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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 4, 1974 - Issue 1
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Original Articles

On the Supposed Isoindole Synthesis from o-Tolunitrile

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Pages 17-19 | Received 27 Dec 1973, Published online: 05 Dec 2006

References

  • Yamada , K. , Ishihara , S. and Iida , H. 1973 . Synth. Commun. , 3 : 181
  • Okano , T. , Goya , S. and Tsuda , Y. 1966 . J. Pharm. Soc. Jap. , 86 : 544
  • Berti , G. and Corti , P. 1959 . Ann. Chim. (Rome) , 49 : 2111
  • White , J. D. and Mann , M. E. 1969 . Advan. Heterocycl. Chem. , 10 : 145
  • van der Goot , H. and Nauta , W. Th. 1972 . Chim. Therap. , 7 : 185
  • Koninklijke , N. V. Pharmaceutische Fabrieken, Neth. Appl. . 6808726. . Chem. Abstr., 71, 13034e (1969)
  • Sodium (5 mg.a.) was added at room temperature to a stirred solution of o-tolunitrile (5 mmol.) in dry tetrahydrofuran under a nitrogen atmosphere. The reaction mixture was then put under a reduced pressure of 130 Torr
  • “ If the diazotization was carried out with added stronger acid (H2SO4) and less attention to temperature control, the 4-position of the isoquinoline ring apparently underwent substitution ” .
  • Bethmann , F. 1899 . Chem. Ber. , 32 : 1104

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