References
- AlFadly, E. D.; Elzahhar, P. A.; Tramarin, A.; Elkazaz, S.; Shaltout, H.; Abu-Serie, M. M.; Janockova, J.; Soukup, O.; Ghareeb, D. A.; El-Yazbi, A. F.; et al. Tackling Neuroinflammation and Cholinergic Deficit in Alzheimer's Disease: Multi-Target Inhibitors of Cholinesterases, Cyclooxygenase-2 and 15-Lipoxygenase. Eur. J. Med. Chem. 2019, 167, 161–186. DOI: https://doi.org/10.1016/j.ejmech.2019.02.012.
- Saxena, M.; Dubey, R. Target Enzyme in Alzheimer’s Disease: Acetylcholinesterase Inhibitors. Curr. Top. Med. Chem. 2019, 19, 264–275. DOI: https://doi.org/10.2174/1568026619666190128125912.
- Mohamed, L. W.; Abuel-Maaty, S. M.; Mohammed, W. A.; Galal, M. A. Synthesis and Biological Evaluation of New Oxopyrrolidine Derivatives as Inhibitors of Acetyl Cholinesterase and β Amyloid Protein as anti – Alzheimer’s agents. Bioorg. Chem. 2018, 76, 210–217. DOI: https://doi.org/10.1016/j.bioorg.2017.11.008.
- Liu, W.; Lang, M.; Youdim, M. B.; Amit, T.; Sun, Y.; Zhang, Z.; Wang, Y.; Weinreb, O. Design, Synthesis and Evaluation of Novel Dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer’s disease. Neuropharmacology. 2016, 109, 376–385. DOI: https://doi.org/10.1016/j.neuropharm.2016.06.013.
- Kumar, A.; Singh, A. A Review on Alzheimer’s Disease Pathophysiology and Its Management: An Update. Pharmacol. Rep. 2015, 67, 195–203. DOI: https://doi.org/10.1016/j.pharep.2014.09.004.
- Trujillo-Ferrara, J.; Montoya Cano, L.; Espinoza-Fonseca, M. Synthesis, Anticholinesterase Activity and Structure–Activity Relationships of m-Aminobenzoic Acid Derivatives. Bioorg. Med. Chem. Lett. 2003, 13, 1825–1827. DOI: https://doi.org/10.1016/S0960-894X(03)00198-7.
- Terry, A. V.; Jr; Buccafusco, J. J. The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development. J. Pharmacol. Exp. Ther. 2003, 306, 821–827. DOI: https://doi.org/10.1124/jpet.102.041616.
- Hardy, J. The Amyloid Hypothesis for Alzheimer’s disease: A Critical Reappraisal. J. Neurochem. 2009, 110, 1129–1134. DOI: https://doi.org/10.1111/j.1471-4159.2009.06181.x.
- Webber, K. M.; Raina, A. K.; Marlatt, M. W.; Zhu, X.; Prat, M. I.; Morelli, L.; Casadesus, G.; Perry, G.; Smith, M. A. The Cell Cycle in Alzheimer Disease: A Unique Target for Neuropharmacology. Mech Ageing Dev. 2005, 126, 1019–1025. DOI: https://doi.org/10.1016/j.mad.2005.03.024.
- Weinstock, M.; Groner, E. Rational Design of a Drug for Alzheimer’s Disease with Cholinesterase Inhibitory and Neuroprotective Activity. Chem. Biol. Interact. 2008, 175, 216–221. DOI: https://doi.org/10.1016/j.cbi.2008.03.014.
- Cummings, J. L.; Doody, R.; Clark, C. Disease-modifying therapies for Alzheimer Disease: Challenges To Early Intervention. Neurology 2007, 69, 1622–1634. DOI: https://doi.org/10.1212/01.wnl.0000295996.54210.69.
- Rodda, J.; Carter, J. Cholinesterase Inhibitors and Memantine for Symptomatic Treatment of Dementia. BMJ. 2012, 344, e2986. DOI: https://doi.org/10.1136/bmj.e2986.
- Więckowska, A.; Kołaczkowski, M.; Bucki, A.; Godyń, J.; Marcinkowska, M.; Więckowski, K.; Zaręba, P.; Siwek, A.; Kazek, G.; Głuch-Lutwin, M.; et al. Novel multi-target-directed ligands for Alzheimer’ Disease: Combining Cholinesterase Inhibitors and 5-HT6 Receptor Antagonists. Design, Synthesis and Biological Evaluation. Eur. J. Med. Chem. 2016, 124, 63–81. DOI: https://doi.org/10.1016/j.ejmech.2016.08.016.
- Yurttaş, L.; Abu Mohsen, U.; Ozkan, Y.; Cobanoglu, S.; Levent, S.; Kaplancikli, Z. A. Synthesis and Biological Evaluation of Some Dibenzofuran-Piperazine Derivatives. J. Enzyme. Inhib. Med. Chem. 2016, 31, 1177–1183. DOI: https://doi.org/10.3109/14756366.2015.1108971.
- Reddy, K. I.; Srihari, K.; Renuka, J.; Sree, K. S.; Chuppala, A.; Jeankumar, V. U.; Sridevi, J. P.; Babu, K. S.; Yogeeswari, P.; Sriram, D. An Efficient Synthesis and Biological Screening of Benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition. Bioorg. Med. Chem. 2014, 22, 6552–6563. DOI: https://doi.org/10.1016/j.bmc.2014.10.016.
- Kirilmis, C.; Ahmedzade, M.; Servi, S.; Koca, M.; Kizirgil, A.; Kazaz, C. Synthesis and Antimicrobial Activity of Some Novel Derivatives of Benzofuran: Part 2. The Synthesis and Antimicrobial Activity of Some Novel 1-(1-Benzofuran-2-yl)-2-Mesitylethanone Derivatives. Eur. J. Med. Chem. 2008, 43, 300–308. DOI: https://doi.org/10.1016/j.ejmech.2007.03.023.
- Koca, M.; Servi, S.; Kirilmis, C.; Ahmedzade, M.; Kazaz, C.; Özbek, B.; Ötük, G. Synthesis and Antimicrobial Activity of Some Novel Derivatives of Benzofuran: Part 1. Synthesis and Antimicrobial Activity of (Benzofuran-2-yl)(3-Phenyl-3-Methylcyclobutyl) Ketoxime Derivatives. Eur. J. Med. Chem. 2005, 40, 1351–1358. DOI: https://doi.org/10.1016/j.ejmech.2005.07.004.
- Mekky, A. E. M.; Sanad, S. M. H. Novel Bis(Pyrazole-Benzofuran) Hybrids Possessing Piperazine Linker: Synthesis of Potent Bacterial Biofilm and MurB Inhibitors. Bioorg. Chem. 2020, 102, 104094. DOI: https://doi.org/10.1016/j.bioorg.2020.104094.
- Ma, Y.; Zheng, X.; Gao, H.; Wan, C.; Rao, G.; Mao, Z. Design, Synthesis, and Biological Evaluation of Novel Benzofuran Derivatives Bearing N-Aryl Piperazine Moiety. Molecules. 2016, 21, 1684. DOI: https://doi.org/10.3390/molecules21121684.
- Gao, H.; Zhang, X.; Pu, X. J.; Zheng, X.; Liu, B.; Rao, G. X.; Wan, C. P.; Mao, Z. W. 2-Benzoylbenzofuran Derivatives Possessing Piperazine Linker as Anticancer agents. Bioorg. Med. Chem. Lett. 2019, 29, 806–810. DOI: https://doi.org/10.1016/j.bmcl.2019.01.025.
- Mao, Z. W.; Zheng, X.; Lin, Y. P.; Hu, C. Y.; Wang, X. L.; Wan, C. P.; Rao, G. X. Design, Synthesis and Anticancer Activity of Novel Hybrid Compounds between Benzofuran and N-Aryl Piperazine. Bioorg. Med. Chem. Lett. 2016, 26, 3421–3424. DOI: https://doi.org/10.1016/j.bmcl.2016.06.055.
- Gu, Z. S.; Zhou, A. N.; Xiao, Y.; Zhang, Q. W.; Li, J. Q. Synthesis and Antidepressant-like Activity of Novel Aralkyl Piperazine Derivatives Targeting SSRI/5-HT1A/5-HT7. Eur. J. Med. Chem. 2018, 144, 701–715. DOI: https://doi.org/10.1016/j.ejmech.2017.12.063.
- Singh, M.; Jadhav, H. R.; Kumar, A. Design, Synthesis and In Vitro Evaluation of Piperazine Incorporated Novel Anticancer Agents. LDDD. 2018, 15, 866–874. DOI: https://doi.org/10.2174/1570180815666171211161501.
- Sanad, S. M. H.; Ahmed, M. S. M.; Mekky, A. E. M.; Abdallah, Z. A. Regioselective Synthesis and Theoretical Calculations of Bis(Pyrido[2′,3′:3,4]Pyrazolo[1,5-a]Pyrimidines) Linked to Benzofuran Units via Piperazine Spacer: A DFT, MM2, and MMFF94 Study. J. Mol. Struct. 2021, 1243, 130802. DOI: https://doi.org/10.1016/j.molstruc.2021.130802.
- Mekky, A. E. M.; Ahmed, M. S. M.; Sanad, S. M. H.; Abdallah, Z. A. Bis(Benzofuran-Enaminone) Hybrid Possessing Piperazine Linker: Versatile Precursor for Microwave Assisted Synthesis of Bis(Pyrido[2′,3′:3,4]Pyrazolo[1,5-a]Pyrimidines). Synth. Commun. 2021, 51, 1085–1099. DOI: https://doi.org/10.1080/00397911.2020.1867745.
- Sanad, S. M. H.; Abdel Fattah, A. M.; Attaby, F. A.; Elneairy, M. A. A. Pyridine-2(1H)-Thiones: Versatile Precursors for Novel Pyrazolo[3,4-b]Pyridine, Thieno[2,3-b]Pyridines and Their Fused Azines. J. Heterocyclic Chem. 2019, 56, 1588–1662. DOI: https://doi.org/10.1002/jhet.3444.
- Teleb, M. A. M.; Mekky, A. E. M.; Sanad, S. M. H. 3-Aminothieno[2,3-b]Pyridine-2-Carboxylate: Effective Precursor for Microwave Assisted Three Components Synthesis of New Pyrido[3',2':4,5]Thieno[3,2-d]Pyrimidin-4(3H)-One Hybrids. J. Heterocyclic Chem. 2021, 58, 1825–1835. DOI: https://doi.org/10.1002/jhet.4313.
- Sanad, S. M. H.; Abdel Fattah, A. M.; Attaby, F. A.; Elneairy, M. A. A. Utility of Pyridine-2(1H)-thiones in the Synthesis of Novel Bis-Thieno[2,3-b]pyridines and Their Fused Azines. J. Heterocyclic Chem. 2019, 56, 1588–1597. DOI: https://doi.org/10.1002/jhet.3537.
- Sanad, S. M. H.; Hawass, M. A. E.; Ahmed, A. A. M.; Elneairy, M. A. A. Efficient Synthesis and Characterization of Novel Pyrido 3′,2′:4,5]Thieno[3,2-d]Pyrimidines and Their Fused [1,2,4]Triazole Derivatives. J. Heterocyclic. Chem. 2018, 55, 2823–2833. [ DOI: https://doi.org/10.1002/jhet.3352.
- Mroueh, M.; Faour, W. H.; Shebaby, W. N.; Daher, C. F.; Ibrahim, T. M.; Ragab, H. M. Synthesis, Biological Evaluation and Modeling of Hybrids from Tetrahydro-1H-Pyrazolo[3,4-b]Quinolines as Dual Cholinestrase and COX-2 Inhibitors. Bioorg. Chem. 2020, 100, 103895. DOI: https://doi.org/10.1016/j.bioorg.2020.103895.
- Umar, T.; Shalini, S.; Raza, M. K.; Gusain, S.; Kumar, J.; Seth, P.; Tiwari, M.; Hoda, N. A Multifunctional Therapeutic Approach: Synthesis, Biological Evaluation, Crystal Structure and Molecular Docking of Diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s Disease. Eur. J. Med. Chem. 2019, 175, 2–19. DOI: https://doi.org/10.1016/j.ejmech.2019.04.038.
- do Carmo Carreiras, M.; Marco-Contelles, J. Five-Membered-Ring-Fused Tacrines as Anti-Alzheimer’s Disease Agents. Synlett. 2021, 32, 1987–2012. DOI: https://doi.org/10.1055/s-0040-1719823.
- Saeedi, M.; Safavi, M.; Allahabadi, E.; Rastegari, A.; Hariri, R.; Jafari, S.; Bukhari, S. N.; Mirfazli, S. S.; Firuzi, O.; Edraki, N.; et al. Pyridine Amines: Synthesis and Evaluation of Tacrine Analogs against Biological Activities Related to Alzheimer’s Disease. Arch. Pharm. 2020, 353, 2000101. DOI: https://doi.org/10.1002/ardp.202000101.
- Zhao, B.; Li, Y.; Xu, P.; Dai, Y.; Luo, C.; Sun, Y.; Ai, J.; Geng, M.; Duan, W. Discovery of Substituted 1H-Pyrazolo[3,4-b]Pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors. ACS Med. Chem. Lett. 2016, 7, 629–634. DOI: https://doi.org/10.1021/acsmedchemlett.6b00066.
- Witherington, J.; Bordas, V.; Gaiba, A.; Naylor, A.; Rawlings, A. D.; Slingsby, B. P.; Smith, D. G.; Takle, A. K.; Ward, R. W. 6-Heteroaryl-Pyrazolo[3,4-b]Pyridines: Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Bioorg. Med. Chem. Lett. 2003, 13, 3059–3062. DOI: https://doi.org/10.1016/S0960-894X(03)00646-2.
- El-Borai, M. A.; Rizk, H. F.; Abd-Aal, M. F.; El-Deeb, I. Y. Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities – Part 1. Eur. J. Med. Chem. 2012, 48, 92–96. DOI: https://doi.org/10.1016/j.ejmech.2011.11.038.
- Quiroga, J.; Villarreal, Y.; Gálvez, J.; Ortíz, A.; Insuasty, B.; Abonia, R.; Raimondi, M.; Zacchino, S. Synthesis and Antifungal in Vitro Evaluation of Pyrazolo[3,4-b]Pyridines Derivatives Obtained by Aza-Diels-Alder Reaction and Microwave Irradiation. Chem. Pharm. Bull. 2017, 65, 143–150. DOI: https://doi.org/10.1248/cpb.c16-00652.
- Nagender, P.; Reddy, G. M.; Kumar, R. N.; Poornachandra, Y.; Kumar, C. G.; Narsaiah, B. Synthesis, Cytotoxicity, Antimicrobial and anti-Biofilm Activities of Novel Pyrazolo[3,4-b]Pyridine and Pyrimidine Functionalized 1,2,3-Triazole Derivatives. Bioorg. Med. Chem. Lett. 2014, 24, 2905–2908. DOI: https://doi.org/10.1016/j.bmcl.2014.04.084.
- Sanad, S. M. H.; Mekky, A. E. M. 3-Aminopyrazolo[3,4-b]Pyridine: Effective Precursor for Barium Hydroxide-Mediated Three Components Synthesis of New Mono- and Bis(Pyrimidines) with Potential Cytotoxic Activity. Chem. Biodivers. 2022, 19, e202100500. DOI: https://doi.org/10.1002/cbdv.202100500.
- Dey, S.; Bajaj, S. O. Promising Anticancer Drug Thapsigargin: A Perspective toward the Total Synthesis. Synth. Commun. 2018, 48, 1–13. DOI: https://doi.org/10.1080/00397911.2017.1386789.
- Nagender, P.; Kumar, R. N.; Reddy, G. M.; Swaroop, D. K.; Poornachandra, Y.; Kumar, C. G.; Narsaiah, B. Synthesis of Novel Hydrazone and Azole Functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents. Bioorg. Med. Chem. Lett. 2016, 26, 4427–4432. DOI: https://doi.org/10.1016/j.bmcl.2016.08.006.
- Barghash, R. F.; Eldehna, W. M.; Kovalová, M.; Vojáčková, V.; Kryštof, V.; Abdel-Aziz, H. A. One-Pot Three-Component Synthesis of Novel Pyrazolo[3,4-b]Pyridines as Potent Antileukemic Agents. Eur. J. Med. Chem. 2022, 227, 113952. DOI: https://doi.org/10.1016/j.ejmech.2021.113952.
- Medeiros, A. C.; Borges, J. C.; Becker, K. M.; Rodrigues, R. F.; Leon, L. L.; Canto-Cavalheiro, M.; Bernardino, A. M.; Souza, M. C. D.; Pedrosa, L. F. Synthesis of New Conjugates 1H-Pyrazolo[3,4-b]Pyridine-Phosphoramidate and Evaluation against Leishmania amazonensis. J. Braz. Chem. Soc. 2018, 29, 159–167. DOI: https://doi.org/10.21577/0103-5053.20170126.
- Mohi El-Deen, E. M.; El-Meguid, A.; Eman, A.; Hasabelnaby, S.; Karam, E. A.; Nossier, E. S. Synthesis, Docking Studies, and in Vitro Evaluation of Some Novel Thienopyridines and Fused Thienopyridine–Quinolines as Antibacterial Agents and DNA Gyrase Inhibitors. Molecules. 2019, 24, 3650–3669. DOI: https://doi.org/10.3390/molecules24203650.
- Mohamed, M. S.; Mansour, Y. E.; Amin, H. K.; El-Araby, M. E. Molecular Modelling Insights into a Physiologically Favourable Approach to Eicosanoid Biosynthesis Inhibition through Novel thieno[2,3-b]pyridine derivatives. J. Enzyme Inhib. Med. Chem. 2018, 33, 755–767. DOI: https://doi.org/10.1080/14756366.2018.1457657.
- Sanad, S. M. H.; Mekky, A. E. M. Synthesis, Cytotoxicity and In Vitro Antibacterial Screening of Novel Hydrazones Bearing Thienopyridine Moiety as Potent COX-2 Inhibitors. J. Iran. Chem. Soc. 2020, 17, 3299–3315. DOI: https://doi.org/10.1007/s13738-020-01987-y.
- Mekky, A. E. M.; Sanad, S. M. H.; Said, A. Y.; Elneairy, M. A. A. Synthesis, Cytotoxicity, in-Vitro Antibacterial Screening and in-Silico Study of Novel Thieno[2,3-b]Pyridines as Potential Pim-1 Inhibitors. Synth. Commun. 2020, 50, 2376–2389. DOI: https://doi.org/10.1080/00397911.2020.1778033.
- Madhusudana, K.; Shireesha, B.; Naidu, V. G. M.; Ramakrishna, S.; Narsaiah, B.; Rao, A. R.; Diwan, P. V. Anti-Inflammatory Potential of Thienopyridines as Possible Alternative to NSAIDs. Eur. J. Pharmacol. 2012, 678, 48–54. DOI: https://doi.org/10.1016/j.ejphar.2011.12.019.
- Kamata, M.; Yamashita, T.; Kina, A.; Funata, M.; Mizukami, A.; Sasaki, M.; Tani, A.; Funami, M.; Amano, N.; Fukatsu, K. Design, Synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 3643–3647. DOI: https://doi.org/10.1016/j.bmcl.2012.04.047.
- Karthikeyan, C.; Malla, R.; Ashby, C. R.; Amawi, H.; Abbott, K. L.; Moore, J.; Chen, J.; Balch, C.; Lee, C.; Flannery, P. C.; et al. Pyrimido[1″,2″:1,5]Pyrazolo[3,4-b]Quinolines: Novel Compounds That Reverse ABCG2-Mediated Resistance in Cancer Cells. Cancer Lett. 2016, 376, 118–126. DOI: https://doi.org/10.1016/j.canlet.2016.03.030.
- Marcade, M.; Bourdin, J.; Loiseau, N.; Peillon, H.; Rayer, A.; Drouin, D.; Schweighoffer, F.; Désiré, L. Etazolate, a Neuroprotective Drug Linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J. Neurochem. 2008, 106, 392–404. DOI: https://doi.org/10.1111/j.1471-4159.2008.05396.x.
- Sanad, S. M. H.; Mekky, A. E. M. Novel Nicotinonitriles and Thieno[2,3-b]Pyridines as Potent Biofilm and COX-2 Inhibitors: Synthesis. In Vitro in Silico Stud. ChemistrySelect. 2020, 5, 8494–8503. DOI: https://doi.org/10.1002/slct.202001208.
- Mekky, A. E. M.; Sanad, S. M. H. Microwave Assisted Synthesis of Novel Bis(Thiazoles) Incorporating Piperazine Moiety. J. Heterocyclic Chem. 2019, 56, 1560–1566. DOI: https://doi.org/10.1002/jhet.3531.
- Mekky, A. E. M.; Sanad, S. M. H. Synthesis of Novel Bis(Chromenes) and Bis(Chromeno[3,4-c]Pyridine) Incorporating Piperazine Moiety. Synth. Commun. 2019, 49, 1385–1395. DOI: https://doi.org/10.1080/00397911.2019.1595658.
- Mekky, A. E. M.; Sanad, S. M. H.; El-Idreesy, T. T. New Thiazole and Thiazole-Chromene Hybrids Possessing Morpholine Units: Piperazine-Mediated One-Pot Synthesis of Potential Acetylcholinesterase Inhibitors. Synth. Commun. 2021, 51, 3332–3344. DOI: https://doi.org/10.1080/00397911.2021.1970774.
- Mekky, A. E. M.; Sanad, S. M. H. Synthesis and in Vitro Study of New Coumarin Derivatives Linked to Nicotinonitrile Moieties as Potential Acetylcholinesterase Inhibitors. J. Heterocyclic. Chem. 2020, 57, 4278–4290. DOI: https://doi.org/10.1002/jhet.4134.
- Sanad, S. M. H.; Mekky, A. E. M. Novel Nicotinonitrile-Coumarin Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, In Vitro and In Silico Studies. J. Iran. Chem. Soc. 2021, 18, 213–224. DOI: https://doi.org/10.1007/s13738-020-02018-6.
- Sanad, S. M. H.; Abdel Fattah, A. M.; Attaby, F. A.; Elneairy, M. A. A. Synthesis and Characterization of Novel Bis(Pyridine-2(1H)-Thiones) and Their Bis(2-Methylsulfanylpyridines) Incorporating 2,6-Dibromophenoxy Moiety. Can. J. Chem. 2019, 97, 53–60. DOI: https://doi.org/10.1139/cjc-2017-0721.
- Sanad, S. M. H.; Hefny, M. I. M.; Ahmed, A. A. M.; Elneairy, M. A. A. Synthesis of Novel Bis[(5-Cyanopyridin-6-yl)Sulfanyl]Butanes, Bis(2-S-Alkylpyridines) and Bis(3-Aminothieno[2,3-b]Pyridines) Incorporating 2,6-Dibromophenoxy Moiety. J. Heterocyclic Chem. 2018, 55, 2046–2054. DOI: https://doi.org/10.1002/jhet.3239.
- Hawass, M. A. E.; Sanad, S. M. H.; Ahmed, A. A. M.; Elneairy, M. A. A. Facile Synthesis and Characterization of Novel Bis(2-S-Alkyl-Pyridines) and Bis(3-Aminothieno[2,3-b]Pyridines) Incorporating 1,3-Diarylpyrazole Moiety. J. Sulfur. Chem. 2018, 39, 388–401. DOI: https://doi.org/10.1080/17415993.2018.1435657.
- Kulikov, A. S.; Epishina, M. A.; Zhilin, E. S.; Shuvaev, A. D.; Fershtat, L. L.; Makhova, N. N. Design and Synthesis of Pyrazolo[3,4-d]Pyridazine-5,6-Dioxides as Novel NO-Donors. Mendeleev Commun. 2021, 31, 42–45. DOI: https://doi.org/10.1016/j.mencom.2021.01.012.
- Mekky, A. E. M.; Sanad, S. M. H. Synthesis, Characterization, and Antimicrobial Evaluation of Novel Thiohydrazonates and Pyrazolo[3,4-b]Pyridines. Polycyclic. Aromat. Compd. 2021, 41, 936–949. DOI: https://doi.org/10.1080/10406638.2019.1631194.
- Sanad, S. M. H.; Mekky, A. E. M.; Said, A. Y.; Elneairy, M. A. A. New Thieno[2,3-b]Pyridine-Fused [1,2,4]Triazolo[4,3-a]Pyrimidinone Hybrids as Potential MRSA and VRE Inhibitors. Mendeleev. Commun. 2021, 31, 370–372. DOI: https://doi.org/10.1016/j.mencom.2021.04.029.
- Holden, C. M.; Greaney, M. F. Modern Aspects of the Smiles Rearrangement. Chemistry. 2017, 23, 8992–9008. DOI: https://doi.org/10.1002/chem.201700353.
- Sanad, S. M. H.; Mekky, A. E. M. Piperazine-Mediated Tandem Synthesis of Bis(Thieno[2,3-b]Pyridines): Versatile Precursors for Related Fused [1,2,4]Triazolo[4,3-a]Pyrimidines. J. Heterocyclic Chem. 2020, 57, 3142–3152. DOI: https://doi.org/10.1002/jhet.4021.
- Ellman, G. L.; Courtney, K. D.; Andres, V.; Feather-Stone, R. M. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem. Pharmacol. 1961, 7, 88–90. DOI: https://doi.org/10.1016/0006-2952(61)90145-9.
- Alipour, M.; Khoobi, M.; Foroumadi, A.; Nadri, H.; Moradi, A.; Sakhteman, A.; Ghandi, M.; Shafiee, A. Novel Coumarin Derivatives Bearing N-Benzyl Pyridinium Moiety: Potent and Dual Binding Site Acetylcholinesterase Inhibitors. Bioorg. Med. Chem. 2012, 20, 7214–7222. DOI: https://doi.org/10.1016/j.bmc.2012.08.052.
- McLellan, M. E.; Kajdasz, S. T.; Hyman, B. T.; Bacskai, B. J. In Vivo Imaging of Reactive Oxygen Species Specifically Associated with Thioflavine S-Positive Amyloid Plaques by Multiphoton Microscopy. J. Neurosci. 2003, 23, 2212–2217. DOI: https://doi.org/10.1523/JNEUROSCI.23-06-02212.2003.
- Feng, Y.; Wang, X. Antioxidant Therapies for Alzheimer’s disease. Oxid. Med. Cell. Longev. 2012, 2012, 472932. DOI: https://doi.org/10.1155/2012/472932.
- Aliev, G.; Obrenovich, M. E.; Reddy, V. P.; Shenk, J. C.; Moreira, P. I.; Nunomura, A.; Zhu, X.; Smith, M. A.; Perry, G. Antioxidant Therapy in Alzheimer’s Disease: Theory And Practice. Mini. Rev. Med. Chem. 2008, 8, 1395–1406. DOI: https://doi.org/10.2174/138955708786369582.
- Frank, B.; Gupta, S. A Review of Antioxidants and Alzheimer’s disease. Ann. Clin. Psychiatry. 2005, 17, 269–286. DOI: https://doi.org/10.3109/10401230500296428.