo R, et al. 13C-breath tests for sucrose digestion in congenital sucrase isomaltase-deficient and sacrosidase-supplemented patients. J Pediatr Gastroenterol Nutr. 2009;48(4):412–418. doi: 10.1097/mpg.0b013e318180cd09.
  • Tooley KL, Howarth GS, Lymn KA, et al. Optimization of the non-invasive 13C-sucrose breath test in a rat model of methotrexate-induced mucositis. Cancer Chemother Pharmacol. 2010;65(5):913–921. doi: 10.1007/s00280-009-1098-2.
  • Opekun AR, Balesh AM, Shelby HT. Use of the biphasic (13)C-sucrose/glucose breath test to assess sucrose maldigestion in adults with functional bowel disorders. Biomed Res Int. 2016;2016:7952891. doi: 10.1155/2016/7952891.

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