1,720
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Therapeutic drug monitoring in inflammatory bowel disease: implementation, utilization, and barriers in clinical practice in Scandinavia

ORCID Icon, ORCID Icon, , , , , , , , , , & show all
Pages 25-33 | Received 26 Jun 2022, Accepted 29 Jul 2022, Published online: 23 Aug 2022

References

  • Ungaro R, Mehandru S, Allen PB, et al. Ulcerative colitis. Lancet. 2017;389(10080):1756–1770.
  • Torres J, Mehandru S, Colombel JF, et al. Crohn's disease. Lancet. 2017;389(10080):1741–1755.
  • Kennedy NA, Heap GA, Green HD, et al. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal crohn's disease: a prospective, multicentre, cohort study. Lancet Gastroenterol Hepatol. 2019;4(5):341–353.
  • Colombel JF, D'Haens G, Lee WJ, et al. Outcomes and strategies to support a treat-to-target approach in inflammatory bowel disease: a systematic review. J Crohns Colitis. 2020;14(2):254–266.
  • Colombel JF, Panaccione R, Bossuyt P, et al. Effect of tight control management on crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet. 2017;390(10114):2779–2789.
  • Singh S, Murad MH, Fumery M, et al. First- and second-line pharmacotherapies for patients with moderate to severely active ulcerative colitis: an updated network meta-analysis. Clin Gastroenterol Hepatol. 2020;18(10):2179–2191.e6.
  • Steenholdt C, Brynskov J, Thomsen OO, et al. Individualised therapy is more cost-effective than dose intensification in patients with Crohn's disease who lose response to anti-TNF treatment: a randomised, controlled trial. Gut. 2014;63(6):919–927.
  • Papamichael K, Chachu KA, Vajravelu RK, et al. Improved long-term outcomes of patients with inflammatory bowel disease receiving proactive compared with reactive monitoring of serum concentrations of infliximab. Clin Gastroenterol Hepatol. 2017;15(10):1580–1588.e3.
  • Papamichael K, Vajravelu RK, Vaughn BP, et al. Proactive infliximab monitoring following reactive testing is associated with better clinical outcomes than reactive testing alone in patients with inflammatory bowel disease. J Crohns Colitis. 2018;12(7):804–810.
  • Vande Casteele N, Ferrante M, Van Assche G, et al. Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease. Gastroenterology. 2015;148(7):1320–1329 e3.
  • Steenholdt C, Bendtzen K, Brynskov J, et al. Optimizing treatment with TNF inhibitors in inflammatory bowel disease by monitoring drug levels and antidrug antibodies. Inflamm Bowel Dis. 2016;22(8):1999–2015.
  • Papamichael K, Afif W, Drobne D, International Consortium for Therapeutic Drug Monitoring, et al. Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives. Lancet Gastroenterol Hepatol. 2022;7(2):171–185.
  • Patel RN, Nigam GB, Jatale RG, et al. An Indian national survey of therapeutic drug monitoring with anti-tumor necrosis (TNF) medications in inflammatory bowel disease. Indian J Gastroenterol. 2020;39(2):176–185.
  • Grossberg LB, Papamichael K, Feuerstein JD, et al. A survey study of gastroenterologists' attitudes and barriers Toward therapeutic drug monitoring of Anti-TNF therapy in inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(1):191–197.
  • Nigam GB, Patel RN, Jatale RG, et al. UK national survey of gastroenterologists’ attitudes and barriers toward therapeutic drug monitoring of anti-TNF therapy in inflammatory bowel disease. Frontline Gastroenterology. 2020;158(6):S-246.
  • Samaan MA, Arkir Z, Ahmad T, et al. Wide variation in the use and understanding of therapeutic drug monitoring for anti-TNF agents in inflammatory bowel disease: an inexact science? Expert Opin Biol Ther. 2018;18(12):1271–1279.
  • Thomas PWA, Chin PKL, Barclay ML. A nationwide survey on therapeutic drug monitoring of anti-tumour necrosis factor agents for inflammatory bowel disease. Intern Med J. 2021;51(3):341–347.
  • Papamichael K, Cheifetz AS, Melmed GY, et al. Appropriate therapeutic drug monitoring of biologic agents for patients With inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2019;17(9):1655–1668 e3.
  • Feuerstein JD, Nguyen GC, Kupfer SS, American Gastroenterological Association Institute Clinical Guidelines Committee, et al. American gastroenterological association institute guideline on therapeutic drug monitoring in inflammatory bowel disease. Gastroenterology. 2017;153(3):827–834.
  • Lamb CA, Kennedy NA, Raine T, IBD guidelines eDelphi consensus group, et al. British society of gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019;68(Suppl 3):s1–s106.
  • Steinhart AH, Panaccione R, Targownik L, et al. Clinical practice guideline for the medical management of perianal fistulizing Crohn's disease: the Toronto consensus. Inflamm Bowel Dis. 2019;25(1):1–13.
  • Cheifetz AS, Abreu MT, Afif W, et al. A comprehensive literature review and expert consensus statement on therapeutic drug monitoring of biologics in inflammatory bowel disease. Am J Gastroenterol. 2021;116(10):2014–2025.
  • Vande Casteele N, Feagan BG, Wolf DC, et al. Therapeutic drug monitoring of tumor necrosis factor antagonists in crohn disease: a theoretical construct to apply pharmacokinetics and guidelines to clinical practice. Inflamm Bowel Dis. 2020;27(8):1346–1355.
  • Mitrev N, Vande Casteele N, Seow CH, IBD Sydney Organisation and the Australian Inflammatory Bowel Diseases Consensus Working Group, et al. Review article: consensus statements on therapeutic drug monitoring of anti-tumour necrosis factor therapy in inflammatory bowel diseases. Aliment Pharmacol Ther. 2017;46(11-12):1037–1053.
  • Sparrow MP, Papamichael K, Ward MG, et al. Therapeutic drug monitoring of biologics During induction to prevent primary Non-Response. J Crohns Colitis. 2020;14(4):542–556.
  • Torres J, Bonovas S, Doherty G, et al. ECCO guidelines on therapeutics in Crohn's disease: medical treatment. J Crohns Colitis. 2020;14(1):4–22.
  • Syversen SW, Jørgensen KK, Goll GL, et al. Effect of therapeutic drug monitoring vs standard therapy during maintenance infliximab therapy on disease control in patients with immune-mediated inflammatory diseases: a randomized clinical trial. Jama. 2021;326(23):2375–2384.
  • Fernandes SR, Bernardo S, Simoes C, et al. Proactive infliximab drug monitoring Is superior to conventional management in inflammatory bowel disease. Inflamm Bowel Dis. 2020;26(2):263–270.
  • Sánchez-Hernández JG, Rebollo N, Martin-Suarez A, et al. A 3-year prospective study of a multidisciplinary early proactive therapeutic drug monitoring programme of infliximab treatments in inflammatory bowel disease. Br J Clin Pharmacol. 2020;86(6):1165–1175.
  • Coskun M, Steenholdt C, de Boer NK, et al. Pharmacology and optimization of thiopurines and methotrexate in inflammatory bowel disease. Clin Pharmacokinet. 2016;55(3):257–274.
  • Kothari MM, Nguyen DL, Parekh NK. Strategies for overcoming anti-tumor necrosis factor drug antibodies in inflammatory bowel disease: case series and review of literature. World J Gastrointest Pharmacol Ther. 2017;8(3):155–161.
  • Syversen SW, Goll GL, Jørgensen KK, et al. Effect of therapeutic drug monitoring vs standard therapy during infliximab induction on disease remission in patients with chronic immune-mediated inflammatory diseases: a randomized clinical trial. JAMA. 2021;325(17):1744–1754.
  • Van Stappen T, Bollen L, Vande Casteele N, et al. Rapid test for infliximab drug concentration allows immediate dose adaptation. Clin Transl Gastroenterol. 2016;7(12):e206.
  • Verstockt B, Moors G, Bian S, et al. Influence of early adalimumab serum levels on immunogenicity and long-term outcome of anti-TNF naive Crohn's disease patients: the usefulness of rapid testing. Aliment Pharmacol Ther. 2018;48(7):731–739.
  • Hindorf U, Andersson P. How are thiopurines used and monitored by swedish gastroenterologists when treating patients with inflammatory bowel disease? Scand J Gastroenterol. 2011;46(10):1215–1221.
  • Cui G, Fan Q, Li Z, et al. Evaluation of anti-TNF therapeutic response in patients with inflammatory bowel disease: current and novel biomarkers. EBioMedicine. 2021;66:103329.
  • Bendtzen K, Ainsworth M, Steenholdt C, et al. Individual medicine in inflammatory bowel disease: monitoring bioavailability, pharmacokinetics and immunogenicity of anti-tumour necrosis factor-alpha antibodies. Scand J Gastroenterol. 2009;44(7):774–781.
  • Gibson DJ, Ward MG, Rentsch C, et al. Review article: determination of the therapeutic range for therapeutic drug monitoring of adalimumab and infliximab in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2020;51(6):612–628.
  • Shukla R, Ananthakrishnan A. Therapeutic drug monitoring of Non-Anti-Tumor necrosis factor biologics. Clin Gastroenterol Hepatol. 2021;19(6):1108–1110.
  • Vande Casteele N, Herfarth H, Katz J, et al. American gastroenterological association institute technical review on the role of therapeutic drug monitoring in the management of inflammatory bowel diseases. Gastroenterology. 2017;153(3):835–857.e6.