Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 53, 2018 - Issue 2
Submit an article Journal homepage
301
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Re-evaluating osteoporosis and fracture risk in Crohn’s disease patients in the era of TNF-alpha inhibitors

Shahrad HakimianDepartment of Medicine, UMass Memorial Medical Center, Worcester, MA, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-1995-5440
ORCID Icon,
Joan KhederDivision of Gastroenterology, UMass Memorial Medical Center, Worcester, MA, USA;
,
Seth ArumDivision of Endocrinology, UMass Memorial Medical Center, Worcester, MA, USA
,
David R. CaveDivision of Gastroenterology, UMass Memorial Medical Center, Worcester, MA, USA;
&
Benjamin HyattDivision of Gastroenterology, UMass Memorial Medical Center, Worcester, MA, USA;
Pages 168-172 | Received 15 Nov 2017, Accepted 06 Dec 2017, Published online: 13 Dec 2017

References

  • Compston JE, Judd D, Crawley EO, et al. Osteoporosis in patients with inflammatory bowel disease. Gut. 1987;28:410–415.
  • Klaus J, Armbrecht G, Steinkamp M, et al. High prevalence of osteoporotic vertebral fractures in patients with Crohn's disease. Gut. 2002;51:654–658.
  • Bernstein CN, Leslie WD, Leboff MS. AGA technical review on osteoporosis in gastrointestinal diseases. Gastroenterology. 2003;124:795–841.
  • Ali T, Lam D, Bronze MS, et al. Osteoporosis in inflammatory bowel disease. Am J Med. 2009;122:599–604.
  • Targownik LE, Bernstein CN, Leslie WD. Inflammatory bowel disease and the risk of osteoporosis and fracture. Maturitas. 2013;76:315–319.
  • Ghishan FK, Kiela PR. Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol. 2011;300:G191–G201.
  • Daniell HW. Osteoporosis and smoking. JAMA. 1972;221:509
  • Smith R. Corticosteroids and osteoporosis. Thorax. 1990;45:573–578.
  • Vestergaard P. Epilepsy, osteoporosis and fracture risk – a meta-analysis. Acta Neurol Scand. 2005;112:277–286.
  • Winkler A, Pressly TA, Wilson D. Androgen deficient osteoporosis. Mo Med. 1988;85:84–86.
  • Andersen BN, Johansen PB, Abrahamsen B. Proton pump inhibitors and osteoporosis. Curr Opin Rheumatol. 2016;28:420–425.
  • Zheng SX, Vrindts Y, Lopez M, et al. Increase in cytokine production (IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis. Maturitas. 1997;26:63–71.
  • Sang C, Zhang J, Zhang Y, et al. TNF-alpha promotes osteoclastogenesis through JNK signaling-dependent induction of Semaphorin3D expression in estrogen-deficiency induced osteoporosis. J Cell Physiol. 2017;232:3396–3408.
  • Veerappan SG, O'Morain CA, Daly JS, et al. Review article: the effects of antitumour necrosis factor-alpha on bone metabolism in inflammatory bowel disease. Aliment Pharmacol Ther. 2011;33:1261–1272.
  • Azzopardi N, Ellul P. Risk factors for osteoporosis in Crohn's disease: infliximab, corticosteroids, body mass index, and age of onset. Inflamm Bowel Dis. 2013;19:1173–1178.
  • Sugimoto K, Ikeya K, Iida T, et al. An increased serum N-Terminal telopeptide of type i collagen, a biochemical marker of increased bone resorption, is associated with infliximab therapy in patients with Crohn's disease. Dig Dis Sci. 2016;61:99–106.
  • Nielsen OH, Ainsworth MA. Tumor necrosis factor inhibitors for inflammatory bowel disease. N Engl J Med. 2013;369:754–762.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–1930.
  • Malutan AM, Dan M, Nicolae C, et al. Proinflammatory and anti-inflammatory cytokine changes related to menopause. Prz Menopauzalny. 2014;13:162–168.
  • Pacifici R. T cells and post menopausal osteoporosis in murine models. Arthritis Res Ther. 2007;9:102.
  • Roggia C, Gao Y, Cenci S, et al. Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci USA. 2001;98:13960–13965.
  • Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995;332:305–311.
  • Abreu MT, Geller JL, Vasiliauskas EA, et al. Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease. J Clin Gastroenterol. 2006;40:55–63.
  • Veerappan SG, Healy M, Walsh BJ, et al. Adalimumab therapy has a beneficial effect on bone metabolism in patients with Crohn's disease. Dig Dis Sci. 2015;60:2119–2129.
  • Veerappan SG, Healy M, Walsh B, et al. A 1-year prospective study of the effect of infliximab on bone metabolism in inflammatory bowel disease patients. Eur J Gastroenterol Hepatol. 2016;28:1335–1344.
  • Krieckaert CL, Nurmohamed MT, Wolbink G, et al. Changes in bone mineral density during long-term treatment with adalimumab in patients with rheumatoid arthritis: a cohort study. Rheumatology (Oxford). 2013;52:547–553.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.