142
Views
25
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Effects of metronidazole and oligofructose on faecal concentrations of sulphate-reducing bacteria and their activity in human volunteers

, MD, , , &
Pages 1296-1303 | Received 15 Sep 2004, Published online: 08 Jul 2009

References

  • Pitcher MCL, Cummings JH. Hydrogen sulphide: a bacterial toxin in ulcerative colitis. Gut 1996; 39: 1–4
  • Smith L, Kryszyna H, Smith RP. The effect of methaemoglobin on the inhibition of cytochrome c oxidase by cyanide, sulfide or azide. Biochem Pharmacol 1977; 22: 47–50
  • Florin THJ, Neale G, Cummings JH. The effect of hydrogen sulphide on isolated colonic epithelium. Inflammatory bowel disease-progress in basic research and clinical implications. Falk Symp 1990; 60: 26
  • Roediger WEW, Duncan A, Kapaniris O, Millard S. Reducing sulfur compounds of the colon impairs colonocyte nutrition: implications for ulcerative colitis. Gastroenterology 1993; 104: 802–9
  • Roediger WEW, Duncan A, Kapaniris O, Millard S. Sulphide impairment of substrate oxidation in rat colonocytes: a biochemical basis for ulcerative colitis?. Clin Sci 1993; 85: 623–7
  • Kitano A, Kobayashi K, Oshiumi H, Ookawa K, Oka S, Tanaka Y, et al. Studies of experimental ulcerative colitis induced by carrageenan in rabbits. Jpn J Gastroenterol 1981; 78: 2104–211
  • Van De Waaji D, Cohen BJ, Anver MR. Mitigation of experimental inflammatory bowel disease in guinea pigs by selective elimination of the aerobic gram-negative intestinal microflora. Gastroenterology 1974; 67: 460–72
  • Onderdonk AB, Hermos JA, Dzink JL, Bartlett JG. Protective effect of metronidazole in experimental ulcerative colitis. Gastroenterology 1978; 74: 521–6
  • Onderdonk AB, Bartlett JG. Bacteriological studies of experimental ulcerative colitis. Am J Clin Nutr 1979; 32: 258–65
  • Ohkusa T, Yamada M, Takenaga T, Kitazume C, Yamamoto N, Sasabe M, et al. Protective effect of metronidazole in experimental ulcerative colitis induced by dextran sulfate sodium. Jpn J Gastroenterol 1987; 84: 2337–46
  • Magee EAM, Cummings JH. Fecal sulfide in the pathogenesis and treatment of ulcerative colitis. Gastroenterology 1997; 112: A891
  • Roediger WEW, Moore J, Babidge W. Colonic sulfide in pathogenesis and treatment of ulcerative colitis. Dig Dis Sci 1997; 42: 1571–9
  • Gibson GR, Beatty ER, Wang X, Cummings JH. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 1995; 108: 975–82
  • Wang X, Gibson GR. Effects of in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J Appl Bacteriol 1993; 75: 373–80
  • Gibson GR, Wang X. Regulatory effects of bifidobacteria on the growth of colonic bacteria. J Appl Bacteriol 1994; 77: 412–20
  • Beerens H. An elective and selective isolation medium for Bifidobacterium spp. Let Appl Microbiol 1990; 11: 155–7
  • Postgate JR. The sulphate-reducing bacteria. 2nd ed. Cambridge: Cambridge University Press; 1984.
  • Florin THJ, Neale G, Gibson GR, Christl SU, Cummings JH. Metabolism of dietary sulphate: absorption and excretion in humans. Gut 1991; 32: 766–73
  • Cline JD. Spectrophotometric determination of hydrogen sulfide in natural water. Limnol Oceanog 1969; 14: 454–8
  • MacFarlane GT, Gibson GR. Sulphate reducing bacteria. Anaerobic microbiology: a practical approach, PN Levett. Oxford University Press, Oxford 1991; 201–22
  • Spiller GA, Chernoff MC, Hill RA, Gates JE, Nassar JJ, Shipley EA. Effect of purified cellulose, pectin, and a low-residue diet on fecal volatile fatty acids, transit time, and fecal weight in humans. Am J Clin Nutr 1980; 33: 754–9
  • Christl SU, Gibson GR, Cummings JH. Role of dietary sulphate in the regulation of methanogenesis in the human large intestine. Gut 1992; 33: 1234–8
  • Pitcher MCL, Beatty ER, Cummings JH. The contribution of sulphate reducing bacteria and 5-aminosalicyclic acid to faecal sulphide in patients with ulcerative colitis. Gut 2000; 46: 64–72
  • Macfarlane GT, Cummings JH, Allison C. Protein degradation by human intestinal bacteria. J Gen Microbiol 1986; 132: 1647–56
  • Magee EAM, Richardson CJ, Hughes R, Cummings JH. Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humans. Am J Clin Nutr 2000; 72: 1488–94
  • Bauer JH. Oral administration of radioactive sulphate to measure extracellular fluid space in man. J Appl Physiol 1976; 40: 648–50
  • Moore JWE, Babidge W, Millard S, Roediger WEW. Colonic luminal hydrogen sulfide is not elevated in ulcerative colitis. Dig Dis Sci 1998; 43: 162–5
  • Pitcher MCL, Beatty ER, Gibson GR, Cummings JH. Incidence and activities of sulphate-reducing bacteria in patients with ulcerative colitis. Gut 1995; 36: A63
  • El Oufir E, Flourié B, Varannes SB, Barry JL, Cloarec D, Bornet F, et al. Relations between transit time, fermentation products, and hydrogen consuming flora in healthy humans. Gut 1996; 38: 870–7
  • Florin THJ, Khalil D, Lenarczyk A, Coweley DM. Sulfur metabolism in colons of carrageenan fed rats. J Gastroenterol Hepatol 1995; 10: A56
  • Levine J, Ellis CJ, Furne JK, Springfield J, Levitt MD. Fecal hydrogen sulfide production in ulcerative colitis. Am J Gastroenterol 1998; 93: 83–7
  • Chapman MAS, Grahn M, Boyle M, Hutton M, Rogers J, Williams NS. Butyrate metabolism is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. Gut 1994; 35: 73–6
  • Roediger WEW. The colonic epithelium in ulcerative colitis: An energy-deficiency disease. Lancet 1980; ii: 712–5
  • Chapman RW, Selby WS, Jewel DP. Controlled trial of metronidazole as an adjunct to corticosteroids in severe ulcerative colitis. Gut 1986; 27: 1210–2
  • Gibson GR, Cummings JH, MacFarlane GT. Growth and activities of sulphate-reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis. FEMS Microbiol Ecol 1991; 86: 103–12
  • Hristova KR, Mau M, Zheng D, Aminov RI, Mackie RI, Gaskins HR, et al. Desulfotomaculum genus- and subgenus-specific 16S rRNA hybridization probes for environmental studies. Environ Microbiol 2000; 2: 143–59
  • Zinkevich V, Beech IB. Screening of sulphate reducing bacteria in colonoscopy samples from healthy and colitic human gut mucosa. FEMS Microbiol Ecol 2000; 34: 147–55
  • Zinkevich V, Kang H, Bogdarina I, Hill MA, Beech IB. The characterisation of exopolymers produced by different species of marine sulphate-reducing bacteria. 1996; 37: 163–72

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.