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Functional Disorder

Serotoninergic and non-serotoninergic effects of two tricyclic antidepressants on visceral nociception in a rat model

, , , , & , FRACP , MD , MBA , FRCP
Pages 680-686 | Received 19 Nov 2008, Published online: 08 Jul 2009

References

  • Akehurst RL, Brazier JE, Mathers N, O'Keefe C, Kaltenthaler E, Morgan A, et al. Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting. PharmacoEconomics 2002; 20: 455–62
  • Chang, L. Review article: epidemiology and quality of life in functional gastrointestinal disorders. Aliment Pharmacol Therapeutics 2004;20(Suppl 7):31–9.
  • Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995; 109: 40–52
  • Clouse RE, Mayer EA, Aziz Q, Drossman DA, Dumitrascu DL, Monnikes H, et al. Functional abdominal pain syndrome. Gastroenterology 2006; 130: 1492–7
  • Cremonini F, Talley NJ. Diagnostic and therapeutic strategies in the irritable bowel syndrome. Minerva Medica 2004; 95: 427–41
  • Tillisch K, Chang L. Diagnosis and treatment of irritable bowel syndrome: state of the art. Curr Gastroenterol Reports 2005; 7: 249–56
  • Crowell MD, Jones MP, Harris LA, Dineen TN, Schettler VA, Olden KW. Antidepressants in the treatment of irritable bowel syndrome and visceral pain syndromes. Curr Opin Invest Drugs 2004; 5: 736–42
  • Quartero, AO, Meineche-Schmidt, V, Muris, J, Rubin, GN dW. Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews 2005.
  • Drossman DA, Toner BB, Whitehead WE, Diamant NE, Dalton CB, Duncan S, et al. Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003; 125: 19–31
  • Clouse RE, Lustman PJ, Geisman RA, Alpers DH. Antidepressant therapy in 138 patients with irritable bowel syndrome: a five-year clinical experience. Aliment Pharmacol Therapeutics 1994; 8: 409–16
  • Gorard DA, Libby GW, Farthing MJ. Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant irritable bowel syndrome. Dig Dis Sci 1995; 40: 86–95
  • Poitras P, Riberdy Poitras M, Plourde V, Boivin M, Verrier P. Evolution of visceral sensitivity in patients with irritable bowel syndrome. Dig Dis Sci 2002; 47: 914–20
  • Bahar RJ, Collins BS, Steinmetz B, Ament ME. Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. J Pediatr 2008; 152: 685–9
  • Choi S, Park CG, Kim MY, Lim GH, Kim JH, Yeum CH, et al. Action of imipramine on activated ATP-sensitive K(+) channels in interstitial cells of Cajal from murine small intestine. Life Sci 2006; 78: 2322–8
  • Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132: 397–414
  • Tack J, Fried M, Houghton LA, Spicak J, Fisher G. Systematic review: the efficacy of treatments for irritable bowel syndrome – a European perspective. Aliment Pharmacol Therapeutics 2006; 24: 183–205
  • Talley NJ, Kellow JE, Boyce P, Tennant C, Huskic S, Jones M. Antidepressant therapy (imipramine and citalopram) for irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial. Dig Dis Sci 2008; 53: 108–15
  • Adam B, Liebregts T, Best J, Bechmann L, Lackner C, Neumann J, et al. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model. Scand J Gastroenterol 2006; 41: 155–60
  • Ness TJ, Gebhart GF. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Res 1988; 450: 153–69
  • Ghelardini C, Galeotti N, Bartolini A. Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors. Jpn J Pharmacol 2000; 82: 130–7
  • Spiegel K, Kalb R, Pasternak GW. Analgesic activity of tricyclic antidepressants. Ann Neurol 1983; 13: 462–5
  • Bulpitt CJ, Dollery CT. Side effects of hypotensive agents evaluated by a self-administered questionnaire. Br Med J 1973; 3: 485–90
  • Greenbaum DS, Mayle JE, Vanegeren LE, Jerome JA, Mayor JW, Greenbaum RB, et al. Effects of desipramine on irritable bowel syndrome compared with atropine and placebo. Dig Dis Sci 1987; 32: 257–66
  • Kawamata T, Omote K, Kawamata M, Namiki A. Analgesic effect of intrathecal desipramine on carrageenan-induced thermal hyperalgesia in the rat. Br J Anaesth 1999; 83: 449–52
  • Gershon MD, Jonakait GM. Uptake and release of 5-hydroxytryptamine by enteric 5-hydroxytryptaminergic neurones: effects of fluoxetine (Lilly 110140) and chlorimipramine. Br J Pharmacol 1979; 66: 7–9
  • Burton MB, Gebhart GF. Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation. J Pharmacol Exp Ther 1998; 285: 707–15
  • Liebregts T, Adam B, Bertel A, Jones S, Schulze J, Enders C, et al. Effect of E. coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model. Neurogastroenterol Motil 2005; 17: 410–4
  • Halpert A, Dalton CB, Diamant NE, Toner BB, Hu Y, Morris CB, et al. Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage. Am J Gastroentero 2005; 100: 664–71
  • Akah PA, Tayo FM. Interactions of 5-hydroxytryptamine and tricyclic antidepressants in the rat stomach strip and the guinea-pig ileum. Arch Int Pharmacodyn Ther 1985; 274: 201–9
  • Bae SK, Yang KH, Aryal DK, Kim YG, Lee MG. Pharmacokinetics of amitriptyline and one of its metabolites, nortriptyline, in rats: little contribution of considerable hepatic first-pass effect to low bioavailability of amitriptyline due to great intestinal first-pass effect. J Pharm Sci. 2009 Apr; 98(4)1587–601
  • Rodriguez de la Torre B, Dreher J, Malevany I, Bagli M, Kolbinger M, Omran H, et al. Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients. Ther Drug Mon 2001; 23: 435–40
  • Coudoré F, Besson A, Shrivastava R, Chevalier A, Eschalier A, Lavarenne J, et al. Comparison of amitriptyline metabolism in hepatocytes from streptozocin-induced diabetic rats and from non-diabetic rats. Cell Biol Toxicol 1997; 13: 131–7
  • Coudoré F, Besson A, Eschalier A, Lavarenne J, Fialip J. Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats. Gen Pharmacol 1996; 27: 215–9
  • Adam B, Liebregts T, Gschossmann JM, Krippner C, Scholl F, Ruwe M, et al. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Pain 2006; 123: 179–86
  • Coutinho SV, Plotsky PM, Sablad M, Miller JC, Zhou H, Bayati AI, et al. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol 2002; 282: G307–16
  • MacQueen GM, Ramakrishnan K, Ratnasingan R, Chen B, Young LT. Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation. Int J Neuropsychopharmacol 2003; 6: 391–6
  • Ghia JE, Blennerhassett P, Collins SM. Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression. J Clin Invest 2008; 118: 2209–18
  • Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ. It doesn't do any harm, but patients feel better”: a qualitative exploratory study on gastroenterologists’ perspectives on the role of antidepressants in inflammatory bowel disease. BMC Gastroenterol 2007; 7: 38
  • Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 2005; 54: 601–7
  • Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J Pain 2008; 9: 497–505
  • Akil H, Liebeskind JC. Monoaminergic mechanisms of stimulation-produced analgesia. Brain Res 1975; 94: 279–96
  • Jensen TS, Smith DF. Role of 5-HT and NA in spinal dopaminergic analgesia. Eur J Pharmacol 1982; 86: 65–70
  • Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, et al. Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J Pharmacol Expe Ther 2007; 321: 1208–25

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