10
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Prognostic Value of Single Measurements of Beta-2-microglobulin, Immunoglobulin A in HIV Disease After Controlling for CD4 Lymphocyte Counts and Plasma HIV RNA Levels

Pages 371-376 | Published online: 08 Jul 2009

  • Cooper EH, Forbes MA, Hambling MH. Serum beta 2-microglobulin and C reactive protein concentrations in viral infections. J Clin Pathol 1984; 37: 1140–3.
  • Smith GM, McVerry BA, Cooper EH. HIV infection in the Edinburgh haemophiliac cohort [Letter; Comment]. Br Med J 1990; 301: 1395–6.
  • Moss AR, Bacchetti P, Osmond D, Krampf W, Chaisson RE, Stites D, et al. Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort. Br Med J (Clin Res Ed) 1988; 296: 745–50.
  • Mocroft A, Johnson MA, Sabin CA, Bofill M, Janossy G, Phillips AN. The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals. Epidemiol Infect 1997; 118: 259–66.
  • Sabin CA, Phillips AN, Lee CA, Elford J, Timms A, Bofill M, Janossy G. Beta-2 microglobulin as a predictor of prognosis in HIV-infected men with haemophilia: a proposed strategy for use in clinical care. Br J Haematol 1994; 86: 366–71.
  • Shi M, Taylor JM, Fahey JL, Hoover DR, Munoz A, Kingsley LA. Early levels of CD4, neopterin, and beta 2-microglobulin indicate future disease progression. J Clin Immunol 1997; 17: 43–52.
  • Yong FH, Taylor JM, Bryant JL, Chmiel JS, Gange SJ, Hoover D. Dependence of the hazard of AIDS on markers. AIDS 1997; 11: 217–28.
  • Zabay JM, Sempere JM, Benito JM, Gonzalez B, Obregon E, Diez J, Fernandez-Cruz E. Serum beta 2-microglobulin and prediction of progression to AIDS in HIV-infected injection drug users. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 8: 266–72.
  • Fahey JL, Taylor JM, Detels R, Hofmann B, Melmed R, Nishanian P, Giorgi JV. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 1990; 322: 166–72.
  • Schwartlander B, Bek B, Skarabis H, Koch J, Burkowitz J, Koch MA. Improvement of the predictive value of CD4+ lymphocyte count by beta 2-microglobulin, immunoglobulin A and erythrocyte sedimentation rate. The Multicentre Cohort Study Group. AIDS 1993; 7: 813–21.
  • Kerlikowske KM, Katz MH, Allen S, Wolf W, Hudes ES, Karita E, et al. Beta 2-microglobulin as a predictor of death in HIV-infected women from Kigali, Rwanda. AIDS 1994; 8: 963–9.
  • Coates RA, Farewell VT, Raboud J, Read SE, Klein M, MacFadden DK, et al. Using serial observations to identify predictors of progression to AIDS in the Toronto Sexual Contact Study. J Clin Epidemiol 1992; 45: 245–53.
  • Gafa S, Giudici MG, Pezzotti P, Rezza G. IgA as a marker of clinical progression among HIV-seropositive intravenous drug users. J Infect 1993; 26: 33–8.
  • Phillips AN, Sabin CA, Elford J, Bofill M, Lee CA, Janossy G. CD8 lymphocyte counts and serum immunoglobulin A levels early in HIV infection as predictors of CD4 lymphocyte depletion during 8 years of follow-up. AIDS 1993; 7: 975–80.
  • Alcabes P, Selwyn PA, Davenny K, Hartel D, Buono D, Schoenbaum EE, et al. Laboratory markers and the risk of developing HIV-1 disease among injecting drug users [published erratum appears in AIDS 1994 Apr; 8(4): following 565]. AIDS 1994; 8: 107–15.
  • Munoz A, Vlahov D, Solomon L, Margolick JB, Bareta JC, Cohn S, et al. Prognostic indicators for development of AIDS among intravenous drug users. J Acquir Immune Defic Syndr 1992; 5: 694–700.
  • Sabin CA, Devereux H, Phillips AN, Janossy G, Loveday C, Lee CA. Immune markers and viral load after HIV-1 seroconversion as predictors of disease progression in a cohort of haemophilic men. AIDS 1998; 12: 1347–52.
  • Fernandez-Cruz E, Desco M, Garcia MM, Longo N, Gonzalez B, Zabay JM. Immunological and serological markers predictive of progression to AIDS in a cohort of HIV-infected drug users. AIDS 1990; 4: 987–94.
  • Hofmann B, Wang YX, Cumberland WG, Detels R, Bozorgmehri M, Fahey JL. Serum beta 2-microglobulin level increases in HIV infection: relation to seroconversion, CD4 T-cell fall and prognosis. AIDS 1990; 4: 207–14.
  • Ashton LJ, Carr A, Cunningham PH, Roggensack M, McLean K, Law M, et al. Predictors of progression in long-term nonprogressors. Australian Long-Term Nonprogressor Study Group. AIDS Res Hum Retroviruses 1998; 14: 117–21.
  • Verhofstede C, Reniers S, Wanzeele F, Plum J. Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease. AIDS 1994; 8: 1421–7.
  • Lafeuillade A, Tamalet C, Pellegrino P, Micco P, Vignoli C, Quilichini R. Correlation between surrogate markers, viral load, and disease progression in HIV-1 infection. J Acquir Immune Defic Syndr 1994; 7: 1028–33.
  • Ullum H, Gøtzsche PC, Victor J, Dickmeiss E, Skinhøj P, Pedersen BK. Defective natural immunity – an early manifestation of human immunodeficiency virus infection. J Exp Med 1995; 182: 789–800.
  • Cozzi Lepri A, Katzenstein T, Ullum H, Gerstoft J, Phillips AN, Skinhøj P, Pedersen BK. The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection. AIDS 1998; 12: 1639–43.
  • Jacobson MA, Abrams DI, Volberding PA, Bacchetti P, Wilber J, Chaisson RE, et al. Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine. J Infect Dis 1989; 159: 1029–36.
  • Mastroianni CM, Paoletti F, Vullo V, Delia S, Sorice F. Serum beta 2-M in asymptomatic HIV-infected patients treated with zidovudine (Letter). AIDS 1990; 4: 1297.
  • Reddy MM, McKinley G, Englard A, Grieco MH. Effect of azidothymidine (AZT) on HIV P24 antigen, beta 2-microglobulin, neopterin, soluble CD8, soluble interleukin-2 receptor and tumor necrosis factor alpha levels in patients with AIDS-related complex or AIDS. Int J Immunopharmacol 1990; 12: 737–41.
  • Bass HZ, Hardy WD, Mitsuyasu RT, Taylor JM, Wang YX, Fischl MA, et al. The effect of zidovudine treatment on serum neopterin and beta 2-microglobulin levels in mildly symptomatic, HIV type 1 seropositive individuals. J Acquir Immune Defic Syndr 1992; 5: 215–21.
  • Swanson CE, Tindall B, Cooper DA. Efficacy of zidovudine treatment in homosexual men with AIDS-related complex: factors influencing development of AIDS, survival and drug intolerance. Australian Zidovudine Study Group. AIDS 1994; 8: 625–34.
  • Mocroft A, Bofill M, Lipman M, Medina E, Borthwick N, Timms A, et al. CD8+, CD38+ lymphocyte percent: a useful immunological marker for monitoring HIV-1-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 14: 158–62.
  • Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, Giorgi JV. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 16: 83–92.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.