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Microbiome alterations in pancreatic cancer: new insights and potential clinical implications

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Pages 202-203 | Received 29 Aug 2023, Accepted 14 Sep 2023, Published online: 27 Sep 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660.
  • Bengtsson A, Andersson R, Ansari D. The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data. Sci Rep. 2020;10(1):16425. doi: 10.1038/s41598-020-73525-y.
  • Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, et al. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell 2022;185(20):3789–3806 e3717. doi: 10.1016/j.cell.2022.09.005.
  • Dohlman AB, Klug J, Mesko M, et al. A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell 2022;185(20):3807–3822 e3812. doi: 10.1016/j.cell.2022.09.015.
  • Zong Z, Zhou F, Zhang L. The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses. Signal Transduct Target Ther. 2023;8:50.
  • Pushalkar S, Hundeyin M, Daley D, et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 2018;8(4):403–416. doi: 10.1158/2159-8290.CD-17-1134.
  • Aykut B, Pushalkar S, Chen R, et al. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 2019;574(7777):264–267. doi: 10.1038/s41586-019-1608-2.
  • Alam A, Levanduski E, Denz P, et al. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell. 2022;40(2):153–167 e111. doi: 10.1016/j.ccell.2022.01.003.
  • Nagata N, Nishijima S, Kojima Y, et al. Metagenomic identification of microbial signatures predicting pancreatic cancer from a multinational study. Gastroenterology 2022;163(1):222–238. doi: 10.1053/j.gastro.2022.03.054.
  • Kartal E, Schmidt TSB, Molina-Montes E, et al. A faecal microbiota signature with high specificity for pancreatic cancer. Gut 2022;71(7):1359–1372. doi: 10.1136/gutjnl-2021-324755.
  • Riquelme E, Zhang Y, Zhang L, et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell 2019;178(4):795–806 e712. doi: 10.1016/j.cell.2019.07.008.
  • Geller LT, Barzily-Rokni M, Danino T, et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science 2017;357(6356):1156–1160. doi: 10.1126/science.aah5043.

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