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Scandinavian Journal of Gastroenterology Volume 56, 2021 - Issue 5
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Original Article

Increased use of biologics in the era of TNF-α inhibitors did not reduce surgical rate but prolonged the time from diagnosis to first time intestinal resection among patients with Crohn’s disease and ulcerative colitis – a Danish register-based study from 2003–2016

Niels Qvista Research Unit for Surgery and IBD-Care, Odense University Hospital, Odense, Denmark;;b University of Southern Denmark, Odense, DenmarkCorrespondence[email protected]
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,
Kasper Vadstrupc Janssen-Cilag, Birkerød, DenmarkView further author information
,
Sarah Alulisc Janssen-Cilag, Birkerød, DenmarkView further author information
,
Andras Borsid Janssen-Cilag, High Wycombe, United KingdomORCID Iconhttps://orcid.org/0000-0003-4612-9830View further author information
ORCID Icon,
Pia Munkholme Gastroenterology Department, North Zealand University Hospital, Frederikssund, DenmarkORCID Iconhttps://orcid.org/0000-0002-7263-1122View further author information
ORCID Icon &
Jens Olsenf Incentive, Holte, DenmarkView further author information
Pages 537-544 | Received 05 Jan 2021, Accepted 24 Feb 2021, Published online: 18 Mar 2021

References

  • Olivera P, Spinelli A, Gower-Rousseau C, et al. Surgical rates in the era of biological therapy: up, down or unchanged? Curr Opin Gastroenterol. 2017;33(4):246–253.
  • Frolkis AD, Dykeman J, Negron ME, et al. Risk of surgery for inflammatory bowel disease has decreased over time. A systematic review and meta-analysis of population-based studies. Gastroenterology. 2013;145(5):996–1006.
  • Rungø C, Langholz E, Andersson M, et al. Changes in medical treatment and surgery rates in inflammatory bowel disease. A nationwide cohort study 1979-2011. Gut. 2014;63(10):1607–1616.
  • Guasch M, Canete F, Ordas I, et al. Changes in the requirement for early surgery in inflammatory bowel disease in the era of biological agents. J Gastroenterol Hepatol. 2020;35(12):2080–2087.
  • Kotze PG, Underwood FE, Damiao AOMC, et al. Progression of inflammatory bowel disease in the era of biological agents. J Gastroenterol Hepatol. 2020;18:304–312.
  • Rahman A, Jairath V, Feagan BG, et al. Declining hospitalization and surgical intervention rates in patients with Crohn’s disease. A population-based cohort. Aliment Pharmacol Ther. 2019;50(10):1086–1093.
  • Larsen MD, Qvist N, Nielsen J, et al. Use of anti-TNFα agents and time to first-time surgery in paediatric patients with ulcerative colitis and Crohn’s disease. J Crohns Colitis. 2016;10(6):650–656.
  • Kuenzig ME, Benchimol EL, Lee L, et al. The impact of inflammatory bowel disease in Canada 2018. Direct costs and health service utilization. J Can Ass Gastroenterol. 2019;2(1):S17–S33.
  • Murthy SK, Begum J, Benchimol E, et al. Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study. Gut. 2020;69(2):274–282.
  • Bouguen G, Peyrin-Biourlet L. Surgery for adult Crohn’s disease: what is the actual risk? Gut. 2011;60(9):1178–1181.
  • Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health. 2011;39(7):30–33.
  • Alulis S, Vadstrup K, Borsi A, et al. Treatment patterns for biologics in ulcerative colitis and Crohn’s disease: a Danish Nationwide Register Study from 2003 to 2015. Scand J Gastroenterol. 2020;55(3):265–271.
  • Rutgeerts P, Feagan BG, Lichtenstein GR, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease. Gastroenterology. 2004;126(2):402–413.
  • Feagan BG, Panaccione R, Sandborn WJ, et al. Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn’s disease. Results from the CHARM Study. Gastroenterology. 2008;135(5):1493–1499.
  • Worsley G, Almoudaris A, Bassett P, et al. Colectomy rates for ulcerative colitis in England 2003-2016. Aliment Pharmacol Ther. 2021;53(4):484–498.
  • Eberhardson M, Söderling JK, Neovius M, et al. Anti-TNF treatment in Crohn’s disease and risk of bowel resection. A population based cohort study. Aliment Pharmacol Ther. 2017;46(6):589–598.
  • Kalman TD, Everhov ÅH, Nordenvall C, et al. Decrease in primary but not in secondary abdominal surgery for Crohn’s disease. Nationwide Cohort Study, 1990-2014. Br J Surg. 2020;107(11):1529–1538.
  • Schmidt M, Schmidt SAJ, Sandegaard JL, et al. The Danish national patient registry. A review of contents, data quality, and research potential. Clin Epidemiol. 2015;7:449–490.

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