Human Granulocytic Ehrlichiosis as a Common Cause of Tick-associated Fever in Southeast Sweden: Report from a Prospective Clinical Study

References

• Anderson BE, Greene CE, Jones DC, Dawson JE. Ehrlichia ewingii sp. nov., the etiologic agent of canine granulocytic ehrlichiosis. Int J Syst Bacteriol 1992; 42: 299–302.
   PubMedGoogle Scholar
• Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE. Site-specific geographic association between Amblyomma americanum (Acari: Ixodidae) infestations and Ehrlichia chaffeensis-reactive (Rickettsiales: Ehrlichieae) antibodies in whitetailed deer. J Med Entomol 1996; 33: 153–8.
   PubMed Web of Science ®Google Scholar
• Buller RS, Arens M, Hmiel SP, et al. Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. N Engl J Med 1999; 341: 148–55.
   PubMed Web of Science ®Google Scholar
• Standaert SM, Yu T, Scott MA, et al. Primary isolation of Ehrlichia chaffeensis from patients with febrile illnesses: clinical and molecular characteristics. J Infect Dis 2000; 181: 1082–8.
   PubMed Web of Science ®Google Scholar
• Pancholi P, Kolbert CP, Mitchell PD, et al. Ixodes dammini as a potential vector of human granulocytic ehrlichiosis. J Infect Dis 1995; 172: 1007–12.
   PubMed Web of Science ®Google Scholar
• von Stedingk LV, Gürtelschmid M, Hanson HS, et al. The human granulocytic ehrlichiosis (HGE) agent in Swedish ticks. Clin Microbiol Infect 1997; 3: 573–4.
   PubMedGoogle Scholar
• Varde S, Beckley J, Schwartz I. Prevalence of tick-borne pathogens in Ixodes scapularis in a rural New Jersey county. Emerg Infect Dis 1998; 4: 97–9.
   Google Scholar
• Chen SM, Dumler JS, Bakken JS, Walker DH. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J Clin Microbiol 1994; 32: 589–95.
   PubMed Web of Science ®Google Scholar
• Anderson BE, Dawson JE, Jones DC, Wilson KH. Ehrlichia chaffeensis, a new species associated with human ehrlichiosis. J Clin Microbiol 1991; 29: 2838–42.
   PubMed Web of Science ®Google Scholar
• Overås J. Tick-borne fever (sjodogg). Som årsak til abort hos sau. Nord Vet Med 1959; 11: 475–82 (in Norwegian, with a summary in English).
   Google Scholar
• Tuomi J. Studies in epidemiology of bovine tick-borne fever in Finland and a clinical description of field cases. Ann Med Exp Biol Fenn 1966; 44 (Suppl 6): 1–62.
   PubMedGoogle Scholar
• Bjöersdorff A, Christenson D, Johnsson A, et al. Granulocytic ehrlichiosis in the horse–the first verified cases in Sweden. Svensk Veterinärtidning 1990; 42: 357–60 (in Swedish, with a summary in English).
   Google Scholar
• Egenvall A, Hedhammar Å, Bjöersdorff A. Clinical features and serology of 14 dogs affected by granulocytic ehrlichiosis in Sweden. Vet Rec 1997; 140: 222–6.
   Google Scholar
• Bakken JS, Dumler SJ, Chen SM, et al. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 1994; 272: 212–8.
   PubMed Web of Science ®Google Scholar
• Petrovec M, Furlan SL, Zupanc TA, et al. Human disease in Europe caused by a granulocytic Ehrlichia species. J Clin Microbiol 1997; 35: 1556–9.
   PubMed Web of Science ®Google Scholar
• Lotric-Furlan S, Petrovec M, Zupanc TA, et al. Human granulocytic ehrlichiosis in Europe: clinical and laboratory findings for four patients from Slovenia. Clin Infect Dis 1998; 27: 424–8.
   Google Scholar
• Bjöersdorff A, Berglund J, Kristiansen BE, et al. Variable presentation and course in human granulocytic ehrlichiosis; 12 case reports of the new tick-borne zoonosis. Läkartidningen 1999; 96: 4200–4 (in Swedish, with a summary in English).
   Google Scholar
• van Dobbenburgh A, van Dam AP, Fikrig E. Human granulocytic ehrlichiosis in western Europe [letter]. N Engl J Med 1999; 340: 1214–6.
   PubMed Web of Science ®Google Scholar
• Karlsson U, Bjöersdorff A, Massung RF, Christensson B. Human granulocytic ehrlichiosis – a clinical case in Scandinavia. Scand J Infect Dis 2001; 33: 73–4.
   PubMedGoogle Scholar
• Sumption KJ, Wright DJ, Cutler SJ, Dale BA. Human ehrlichiosis in the UK [letter]. Lancet 1995; 346: 1487–8.
   PubMed Web of Science ®Google Scholar
• Bakken JS, Krueth J, Tilden RL, et al. Serological evidence of human granulocytic ehrlichiosis in Norway. Eur J Clin Microbiol Infect Dis 1996; 15: 829–32.
   PubMed Web of Science ®Google Scholar
• Fingerle V, Goodman JL, Johnson RC, et al. Human granulocytic ehrlichiosis in southern Germany: increased seroprevalence in high risk groups. J Clin Microbiol 1997; 35: 3244–7.
   PubMed Web of Science ®Google Scholar
• Dumler SJ, Dotevall L, Gustafson R, Granström M. A population-based seroepidemiologic study of human granulocytic ehrlichiosis and Lyme borreliosis on the west coast of Sweden. J Infect Dis 1997; 175: 720–2.
   Google Scholar
• Pusterla N, Weber R, Wolfensberger C, et al. Serological evidence of human granulocytic ehrlichiosis in Switzerland. Eur J Clin Microbiol Infect Dis 1998; 17: 207–9.
   PubMed Web of Science ®Google Scholar
• Lebech AM, Hansen K, Pancholi P, et al. Immunoserologic evidence of human granulocytic ehrlichiosis in Danish patients with Lyme neuroborreliosis. Scand J Infect Dis 1998; 30: 173–6.
   PubMedGoogle Scholar
• Seroprevalence of ehrlichiosis in south Estonia. First Congress of the European Society for Emerging Infections, Budapest, Hungary, 1998.
   Google Scholar
• Bjöersdorff A, Brouqui P, Eliasson I, et al. Serological evidence of Ehrlichia infection in Swedish Lyme borreliosis patients. Scand J Infect Dis 1999; 31: 51–5.
   Google Scholar
• Christova IS, Dumler SJ. Human granulocytic ehrlichiosis in Bulgaria. Am J Trop Med Hyg 1999; 60: 58–61.
   PubMed Web of Science ®Google Scholar
• Dumler SJ, Bakken JS, Mitchell PD, et al. Human granulocytic ehrlichiosis (HGE), Lyme disease, and babesiosis in the upper midwest: Evidence for concurrent infections. 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1995, San Francisco, CA, 1995.
   Google Scholar
• Mitchell PD, Reed KD, Hofkes JM. Immunoserologic evidence of coinfection with Borrelia burgdorferi, Babesia microti, and human granulocytic Ehrlichia species in residents of Wisconsin and Minnesota. J Clin Microbiol 1996; 34: 724–7.
   Google Scholar
• Nadelman RB, Horowitz HW, Hsieh T, et al. Simultaneous human granulocytic ehrlichiosis and Lyme borreliosis. N Engl J Med 1997; 337: 27–30.
   PubMed Web of Science ®Google Scholar
• Belongia EA, Reed KD, Mitchell PD, et al. Clinical and epidemiological features of early Lyme disease and human granulocytic ehrlichiosis in Wisconsin. Clin Infect Dis 1999; 29: 1472–7.
   PubMed Web of Science ®Google Scholar
• Levin ML, Fish D. Acquisition of coinfection and simultaneous transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis ticks. Infect Immun 2000; 68: 2183–6.
   PubMed Web of Science ®Google Scholar
• Centers For Disease Control and Prevention. Case definitions for infectious conditions under public health surveillance. MMWR Morb Mortal Wkly Rep 1997; 46 (RR-10): 46–7.
   Google Scholar
• Ristic M, Huxsoll DL, Weisiger RM, et al. Serological diagnosis of tropical canine pancytopenia by indirect immunofluorescence. Infect Immun 1972; 6: 226–31.
   PubMed Web of Science ®Google Scholar
• Massung RF, Slater K, Owens JH, et al. Nested PCR assay for detection of granulocytic Ehrlichiae. J Clin Microbiol 1998; 36: 1090–5.
   PubMed Web of Science ®Google Scholar
• Devereux J, Haeberli P, Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucl Acids Res 1984; 12: 387–95.
   PubMed Web of Science ®Google Scholar
• Dear S, Staden R. A sequence assembly and editing program for efficient management of large projects. Nucl Acids Res 1991; 19: 3907–11.
   PubMed Web of Science ®Google Scholar
• Bjöersdorff A, Svendenius L, Owens JH, Massung RF. Feline granulocytic ehrlichiosis – a report of a new clinical entity and characterisation of the infectious agent. J Small Anim Pract 1999; 40: 20–4.
   Google Scholar
• Engvall EO, Pettersson B, Persson M, et al. A 16S rRNA-based PCR assay for detection and identification of granulocytic Ehrlichia species in dogs, horses, and cattle. J Clin Microbiol 1996; 34: 2170–4.
   PubMed Web of Science ®Google Scholar
• Johansson KE, Pettersson B, Uhlen M, et al. Identification of the causative agent of granulocytic ehrlichiosis in Swedish dogs and horses by direct solid phase sequencing of PCR products from the 16S rRNA gene. Res Vet Sci 1995; 58: 109–12.
   PubMed Web of Science ®Google Scholar
• Bakken JS, Krueth J, Wilson-Nordskog C, et al. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 1996; 275: 199–205.
   Google Scholar
• Longhofer SL. Chemotherapy of rickettsial, protozoal and chlamydial diseases. Vet Clin North Am Small Anim Pract 1988; 18: 1183–96.
   PubMed Web of Science ®Google Scholar
• Aguero-Rosenfeld ME, Horowitz HW, Wormser GP, et al. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann Intern Med 1996; 125: 904–8.
   Google Scholar
• Foley JE, Crawford-Miksza L, Dumler JS, et al. Human granulocytic ehrlichiosis in Northern California: two case descriptions with genetic analysis of the Ehrlichiae. Clin Infect Dis 1999; 29: 388–92.
   PubMed Web of Science ®Google Scholar
• Horowitz HW, Hsieh TC, Aguero-Rosenfeld ME, et al. Antimicrobial susceptibility of Ehrlichia phagocytophila. Antimicrob Agents Chemother 2001; 45: 786–8.
   PubMed Web of Science ®Google Scholar
• Lotric-Furlan S, Petrovec M, Avsic-Zupanc T, Strle F. Clinical distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. J Infect 2000; 40: 55–8.
   Google Scholar
• Haglund M. Tick-borne encephalitis – prognosis, immunization and virus strain characterization. Stockholm, Sweden: Karolinska Institutet, 2000.
   Google Scholar
• Lotric-Furlan S, Petrovec M, Avsic-Zupanc T, Strle F. Ehrlichia antibodies, leukopenia and thrombocytopenia in initial phase of tick-borne encephalitis. Infection 1998; 26: 253.
   Google Scholar