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Research Article

Pioglitazone, a Specific Ligand of the Peroxisome Proliferator-Activated Receptor Gamma Reduces Gastric Mucosal Injury Induced by Ischaemia/Reperfusion in Rat

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Pages 468-476 | Published online: 08 Jul 2009

References

  • Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, et al. The nuclear receptor superfamily: the second decade. Cell 2002;83:835–9.
  • Corton JC, Anderson SP, Stauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Ann Rev Pharmacol Toxicol 2000;40:491–518.
  • Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002;53:409–35.
  • Kliewer SA, Willson TM. The nuclear receptor PPARy: bigger than fat. Curr Opin Genet Dev 1998;8:576–81.
  • Jiang C, Ting AT, Seed B. PPARy agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82–6.
  • Su CG, Wen X, Bailey ST, Jiang W, Rangwalo SM, Keilhough SA, Flanigan A, et al. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 1999;104:383–9.
  • Kojima K, Shimada T, Mitobe Y, Yoshiura K, Hiraishi M, Terano A. Effect of PPARgamma Ligands on the viability of gastric epithelial cells. Aliment Pharmacol Ther 2002;16:67–73.
  • Naito Y, Takagi T, Matsuyama K, Yoshida N, Yoshikawa T. Pioglitazone, a specific PPAR-y ligand, inhibits aspirin-induced gastric mucosal injury in rats. Aliment Pharmacol Ther 2001;15: 865–73.
  • Wada K. A new gastric ulcer model induced by ischemia- reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life Sci 1996;59:295–301.
  • Konturek PC, Duda A, Brzozowski T, Konturek SJ, Kwiecien S, Drozdowicz D, et al. Activation of genes for superoxide dismutase, interleukin 1β, tumor necrosis factor alpha, and intercellular adhesion molecule-1 during healing of ischemia- reperfusion induced gastric injury. Scand J Gastroenterol 2000; 35:452–63.
  • Konturek PC, Brzozowski T, Konturek SJ, Kwiecien S, Dembinski A, Hahn EG. Influence of bacterial lipopolysaccharide on healing of chronic experimental ulcer in rat. Scand J Gastroenterol 2001;36:1239–47.
  • Bado A, Lavasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, et al. The stomach is a source of leptin. Nature 2002;394:790–3.
  • Galli A, Crabb D-W, Ceni E, Salzano R, Mello T, Sveglati- Baroni G, et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 2002;122:1924–40.
  • Nakijima A, Wada K, Miki H, Kubota N, Nakajimo N, Terauchi Y, et al. Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 2001;120:460–9.
  • Uchinami H, Yamamoto Y, Kume M, Yonezawa K, Ishikawa Y, Tauro K, et al. Effect of heat shock preconditioning on NF- kappaB/I-kappaB pathway during I/R injury of the rat liver. Am J Physiol Gastrointest Liver Physiol 2002;282:G962–71.
  • Murphy GJ, Holder CJ. PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 2000; 21:469–74.
  • Ricote M, Li AC, Willson TM, Gass CK. The peroxisome proliferator-γ is a negative regulator of macrophage activation. Nature 1998;391:79–82.
  • Fiorucci S, Antonelli E. Cyclo-oxygenase isoenzymes. Structural basis for selective inhibition of cyclo-oxygenases by antiinflammatory agents. Digest Liver Dis 2001;33 Suppl 2:S2–7.
  • Kishimoto Y, Wada K, Nakamoto K, Ashida K, Kamisaki Y, Kamisaki H, et al. Quantitative analysis of cyclooxygenase-2 gene expression on acute gastric injury induced by ischemia- reperfusion in rats. Life Sci 1997;60:127–33.
  • Konturek PC, Brzozowski T, Konturek SJ, Taut T, Sliwowski Z, Stachuro J, et al. Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage. Eur J Pharmacol 1998;343:55–65.
  • Cuzzocrea S, Wayman NS, Mazzon E, Dugo L, Di Paola R, Serraino I, et al. The cyclopentenone prostaglandin 15-deoxy- Delta(12,14)-prostaglandin J2 attenuates the development of acute and chronic inflammation. Mol Pharmacol 2002;61:997–1007.
  • Subbaramaiah K, Lin DT, Hart JC. Peroxisome proliferator- activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. J Biol Chem 2001;276: 12440–8.
  • Gronbech JE, Lacy ER. Role of gastric blood flow in impaired defense and repair of aged rat stomach. Am J Physiol 1995;269: G737–44.
  • Konturek PC, Brzozowski T, Sulekova Z, Meixner H, Hahn EG, Konturek SJ. Enhanced expression of leptin following acute gastric injury in rat. J Physiol Pharmacol 1999;50:587–95.
  • Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Dude A, Pienchalski P, et al. Leptin in gastroprotection induced by cholecystokinin or by a meal. Eur J Pharmacol 1999;373:263–76.
  • Konturek PC, Brzozowski T, Sulekova Z, et al. Role of leptin in ulcer healing. Eur J Pharmacol 2001;414:87–97.
  • De Vos P, Lefebvre AM, Miller SG, Guerre-Millo M, Wong K, Saladin R, et al. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 1996;98:1004–9.
  • Reasner CA. Promising new approaches. Diabetes Obes Metab 1999;Suppl 1:S41–8.

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