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Original Article

Effect of high dose oral zinc in mice with severe infection with Streptococcus pneumoniae

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Pages 363-367 | Received 30 Sep 2007, Published online: 08 Jul 2009

References

  • Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ. Zinc: health effects and research priorities for the 1990s. Environ Health Perspect 1994; 2: 5–46
  • Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68(Suppl 2)S447–63
  • Beisel WR. Zinc metabolism in infection. Zinc metabolism: current aspects in health and disease, GJ Brewer, AS Prasad. Alan R Liss, New York 1977; 973–7
  • Schroeder JJ, Cousins RJ. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc Natl Acad Sci U S A 1990; 87: 3137–41
  • Strand TA, Adhikari RK, Chandyo RK, Sharma PR, Sommerfelt H. Predictors of plasma zinc concentrations in children with acute diarrhoea. Am J Clin Nutr 2004; 79: 451–6
  • Bhandari N, Bahl R, Taneja S, Strand T, Molbak K, Ulvik RJ, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 y: randomized controlled trial in an urban slum. Br Med J 2002; 324: 1358
  • Bhandari N, Bahl R, Taneja S, Strand T, Molbak K, Ulvik RJ, et al. Substantial reduction in severe diarrhoeal morbidity by daily zinc supplementation in young north Indian children. Pediatrics 2002; 109: 86
  • Sazawal S, Black RE, Bhan MK, Jalla S, Sinha A, Bhandari N. Efficacy of zinc supplementation in reducing the incidence and prevalence of acute diarrhoea: a community based, double-blind, controlled trial. Am J Clin Nutr 1997; 66: 413–8
  • Bhandari N, Bahl R, Taneja S, Strand T, Molbak K, Ulvik RJ, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 y: randomized controlled trial in an urban slum. Br Med J 2002; 324: 1358
  • Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, et al. Prevention of diarrhoea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. J Pediatr 1999; 135: 689–97
  • Bahl R, Bhandari N, Saksena M, Strand T, Kumar GT, Bhan MK, et al. Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhoea. J Pediatr 2002; 141: 677–82
  • Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al. Therapeutic effects of oral zinc in acute and persistent diarrhoea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr. 2000; 72: 1516–22
  • Strand TA, Chandyo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, et al. Effectiveness and efficacy of zinc for the treatment of acute diarrhoea in young children. Pediatrics 2002; 109: 898–903
  • Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, Vaughan JP. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomized trial. Br Med J 2002; 325: 1059
  • Brooks WA, Yunus M, Santosham M, Wahed MA, Nahar K, Yeasmin S, et al. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 2004; 363: 1683–8
  • Bose A, Coles CL, Gunavathi, John H, Moses P, Raghupathy P, , et al Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old. Am J Clin Nutr 2006;83:1089–96; quiz 1207.
  • Doherty CP, Sarkar MA, Shakur MS, Ling SC, Elton RA, Cutting WA. Zinc and rehabilitation from severe protein-energy malnutrition: higher-dose regimens are associated with increased mortality. Am J Clin Nutr 1998; 68: 742–8
  • Braunschweig CL, Sowers M, Kovacevich DS, Hill GM, August DA. Parenteral zinc supplementation in adult humans during the acute phase response increases the febrile response. J Nutr 1997; 127: 70–4
  • Strand TA, Briles DE, Gjessing HK, Maage A, Bhan MK, Sommerfelt H. Pneumococcal pulmonary infection, septicaemia and survival in young zinc-depleted mice. Br J Nutr 2001; 86: 301–6
  • Briles DE, Hollingshead SK, Paton JC, Ades EW, Novak L, van Ginkel FW, Benjamin WH, Jr. J Infect Dis 2003;188:339.
  • Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am J Clin Nutr 2004; 79: 430–6
  • Mahalanabis D, Chowdhury A, Jana S, Bhattacharya MK, Chakrabarti MK, Wahed MA, Khaled MA. Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial. Am J Clin Nutr 2002; 76: 604–7
  • Brooks WA, Santosham M, Naheed A, Goswami D, Wahed MA, Diener-West M, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 y in an urban, low-income population in Bangladesh: randomized controlled trial. Lancet 2005; 366: 999–1004
  • Bergeron Y, Oellet N, Deslauriers AM, Simard M, Oliver M, Bergeron MG, et al. Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice. Infect Immun 1998; 66: 912–22
  • Doherty CP, Weaver LT, Prentice AM. Micronutrient supplementation and infection: a double-edged sword?. J Pediatr Gastroenterol Nutr 2002; 34: 346–52
  • Fraker PJ, Haas SM, Luecke RW. Effect of zinc deficiency on the immune response of the young adult A/J mouse. J Nutr 1977; 107: 1889–95
  • Benton KA, Everson MP, Briles DE. A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteraemia rather than acute sepsis in mice. Infect Immun 1995; 63: 448–55
  • Briles DE, Ades E, Paton JC, Sampson JS, Carlone GM, Huebner RC, et al. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect Immun 2000; 68: 796–800
  • Strand TA, Hollingshead SK, Julshamn K, Briles DE, Blomberg B, Sommerfelt H. Effects of zinc deficiency and pneumococcal surface protein a immunization on zinc status and the risk of severe infection in mice. Infect Immun 2003; 71: 2009–13

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