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Scandinavian Journal of Clinical and Laboratory Investigation Volume 52, 1992 - Issue 4
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Original

Sorbitol in isolation of rat pancreatic islets. Effects on islet yield, insulin secretion and accumulation of inositol phosphates

B. Vonen Laboratory of Gastroenterology, Department of Medicine, University Hospital of Tromsø, Norway; Department of Surgery, University Hospital of Tromsø, Norway
,
J. Florholmen Laboratory of Gastroenterology, Department of Medicine, University Hospital of Tromsø, Norway; Institute for Clinical Medicine, University of Tromsø, Tromsø, Norway
,
D. Malm Laboratory of Gastroenterology, Department of Medicine, University Hospital of Tromsø, Norway; Institute for Clinical Medicine, University of Tromsø, Tromsø, Norway
&
P. G. Burhol Laboratory of Gastroenterology, Department of Medicine, University Hospital of Tromsø, Norway
Pages 237-243 | Received 22 Aug 1991, Accepted 02 Nov 1991, Published online: 29 Mar 2011

References

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  • Turk J, Wolf B A, McDaniel M L. The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositholtrisphosphate and of intacellular Ca2+ in glucose-induced insulin secretion by pancreatic islets. Prog Lipid Res 1987; 26: 125–81
  • Pace C S, Clements R S. Myo-inositol and the maintenance of beta-cell function in cultured rat pancreatic islets. Diabetes 1981; 30: 621–5
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  • Florholmen J, Malm D, Vonen B, Burhol P G. Effects of cholecystokinin on the accumulation of inositol phosphates in isolated pancreatic islets. Am J Physiol 1989; 257: G865–70
  • MacKenzie K M, Hauck W N. Three-generation reproduction study of rats ingesting up to 10% sorbitol in the diet—and a brief review of the toxicological status of sorbitol. Fd Chem Toxic 1986; 24: 191–200
  • Wolf B A, Florholmen J, Turk J, McDaniel M L. Studies of the Ca requirements for glucose-and carbachol-induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitoninpermeabilized islets. J Biol Chem 1988; 263: 3565–75

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