References
- Allan RN, Rhodes JM, Hanauer SB, Keighley MRB, AlexanderWilliams J, Fazio VW, editors. Inflammatory bowel diseases. 3rd ed. New York: Churchill Livingstone; 1997.
- Roth M-P, Petersen GM, McElree C, Vadheim CM, Panish JF, Rotter JI. Familial empiric risk estimates of inflammatory bowel disease in Ashkenazi Jews. Gastroenterology 1989;96:1016–20.
- Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn’s disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988;29:990–6.
- Orholm M, Munkholm P, Langholtz E, Neilsen OH, Sørensen TIA, Binder V. Familial occurence of inflammatory bowel disease. N Engl J Med 1991;324:84–8.
- McLeod RS, Steinhart AH, Siminovitch KA, Greenberg GR, Bull SB, Blair JE, et al. Preliminary report on the Mount Sinai Hospital Inflammatory Bowel Disease Genetics Project. Dis Colon Rectum 1997;40:553–7.
- Lee JC, Lennard-Jones JE. Inflammatory bowel disease in 67 families each with three or more affected first-degree relatives. Gastroenterology 1996;111:587–96.
- Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, et al. Mapping of a susceptibility locus for Crohn’s disease on chromosome 16 [see comments]. Nature 1996;379:821–3.
- Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996;14:199–202.
- Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095–147.
- Nakamura M, Saito H, Kasanuki J, Tamura Y, Yoshida S. Cytokine production in patients with inflammatory bowel disease. Gut 1992;33:933–7.
- Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clin Exp Immunol 1993;94:174–181.
- McCall RD, Haskill S, Zimmermann EM, Lund PK, Thompson RC, Sartor RB. Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats. Gastroenterology 1994;106:960–72.
- Hyams JS, Fitzgerald JE, Wyzga N, Muller R, Treem WR, Justinich CJ, et al. Relationship of interleukin-1 receptor antagonist to mucosal inflammation in inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1995;21:419–25.
- Cominelli F, Kam L, Casini-Raggi V, Jin Y. Specific mucosal imbalance of IL-1 and IL-1 receptor antagonist (IL-1ra) in IBD: a potential mechanism of chronic inflammation. Gastroenterology 1994;106:A667.
- Andus T, Gross VJS. Elevated circulatory interleukin-1 receptor antagonist levels in serum of patients with active Crohn’s disease and ulcerative colitis. Gastroenterology 1995;104:A660.
- Casini-Raggi V, Kam L, Chong YJ, Fiocchi C, Pizarro TT, Cominelli F. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J Immunol 1995;154: 2434–40.
- Mansfield JC, Holden H, Tarlow JK, Di Giovine FS, McDowell TL, Wilson AG, et al. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin- 1 receptor antagonist. Gastroenterology 1994;106: 637–42.
- Tountas NA, Kam L, DiGiovine FS, Casini-Raggi V, Cominelli F. Genetic association between allele 2 of IL-1 receptor antagonist (Il-1ra) and ulcerative colitis (UC) in a Los Angeles based hispanic population. Gastroenterology 1995;108:A930.
- Duerr RH, Tran T. Association between ulcerative colitis and a polymorphism in intron 2 of the interleukin-1 receptor antagonist gene. Gastroenterology 1995;108:A812.
- Bioque G, Bouma G, Crusius JB, Koutroubakis I, Kostense PJ, Meuwissen SG, et al. Evidence of genetic heterogeneity in IBD. I. The interleukin-1 receptor antagonist in the predisposition to suffer from ulcerative colitis. Eur J Gastroenterol Hepatol 1996;8:105–10.
- Tountas NA, Yang H, Coulter DL, Rotter JI, Cominelli F. Increased carriage of allele 2 of IL-1 receptor antagonist (IL-1ra) in jewish populations: the strongest known genetic association in ulcerative colitis. Gastroenterology 1996;110:A1029.
- Hacker UT, Gomolka M, Keller E, Eigler A, Folwaczny C, Fricke H, et al. Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis. Gut 1997;40:623–7.
- Bioque G, Crusius JB, Koutroubakis I, Bouma G, Kostense PJ, Meuwissen SG, et al. Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease. Clin Exp Immunol 1995;102:379–83.
- Heresbach D, Alizadeh M, Dabadie A, Le Berre N, Colombel JF, Yaouanq J, et al. Significance of interleukin-1beta and interleukin-1 receptor antagonist genetic polymorphism in inflammatory bowel diseases. Am J Gastroenterol 1997;92: 1164–9.
- Hacker UT, Bidlingmaier C, Gomolka M, Keller E, Eigler A, Hartmann G, et al. Inflammatory bowel disease: no association between allele combinations of the interleukin (IL)-I beta and IL-I receptor antagonist gene polymorphisms. Eur J Clin Invest 1998;28:214–9.
- Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol 1989;24 Suppl 170:2–6; discussion 16–19.
- Pociot F, Molvig J, Wogensen L, Worsaae HJN. A TaqI polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur J Clin Invest 1992;22:396–402.
- Koeleman BPC, Reitsma PH, Burton RM. Linkage mapping around the PORCH gene. Cytogenet Cell Genet 1993;64:A:89.
- Tarlow JK, Blakemore AI, Lennard A, Solari R, Hughes HN, Steinkasserer A, et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 1993;91:403–4.
- Cramer H Mathematical methods of statistics. Princeton (NJ): Princeton University Press; 1954. Chapter 30. p. 416–51.
- Louis E, Satsangi J, Roussomoustakaki M, Parkes M, Fanning G, Welsh K, et al. Cytokine gene polymorphisms in inflammatory bowel disease. Gut 1996;39:705–10.
- Roussomoustakaki M, Satsangi J, Welsh K, Louis E, Fanning G, Targan S, et al. Genetic markers may predict disease behavior in patients with ulcerative colitis. Gastroenterology 1997;112:1845–53.