Transforming Growth Factor-alpha Delays Gastric Emptying and Small Intestinal Transit in Suckling Rats

References

• Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 1995;108: 564–80.
   Google Scholar
• de Larco JE, Todaro GJ. Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci USA 1978;75: 4001–5.
   PubMed Web of Science ®Google Scholar
• Derynck R. Transforming growth factor-alpha: structure and biological activities. J Cell Biochem 1986;32:293–304.
   PubMed Web of Science ®Google Scholar
• Massague J. Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem 1983; 258:13614–20.
   Google Scholar
• Derynck R. Transforming growth factor-alpha. Mol Reprod Dev 1990;27:3–9.
   PubMed Web of Science ®Google Scholar
• Chailler P, Menard D. Ontogeny of EGF receptors in the human gut. Front Biosci 1999;4:D87–101.
   PubMedGoogle Scholar
• Tarnawski A, Stachura J, Durbin T, Gergely H. Expression of epidermal growth factor receptor in rat gastric oxyntic mucosa. J Clin Gastroenterol 1991;13:S109–13.
   PubMed Web of Science ®Google Scholar
• Malden LT, Novak U, Burgess AW. Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract. Int J Cancer 1989;43:380–4.
   Google Scholar
• Koyama SY, Podolsky DK. Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells. J Clin Invest 1989;83:1768–73.
   PubMed Web of Science ®Google Scholar
• Suemori S, Ciacci C, Podolsky DK. Regulation of transforming growth factor expression in rat intestinal epithelial cell lines. J Clin Invest 1991;87:2216–21.
   Google Scholar
• Thomas DM, Nasim MM, Gullick WJ, Alison MR. Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract. Gut 1992;33:628–31.
   PubMed Web of Science ®Google Scholar
• Dvořák B, Koldovský O. The presence of transforming growth factor-alpha in the suckling rat small intestine and pancreas and the absence in rat milk. Pediatr Res 1994;35:348–53.
   PubMed Web of Science ®Google Scholar
• Perez-Tomas R, Cullere X, Diaz C. Immunohistochemical localization of transforming growth factor alpha in the developing rat colon. Gastroenterology 1993;104:789–95.
   PubMed Web of Science ®Google Scholar
• Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996;110: 975–84.
   Google Scholar
• Back W, Rohr G. Morphologic distribution of transforming growth factor alpha in the gastrointestinal tract—its presence in neuroendocrine cell type of the colon mucosa. Gen Diagn Pathol 1996;142:17–24.
   PubMedGoogle Scholar
• Goodlad RA, Wright NA. Epidermal growth factor and transforming growth factor-alpha actions on the gut. Eur J Gastroenterol Hepatol 1995;7:928–32.
   PubMed Web of Science ®Google Scholar
• Hormi K, Lehy T. Transforming growth factor-alpha in vivo stimulates epithelial cell proliferation in digestive tissues of suckling rats. Gut 1996;39:532–8.
   PubMed Web of Science ®Google Scholar
• Bade EG, Feindler S. Liver epithelial cell migration induced by epidermal growth factor or transforming growth factor alpha is associated with changes in the gene expression of secreted proteins. In Vitro Cell Dev Biol 1988;24:149–54.
   PubMed Web of Science ®Google Scholar
• Barrandon Y, Green H. Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor. Cell 1987;50: 1131–7.
   PubMed Web of Science ®Google Scholar
• Kong W, Yee LF, Mulvihill SJ. Hepatocyte growth factor stimulates fetal gastric epithelial cell growth in vitro. J Sur Res 1998;78:161–8.
   Google Scholar
• Kelly EJ, Newell SJ, Brownlee KG, Farmery SM, Cullinane C, Reid WA, et al. Role of epidermal growth factor and transforming growth factor alpha in the developing stomach. Arch Dis Child Fetal Neonat 1997;76:F158–62.
   PubMed Web of Science ®Google Scholar
• Guglietta A, Lesch CA, Romano M, McClure RW, Coffey RJ. Effect of transforming growth factor-alpha on gastric acid secretion in rats and monkeys. Dig Dis Sci 1994;39:177–82.
   Google Scholar
• Konturek PC, Bobrzynski A, Konturek SJ, Bielanski W, Faller G, Kirchner T, et al. Epidermal growth factor and transforming growth factor alpha in duodenal ulcer and non-ulcer dyspepsia patients before and after Helicobacter pylori eradication. Scand J Gastroenterol 1998;33:143–51.
   PubMed Web of Science ®Google Scholar
• Egger B, Carey HV, Procaccino F, Chai NN, Sandgren EP, Lakshmanan J, et al. Reduced susceptibility of mice overexpressing transforming growth factor alpha to dextran sodium sulphate induced colitis. Gut 1998;43:64–70.
   PubMed Web of Science ®Google Scholar
• Kelly SM, Hunter JO. Epidermal growth factor stimulates synthesis and secretion of mucus glycoproteins in human gastric mucosa. Clin Sci 1990;79:425–7.
   Web of Science ®Google Scholar
• Shinohara H, Williams C, Yakabe T, Koldovský O. Epidermal growth factor delays gastric emptying and small intestinal transit in suckling rats. Pediatr Res 1996;39:281–6.
   Google Scholar
• Shinohara H, Williams CS, Koldovský O, Philipps AF, Dvořák B. Transforming growth factor-alpha (TGF-α) delays gastric emptying and intestinal propulsive motility in suckling rats. Gastroenterology 1999;116:1033A.
   Google Scholar
• Shinohara H, Williams C, Koldovský O. The use of poly R-478 as a marker to determine gastric emptying and intestinal propulsive motility in suckling rats. Physiol Res 1995;44: 281–6.
   Google Scholar
• Dupas JL, Moreau M, Hofmann AF. Polymeric dyes: useful nonabsorbable reference markers for intestinal perfusion studies in animals. J Pharm Sci 1985;74:328–30.
   Google Scholar
• Stahl GE, Fayer JC, Ling SC, Watkins JB. Comparison of nonabsorbable markers Poly R-478 and [14C]PEG-4,000 for use in developmental absorption studies. J Pediatr Gastroenterol Nutr 1991;12:485–93.
   PubMed Web of Science ®Google Scholar
• Ebner R, Derynck R. Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul 1991;2: 599–612.
   PubMedGoogle Scholar
• Dvořák B, Holubec H, LeBouton AV, Wilson JM, Koldovský O. Epidermal growth factor and transforming growth factor-alpha mRNA in rat small intestine: in situ hybridization study. FEBS Lett 1994;352:291–5.
   Google Scholar
• Hardin JA, Gall DG. The effect of TGF alpha on intestinal solute transport. Reg Pep 1992;39:169–76.
   PubMedGoogle Scholar
• Schaudies RP, Grimes J, Davis D, Rao RK, Koldovský O. EGF content in the gastrointestinal tract of rats: effect of age and fasting/feeding. Am J Physiol 1989;256:G856–61.
   Google Scholar
• Dvořák B, Williams CS, McWilliam DL, Shinohara H, Dominguez JA, McCuskey RS, Philipps AF, Koldovský O. Milk-borne epidermal growth factor modulates intestinal transforming growth factor-α levels in neonatal rats. Pediatr Res 2000;47:194–200.
   Google Scholar
• Thompson JF, van den Berg M, Stokkers PC. Developmental regulation of epidermal growth factor receptor kinase in rat intestine. Gastroenterology 1994;107:1278–87.
   PubMed Web of Science ®Google Scholar
• Jones MK, Tomikawa M, Mohajer B, Tarnawski AS. Gastrointestinal mucosal regeneration: role of growth factors. Frontiers Biosci 1999;4:D303–9.
   PubMedGoogle Scholar
• Hollenberg MD, Muramatsu I, Itoh H, Patel P, Yang SG, Lederis K. Contractile actions of epidermal growth factor-urogastrone in isolated smooth muscle preparations from guinea pig stomach: structure-activity relationships and comparison with the effects of human transforming growth factor-alpha. J Pharmacol Exper Ther 1989;248:384–90.
   PubMed Web of Science ®Google Scholar
• Heller J. The role of emptying of the stomach in absorption of a water load in the rat during ontogenesis. Physiol Bohemoslov 1963;21:526–53.
   Google Scholar
• Koldovský O, Danysz J, Faltova E, Hahn P. The postnatal proximodistal development of glucose absorption, intestinal alkaline phosphatase activity and propulsive motility of the intestine in rats. Physiol Bohemoslov 1963;12:208–12.
   PubMedGoogle Scholar
• Jiang Q, Koldovský O, Bedrick A, Pollack P, Porreca F. Bombesin differentially affects gastric emptying in suckling, weanling and adult rats. J Pharmacol Exper Therap 1991;257: 603–7.
   PubMed Web of Science ®Google Scholar
• Lorenz DN. Gastric emptying of milk in rat pups. Am J Physiol 1985;248:R732–8.
   PubMed Web of Science ®Google Scholar
• Porreca F, Burks TF. Centrally administered bombesin affects gastric emptying and small and large bowel transit in the rat. Gastroenterology 1983;85:313–7.
   PubMed Web of Science ®Google Scholar
• Bueno L, Ferre JP. Central regulation of intestinal motility by somatostatin and cholecystokinin octapeptide. Science 1982; 216:1427–9.
   PubMed Web of Science ®Google Scholar
• LaHann TR, Horita A. Thyrotropin releasing hormone: centrally mediated effects on gastrointestinal motor activity. J Pharmacol Exper Ther 1982;222:66–70.
   PubMed Web of Science ®Google Scholar
• Hui WM, Chen BW, Kung AW, Cho CH, Luk CT, Lam SK. Effect of epidermal growth factor on gastric blood flow in rats: possible role in mucosal protection. Gastroenterology 1993;104: 1605–10.
   PubMed Web of Science ®Google Scholar
• Hoffmann P, Zeeh JM, Lakshmanan J, Liu L, Cooray D, Barajas L, et al. Transforming growth factor alpha-immunoreactivity in neural tissues of the rat stomach. Regul Pept 1997;69:121–5.
   PubMedGoogle Scholar