Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 17
179
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of N-Substituted Carbonylamino-1,2,3,6-tetrahydropyridines as Potential Anti-Inflammatory Agents

, , &
Pages 2615-2623 | Received 03 Mar 2010, Published online: 29 Jun 2011

REFERENCES

  • Merriam-Webster Online Medical Dictionary ; Merriam Webster Inc. , http://www.merriam-webster.com/medical/inflammation (accessed February 15, 2010) .
  • Vane , J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs . Nature New Biol. 1971 , 231 , 232 – 235 .
  • Smith , J. B. ; Willis , A. L. Aspirin selectively inhibits prostaglandin production in human platelets . Nature New Biol. 1971 , 231 , 235 – 237 .
  • Lombardino , J. G. Nonsteroidal Antiinflammatory Drugs, , 1st ed. ; John Wiley & Son, Inc. : New York , 1985 .
  • Williams , D. A. ; Lemke , T. L. Foye's Principles of Medicinal Chemistry, ; , 6th ed. Lippincott Williams & Wilkins : Philadelphia , 2008 ; p. 459 .
  • Redda , K. K. ; Kode , R. N. ; Heiman , A. S. ; Melles , H. Synthesis and pharmacological evaluation of some N-[pyridyl(phenyl)carbonylamino]methyl-1,2,3,6-tetrahydropyridines . J. Pharm. Sci. 1992 , 81 ( 5 ), 463 – 466 .
  • Mateeva , N. N. , Winfield , L. L. , Redda , K. K. The chemistry and pharmacology of tetrahydropyridines . Curr. Med. Chem. 2005 , 12 ( 5 ), 551 – 571 .
  • Redda , K. K. ; Corleto , L. A. ; Knaus , E. E. Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and anti-inflammatory activity . J. Med. Chem. 1979 , 22 ( 9 ), 1079 – 1082 .
  • Kode , N. R. ; Redda , K. K. ; Onayemi , F. Y. ; Melles , H. ; Choi , J. O. Synthesis of some N-[pyridyl(phenyl)carbonylamino]-hydroxyalkyl(benzyl)-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents. J. Heterocycl. Chem. 1995, 32(1), 307–315.
  • Redda , K. K. ; Kode , N. R. ; Heiman , A. S. ; Onayemi , F. Y. ; Clark , J. B. Synthesis and anti-inflammatory activities of some N-[pyridyl(phenyl)carbonylamino]-tert-butyl/phenyl-1,2,3,6- tetrahydropyridines . Chem. Pharm. Bull. 1991 , 39 ( 3 ), 786 – 791 .
  • Mochona , B. ; Wilson , T. ; Redda , K. Synthesis and anti-inflammatory activities of N-benzoylamino-1,2,3,6-tetrahydropyridine analogs . Drugs Exp. Clin. Res. 2003 , 29 ( 4 ), 131 – 140 .
  • Okoro , C. O. ; Wilson , T. L. ; Redda , K. K. Conformational analysis and molecular properties of N-(substituted phenyl carbonylamino)-4-(1-hydroxymethylphenyl)-1,2,3,6-tetrahydropyridines . Curr. Med. Chem. 2003 , 10 ( 4 ), 313 – 320 .
  • Yoon , K. ; Soliman , K. ; Redda , K. Inhibitory effects of N-(substituted benzoylamino)-4-ethyl-1,2,3,6-tetrahydropyridines on nitric oxide generation in stimulated raw 264.7 macrophages . Drugs Exp Clin Res. 2002 , 28 ( 2–3 ), 83 – 90 .
  • Choi , J. ; Wilson , T. L. ; Ly , A. M. ; Okoro , C. O. ; Onubogu , U. C. ; Redda , K. K. Synthesis of some N-(phenylsulfonylamino)-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents . Med. Chem. Res. 1995 , 5 , 281 – 295 .
  • Wilson , T. L. ; Redda , K. K. Synthesis and anti-inflammatory activity determinations of some N-[substituted benzoyl (phenylsulfonyl) amino]-5-Ethyl-1,2,3-tetrahydropyridines . Med. Chem. Res. 2003 , 12 ( 2 ), 69 – 86 .
  • Tamura , Y. ; Minamikawa , J. ; Ikeda , M. O-Mesitylenesulfonylhydroxylamine and related Compounds—powerful aminating reagents . Synthesis 1977 , 1 , 1 – 18 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.