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Article

Colitis up‐regulates local glucocorticoid activation and down‐regulates inactivation in colonic tissue

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Pages 549-553 | Received 30 May 2003, Accepted 21 Dec 2003, Published online: 08 Jul 2009

References

  • Brattsand R, Linden M. Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment Pharmacol Ther 1996;10 Suppl 2:81–90.
  • Bantel H, Schmitz ML, Raible A, Gregor M, Schulze-Osthoff K. Critical role of NK-KB stress-activated protein kinases in steroid unresponsiveness. FASEB J 2002;16:1832–4.
  • Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T, et al. Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 2000;118:859–66.
  • Schottelius A, Wedel S, Weltrich R, Rohde W, Buttgereit F, Schreiber S, et al. Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease. Am J Gastroenterol 2000;95:1994–9.
  • Shimada T, Hiwatashi N, Yamazaki H, Kinouchi Y, Toyota T. Relationship between glucocorticoid receptor and response to glucocorticoid therapy in ulcerative colitis. Dis Colon Rectum 1997;40 Suppl:S54–8.
  • Stewart PM, Krozowski ZS. 11 β-hydroxysteroid dehydrogenase. Vitam Horm 1999;57:249–324.
  • Escher G, Frey FJ, Frey BM. 11 β-hydroxysteroid dehydrogenase accounts for low prednisolone/prednisone ratios in the kidney. Endocrinology 1994;135: 101–6.
  • Siebe H, Baude G, Lichtenstein I, Wang D, Buhler H, Hoyer GA, et al. Metabolism of dexamethasone: sites and activity in mammalian tissues. Ren Physiol Biochem 1993;16:79–88.
  • Whorwood CB, Ricketts ML, Stewart PM. Epithelial cell localization of type 2 11 β-hydroxysteroid dehydrogenase in rat and human colon. Endocrinology. 1994;135: 2533–41.
  • Hammami MM, Siiteri PK. Regulation of 11 β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. J Clin Endocrinol Metab 1991;73:326–34.
  • Thieringer R, Le Grand CB, Carbin L, Cai T-Q, Wong B, Wright SD, et al. 11 β-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages. J Immunol 2001;167: 30–5.
  • Hennebold JD, Ryu S-Y, Mu H-H, Galbraith A, Daynes RA. 11 β-hydroxysteroid dehydrogenase modulation of glucocorticoid activities in lymphoid organs. Am J Physiol 1996; 270: R1296–R306.
  • Escher G, Galli I, Vishwanath BS, Frey BM, Frey FJ. Tumor necrosis factor α and interleukin 1β enhance the cortisone/ cortisol shuttle. J Exp Med 1997;186: 189–98.
  • Hennebold JD, Daynes RA. Inhibition of skin 11 β-hydroxysteroid dehydrogenase activity in vivo potentiates the anti-inflammatory actions of glucocorticoids. Arch Dermatol Res 1998/290: 413–9.
  • Cooper MS, Bujalska I, Rabbitt E, Walker EA, Bland R, Sheppard MC, et al. Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: An autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res 2001;16:1037–44.
  • Takahashi K-I, Fukushima K, Sasano H, Sasaki I, Matsuno S, Krozowski ZS, et al. Type II 11 β-hydroxysteroid dehydrogenase expression in human colonic epithelial cells of inflammatory bowel disease. Dig Dis Sci 1999;44: 2516–22.
  • Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989;96:795–803.
  • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990;98:694–702.
  • Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78: 206–9.
  • Pácha J, Mikšík I. 11 β-hydroxysteroid dehydrogenase in developing rat intestine. J Endocrinol 1996;148:561–6.
  • Mazancová K, Mikšík I, Kuneš J, Pácha J. Placental 11 β-hydroxysteroid dehydrogenase in Dahl and spontaneously hypertensive rats. Am J Hypertens 2003;16:401–6.
  • Laksmi V, Monder C. Purification and characterization of the corticosteroid 11 β-dehydrogenase component of the rat liver 11 β-hydroxysteroid dehydrogenase complex. Endocrinology 1988;123:2390–8.
  • Horigome H, Hirano T, Oka K. Therapeutic effect of glycyrrhetinic acid in MRL lpr/lpr mice. Implications of alteration of corticosteroid metabolism. Life Sci 2001;69:2429–38.
  • Collins SM, McHugh K, Jacobson K, Khan I, Riddell R, Murase K, et al. Previous inflammation alters the response of the rat colon to stress. Gastroenterology 1996;111:1509–15.
  • Colon AL, Menchen LA, Hurtado O, De Cristobal J, Lizasoain I, Leza JC, et al. Implication of TNF-α convertase (TACE/ ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Cytokine 2001;16: 220–6.
  • Cai T-Q, Wong B, Mundt SS, Thieringer R, Wright SD, Hermanowski-Vosatka A. Induction of 11 β-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli. J Steroid Biochem Mol Biol 2001; 77:117–22.
  • Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, et al. Regulation of expression of 11 β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 2001;142:1982–9.
  • Handoko K, Yang K, Strutt B, Khalil W, Killinger D. Insulin attenuates the stimulatory effects of tumor necrosis factor α on 11 β-hydroxysteroid dehydrogenase 1 in human adipose stromal cells. J Steroid Biochem Mol Biol 2000;72: 163–8.
  • Costas M, Trapp T, Pereda MP, Sauer J, Rupprecht R, Nahmod VE, et al. Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-α priming increases glucocorticoid inhibition of TNF-α-induced cytotoxicity/apoptosis. J Clin Invest. 1996;98:1409–16.

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