Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 38, 2003 - Issue 9
Submit an article Journal homepage
71
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Dysplasia in Fundic Gland Polyps is Associated with Nuclear β-Catenin Expression and Relatively High Cell Turnover Rates

Jalving M. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
,
Koornstra J. J. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
,
Boersma-van Ek W. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
,
de Jong S. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
,
Karrenbeld A. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
,
Hollema H. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
,
de Vries E. G. E. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
&
Kleibeuker J. H. Dept. of Gastroenterology and Hepatology, Medical Oncology and Pathology University Hospital Groningen Groningen The Netherlands
 show all
Pages 916-922 | Published online: 08 Jul 2009

  • Oberhuber G, Stolte M. Gastric polyps: an update of their pathology and biological significance. Virchows Arch 2000:437: 581-90.
  • Stolte M, Sticht T, Eidt S, Ebert D, Finkenzeller G. Frequency, location, and age and sex distribution of various types of gastric polyp. Endoscopy 1994:26:659-65.
  • Odze RD, Marcial MA, Antonioli D. Gastric fundic gland polyps: a morphological study including mucin histochemistry, stereometry, and MIB-I immunohistochemistry. Hum Pathol 1996:27:896-903.
  • Lynch HT, Smyrk T, McGinn T, Lanspa S, Cavalieri .1, Lynch .1, et al. Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP. Cancer 1995:76:2427-33.
  • Declich P, Isimbaidi G, Sironi M, Galli C, Ferrara A, Caruso S, et al. Sporadic fundic gland polyps: an immunohistochemical study of their antigenic profile. Pathol Res Pract 1996:1928:808-15.
  • Iida M, Yao T, Watanabe H, Itoh H, Iwashita A. Fundic gland polyposis in patients without familial adenomatosis coli: its incidence and clinical features. Gastroenterology 1984:86:1437-42.
  • Kinoshita Y, ToJo M, Yano T, Kitajima N, Itoh T, Nishiyama K, et al. Incidence of fundic gland polyps in patients without familial adenomatous polyposis. Gastrointest Endosc 1993:39: 161-3.
  • Burt RW, Berenson MM, Lee RG, Tolman KG, Freston JW, Gardner EJ. Upper gastrointestinal polyps in Gardner's syndrome. Gastroenterology 1984:86:295-301.
  • Domizio P, Talbot IC, Spigelman AD, Williams CB, Phillips RK. Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients. J Clin Pathol 1990:43:738-43.
  • Iida M, Yao T, Itoh H, Watanabe H, Kohrogi N, Shigematsu A, et al. Natural history of fundic gland polyposis in patients with familial adenomatosis coli/Gardner's syndrome. Gastroenterology 1985:89:1021-5.
  • Sarre RG, Frost AG, Jagelman DG, Petras RE, Sivak MV, McGannon E. Gastric and duodenal polyps in familial adenomatous polyposis: a prospective study of the nature and prevalence of upper gastrointestinal polyps. Gut 1987:28:306-14.
  • Sawada T, Muto T. Familial adenomatous polyposis: should patients undergo surveillance of the upper gastrointestinal tract? Endoscopy 1995:27:6-11.
  • Wu TT, Kornacki S, Rashid A, Yardley JH, Hamilton SR. Dysplasia and dysregulation of proliferation in foveolar and surface epithelia of fundic gland polyps from patients with familial adenomatous polyposis. Am J Surg Pathol 1998:22: 293-8.
  • Lee RG, Burt RW. The histopathology of fundic gland polyps of the stomach. Am J Clin Pathol 1986:86:498-503.
  • Coffey RJ, Jr, Knight CD, Jr, van Heerden JA, Weiland LH. Gastric adenocarcinoma complicating Gardner's syndrome in a North American woman. Gastroenterology 1985:88:1263-6.
  • Odze RD, Quinn PS, Terrault NA, Vivona AA, Ward MA, Cohen Z, et al. Advanced gastroduodenal polyposis with ras mutations in a patient with familial adenomatous polyposis. Hum Pathol 1993:24:442-8.
  • Lakshman V, Shah AN, Ryan CK. The presence of dysplasia and carcinoma in gastric fundic gland polyps in patients with familial adenomatous polyposis. Gastroenterology 1997:112:A599.
  • Zwick A, Munir M, Ryan CK, Gian J, Burt RW, Leppert M, et al. Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli. Gastroenterology 1997:113:659-63.
  • Hofgartner WT, Thorp M, Ramus MW, Delorefice G, Chey WY, Ryan CK, et al. Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis. Am J Gastroenterol 1999:94:2275-81.
  • McGarrity TJ, Ruggiero FM, Chey WY, Bajaj R, Kelly JE, Kauffman GL, Jr. Giant fundic polyp complicating attenuated familial adenomatous polyposis. Am J Gastroenterol 2000:95: 1824-8.
  • Attard TM, Giardiello FM, Argani P, Cuffari C. Fundic gland polyposis with high-grade dysplasia in a child with attenuated familial adenomatous polyposis and familial gastric cancer. J Pediatr Gastroenterol Nutr 2001:32:215-8.
  • Bertoni G, Sassatelli R, Nigrisoli E, Pennazio M, Tansini P, Arrigoni A, et al. Dysplastic changes in gastric fundic gland polyps of patients with familial adenomatous polyposis. Ital J Gastroenterol Hepatol 1999:31:192-7.
  • Abraham SC, Nohukawa B, Giardiello FM, Hamilton SR, Wu TT. Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations. Am J Pathol 2000:157:747-54.
  • Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR, Wu TT. Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene. Am J Pathol 2001:158:1005-10.
  • Goss KH, Groden J. Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol 2000:18:1967-79.
  • Shand AG, Taylor AC, Banerjee M, Lessels A, Coia J, Clark C, et al. Gastric fundic gland polyps in south-east Scotland: absence of adenomatous polyposis coli gene mutations and a strikingly low prevalence of Helicohacler pylori infection. J Gastroenterol Hepatol 2002:17:1161-4.
  • Abraham SC, Park SJ, Mugartegui L, Hamilton SR, Wu TT. Sporadic fundic gland polyps with epithelial dysplasia: evidence for preferential targeting for mutations in the adenomatous polyposis coli gene. Am J Pathol 2002:161:1735-42.
  • Watson SA. Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis. Lancet 2001:357:572-3.
  • Hamilton SR, Aaltonen LA. Tumours of the digestive system. WHO Classification. IARC Lyon; 2000. p. 47-8.
  • Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997:138:1379-94.
  • Miyazawa K, Iwaya K, Kuroda M, Harada M, Serizawa H, Koyanagi Y, et al. Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion. Virchows Arch 2000:437:508-13.
  • Miirakami K, Mitomi H, Yamashita K, Tanabe S, Saigenji K, Okayasu I. p53, hut not c-Ki-ras, mutation and down-regulation of p2IWAFl/CIPl and cyclin Dl are associated with malignant transformation in gastric hyperplastic polyps. Am J Clin Pathol 2001:115:224-34.
  • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997:88:323-31.
  • Declich P, Amhrosiani L, Bellone S, Tavani E, Sironi M. Do fundic gland polyps enter the mainstream of gastric carcino-genesis? Am J Gastroenterol 1998:93:2636.
  • Odze RD. Gastric fundic gland polyps: are they preneoplastic lesions? Gastroenterology 1998:114:422-3.
  • Toyooka M, Konishi M, Kikuchi-Yanoshita R, Iwama T, Miyaki M. Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis. Cancer Res 1995:55:3165-70.
  • Sekine S, Shibata T, Yamauchi Y, Nakanishi Y, Shimoda T, Sakamoto M, et al. Beta-Catenin mutations in sporadic fundic gland polyps. Virchows Arch 2002:440:381-6.
  • Evan G, Littlewood T. A matter of life and cell death. Science 1998:281:1317-22.
  • Kohayashi M, Honma T, Matsuda Y, Suzuki Y, Narisawa R, Ajioka Y, et al. Nuclear translocation of beta-catenin in colorectal cancer. Br J Cancer 2000:82:1689-93.
  • Kikuchi Y, Dinjens WN, Bosman FT. Proliferation and apoptosis in proliferative lesions of the colon and rectum. Virchows Arch 1997:431:111-7.
  • Mills SJ, Mathers JC, Chapman PD, Burn J, Gunn A. Colonie crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis. Gut 2001:48:41-6.
  • Wei J, Chirihoga L, Yee H, Mizaguchi M, Li E, Sidhu GS, et al. Altered cellular distribution of tuherin and glucocorticoid receptor in sporadic fundic gland polyps. Mod Pathol 2002:15: 862-9.
  • Choudhry U, Boyce HW, Jr, Coppola D. Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopie, histologie, and ultrastructural characteristics. Am J Clin Pathol 1998:110:615-21.
  • Graham JR. Omeprazole and gastric polyposis in humans. Gastroenterology 1993;104:1584.
  • Cats A, Schenk BE, Bloemena E, Roosedaal R, Eindeman J, Biemond I, et al. Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment. Hum Pathol 2000:31: 684-90.
  • Vieth M, Stolte M. Fundic gland polyps are not induced by proton pump inhibitor therapy. Am J Clin Pathol 2001:1 16:716-20.
  • Hirt M, Eee SW, Weinstein WM. Fundic gland polyps: a comparison of the omeprazole-associated and the sporadic types. Gastroenterology 1996:110:A135.
  • Stolte M, Bethke B, Seifen E, Armbrecht U, Lutke A, Goldbrunner P, et al. Observation of gastric glandular cysts in the corpus mucosa of the stomach under omeprazole treatment. Z Gastroenterol 1995:33:146-9.
  • Muehldorfer SM, Stolte M, Martus P, Hahn EG, Ell C. Diagnostic accuracy of forceps biopsy versus polypectomy for gastric polyps: a prospective multicentre study. Gut 2002:50:465-70.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.