Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 21
572
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Improved Synthesis of Valsartan via Nucleophilic Aromatic Substitution on Aryloxazoline

, , &
Pages 3880-3887 | Received 12 Nov 2008, Published online: 07 Oct 2009

REFERENCES

  • Duncia , J. V. ; Chiu , A. T. ; Carini , D. J. ; Gregory , G. B. ; Johnson , A. L. ; Price , W. A. ; Wells , G. J. ; Wong , P. C. ; Calabrese , J. C. ; Timmermans , P. B. M. W. M. The discovery of potent nonpeptide angiotensin II receptor antagonists: A new class of potent antihypertensives . J. Med. Chem. 1990 , 33 , 1312 .
  • Wyvratt , M. J. ; Patchett , A. A. Recent developments in the design of angiotensin-converting enzyme inhibitors . Med. Res. Rev. 1985 , 5 , 483 .
  • Bühlmayer , P. ; Furet , P. ; Criscione , L. ; de Gasparo , M. ; Whitebread , S. ; Chmidlin , T. ; Lattmann , R. Wood. Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series . J. Bioorg. Med. Chem. Lett. 1994 , 4 , 29 .
  • Carini , D. ; Duncia , J. ; Aldrich , P. ; Chiu , A. ; Johnson , A. ; Pierce , M. ; Price , W. ; Santella , III, J. ; Wells , G. ; Wexler , R. ; Wong , P. ; Yoo , S. E. ; Timmermans , P. Nonpeptide angiotensin II receptor antagonist: The discovery of a series of N-(biphenyl methyl)imidazoles as potent, orally active antihypertensives . J. Med. Chem. 1991 , 34 , 2525 – 2547 .
  • Negishi , E. ; King , A. O. ; Okukado , N. Selective carbon–carbon bond formation via transition metal catalysis, 3: A highly selective synthesis of unsymmetrical biaryls and diarylmethanes by the nickel- or palladium-catalyzed reaction of aryl- and benzylinic derivatives with aryl halides . J. Org. Chem. 1977 , 42 , 1821 – 1823 .
  • Fanta , P. E. The Ullmann synthesis of biaryls, 1945–1963 . Chem. Rev. 1964 , 64 , 613 – 632 .
  • Miyaura , N. ; Suzuki , A. Palladium-catalyzed cross-coupling reactions of organoboron compounds . Chem. Rev. 1995 , 95 , 2457 – 2483 .
  • Martins , C. I. ; Coelho , P. J. ; Carvalho , L. M. ; Oliveira-Campos , A. M. F. ; Samat , A. ; Guglielmetti , R. Photochromic properties of new benzoindene-fused 2H-chromenes . Helv. Chim. Acta 2003 , 86 , 570 – 578 .
  • Goossen , L. J. ; Melzer , B. Synthesis of valsartan via decarboxylative biaryl coupling . J. Org. Chem. 2007 , 72 , 7473 – 7476 .
  • Rizzacasa , M. A. ; Sargent , M. V. Synthetic approaches to the napthyl-isoquinoline alkaloids, part 1: Dehydroancistrocladisine . J. Chem. Soc., Perkin Trans. 1 1991 , 840 – 844 .
  • Dordor , I. M. ; Mellor , J. M. ; Kennewell , P. D. Reaction of oxazolines with phosphorous oxychloride . J. Chem. Soc., Perkin Trans. 1 1984 , 1253 – 1258 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.