Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 24
944
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Practical and Economical Approach to Synthesize Sitagliptin

, &
Pages 3281-3286 | Received 04 Dec 2012, Published online: 05 Sep 2013

REFERENCES

  • Mclntosh , C. H. S. Dipeptidyl peptidase IV inhibitors and diabetes therapy . Front. Biosci. 2008 , 13 , 1753 – 1773 .
  • Kieffer , T. J. ; McIntosh , C. H. ; Pederson , R. A. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV . Endocrinology 1995 , 136 , 3585 – 3596 .
  • Farilla , L. ; Hui , H. ; Bertolotto , C. ; Kang , E. ; Bulotta , A. ; Di Mario , U. ; Perfetti , R. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in zucker diabetic rats . Endocrinology 2002 , 143 , 4397 – 4408 .
  • Hansen , K. B. ; Balsells , J. ; Dreher , S. ; Hsiao , Y. ; Kubryk , M. ; Palucki , M. ; Rivera , N. ; Steinhuebel , D. ; Armstrong III , J.D. ; Askin , D. First generation process for the preparation of the DPP-IV inhibitor sitagliptin . Org. Process Res. Dev. 2005 , 9 ( 5 ), 634 – 639 .
  • Hansen , K. B. ; Hsiao , Y. ; Xu , F. ; Rivera , N. ; Clausen , A. ; Kubryk , M. ; Krska , S. ; Rosner , T. ; Simmons , B. ; Balsells , J. Highly efficient asymmetric synthesis of sitagliptin . J. Am. Chem. Soc. 2009 , 131 ( 25 ), 8798 – 8804 .
  • Steinhuebel , D. ; Sun , Y. ; Matsumura , K. ; Sayo , N. ; Saito , T. Direct asymmetric reductive amination . J. Am. Chem. Soc. 2009 , 131 ( 32 ), 11316 – 11317 .
  • Dreher , S. ; Ikemoto , N. ; Njolito , E. Process to chiral β-amino acid derivatives. WO patent 2004085661, 2004 .
  • Reddy , P. P. ; Babu , I. ; Srinivas , P. ; Shailaja , P. ; Kavitha , N. ; Anand , R. V. ; Reddy , V. R. Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof. WO patent 2009085990, 2008 .
  • Balsells , J. ; Hsiao , Y. ; Hansen , K. B. ; Xu , F. ; Ikemoto , N. ; Clausen , A. ; Armstrong , J. D. Synthesis of sitagliptin, the active ingredient in januvia and janumet . Green Chem. Pharm. Ind. 2010 , 101 – 126 .
  • Jona , H. ; Shibata , J. ; Asai , M. ; Goto , Y. ; Arai , S. ; Nakajima , S. ; Okamoto , O. ; Kawamoto , H. ; Iwasawa , Y. Efficient and practical asymmetric synthesis of 1-tert-butyl-3-methyl-(3R,4R)-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1,3-dicarboxylate, a useful intermediate for the synthesis of nociception antagonists . Tetrahedron: Asymmetry 2009 , 20 ( 21 ), 2439 – 2446 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.